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Neoadjuvant EGFR TKIs: toward personalized management in non-small-cell lung cancer

   
@article{TLCR553,
	author = {Antonio Passaro and Enrico Cortesi},
	title = {Neoadjuvant EGFR TKIs: toward personalized management in non-small-cell lung cancer},
	journal = {Translational Lung Cancer Research},
	volume = {1},
	number = {4},
	year = {2012},
	keywords = {},
	abstract = {Lung cancer remains the leading cause of cancer-specific death in men and women. Unfortunately, the majority of patients with non-small-cell lung cancer (NSCLC) have locally advanced or metastatic disease at diagnosis with a 5-year survival rate of only 4% (1). However, a minority of patients with NSCLC present at diagnosis with resectable disease. Treatment for early-stage disease in fit patients is focused on curative surgery, but 30% to 70% of patients with completely resected disease experience relapse (2,3), often by distant metastases, suggesting that early-stage NSCLC is frequently a micrometastatic disease at diagnosis (4,5) and adjuvant and/or neoadjuvany cisplatin-based chemotherapy are advised for patients with early-stage (6-8).},
	issn = {2226-4477},	url = {https://tlcr.amegroups.org/article/view/553}
}