TY  - JOUR
AU  - Ozakinci, Hilal
AU  - Desai, Bina
AU  - Kalos, Denise
AU  - Chen, Dung-Tsa
AU  - Henry, Menkara
AU  - Solanki, Hitendra
AU  - Boyle, Theresa A.
AU  - Trejo Bittar, Humberto E.
AU  - Nazario, Gina S.
AU  - Haura, Eric B.
AU  - Marusyk, Andriy
AU  - Pellini, Bruna
PY  - 2026
TI  - Pre-clinical efficacy of trastuzumab deruxtecan plus sotorasib in KRASG12C-mutant non-small cell lung cancer and exploratory HER2 profiling in human tumors
JF  - Translational Lung Cancer Research; Vol 15, No 4 (April 30, 2026): Translational Lung Cancer Research
Y2  - 2026
KW  - 
N2  -  KRASG12C inhibitors such as adagrasib and sotorasib have shown promise in treating KRASG12C-mutant non-small cell lung cancer (NSCLC), but treatment resistance remains a major challenge. In this study, we investigated the therapeutic potential of combining trastuzumab deruxtecan (T-DXd), an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC), with sotorasib in KRASG12C-mutant NSCLC xenografts and evaluated HER2 expression in NSCLC patient samples.
UR  - https://tlcr.amegroups.org/article/view/116522