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Is the third generation EGFR TKIs the solution for making EGFR mutant NSCLC a curable disease?

   
@article{TLCR3454,
	author = {Fred R. Hirsch},
	title = {Is the third generation EGFR TKIs the solution for making EGFR mutant NSCLC a curable disease?},
	journal = {Translational Lung Cancer Research},
	volume = {3},
	number = {6},
	year = {2014},
	keywords = {},
	abstract = {Much promise and encouragement has been linked to the treatment of patients with advanced NSCLC harboring EGFR mutations. The first generation EGFR TKIs (e.g., erlotinib/gefitinib) gave promise as single agent therapy in the first-line setting (1). The second generation EGFR TKI with covalent irreversible binding to the receptor and with the potential to target heterodimers of the Erb-B receptors gave further promise regarding response, progressionfree survival and overall survival, particularly in patients with exon 19 deletions (2-4).},
	issn = {2226-4477},	url = {https://tlcr.amegroups.org/article/view/3454}
}