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Best supportive care in stage I–III non-small cell lung cancer: survival by reason for curative treatment omission in a real-world study population

   
@article{TLCR122240,
	author = {Guus R. M. van den Heuvel and Bas L. R. Mandos and Hans J. M. Smit and Olga C. J. Schuurbiers and Francesco Ciompi and Erik H. J. G. Aarntzen and Kaamar Azijli and Iris Walraven and Michel M. van den Heuvel},
	title = {Best supportive care in stage I–III non-small cell lung cancer: survival by reason for curative treatment omission in a real-world study population},
	journal = {Translational Lung Cancer Research},
	volume = {15},
	number = {7},
	year = {2026},
	keywords = {},
	abstract = {Background: Despite advances in stage I–III non-small cell lung cancer (NSCLC) treatment, curative-intent therapy is withheld in patients deemed ineligible or preferring no treatment. Limited real-world data exist on overall and cancer-related survival outcomes in patients receiving primary best supportive care (BSC). The main aim of this study was to compare median overall survival (OS) by reason for BSC (patient preference versus other factors).Methods: We retrospectively analyzed overall and lung cancer-specific survival (LCSS) in patients with stage I–III NSCLC diagnosed between 2015 and 2019 in the Netherlands. Patients received primary BSC or curative treatment (surgery, radiotherapy or chemoradiation). The BSC cohort was categorized by main decisive factor: (I) patient preference; (II) insufficient performance status; or (III) relevant comorbidities. Survival data were compared using log-rank tests and Cox regression models.Results: Out of 1,895 patients, 234 (12%) received primary BSC, including 82 based on patient preference. Median OS was 5.9 months in the total BCS cohort and 9.6 months in the patient-preference cohort, compared to 54.1 months in the curative treatment cohort [hazard ratio (HR) 0.17; 95% confidence interval (CI): 0.13–0.22; P},
	issn = {2226-4477},	url = {https://tlcr.amegroups.org/article/view/122240}
}