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Two are better than one on progression through MET mechanism for EGFR+ NSCLC patients

   
@article{TLCR25954,
	author = {Waleed Kian and Laila C. Roisman and Nir Peled},
	title = {Two are better than one on progression through MET mechanism for EGFR+ NSCLC patients},
	journal = {Translational Lung Cancer Research},
	volume = {7},
	number = {Suppl 4},
	year = {2018},
	keywords = {},
	abstract = {Recent years have borne witness to the development of numerous acquired resistances to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) treatment for patients with EGFR-mutated non-small cell lung cancer (NSCLC). Mechanism of resistant includes EGFR T790M, MET gene amplification (1,2), transformation to small cell lung cancer and others. Approximately 5 to 26 percent of these acquired modifications occur due to dysregulation of the mesenchymal-epithelial transition factor (MET) either by amplification or overexpression patterns. Previous studies have failed to show efficacy of adding MET inhibitors to EGFR-TKI therapies upon progression (3).},
	issn = {2226-4477},	url = {https://tlcr.amegroups.org/article/view/25954}
}