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Treatment for small cell lung cancer, where are we now?—a review

   
@article{TLCR6537,
	author = {Gabriela Alvarado-Luna and Daniela Morales-Espinosa},
	title = {Treatment for small cell lung cancer, where are we now?—a review},
	journal = {Translational Lung Cancer Research},
	volume = {5},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Small cell lung cancer (SCLC) represents between 13% and 15% of all diagnosed lung cancers worldwide. It is an aggressive neoplasia, with a 5-year mortality of 90% or more. It has historically been classified as limited disease (LD) and extensive disease (ED) in most study protocols. The cornerstone of treatment for any stage of SCLC is etoposide-platinum based chemotherapy; in limited stage (LS), concomitant radiotherapy to thorax and mediastinum. Prophylactic radiotherapy to the central nervous system (CNS) [prophylactic cerebral irradiation (PCI)] has diminished the incidence of brain metastasis as the site for relapse in LD and ED patients, therefore it should be offered to patients with complete response to induction first-line treatment. Regarding second-line treatment, results are more modest and topotecan is accepted as treatment for this scenario offering a modest benefit.},
	issn = {2226-4477},	url = {https://tlcr.amegroups.org/article/view/6537}
}