Vol 14, No 8 (August 31, 2025): Translational Lung Cancer Research

Editorial Commentary

XPO1 inhibition in KRAS-mutant cancers: time for clinical trials but how?
Misako Nagasaka, Husain Y. Khan, Faustine Luo, Mohammed Najeeb Al-Hallak, Muhammad Wasif Saif, Ramzi M. Mohammad, Asfar S. Azmi
Translational Lung Cancer Research  
2025;
14
(8)
:2895-2899
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 (31 August 2025) 
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Extending the clinical indications of liquid biopsy: plasma next-generation sequencing in suspected lung cancer
Alessandro Russo, Christian Rolfo, Edgardo S. Santos
Translational Lung Cancer Research  
2025;
14
(8)
:2900-2905
.
 (31 August 2025) 
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Positioning amivantamab and lazertinib in the therapeutic sequence for EGFR-mutant NSCLC: insights from CHRYSALIS-2 cohort A
Faith Abodunrin, Dillon E. Berlin, Christine M. Bestvina
Translational Lung Cancer Research  
2025;
14
(8)
:2906-2911
.
 (31 August 2025) 
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The OPEN trial—from the darkness, comes light
Richard Pham, Surein Arulananda
Translational Lung Cancer Research  
2025;
14
(8)
:2912-2917
.
 (31 August 2025) 
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Decoding the immune landscape: KRAS and STK11 genes mutations shape CD8+ T cell response in resectable non-small-cell lung cancer after neoadjuvant therapy
Kamila Wojas-Krawczyk, Magdalena Knetki-Wróblewska, Maciej Krzakowski
Translational Lung Cancer Research  
2025;
14
(8)
:2918-2921
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 (31 August 2025) 
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Long-term survival outcomes of lorlatinib in advanced anaplastic lymphoma kinase (ALK)-fusion positive non-small cell lung cancer
Masahiro Morise, Ichidai Tanaka, Makoto Ishii
Translational Lung Cancer Research  
2025;
14
(8)
:2922-2927
.
 (31 August 2025) 
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Original Article

Effect of type 2 diabetes mellitus on systemic treatment for advanced non-small cell lung cancer
Yasuhiro Kato, Eri Kuramochi, Rei Yamaguchi, Erika Mikami, Kaoruko Shinbu, Jyunichi Aoyama, Shunsuke Kobayashi, Fumitaka Okajima, Masahiro Seike, Tetsuya Okano
Translational Lung Cancer Research  
2025;
14
(8)
:2928-2941
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 (31 August 2025) 
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International cost-effectiveness analysis of durvalumab consolidation treatment after chemoradiotherapy for patients with limited-stage small-cell lung cancer
Kun Liu, Youwen Zhu, Hong Zhu
Translational Lung Cancer Research  
2025;
14
(8)
:2942-2953
.
 (31 August 2025) 
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Comparative investigation of neoadjuvant chemoimmunotherapy versus perioperative (chemo)immunotherapy in resectable non-small cell lung cancer: a real-world retrospective cohort study
Yehao Yang, Sini Li, Qian Zhang, Wanchen Zhai, Haicheng Wu, Hui Li, Yun Fan
Translational Lung Cancer Research  
2025;
14
(8)
:2954-2968
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 (31 August 2025) 
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The impact of spread through air spaces on intrapulmonary metastasis in lung cancer: a retrospective study of multiple primary lung adenocarcinomas with confirmed common origin based on histological classification alone and combined histological-molecular classification
Chenxi Yan, Shaojie Hu, Yitao Tian, Xiaoxue Zhang, Wei Sun
Translational Lung Cancer Research  
2025;
14
(8)
:2969-2982
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 (31 August 2025) 
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Development and validation of a serum inflammatory biomarker-driven machine-learning model for prognostic stratification in surgical limited-stage small cell lung cancer
Zhiyuan Yao, Changlei Li, Fengyi Han, Yi Qin, Xiao Sun, Guohua Wang, Enzheng Yu, Peng Song, Hanqun Liu, Wenjie Jiao
Translational Lung Cancer Research  
2025;
14
(8)
:2983-2995
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 (31 August 2025) 
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Short-course hypofractionated radiotherapy of 4 Gy per fraction for limited-stage small cell lung cancer: a randomized pilot trial
Xiao-Yang Li, Bing Yan, Jun-Qiang Zhang, Yan Li, Da-Qing Xia, Wang Xie, Yuan He, Jian-Guo Wang, Jun Ma, Le-Jie Cao, Dong Qian
Translational Lung Cancer Research  
2025;
14
(8)
:2996-3008
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 (31 August 2025) 
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Associations of body composition and inflammatory parameters with survival in patients with resectable non-small cell lung cancer receiving neoadjuvant chemoimmunotherapy
Yuting Zheng, Qinyue Luo, Yimeng He, Hanting Li, Mengting Huang, Chengyu Ding, Xiaoyu Han, Heshui Shi
Translational Lung Cancer Research  
2025;
14
(8)
:3009-3023
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 (31 August 2025) 
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STK11/KEAP1 co-mutations in SMARCA4-mutant advanced non-small cell lung cancer: genetic characteristics and impact on immunotherapy efficacy
Ziyi Dong, Ran Zuo, Yaoyang Guo, Xinyi Wen, Gang Zhao, Zhansheng Jiang
Translational Lung Cancer Research  
2025;
14
(8)
:3024-3041
.
 (31 August 2025) 
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Preoperative diagnostic accuracy of dominant lesion in multifocal pulmonary nodules
Bowen Zhao, Xiaoyun Su, Yu Huang, Chi Zhang, Guanchao Ye, Junhua Wu, Shiwen Fan, Ming Chen, Kuo Li, Fan Yang, Guangyao Wu, Yongde Liao
Translational Lung Cancer Research  
2025;
14
(8)
:3042-3053
.
 (31 August 2025) 
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Shared genetics of lung cancer and type 2 diabetes: a large-scale genome-wide cross-trait analysis
Ze Wang, Hongsheng Deng, Enting Ji, Yao Lu, Weixiang Lu, Jianxing He, Wenlong Shao
Translational Lung Cancer Research  
2025;
14
(8)
:3054-3066
.
 (31 August 2025) 
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A systematic review and network meta-analysis of immune checkpoint inhibitors in operable NSCLC: neoadjuvant, adjuvant, or perioperative?
Fausto Petrelli, Lorenzo Dottorini, Mauro Rossitto, Fausto Meriggi, Sara Cherri, Alberto Zaniboni, Antonio Ghidini
Translational Lung Cancer Research  
2025;
14
(8)
:3067-3075
.
 (31 August 2025) 
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Enhancing the sensitivity of lung adenocarcinoma to immune therapeutic agents through SPRED1
Chen Wu, Lingling Ma, Yi Wang, Joanna Bidzińska, Yilang Wang
Translational Lung Cancer Research  
2025;
14
(8)
:3076-3089
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 (31 August 2025) 
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Tumor-educated platelet RNA as a diagnostic biomarker for ground-glass opacity-related lung adenocarcinoma
Mengqi Shao, Jieming Cao, Ruoyao Wang, Yazhuo Liu, Yan Hu, Weixuan Lei, Li Wang, Wenliang Liu
Translational Lung Cancer Research  
2025;
14
(8)
:3090-3106
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 (31 August 2025) 
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The role of immunogenic cell death in the prognosis and development of treatment strategies for non-small cell lung cancer: a multiomics and machine learning approach for predictive and personalized treatment
Yichen Sun, Hao Chen, Zhaoyang Wang, Rui Jiao, Franz Zehentmayr, Fabrizio Tabbò, Chengyang Wu, Tao Zhang, Hanyu Yan, Jian Wang, Xiaolong Yan
Translational Lung Cancer Research  
2025;
14
(8)
:3107-3125
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 (31 August 2025) 
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Review Article

Advancements in 3D lung models for minimally invasive lung cancer surgery: from static to real-time dynamic modeling
Iris E. W. G. Laven, Aimée J. P. M. Franssen, Lori M. van Roozendaal, Juliette H. R. J. Degens, Alex Korsten, Frank R. Halfwerk, Amir H. Sadeghi, Francesco Guerrera, Karel W. E. Hulsewé, Yvonne L. J. Vissers, Erik R. de Loos
Translational Lung Cancer Research  
2025;
14
(8)
:3126-3141
.
 (31 August 2025) 
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Adjuvant radiotherapy in the era of new peri-operative systemic treatments for surgically resected non-small-cell lung cancer: where do we stand?
Francesca R. Ogliari, Jarno W. J. Huijs, Mandy Jongbloed, Jonas Willmann, Lizza E. L. Hendriks, Dirk K. M. De Ruysscher
Translational Lung Cancer Research  
2025;
14
(8)
:3142-3152
.
 (31 August 2025) 
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Current evidence and ongoing trials for surgery versus stereotactic body radiation therapy (SBRT) for early-stage non-small cell lung cancer: a narrative review
Lauren Drake, Robert Timmerman, Hiran C. Fernando
Translational Lung Cancer Research  
2025;
14
(8)
:3153-3160
.
 (31 August 2025) 
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The evolution of chest tube management following lung cancer surgery: many options, scarce evidence
Lars Geenen, Koen C. H. A. Verkoulen, Aimée J. P. M. Franssen, Juliette H. R. J. Degens, Karel W. E. Hulsewé, Yvonne L. J. Vissers, Erik R. de Loos
Translational Lung Cancer Research  
2025;
14
(8)
:3161-3169
.
 (31 August 2025) 
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Complex uniportal robotic-assisted sleeve resections under spontaneous ventilation and with double lumen intubation: a case series and a narrative review of the literature
Diego Gonzalez-Rivas, Pablo Gomes-da Silva de Rosenzweig, Luis Fernando Arana Bolaños, Adriana Simoneta Pimienta Ibarra, Hasanali David Walji, Patricio Santillan Dohetty, Jun Zhao, Chang Li, Mugurel Bosinceanu, Francina Valezka Bolaños Morales
Translational Lung Cancer Research  
2025;
14
(8)
:3170-3182
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 (31 August 2025) 
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Beyond the tumor: towards a cachexia-based host phenotype through body composition analysis in patients with resectable lung cancer
Koen C. H. A. Verkoulen, Lars Geenen, Aimée J. P. M. Franssen, Anne M. A. Verzijl, Yvonne L. J. Vissers, Karel W. E. Hulsewé, Juliette H. R. J. Degens, David P. J. van Dijk, Erik R. de Loos
Translational Lung Cancer Research  
2025;
14
(8)
:3183-3195
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 (31 August 2025) 
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Deep learning enhances precision diagnosis and treatment of non-small cell lung cancer: future prospects
Xinran Zhang, Jia Liu, Wen Zhou, Junfei Lu, Liqin Wu, Yan Li, Yiyuan Wang, Zhichao Wang, Jun Cai
Translational Lung Cancer Research  
2025;
14
(8)
:3196-3215
.
 (31 August 2025) 
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Advances in the research of leptomeningeal metastases in non-small cell lung cancer: a narrative review
Jiaojiao Hong, Yue Hao, Jiangxia Yuan, Xianzi Dai, Chengyu Chen, Zhengxing Huo, Jia Zhu, Qian Wang
Translational Lung Cancer Research  
2025;
14
(8)
:3216-3232
.
 (31 August 2025) 
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Molecular mechanisms and clinical insights in transformed small cell lung cancer: a narrative review
Xianzi Dai, Yue Hao, Jiaojiao Hong, Jiangxia Yuan, Chengyu Chen, Zhengxing Huo, Jia Zhu, Qian Wang
Translational Lung Cancer Research  
2025;
14
(8)
:3233-3248
.
 (31 August 2025) 
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A narrative review of immunotherapy for non-small cell lung cancer: current progress, sensitization approaches, and synergistic strategies
Lu Zhou, Takehiro Uemura, Baptiste Abbar, Senyi Deng
Translational Lung Cancer Research  
2025;
14
(8)
:3249-3269
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 (31 August 2025) 
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Case Report

Long-term survival with adaptive dual-targeted therapy in an epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer patient with mesenchymal-epithelial transition (MET) amplification guided by minimal residual disease (MRD) assessments: a case report and literature review
Xinyin Liu, Shidai Jin, Jun Li, Jiali Xu, Lei Song, Wen Gao, Jun Wang, Zhihong Zhang, Renhua Guo
Translational Lung Cancer Research  
2025;
14
(8)
:3270-3279
.
 (31 August 2025) 
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