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Endothelial Dll4-Notch signaling in tumor microenvironment: is there any hidden therapeutic opportunity?

   
@article{TLCR1593,
	author = {Amit Kumar and Sejal Desai and Badri N. Pandey},
	title = {Endothelial Dll4-Notch signaling in tumor microenvironment: is there any hidden therapeutic opportunity?},
	journal = {Translational Lung Cancer Research},
	volume = {2},
	number = {6},
	year = {2013},
	keywords = {},
	abstract = {Tumor microenvironmental cross-talk between endothelial and cancer cells plays an essential role in growth, progression and therapeutic outcome of cancer. In response to tumor cell-derived vascular endothelial growth factor (VEGF), the endothelial delta-like ligand 4 (Dll4) regulates angiogenesis and tumor growth via Notch signaling. However, in view of intriguing effects of emerging Dll4-Notch signaling in various tumor types, the missing links need to be elucidated for development of this signaling as a possible therapeutic target for cancer therapy.},
	issn = {2226-4477},	url = {https://tlcr.amegroups.org/article/view/1593}
}