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Baseline IL-6, IL-8, IFN-ω, and perforin as prognostic biomarkers in immune checkpoint inhibitor-treated metastatic non-small cell lung cancer

   
@article{TLCR122228,
	author = {Varshini Odayar and Hyojung Jang and Ashley Pearson and Jadyn James and Emily Kloska and Benjamin H. Singer and Shadia Jalal and Charles J. Nock and Lili Zhao and Michael Green and Nithya Ramnath},
	title = {Baseline IL-6, IL-8, IFN-ω, and perforin as prognostic biomarkers in immune checkpoint inhibitor-treated metastatic non-small cell lung cancer},
	journal = {Translational Lung Cancer Research},
	volume = {15},
	number = {7},
	year = {2026},
	keywords = {},
	abstract = {Background: Prognostic serum biomarkers of immune checkpoint inhibitor (ICI) efficacy in non-small cell lung cancer (NSCLC) are sparse. We evaluated baseline cytokines as markers of outcomes in ICI-treated metastatic NSCLC.Methods: Baseline serum cytokines were quantified in 96 patients with metastatic NSCLC receiving ICIs. Separate multivariable models were fit for progression-free survival (PFS) and overall survival (OS), adjusting for clinical covariates. Hazard ratios (HRs) were expressed per doubling in cytokine concentration. Significant cytokines were then incorporated into multivariable Cox models, and model discrimination was assessed using time-dependent area under the curve (AUC). Latent class analysis (LCA) was performed to identify cytokine-defined patient phenotypes associated with survival.Results: Each doubling of interleukin-6 (IL-6) increased the hazard of death by 34% [HR =1.34; 95% confidence interval (CI): 1.13–1.60; P},
	issn = {2226-4477},	url = {https://tlcr.amegroups.org/article/view/122228}
}