TY  - JOUR
AU  - Huang, Weizhe
AU  - Zhao, Shen
AU  - Xu, Wei
AU  - Zhang, Zhikui
AU  - Ding, Xiangdong
AU  - He, Jianxing
AU  - Liang, Wenhua
PY  - 2019
TI  - Presence of intra-tumoral CD61+ megakaryocytes predicts poor  prognosis in non-small cell lung cancer
JF  - Translational Lung Cancer Research; Vol 8, No 4 (August 31, 2019): Translational Lung Cancer Research
Y2  - 2019
KW  - 
N2  - Background: Lung is a reservoir for megakaryocytes (MKs). The relationship between intra-tumoral MKs and non-small cell lung cancer (NSCLC) is unknown. We investigate relationship between high intra-tumoral MKs with the recurrence of NSCLC.  Methods: The tissue sections of 629 patients with resected NSCLC were stained with hematoxylin, anti-CD61, anti-CD34 and stromal cell-derived factor-1 (SDF-1). CD61+ giant cells localized in CD34+ capillaries were identified as MKs. The impact of MKs and preoperative platelet count on disease-free survival (DFS) was investigated.  Results: Overall, 18.9% of patients were positive for the presence of MKs. In univariate analysis, the median DFS of the MK+ group was shorter than the median DFS of the MK- group (69.1 vs. 80.5 months; P=0.021). Multivariate analysis indicated that MKs in tumor tissue was an unfavorable prognostic factor for DFS (HR 1.351, P=0.065), the impact of which was more significant in non-squamous cell carcinoma (NSCC) (HR 1.710, P=0.008) and in patients with N0 (HR 1.883, P=0.009). Although systemic platelet count of the MK+ group was significantly higher than the MK- group (270.6×109 vs. 243.6×109/L, P=0.007), the stratified subgroup DFS curves (P=0.003) showed that the effect of MKs on prognosis was independent of the blood platelet count.  Conclusions: Our results demonstrate that CD61+ MKs in tumor tissue predict unfavorable prognosis in NSCLC.
UR  - https://tlcr.amegroups.org/article/view/31121