Home - Translational Lung Cancer Research

Join us at the 33rd Annual Meeting of the European Society of Thoracic Surgery (ESTS)

The 33rd Annual Meeting of the European Society of Thoracic Surgery is going to be held in May 25-27, 2025 in Budapest, Hungary: https://estsmeeting.com.

This time, Translational Lung Cancer Research (TLCR) as well as its sister journals and books published by AME Publishing Company will be on display during this exciting academic event! We would like to seize this great opportunity to meet our authors, editorial board members and readers.

Interviews with Outstanding Authors (2025)

In 2025, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors, with a brief interview of their thoughts and insights as authors. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Reviewer of the Month (2025)

In 2025, TLCR reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Join us at the 105th Annual Meeting of American Association for Thoracic Surgery (AATS)

The 105th Annual Meeting of American Association for Thoracic Surgery (AATS) is going to be held at the Seattle Convention Center, Seattle, WA, USA from May 2 to 5, 2025: https://events.aats.org/am25.

As the world's most prestigious thoracic surgery event, the annual meeting of AATS helps grow one’s expertise, network with leading experts, and build the future of thoracic surgery.

This year Translational Lung Cancer Research (TLCR) as well as its sister journals and books published by AME Publishing Company will be on display during this exciting academic event! We would like to seize this great opportunity to meet our authors, editorial board members and readers.

TLCR Annual Report 2024

Welcome to the 2024 annual report for Translational Lung Cancer Research. In 2024, the TLCR has continued its mission to increase the quality and impact of the journal, and to provide readers with a novel, well-organized, informative, enlightening and educational journal.

We would like to sincerely thank our Editorial Board Members, Guest editors, Reviewers, Authors, Readers for all your supports and contributions to TLCR in 2024, and we look forward to continuing our work with you in the new year.

Interviews with Editorial Board Members

TLCR features a distinguished editorial board, the members of which continue to instill the power of their expertise for the journal’s development. By launching this column, we are glad to introduce to you some of them in the form of interviews, in which they will share their unique career experiences and perspectives. We believe their insights will shed light on the knowledge of related fields.

Interviews with Guest Editors

Over the years, a number of TLCR guest editors have made valuable contributions to the journal. This column features interviews with our guest editors, who graciously share their experience in scientific careers and provide insightful perspectives on the special series.

New Impact Factor for Translational Lung Cancer Research: 4

We are pleased to announce that the Translational Lung Cancer Research (TLCR) has attained its latest impact factor update for the 2023 citation year: 4.

Translational Lung Cancer Research 2023 CiteScore Released: 7.2

We are pleased to announce that the Translational Lung Cancer Research (TLCR) has received its 2023 CiteScore: 7.2, ranking 92 out of 404 journals in the Oncology category.

Furthermore, we are delighted to highlight the remarkable achievements made by all AME journals in the CiteScore ranking.

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Vol 14, No 3 (March, 2025)

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Editorial Commentary

Will INSPIRE crown iruplinalkib as a new standard choice in first-line advanced ALK-positive non-small cell lung cancer?

Blerina Resuli, Diego Kauffmann-Guerrero

PDF Pages: 653-656 Full Text (141) Peer Review File COI Form Open Access

Optimizing long-term treatment with ALK inhibitors: balancing efficacy and safety

Ayuka Dai, Takaaki Sasaki

PDF Pages: 657-661 Full Text (158) Peer Review File COI Form Open Access

Original Article

ANKRD11 as a potential biomarker for brain metastasis from lung adenocarcinoma via cerebrospinal fluid liquid biopsy

Qinhong Sun, Peng Xing, Qinglin Wang, Zhijun Xia, Jianyu Li, Zhitong Li, Fancheng Meng, Tongyan Liu, Siwei Wang, Rong Yin

PDF Pages: 662-676 Full Text (180) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Persistent and novel changes in plasma microRNA profiles in patients with non-small cell lung cancer following tumour resection

Maria Sromek, Maciej Głogowski, Magdalena Chechlińska, Mariusz Kulińczak, Michalina Zajdel, Natalia Żeber-Lubecka, Aneta Bałabas, Łukasz M. Szafron, Maria Kulecka, Jan K. Siwicki

PDF Pages: 677-706 Full Text (117) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Amivantamab as a salvage therapy post-EGFR-tyrosine kinase inhibitor failure in patients with mutated EGFR non-small cell lung cancer

Bilal Krayim, Waleed Kian, Maria Spector, Inbal Granot, Julia Dudnik, Michal Nissim, Dolev Kahala, Areen Abu Remilah, Naama R. Bogot, Gleb Kornev, Noam Asna, Nir Peled, Laila C. Roisman

PDF Pages: 707-717 Full Text (151) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Circulating lung cancer exosomes damage the niche of intestinal stem cells

Ke Wang, Lu Xu, Jianhua Feng, Shubin Wang, Xi Wang, Junyi Zou, Zhenni Xu, Lingxiao Huang, Wenjun Jiang, Jin Zhou, Xudan Lei, Dengqun Liu

PDF Pages: 718-735 Full Text (96) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Predicting survival in small cell lung cancer patients undergoing various treatments: a machine learning approach

Ziran Zhao, Xi Cheng, Yibo Gao, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He

PDF Pages: 736-748 Full Text (119) Reporting Checklist Peer Review File COI Form Open Access

Prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in second-line immunotherapy for patients with non-small cell lung cancer

Magdalena Knetki-Wróblewska, Aleksandra Grzywna, Paweł Krawczyk, Kamila Wojas-Krawczyk, Izabela Chmielewska, Tomasz Jankowski, Janusz Milanowski, Maciej Krzakowski

PDF Pages: 749-760 Full Text (127) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Connecting the dots: (RANKL⁺) extracellular vesicle count in blood plasma in relation to bone metastases, skeletal related events and osimertinib treatment in patients with EGFR mutated non-small cell lung cancer

Anita J. W. M. Brouns, Iris J. Robbesom-van den Berge, Sophie M. Ernst, Christi M. J. Steendam, Wouter W. Woud, Liang Wu, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Marjolein van Driel

PDF Pages: 761-774 Full Text (77) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A better option for localization of multiple pulmonary nodules in the ipsilateral lung: electromagnetic navigation bronchoscopy-guided preoperative localization

Rui Wang, Yongjiang Chen, Chudong Wang, Zijian Li, Yunpeng Zhong, Yunjuan Liang, Shuben Li

PDF Pages: 775-784 Full Text (106) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Short-term peri- and intra-tumoral CT radiomics to predict immunotherapy response in advanced non-small cell lung cancer

Ting Wang, Lei Chen, Xiao Bao, Zijuan Han, Zezhou Wang, Shengdong Nie, Yajia Gu, Jing Gong

PDF Pages: 785-797 Full Text (86) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Diagnostic utility of bronchoscopy for newly emerging peripheral pulmonary lesions after pulmonary resection

Takahiro Suzuki, Yuji Matsumoto, Hideaki Furuse, Keigo Uchimura, Tatsuya Imabayashi, Takaaki Tsuchida

PDF Pages: 798-809 Full Text (71) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Closer proximity of pre-treatment CD4⁺ T cells to CD8⁺ T cells favor response to neoadjuvant immunotherapy in patients with PD-L1 low-expressing non-small cell lung cancer

Liying Yang, Jiaxiao Geng, Hao Yang, Miaoqing Zhao, Hongtu Yuan, Yushan Yan, Li Wu, Fanghan Cao, Ligang Xing, Xiaorong Sun

PDF Pages: 810-823 Full Text (116) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Single cell RNA-seq and bulk RNA-seq analysis identifies MUC1 as a key gene for lung adenocarcinoma to neuroendocrine transformation

Hongxia Li, Tiantian Yang, Yu Chen, Zhiqin Xie

PDF Pages: 824-841 Full Text (173) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Nomogram based on computed tomography radiomics features and clinicopathological factors to predict the prognosis of patients with non-small cell lung cancer receiving immune checkpoint inhibitor rechallenge

Junfeng Zhao, Ying Li, Ruyue Li, Xiujing Yao, Xue Dong, Lin Su, Yintao Li

PDF Pages: 842-856 Full Text (99) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Integrated multiomics machine learning and mediated Mendelian randomization investigate the molecular subtypes and prognosis lung squamous cell carcinoma

Zhanghao Huang, Jing Li, You Lang Zhou, Jiahai Shi

PDF Pages: 857-877 Full Text (81) Reporting Checklist Peer Review File COI Form Open Access

Targeting of arachidonic acid-modulated autophagy to enhance the sensitivity of ROS1⁺ or ALK⁺ non-small cell lung cancer to crizotinib therapy

Hui Jie, Hongjin Lai, Zihuai Wang, Min Yi, Yi Liu, Edyta Maria Urbanska, Eric Santoni-Rugiu, Shiyou Wei, Yuhao Chen, Chuan Li, Tengyong Wang, Nanzhi Luo, Lunxu Liu, Senyi Deng, Chenglin Guo

PDF Pages: 878-896 Full Text (161) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Enhancing the precision of auxiliary diagnosis for lung cancer through use of SHOX2 and RASSF1A methylation status in lung biopsy and lymph node biopsy specimens

Ping Gu, Yue Wang, Chunlei Shi, Yuqing Chen, Jialin Qian, Yanjie Niu, Hai Zhang, Yunxia Bao, Bin She, Xiaosha Ren, Iyare Izevbaye, Baohui Han, Hua Zhong, Yu Dong

PDF Pages: 897-911 Full Text (86) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Analysis of baseline interstitial lung abnormality on the risk of checkpoint inhibitor-related pneumonitis and survival in advanced non-small cell lung cancer patients treated with first-line PD-1/PD-L1 inhibitors

Yu Li, Shuo Liang, Yanjun Du, Jun Yao, Yuxin Jiang, Wanjun Lu, Qiuxia Wu, Fumihiro Yamaguchi, Marko Jakopović, Wolfgang M. Brueckl, Dong Wang, Fang Zhang, Qin Wang, Tangfeng Lv, Ping Zhan

PDF Pages: 912-930 Full Text (106) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Palliative surgery is effective in patients with EGFR-mutant lung adenocarcinoma with pleural metastasis

Yue Liu, Yifei Zhou, Shuangyi Li, Qianxin Zhou, Jun Li, Nobuhiro Kanaji, Sara Ricciardi, Raja M. Flores, Marcello Migliore, Kakeru Hisakane, Yuming Zhu, Wenxin He, Linsong Chen, Dongliang Bian

PDF Pages: 931-939 Full Text (96) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Identification and validation of crotonylation-related diagnostic markers for lung adenocarcinoma via weighted correlation network analysis and machine learning

Bowen Hu, Xin Chen, Dan Zou, Xiaoyue Du, Sitong Feng, Yiwen Shen, Xiaofeng Sha, Feng Jiang, Guoren Zhou, Fan Lin, Lukas Käsmann, Bo Shen

PDF Pages: 940-962 Full Text (111) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Neoadjuvant immunochemotherapy demonstrated improved efficacy and comparable safety to neoadjuvant chemotherapy for limited-stage small-cell lung cancer: a cohort study

Lijiang Song, Xiaowei Mao, Haichuan Hu, Hu Zhang, Xinxin Ying, Lichen Zhang, Kai Liu, Huiyong Han, Dongde Li, Zhengfu He

PDF Pages: 963-974 Full Text (114) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Review Article

Recent advancements in lung cancer research: a narrative review

Fuk Hay Tang, Heylie Y. T. Wong, Phyllis S. W. Tsang, Mabel Yau, Shing Yau Tam, Lawla Law, Katherine Yau, Jade Wong, Fatema Hassan Mustafa Farah, Jacky Wong

PDF Pages: 975-990 Full Text (197) Reporting Checklist Peer Review File COI Form Open Access

Multidisciplinary management of N2 stage III non-small cell lung cancer: opportunities and challenges for radiation oncology

Hongcheng Zhu, Daniel G. Schep, Marta Isolano, Piergiorgio Muriana, Sarayut L. Geater, Giulia Veronesi, Fangqiu Fu, Roberto Ferrara, Kuaile Zhao, Alexander V. Louie

PDF Pages: 991-1006 Full Text (84) Peer Review File COI Form Open Access

Clinical application of minimal residual disease detection by ctDNA testing in non-small cell lung cancer: a narrative review

Yishan Wang, Wenjun Shao, Hui Li, Peiyan Zhao, Lin Tian, Liang Zhang, Shaowei Lan, Rui Zhong, Shuang Zhang, Ying Cheng

PDF Pages: 1007-1020 Full Text (119) Reporting Checklist Peer Review File COI Form Open Access

Case Report

Metachronous development of L858R and T790M EGFR mutations following ALK inhibitor therapy in stage IV lung adenocarcinoma: a case report

So-Yun Kim, Jisoo Lee, Dongil Park, Jeong Eun Lee, Joo-Eun Lee, Hyun-Yi Kim, Da Hyun Kang, Chaeuk Chung

PDF Pages: 1021-1031 Full Text (101) Reporting Checklist Peer Review File COI Form Open Access

Pathological complete response and long-term survival by pembrolizumab based immunochemotherapy in epidermal growth factor receptor mutated non-small cell lung cancer post-tyrosine kinase inhibitor failure: a case report and tumor microenvironment analysis

Sangtian Liu, Wenhua Liang, Shicui Quan, Qilin Deng, Wenhai Fu, Yalei Zhang, Hong Du, Jianxing He

PDF Pages: 1032-1041 Full Text (102) Reporting Checklist Peer Review File COI Form Open Access

Review Articles

Management of ground-glass opacities: should all pulmonary lesions with ground-glass opacity be surgically resected?

Yoshihisa Kobayashi, Tetsuya Mitsudomi

Published online: 22 October 2013

PDF Pages: 354-363 Full Text (338534) Open Access

Editorial Commentary

Ground glass nodules with 5 years’ stability can grow after 10-year follow-up: do genetic features determine the fate?

Yoshihisa Kobayashi, Tetsuya Mitsudomi

Published online: 31 December 2019

PDF Pages: S425-S427 Full Text (83314) Open Access

Review Article

Non-small cell lung cancer: current treatment and future advances

Cecilia Zappa, Shaker A. Mousa

Published online: 30 June 2016

PDF Pages: 288-300 Full Text (77504) Open Access

Review Articles

Irreversible EGFR-TKIs: dreaming perfection

Lorenza Landi, Federico Cappuzzo

Published online: 14 January 2013

PDF Pages: 40-49 Full Text (70174) Open Access

Review Article

Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Jian-Wei Gao, Stefania Rizzo, Li-Hong Ma, Xiang-Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia-Wei Zou, Qian Li, Marco Femia, Tang-Feng Lv, Yong Song, written on behalf of the AME Lung Cancer Collaborative Group

Published online: 28 February 2017

PDF Pages: 68-75 Full Text (59452) Open Access

Review Article

Recurrence after surgery in patients with NSCLC

Hidetaka Uramoto, Fumihiro Tanaka

Published online: 28 August 2014

PDF Pages: 242-249 Full Text (47131) Open Access

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future

Bryan A. Chan, Brett G.M. Hughes

Published online: 24 February 2015

PDF Pages: 36-54 Full Text (43079) Open Access

Review Article

Lung cancer prediction using machine learning and advanced imaging techniques

Timor Kadir, Fergus Gleeson

Published online: 14 June 2018

PDF Pages: 304-312 Full Text (42810) Open Access

Review Article

Treatment of uncommon EGFR mutations in non-small cell lung cancer: new evidence and treatment

Tianli Zhang, Bing Wan, Yuan Zhao, Chuling Li, Hongbing Liu, Tangfeng Lv, Ping Zhan, Yong Song

Published online: 30 June 2019

PDF Pages: 302-316 Full Text (42476) Open Access

Review Article

The past, present and future of immunotherapy against tumor

Tao Jiang, Caicun Zhou

Published online: 24 June 2015

PDF Pages: 253-264 Full Text (39438) Open Access

Review Article

Ground-glass nodules of the lung in never-smokers and smokers: clinical and genetic insights

Yoshihisa Kobayashi, Chiara Ambrogio, Tetsuya Mitsudomi

Published online: 28 August 2018

PDF Pages: 487-497 Full Text (37049) Chinese (5314) Open Access

Review Article

The epidemiology of lung cancer

Patricia M. de Groot, Carol C. Wu, Brett W. Carter, Reginald F. Munden

Published online: 14 June 2018

PDF Pages: 220-233 Full Text (33784) Open Access

Review Article

Lung cancer screening: nodule identification and characterization

Ioannis Vlahos, Konstantinos Stefanidis, Sarah Sheard, Arjun Nair, Charles Sayer, Joanne Moser

Published online: 14 June 2018

PDF Pages: 288-303 Full Text (32830) Open Access

Review Articles

KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach

Javier de Castro Carpeño, Cristóbal Belda-Iniesta

Published online: 03 April 2013

PDF Pages: 142-151 Full Text (32380) Open Access

Review Article

Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey

Jeffrey P. Gregg, Tianhong Li, Ken Y. Yoneda

Published online: 30 June 2019

PDF Pages: 286-301 Full Text (32014) Open Access

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung

Yoon Jin Cha, Hyo Sup Shim

Published online: 11 October 2017

PDF Pages: 508-512 Full Text (31925) Open Access

Consensus

Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou)

Jianxing He, Hengrui Liang, Wei Wang, Andrey Akopov, Alberto Aiolfi, Keng-Leong Ang, Luca Bertolaccini, Kaican Cai, Qingdong Cao, Baojun Chen, Chang Chen, Chun Chen, Donglai Chen, Fengxia Chen, Jun Chen, Lei Chen, Mingwu Chen, Yongbing Chen, Zhuxing Chen, Chao Cheng, Dong Cui, Fei Cui, Tianyang Dai, Qinglong Dong, Paolo A. Ferrari, Raja M. Flores, Junke Fu, Soichiro Funaki, Marios E. Froudarakis, Xiangfeng Gan, Mingfei Geng, Jialong Guo, Qiang Guo, Yongtao Han, Jintao He, Kaiming He, Kyoji Hirai, Jian Hu, Shuqiao Hu, Jian Huang, Jun Huang, Wenfa Jiang, Kyung Soo Kim, Gabor Kiss, Fanyi Kong, Lan Lan, Xuefeng Leng, Bin Li, Gaofeng Li, Hecheng Li, Hefei Li, Heng Li, Jiwei Li, Xiaoqiang Li, Shuben Li, Yinfen Li, Zhuoyi Li, Yi Liang, Lixia Liang, Wenhua Liang, Yongde Liao, Wanli Lin, Xu Lin, Hongxu Liu, Hui Liu, Jixian Liu, Jun Liu, Xiang Liu, Zihao Liu, Xingzhao Lu, Qingquan Luo, Naiquan Mao, Qi Pan, Dazhi Pang, Jun Peng, Jun Peng, Eugenio Pompeo, Rulin Qian, Kun Qiao, Bassam Redwan, Zi Sang, Wenlong Shao, Jianfei Shen, Weiyu Shen, Sook-Whan Sung, Wenfang Tang, Tianhu Wang, Guangsuo Wang, Haitao Wang, Huien Wang, Jiyong Wang, Wen Wang, Yongyong Wang, Zhenyuan Wang, Li Wei, Wei Wei, Hao Wu, Jie Wu, Zhaohua Xia, Chenyang Xu, Enwu Xu, Hai Xu, Ning Xu, Quan Xu, Rongyu Xu, Shun Xu, Chaokun Yang, Hanyu Yang, Shengli Yang, Jun Yi, Guangjian Zhang, Hao Zhang, Jia Zhang, Man Zhang, Xiao Zhang, Yajie Zhang, Zhe Zhang, Zhifeng Zhang, Honglin Zhao, Jian Zhao, Xiaodong Zhao, Jianping Zhou, Yanran Zhou, Chengchu Zhu, Shaojin Zhu, Xinhai Zhu, Jian Cui, Yubo Yan, Ke-Neng Chen

Published online: 28 August 2021

PDF Pages: 3503-3519 Full Text (30251) COI Form Open Access

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer

Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto

Published online: 19 April 2015

PDF Pages: 156-164 Full Text (29238) Open Access

Review Articles

New TNM classification: achievements and hurdles

Peter Goldstraw

Published online: 17 August 2013

PDF Pages: 264-272 Full Text (28921) Open Access

Review Articles

Angiogenesis in cancer: anti-VEGF escape mechanisms

Gerald W. Prager, Marina Poettler, Matthias Unseld, Christoph C. Zielinski

Published online: 18 February 2012

PDF Pages: 14-25 Full Text (28772) Open Access

Full Most Read article list >>

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis

Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song

BRAF mutations in non-small cell lung cancer

Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper

The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer

Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper

Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice

Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song

Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer

Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song

Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer

Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen

The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants

Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden

The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices

Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer

Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto

Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement

Hyojin Kim, Jin-Haeng Chung

Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer

Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu

Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review

Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao

Clinical trials for lung cancer in China

Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu

Recurrence after surgery in patients with NSCLC

Hidetaka Uramoto, Fumihiro Tanaka

Prognostic markers in lung cancer: is it ready for prime time?

Chang-Qi Zhu, Ming-Sound Tsao

Potential biomarkers for lung cancer screening

Gabriella Sozzi, Mattia Boeri

Particle therapy in non-small cell lung cancer

Zhongxing Liao, Charles B. Simone II

Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions

Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai

Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer

Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft

Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors

Suchit H. Patel, Andreas Rimner, Roger B. Cohen

Intraoperative near-infrared imaging of mesothelioma

Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal

BAP1, a tumor suppressor gene driving malignant mesothelioma

Mitchell Cheung, Joseph R. Testa

Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation

Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh

Diagnostic and prognostic biomarkers for malignant mesothelioma: an update

Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang

Immunotherapy for malignant pleural mesothelioma: current status and future directions

Jordan Dozier, Hua Zheng, Prasad S. Adusumilli

Biology and clinical significance of circulating tumor cell subpopulations in lung cancer

Linda O’Flaherty, Harriet Wikman, Klaus Pantel

Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?

Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace

Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer

Sumitra Mohan, Francesca Chemi, Ged Brady

Biophysical technologies for understanding circulating tumor cell biology and metastasis

Derrick W. Su, Jorge Nieva

Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer

Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno

Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer

Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Editorial

An alternative way to initiate Notch1 signaling in non-small cell lung cancer

Yi-Lin Yang, David Jablons, Liang You

Combination MET- and EGFR-directed therapy in MET-overexpressing non-small cell lung cancers: time to move on to better biomarkers?

Fernando C. Santini, Siddharth Kunte, Alexander Drilon

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis

Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

China Lung Cancer Research Highlight

Dll4/Notch1 signaling from tip/stalk endothelial cell specification to stroma-dependent lung tumor inhibition: a flavor of Dll4/Notch1 pleiotropy in tumor cell biology

Maria Felice Brizzi, Paola Defilippi

Editorials

Dulanermin in cancer therapy: Still much to do

Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data

Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner

Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung

Pedro Mendez, Jose Luis Ramirez

Role of HGF/MET axis in resistance of lung cancer to contemporary management

Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr

Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review

Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Ceritinib

Clinical development and approval of second generation ALK inhibitors for ALK rearranged lung cancer

Daniel B. Costa

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack

Lorenza Landi, Federico Cappuzzo

Nivolumab

Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients with advanced non-small cell lung cancer

Arun Rajan, James L. Gulley

Brief Report

The role of Imaging and Radiation Oncology Core for precision medicine era of clinical trial

Ying Xiao, Mark Rosen

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung

Yoon Jin Cha, Hyo Sup Shim

Immunohistochemistry for predictive biomarkers in non-small cell lung cancer

Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

Review Article

SMARCA4 deficiency: implications for non-small cell lung cancer and management strategies, with relevance to and distinctions from thoracic undifferentiated tumor

Xin Zou, Xiaoqing Zhou, Xian Guo, Lei Pan, Wangping Li

Published online: 24 April 2025

Original Article

Efficacy and safety of anlotinib plus EGFR tyrosine kinase inhibitors in slow- or locally progressing non-small cell lung cancer after adjuvant therapy

Jiayue Ye, Jiacong Liu, Yucheng Ma, Wang Lv, Wenzhen Xu, Masaya Aoki, Yuhong Yang, Pinghui Xia, Luming Wang, Linhai Zhu, Jian Hu

Published online: 23 April 2025

Original Article

Nanoassemblies loaded with low-dose paclitaxel can enhance the response of lung cancer immunotherapy by activating dendritic cells

Jianlin Long, Dairong Li, Wei Zhao, Guanzhong Liang, Lumi Huang, Shuangyi Lei, Yan Li

Published online: 23 April 2025

Original Article

DNA damage and repair (DDR) gene mutation profiles in driver gene wild-type advanced non-small cell lung cancer and the predictive role of response to platinum-based chemotherapy

Tianxiu Wu, Yu Xu, Qiuyue Song, Xiuqing Liao, Wei Yao, Guangsong Wang, Yu Yang, Bin Wang, Liang Guo, Mingzhou Zhang, Guoming Wu, Li Luo, Li Bai, Yan Wang, Mingdong Hu, Zhi Xu

Published online: 22 April 2025

Original Article

Comparison of the effectiveness of alectinib versus crizotinib followed by alectinib in patients with ALK-positive advanced non-small-cell lung cancer in real-world setting and in the ALEX study

Xue Yang, Yutao Liu, Gen Lin, Jinliang Wang, Yudong Wang, Yan Zhang, Qinxiang Guo, Fei Liang, Jun Zhao, Bo Jin, Xiaorong Dong

Published online: 21 April 2025

Original Article

Prevalence of EGFR gene mutations in patients with early-stage resectable non-small cell lung cancer in Spain: the ORIGEN study

Mar Varela, Cristina Teixidó, Carlos Álvarez-Fernández, Hugo Arasanz, Sergio Peralta, Martín Lázaro, Virginia Calvo, Rosa Álvarez, Javier Baena, Javier Valdivia, Edurne Arriola, Reyes Bernabé, Dolores Isla, Carmen Camacho, Bartomeu Massutí, Ana Blasco, Teresa García, Manuel Cobo, Marc Campayo, Sara Hijazo-Pechero, Ángel Callejo, Marta Domínguez, Ernest Nadal

Published online: 21 April 2025

Original Article

Deep learning model for predicting spread through air spaces of lung adenocarcinoma based on transfer learning mechanism

Jia-Ning Zhang, Zhuo-Fu Li, Sun-Yi Zheng, Jiao-Jiao Li, Lei-Na Sun, Zhao-Xiang Ye

Published online: 18 April 2025

Original Article

Factors predicting early recurrence in patients with unresectable stage III non-small cell lung cancer on durvalumab consolidation after chemoradiotherapy

Ji Eun Park, Chanmi Kim, Sun Ha Choi, Jong Geol Jang, Kyung Soo Hong, Yong Shik Kwon, Keum-Ju Choi, Jung Seop Eom, Saerom Kim, Hee Yun Seol, Jehun Kim, Insu Kim, Jin Han Park, Tae Hoon Kim, June Hong Ahn

Published online: 18 April 2025

Review Article

Comprehensive management of MET tyrosine kinase inhibitor-induced peripheral edema in patients with MET-altered non-small-cell lung cancer: a narrative review

Jia-Xin Lin, Hao Sun, Ying-Long Peng, Zhi Xie, Si-Yang Maggie Liu, Yi-Long Wu

Published online: 17 April 2025

Original Article

Impact of immune-related adverse events on clinical outcomes in patients with advanced non-small cell lung cancer with low PD-L1 expression, focusing on pneumonitis: a multicenter retrospective study in Japan

Shiho Goda, Tadaaki Yamada, Kenji Morimoto, Tae Hata, Yasuhiro Goto, Akihiko Amano, Yoshiki Negi, Satoshi Watanabe, Naoki Furuya, Tomohiro Oba, Tatsuki Ikoma, Akira Nakao, Keiko Tanimura, Hirokazu Taniguchi, Akihiro Yoshimura, Tomoya Fukui, Daiki Murata, Kyoichi Kaira, Shinsuke Shiotsu, Asuka Okada, Makoto Hibino, Yusuke Chihara, Takashi Kijima, Koichi Takayama

Published online: 17 April 2025

Expert Consensus

Multidisciplinary international expert consensus on perioperative airway management

Hengrui Liang, Guowei Che, Fei Cui, Junguo Dong, Weiquan Gu, Chundong Gu, Shun Xu, Yufeng Ba, Kaican Cai, Qingdong Cao, Chang Chen, Chun Chen, Qixun Chen, Liyang Cheng, Gang Feng, Yunjiu Gou, Wenwei Guo, Jinxi He, Junming He, Jian Hu, Ying Huang, Wenxi Wang, Wenjie Jiao, Shunjun Jiang, Jun Liu, Lan Lan, Wei Li, Xiaofei Li, Zhongcheng Li, Yin Li, Zhu Liang, Hongxu Liu, Yingbin Liu, Xinyu Mei, Xicheng Song, Daqiang Sun, Hui Tian, Ziqiang Tian, Jianhua Wang, Guangsuo Wang, Xin Xu, Xudong Xiang, Guobing Xu, Tao Xue, Chao Yang, Xiaolong Yan, Nuo Yang, Feng Yao, Dalong Yin, Xiaochuan Yin, Bentong Yu, Wei Zhai, Yu Zhang, Guangjian Zhang, Xiaowen Zhang, Qiang Zhang, Yi Zhang, Jun Zhao, Haihui Zhong, Alessandro Brunelli, Till Ploenes, Luca Bertolaccini, John Kit Chung Tam, Min P. Kim, Majed Refai, Michel Gonzalez, Adam R. Dyas, Nicoletta Pia Ardò, Hiran C. Fernando, Giulio Maurizi, Gregor J. Kocher, Giuseppe Marulli, Álvaro Fuentes-Martín, Gianluca Perroni, Kyung Soo Kim, Maria Rodriguez, Marcus Taylor, Xusen Zou, Wei Wang, Jianxing He

Published online: 16 April 2025

Original Article

Uniportal video-assisted thoracoscopic surgery does not increase recurrence rates following pneumonectomy in non-small cell lung cancer: a retrospective study from the National Cancer Center of China

Sikai Wu, Xiaowei Chen, Guangyu Bai, Yang Liu, Zhenlin Yang, Shugeng Gao

Published online: 16 April 2025

Original Article

Exosomal miR-182-5p is a potential diagnostic marker for malignant pleural effusion

Wen Zhao, Jian-Xun Wen, Yan Niu, Li Yan, Mei-Ying Wang, Wei Jiao, Ya-Fei Wang, Wen-Hui Gao, Dan-Ni Yang, Wen-Qi Zheng, Zhi-De Hu

Published online: 16 April 2025

Original Article

Efficacy and safety of finotonlimab plus docetaxel vs. docetaxel in previously treated advanced squamous cell non-small-cell lung cancer: a randomized, double-blinded, phase III trial

Baohui Han, Lin Wu, Runxiang Yang, Hongbo Wu, Wei Li, Yan Yu, Mingjuan Zhang, Hongmei Sun, Tianqing Chu, Fukuan Zhong, Yong Fang, Rong Wu, Tao Bian, Xiaoqing Guo, Meili Sun, Yanming Zhang, Lianke Liu, Xuewen Liu, Yueyin Pan, Ou Jiang, Zonghui Wei, Haifeng Lin, Wei Guo, Jian Fang, Jialei Wang, Cuimin Ding, Yanping Hu, Feng Ye, Wu Zhuang, Shucheng Ye, Lihong Wang, Zhe Huang, Chang Liu, Ling Yang, Jinling Wang, Liangzhi Xie

Published online: 16 April 2025

Original Article

Using human genetics to understand the epidemiological association between neuroticism and lung cancer

Dongsheng Wu, Yongcheng Liu, Shuqiao Liu, Xiaohu Hao, Xin Li, Quan Zheng, Tengyong Wang, Yuchen Huang, Shiyou Wei, Jian Zhou, Lunxu Liu

Published online: 15 April 2025

Original Article

Effect of the number of induction chemotherapy cycles on the efficacy of first-line atezolizumab combined with chemotherapy in extensive-stage small cell lung cancer

Mengxing You, Jiayu Liu, Fei Teng, Lige Wu, Haifeng Qin, Yan Zhang, Cuiying Zhang, Ziling Liu, Kewei Ma, Esteban C. Gabazza, Jacopo Vannucci, Xuezhi Hao, Junling Li, Puyuan Xing

Published online: 15 April 2025

Original Article

Integrating radiomics and deep learning for enhanced prediction of high-grade patterns in stage IA lung adenocarcinoma

Zhongxiao Chen, Hao Liu, Hua Sun, Cheng Xu, Bingyu Hu, Luyu Qu, William C. Cho, Thivanka Witharana, Chengchu Zhu, Jianfei Shen

Published online: 15 April 2025

Original Article

Tracheobronchial resection and reconstruction: to wrap or not to wrap the anastomosis?

Chudong Wang, Zihao Liu, Rui Wang, Biao Hu, Binbin Xiang, Zijian Li, Jianxing He, Shuben Li

Published online: 11 April 2025

Review Article

Molecular heterogeneity of small cell lung cancer and new therapeutic possibilities: a narrative review of the literature

Valeria Cognigni, Ilaria Toscani, Simona D’Agnelli, Federica Pecci, Luisella Righi, Rossana Berardi, Marcello Tiseo

Published online: 07 April 2025

Journal Highlight more

Translational Lung Cancer Research is an international, peer-reviewed, open-access journal indexed by Science Citation Index Expanded (SCIE) and PubMed/PubMed Central, focusing on cutting-edge development on the transition from preclinical to clinical research, including but not limited to multimodality therapy, markers, imaging, tumor biology, pathology, chemoprevention, and technical advances related to lung cancer and relevant thoracic diseases.