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Expert Consensus

International Consensus on Severe Lung Cancer—The Second Edition
Xinqing Lin, Qian Chu, Yuchao Dong, Min Li, Tangfeng Lv, Gen Lin, Ling Sang, Panwen Tian, Yang Xia, Zhanhong Xie, Haiming Chen, Cheng Hong, Juan Jiang, Haoru Jin, Zhongkai Kuai, Ming Liu, Weizhan Luo, Yongbei Luo, Qian Miao, Wei Mo, Dan Pu, Yuan Qiu, Zhe Qian, Jiancong Sun, Hui Shi, Qinying Sun, Yutao Sun, Zihui Yu, Xiaohong Xie, Wanting Xu, Minxiao Yi, Dongmei Yuan, Longfeng Zhang, Fei Zhao, Changhao Zhong, Ping Zhan, Xiaobin Zheng, Cunxue Bai, Enguo Chen, Rui Chen, Xin Chen, Yuan Cheng, Quanfang Chen, Linbo Cai, Xiuyu Cai, Liangan Chen, Yan Chen, Wen Dong, Haiyi Deng, Wenfeng Fang, Xin Gan, Yue Hao, Weidong Hu, Yong He, Yi Hu, Jie Hu, Baohui Han, Chengping Hu, Minjuan Hu, Yongliang Jiang, Yang Jin, Dan Liu, Weiting Liu, Wen Li, Jing Li, Laiyu Liu, Jun Liu, Weifeng Li, Wenhua Liang, Jie Lin, Hongbing Liu, Ziming Li, Weimin Li, NiHong Lu, Shun Lu, Chuanyong Mu, Hongxia Ma, Liyun Miao, Xinlin Mu, Xingxiang Pu, Jing Peng, Hongbing Peng, Jianwen Qin, Yinyin Qin, Shengxiang Ren, Longhua Sun, Chunxia Su, Yong Song, Xiaowu Tan, Kejing Tang, Xiaomei Tang, Jianlin Tong, Wenxian Wang, Di Wu, Lin Wu, Mengzhao Wang, Huijuan Wang, Yuehong Wang, Hongmei Wang, Qi Wang, Zhijie Wang, Jie Wang, Kai Wang, Fei Wang, Chunwei Xu, Min Xie, Aiguo Xu, Kui Xiao, Xin Xu, Fei Xu, Xianwei Ye, Meng Yang, Boyan Yang, Xiaoqun Ye, Feng Ye, Zongyang Yu, Dongsheng Yue, Qichuan Zhang, Juntao Zou, Jian Zhang, Li Zhuang, Jianying Zhou, Jianya Zhou, Bicheng Zhang, Jian Zhang, Jianqing Zhang, Xiaoju Zhang, Wei Zhao, Bo Zhu, Zhengfei Zhu, Wenzhao Zhong, Caicun Zhou, Yanbin Zhou, Jianxing He, Nanshan Zhong, Yuichi Saito, Satoshi Watanabe, Francesco Petrella, Takeo Nakada, Taichiro Goto, Alfonso Fiorelli, Piergiorgio Solli, Rossana Berardi, Yoshinobu Ichiki, Marcin Braun, Misako Nagasaka, Christos Chouaïd, Rajat Thawani, Pedro Gonzalez Santa-Catalina, Kim Styrvoky, Baptiste Abbar, Mariano Provencio, Shiyue Li, Rongchang Chen, Chengzhi Zhou
Translational Lung Cancer Research  
2026;
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:69
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 (30 April 2026) 
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Original Article

Deep learning model based on automated CT image segmentation for predicting the optimal radiotherapy protocol in limited-stage small cell lung cancer patients: a multicenter study
Junfeng Zhao, Zongqian Yuan, Jinquan Yao, Ying Li, Haining Luo, Chengxin Liu
Translational Lung Cancer Research  
2026;
15
(4)
:70
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 (30 April 2026) 
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Association of PD-L1 expression and clinical outcomes in ROS1-rearranged advanced non-small cell lung cancer treated with entrectinib
Lixuan Chen, Wenhui Shi, Zhengqi Cao, Li Lu, Anni Wang, Jing Sun, Yuxin Ouyang, Peiyi Xu, Junjie Tang, Ziming Li
Translational Lung Cancer Research  
2026;
15
(4)
:71
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 (30 April 2026) 
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DNA hypomethylation-activated PRAME drives early-stage lung adenocarcinoma recurrence via ZNF740 and PI3K/AKT/mTOR signaling
Guo-Nian Zhu, Qian Zheng, Pan Yang, Xue-Fei He, Pan Tang, Cheng-Di Wang, Jun Tang, Wei-Min Li, Zhou-Feng Wang
Translational Lung Cancer Research  
2026;
15
(4)
:72
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 (30 April 2026) 
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Predictors of radiation pneumonitis after postoperative radiotherapy in completely resected pathologic stage III-N2 non-small cell lung cancer: a secondary analysis of a prospective cohort
Nengyang Wang, Aihui Feng, Hongxuan Li, Changlu Wang, Jindong Guo, Yuxi Yi, Qin Zhang, Jun Liu, Wen Yu, Zhiyong Xu, Xuwei Cai, Wen Feng, Xiaolong Fu
Translational Lung Cancer Research  
2026;
15
(4)
:73
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 (30 April 2026) 
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Perioperative anxiety and depression predict long-term survival after neoadjuvant therapy in non-small cell lung cancer: a multicenter analysis
Yuxing Lin, Qichang Xie, Maojie Pan, Xin Yan, Renjie Huang, Guobing Xu, Bin Zheng, Zhang Yang, Chun Chen
Translational Lung Cancer Research  
2026;
15
(4)
:74
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 (30 April 2026) 
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TLR7 induces autophagy in non-small cell lung cancer tumor cells and influences anti-tumors responses in patients
Lucas Leonardi, Solenne Marmier, Nathalie Josseaume, Sophie Sibéril, Mathilde Prieto, Karen Leroy, Audrey Mansuet-Lupo, Diane Damotte, Marco Alifano, Isabelle Cremer, Pierre-Emmanuel Joubert
Translational Lung Cancer Research  
2026;
15
(4)
:75
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 (30 April 2026) 
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Prognostic nomogram for extensive-stage small-cell lung cancer in the immunotherapy era: a multicenter study of first-line platinum-etoposide with or without a PD-1/PD-L1 inhibitor
Yuhao Jing, Yifan Zhao, Zhenbao Zhou, Jianyu Wang, Yanbo Wang, Kai Ma, Zhiguang Sun, Qiuqiao Mu, Wei Li, Yun Ding, Han Zhang, Yuhang Jiang, Xiaoteng Jia, Lin Tan, Meng Wang, Xin Li
Translational Lung Cancer Research  
2026;
15
(4)
:76
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 (30 April 2026) 
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LUADnet: a deep learning model for prediction of clinical outcomes in lung adenocarcinoma based on gene expression signatures
Cheng Cheng, Zhanlue Liang, Renjie Xu, Yanlin Gu, Shicheng Wu, Haoyu Wang, Nini Shi, Die Zhang, Huilin Zhong, Yiwen Tao, Weimin Li
Translational Lung Cancer Research  
2026;
15
(4)
:77
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 (30 April 2026) 
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Perioperative inflammation, anesthesia modulation and cellular signaling in lung cancer: an integrated transcriptomic and single-cell analysis
Weixiang Lu, Qing Ai, Ze Wang, Tao Zhang, Shiyu Deng, Jianxing He, Wenlong Shao
Translational Lung Cancer Research  
2026;
15
(4)
:78
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 (30 April 2026) 
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Mid-term efficacy and safety of transbronchial cryoablation for stage IA peripheral lung cancer: a retrospective analysis
Rui Yang, Junxiang Chen, Fangfang Xie, Chuanjia Gu, Siyuan Hong, Haiyu Zhu, Yifeng Jiang, Jiayuan Sun
Translational Lung Cancer Research  
2026;
15
(4)
:79
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 (30 April 2026) 
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Preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)-based strategy for predicting negative mediastinal lymph node metastasis status in non-small cell lung cancer
Juntian Yao, Fangqiu Fu, Nan Li, Chaoqiang Deng, Shaoli Song, Yang Zhang, Haiquan Chen
Translational Lung Cancer Research  
2026;
15
(4)
:80
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 (30 April 2026) 
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Distinct mutation landscape with similar immune microenvironment in primary simultaneous operable squamous cell carcinoma and peripheral-type small-cell lung cancer
Xiaoke Chen, Liqiang Qian, Jia Huang, Wei Mao, Jiaxin Zhong, Xiaoling Weng, Ting Wang, Zhengping Ding, Yun Liu, Fatao Liu, Xiaomin Niu
Translational Lung Cancer Research  
2026;
15
(4)
:81
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 (30 April 2026) 
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Impact of effective dose to immune cells (EDIC) on survival in limited-stage small cell lung cancer treated with radiotherapy and immunotherapy
Mengqian Jiang, Yuantao Qi, Zihong Zhu, Wenqing Cui, Ran Zhang, Jinming Yu, Dawei Chen
Translational Lung Cancer Research  
2026;
15
(4)
:82
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 (30 April 2026) 
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Air pollution, driver mutations, and survival in non-small cell lung cancer: insights from a high-altitude Hispanic cohort
Mateo Tamayo, Nicolás Duque-Clavijo, Astrid Berena Herrera-López, Manuela Estrada-Schweineberg, Andres Felipe Bejarano, Juliana Pardo-Aljure, Laura Baldovino-Chiquillo, David Uscategui-López, Sebastián Dueñas-Hernández, María Paula Molina, María José García, Diana Cañon, Margarita Baldión, Sergio Cruz, Luis Eduardo Pino, Henry Vargas, Javier Segovia, Erick Cantor, Omaira Valencia-Estupiñan, Olga L. Sarmiento, Andrés F. Cardona, Beatriz Wills
Translational Lung Cancer Research  
2026;
15
(4)
:83
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 (30 April 2026) 
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TROP2 expression as a prognostic predictor for osimertinib in patients with EGFR-mutant non-small cell lung cancer
Naohito Hashimoto, Kyoichi Kaira, Hisao Imai, Shota Takei, Kosuke Hashimoto, Ou Yamaguchi, Atsuto Mouri, Mei Hamada, Taku Honma, Hiroshi Kagamu
Translational Lung Cancer Research  
2026;
15
(4)
:84
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 (30 April 2026) 
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Occupational physical workload and risk of lung cancer and chronic respiratory diseases: a prospective cohort study of the UK Biobank
Shuxiao Ma, Yi Liu, Zihuai Wang, Xuyuan Shi, Min Yi, Lunxu Liu
Translational Lung Cancer Research  
2026;
15
(4)
:85
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 (30 April 2026) 
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Accelerating tumor evolution and enhancing immunotherapy efficacy in lung adenocarcinoma based on EXO1 inhibition
Xianfei Zhang, Liangjiao Yao, Zhengxin Yin, Fangxiu Luo, Yu Li, Anqi Yang, Runsen Jin, Wei Lu, Hecheng Li
Translational Lung Cancer Research  
2026;
15
(4)
:86
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 (30 April 2026) 
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“Variant matters”: the impact of ALK fusion subtypes on progression and response in non-small-cell lung cancer—data from clinical practice from Polish centers
Kinga Winiarczyk, Katarzyna Seliga, Paweł Krawczyk, Aleksandra Nowak, Izabela Chmielewska, Andrzej Tysarowski, Małgorzata Szołkowska, Michał Gil, Dariusz M. Kowalski, Janusz Milanowski, Maciej Krzakowski
Translational Lung Cancer Research  
2026;
15
(4)
:87
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 (30 April 2026) 
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Association between patient-reported outcomes and pathological response in neoadjuvant chemoimmunotherapy—a post hoc analysis of the TD-FOREKNOW trial
Bengang Hui, Na Zhang, Jiangnan Duan, Xiaojing Wang, Runmin Jiang, Rongxin Shang, Bowei Qiao, Weibo Yang, Chao Wang, Yanning Zhang, Xiaolong Yan, Tao Jiang, Jie Lei
Translational Lung Cancer Research  
2026;
15
(4)
:88
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 (30 April 2026) 
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Evaluating the early therapeutic response of radiofrequency ablation in rabbit VX2 lung tumors: a comparison of four diffusion weighted imaging models
Qinqin Yan, Wen Ye, Fei Shan, Yuxin Shi, Zhiyong Zhang, Zenghui Cheng
Translational Lung Cancer Research  
2026;
15
(4)
:89
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 (30 April 2026) 
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Novel lipid metabolism-related gene signature associated with clinical and immune features in lung adenocarcinoma patients experiencing lymph node metastasis
Shen Lao, Zisheng Chen, Yuan Zhang, Jianfu Li, Hengrui Liang, Yongmei Zheng, Xiaoyan Liu, Wei Wang, Wenhua Liang
Translational Lung Cancer Research  
2026;
15
(4)
:90
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 (30 April 2026) 
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Assessing current diagnostic, staging, and treatment practices in community and academic centers for individuals with stage IB–IIIA non-small cell lung cancer
Matthew P. Smeltzer, Jhanelle E. Gray, Michelle Shiller, Jamie L. Studts, David J. Feller-Kopman, Jennifer Aversano, Percy Lee, Brendon M. Stiles, Benjamin Wei, Bianca Alvarez, Ashley Lile, Molly Kisiel, Rania Emara, Joseph Kim, Elana Plotkin
Translational Lung Cancer Research  
2026;
15
(4)
:91
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 (30 April 2026) 
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The IASLC grading system as a predictor for EGFR-TKI therapy in patients with EGFR-mutant lung adenocarcinoma
Chaoqiang Deng, Molin Zhang, Fangqiu Fu, Qiang Zheng, Yuan Li, Yang Zhang, Haiquan Chen
Translational Lung Cancer Research  
2026;
15
(4)
:92
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 (30 April 2026) 
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Beyond miRNAs: exploratory profiling of PIWI-interacting RNAs and small nucleolar RNAs in non-small cell lung cancer-related malignant pleural effusions
Joel Gabàs, Rui Alves, José M. Porcel, Anabel Sorolla
Translational Lung Cancer Research  
2026;
15
(4)
:93
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 (30 April 2026) 
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Pre-clinical efficacy of trastuzumab deruxtecan plus sotorasib in KRASG12C-mutant non-small cell lung cancer and exploratory HER2 profiling in human tumors
Hilal Ozakinci, Bina Desai, Denise Kalos, Dung-Tsa Chen, Menkara Henry, Hitendra Solanki, Theresa A. Boyle, Humberto E. Trejo Bittar, Gina S. Nazario, Eric B. Haura, Andriy Marusyk, Bruna Pellini
Translational Lung Cancer Research  
2026;
15
(4)
:94
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 (30 April 2026) 
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Timing of definitive pleural intervention within systemic anticancer therapy in malignant pleural effusion from high-response lung cancers: a retrospective single-center cohort study
Ana Pardessus Otero, Sergio Martínez-Recio, Albert Rafecas-Codern, Génesis Parada Pérez, Joel Lakhani Lakhani, Carlos Reyes, Ángel Fernández i Rebollo, Havid Jesús Colina Beltrán, Andrés Barba Joaquín, Margarita Majem, Juan Carlos Trujillo, Elisabeth Martínez, Pere Serra-Mitjà, Virginia Pajares
Translational Lung Cancer Research  
2026;
15
(4)
:95
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 (30 April 2026) 
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Consolidative thoracic radiotherapy after first-line chemoimmunotherapy in extensive-stage small-cell lung cancer: a multicenter retrospective study
Shengxin Zhang, Nan Lin, Xiaojuan Gu, Ziyang Cheng, Xiang Lin, Xiao Liang, Xinggang Yang, Jie Chen, Xuelei Ma, Hu Liao
Translational Lung Cancer Research  
2026;
15
(4)
:96
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 (30 April 2026) 
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Real-world effectiveness and safety of adebrelimab as first-line treatment in patients with extensive-stage small cell lung cancer
Tangfeng Lv, Bi Chen, Wei Chen, Yanmin Wu, Haitao Fei, Surong Fang, Lingfeng Min, Chong Li, Shuhua Han, Zhitong Zuo, Shencun Fang, Yahui Shen, Fenhong Qian, Bo Shen, Haitao Zhang, Ruifeng Zhang, Hui Liu, Lifeng Wang, Yong Song
Translational Lung Cancer Research  
2026;
15
(4)
:97
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 (30 April 2026) 
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Identification of prognostic biomarkers and immunotherapy response predictors in lung adenocarcinoma: integrative Mendelian randomization and machine learning analysis
Chenlin Cao, Wan Qin, Ruoxuan Gong, Zhiyong Luo, Hong Zhang, Xianglin Yuan, Yanmei Zou, Shengling Fu, Hua Xiong
Translational Lung Cancer Research  
2026;
15
(4)
:98
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 (30 April 2026) 
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Cadonilimab induction and consolidation for unresectable stage III non-small cell lung cancer patients receiving concurrent chemoradiation: safety run-in results of a prospective, phase II trial
Jianjiao Ni, Zilu Zheng, Xi Yang, Xiao Chu, Yue Zhou, Yechun Pang, Hongru Chen, Silai Yu, Fei Liang, Zhengfei Zhu, Li Chu
Translational Lung Cancer Research  
2026;
15
(4)
:99
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 (30 April 2026) 
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Gender disparities in the overall survival of patients with minimally invasive squamous cell carcinoma of the lung: a retrospective analysis of the Surveillance, Epidemiology, and End Results Program database
Yucheng Ma, Jiayue Ye, Jiacong Liu, Yonghui Wang, Wang Lv, Luming Wang, Sheng Hu, Jian Hu
Translational Lung Cancer Research  
2026;
15
(4)
:100
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 (30 April 2026) 
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Review Article

The resistance landscape of EGFR tyrosine kinase inhibitors in advanced non-small cell lung cancer: molecular mechanisms and novel therapeutic strategies
Shuotong Liu, Linsen Zhou, Yongze He, Qianyi Liu, Ying Tang, Zhen Liu, Xianhu Zeng, Jiangping Li
Translational Lung Cancer Research  
2026;
15
(4)
:101
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 (30 April 2026) 
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Understanding the dual role of granulocyte-macrophage colony-stimulating factor in the lung cancer tumor microenvironment and its therapeutic implications
Gang Wei, Xuanji Zhu, Rui Zhong
Translational Lung Cancer Research  
2026;
15
(4)
:102
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 (30 April 2026) 
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From biology to the clinic: research evidence and therapeutic advances of TROP2-targeted antibody-drug conjugates in small cell lung cancer
Haoyu Lu, Meiying Zhu, Yaning Luo, Qiyu Fan, Lihan Shang, Na Wang, Fanming Kong
Translational Lung Cancer Research  
2026;
15
(4)
:103
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 (30 April 2026) 
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Pulmonary ground glass opacity tumor: a curable subtype of lung cancer when treated within the “surgical curative time window”
Ting Ye, Haoxuan Wu, Haiquan Chen
Translational Lung Cancer Research  
2026;
15
(4)
:104
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 (30 April 2026) 
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Methylated circulating tumor DNA: technical challenges and clinical applications in non-small cell lung cancer patients—a narrative review
Manon Robert, Chloé Sauzay, Sandrine Théoleyre, Audrey Vallée, Delphine Fradin, Elvire Pons-Tostivint, Marc G. Denis
Translational Lung Cancer Research  
2026;
15
(4)
:105
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 (30 April 2026) 
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Targeted therapy for stage IA non-small cell lung cancer with EGFR mutations: a scoping review
Yafei Xie, Liang Xia, Zhenyi Niu, Xiaolong Zhang, Yikai Xing, Xingqi Mi, Zhangyi Dai, Guangjian Zhang, Jian Hu, Qiang Pu
Translational Lung Cancer Research  
2026;
15
(4)
:106
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 (30 April 2026) 
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Lung cancer associated with cystic airspaces in the perioperative immunotherapy era: radiologic and pathologic pitfalls, surgical extent, and management implications
Xue He, Qi Liu, Weijia Zeng, Qingchun Liang, Jiadi Luo, Juan Chen, Fenglei Yu, Wenliang Liu, Chen Chen
Translational Lung Cancer Research  
2026;
15
(4)
:107
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 (30 April 2026) 
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Narrative review of the similarities and differences between immune checkpoint inhibitor- and antibody-drug conjugate-associated pneumonitis
Ruiting Tan, Fangfei Qian, Yao Zhang, Shuhui Cao, Hua Zhong
Translational Lung Cancer Research  
2026;
15
(4)
:108
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 (30 April 2026) 
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Case Report

A lung squamous cell carcinoma demonstrating spontaneous partial regression of the primary tumor with lymph node metastasis: a case report with analysis of the tumor immune microenvironment
Hiroyuki Yamada, Yoshihiro Komohara, Takamasa Koga, Shukang Zhao, Rin Yamada, Shoichi Murai, Ko Nakao, Taro Muramoto, Yusuke Shinchi, Eri Matsubara, Kosuke Fujino, Koei Ikeda, Makoto Suzuki
Translational Lung Cancer Research  
2026;
15
(4)
:109
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 (30 April 2026) 
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Prolonged complete metabolic response to chemotherapy combined with amivantamab with high grade cutaneous toxicity after osimertinib resistance in an uncommon T751_I759delinsAsp EGFR-mutant lung adenocarcinoma: a case report
Jean-Baptiste Barbe-Richaud, Erwan Pencreach, Roland Schott, Emilie Holder, Laura Somme
Translational Lung Cancer Research  
2026;
15
(4)
:110
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 (30 April 2026) 
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Clonal relationship in a rare pulmonary mixed tumor: shared ALK fusion in atypical carcinoid and adenocarcinoma—a case report
Kyoung Min Kim, Jong Hun Kim, Myoung Ja Chung
Translational Lung Cancer Research  
2026;
15
(4)
:111
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 (30 April 2026) 
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Two-year treatment-free sustained remission after chemo-immunotherapy in a 52-year-old male with recurrent ARID1A-mutant lung adenocarcinoma: a case report
Pedro Gonzalez Santa-Catalina, Daniel Morchón-Araujo, Marta Rodríguez-González, José María Sayagués, Mar Abad, Lorena Bellido-Hernández, Emilio Fonseca-Sánchez, Alejandro Olivares-Hernández, Edel del Barco-Morillo
Translational Lung Cancer Research  
2026;
15
(4)
:112
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 (30 April 2026) 
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ALK-tyrosine kinase inhibitor resistance due to acquired MET amplification in ALK-fusion positive advanced NSCLC effectively treated by lorlatinib-vebreltinib combination: a case report and literature review
Peng Song, Dahong Liu, Yi Liu
Translational Lung Cancer Research  
2026;
15
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:113
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 (30 April 2026) 
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Editorial Commentary

Precision medicine in the first-line treatment of EGFR-mutated non-small cell lung cancer: moving beyond “one-size-fits-all”
Hiroaki Ikushima, Hidenori Kage
Translational Lung Cancer Research  
2026;
15
(4)
:114
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 (30 April 2026) 
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Survival, toxicity, and sequencing: navigating the new first-line standard established by FLAURA2
Satoshi Ikeda, Keigo Araki, Mai Kitagawa, Natsuno Makihara, Yutaro Nagata, Kazuki Fujii, Kiyori Yoshida, Tatsuki Ikoma, Kahori Nakahama, Yuki Takeyasu, Utae Katsushima, Yuta Yamanaka, Takayasu Kurata
Translational Lung Cancer Research  
2026;
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(4)
:115
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 (30 April 2026) 
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Review Articles 
Management of ground-glass opacities: should all pulmonary lesions with ground-glass opacity be surgically resected?
Yoshihisa Kobayashi, Tetsuya Mitsudomi
Published online: 22 October 2013
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Editorial Commentary 
Ground glass nodules with 5 years’ stability can grow after 10-year follow-up: do genetic features determine the fate?
Yoshihisa Kobayashi, Tetsuya Mitsudomi
Published online: 31 December 2019
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Review Article 
Non-small cell lung cancer: current treatment and future advances
Cecilia Zappa, Shaker A. Mousa
Published online: 30 June 2016
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Review Articles 
Irreversible EGFR-TKIs: dreaming perfection
Lorenza Landi, Federico Cappuzzo
Published online: 14 January 2013
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Review Article 
Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology
Jian-Wei Gao, Stefania Rizzo, Li-Hong Ma, Xiang-Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia-Wei Zou, Qian Li, Marco Femia, Tang-Feng Lv, Yong Song, written on behalf of the AME Lung Cancer Collaborative Group
Published online: 28 February 2017
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Review Article 
Recurrence after surgery in patients with NSCLC
Hidetaka Uramoto, Fumihiro Tanaka
Published online: 28 August 2014
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Review Article 
Treatment of uncommon EGFR mutations in non-small cell lung cancer: new evidence and treatment
Tianli Zhang, Bing Wan, Yuan Zhao, Chuling Li, Hongbing Liu, Tangfeng Lv, Ping Zhan, Yong Song
Published online: 30 June 2019
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Review Article 
Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
Bryan A. Chan, Brett G.M. Hughes
Published online: 24 February 2015
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Review Article 
Ground-glass nodules of the lung in never-smokers and smokers: clinical and genetic insights
Yoshihisa Kobayashi, Chiara Ambrogio, Tetsuya Mitsudomi
Published online: 28 August 2018
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Review Article 
Lung cancer prediction using machine learning and advanced imaging techniques
Timor Kadir, Fergus Gleeson
Published online: 14 June 2018
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Review Article 
The past, present and future of immunotherapy against tumor
Tao Jiang, Caicun Zhou
Published online: 24 June 2015
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Review Article 
The epidemiology of lung cancer
Patricia M. de Groot, Carol C. Wu, Brett W. Carter, Reginald F. Munden
Published online: 14 June 2018
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Review Article 
Lung cancer screening: nodule identification and characterization
Ioannis Vlahos, Konstantinos Stefanidis, Sarah Sheard, Arjun Nair, Charles Sayer, Joanne Moser
Published online: 14 June 2018
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Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer 
Biology of invasive mucinous adenocarcinoma of the lung
Yoon Jin Cha, Hyo Sup Shim
Published online: 11 October 2017
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Review Article 
Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey
Jeffrey P. Gregg, Tianhong Li, Ken Y. Yoneda
Published online: 30 June 2019
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Review Articles 
KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach
Javier de Castro Carpeño, Cristóbal Belda-Iniesta
Published online: 03 April 2013
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Consensus 
Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou)
Jianxing He, Hengrui Liang, Wei Wang, Andrey Akopov, Alberto Aiolfi, Keng-Leong Ang, Luca Bertolaccini, Kaican Cai, Qingdong Cao, Baojun Chen, Chang Chen, Chun Chen, Donglai Chen, Fengxia Chen, Jun Chen, Lei Chen, Mingwu Chen, Yongbing Chen, Zhuxing Chen, Chao Cheng, Dong Cui, Fei Cui, Tianyang Dai, Qinglong Dong, Paolo A. Ferrari, Raja M. Flores, Junke Fu, Soichiro Funaki, Marios E. Froudarakis, Xiangfeng Gan, Mingfei Geng, Jialong Guo, Qiang Guo, Yongtao Han, Jintao He, Kaiming He, Kyoji Hirai, Jian Hu, Shuqiao Hu, Jian Huang, Jun Huang, Wenfa Jiang, Kyung Soo Kim, Gabor Kiss, Fanyi Kong, Lan Lan, Xuefeng Leng, Bin Li, Gaofeng Li, Hecheng Li, Hefei Li, Heng Li, Jiwei Li, Xiaoqiang Li, Shuben Li, Yinfen Li, Zhuoyi Li, Yi Liang, Lixia Liang, Wenhua Liang, Yongde Liao, Wanli Lin, Xu Lin, Hongxu Liu, Hui Liu, Jixian Liu, Jun Liu, Xiang Liu, Zihao Liu, Xingzhao Lu, Qingquan Luo, Naiquan Mao, Qi Pan, Dazhi Pang, Jun Peng, Jun Peng, Eugenio Pompeo, Rulin Qian, Kun Qiao, Bassam Redwan, Zi Sang, Wenlong Shao, Jianfei Shen, Weiyu Shen, Sook-Whan Sung, Wenfang Tang, Tianhu Wang, Guangsuo Wang, Haitao Wang, Huien Wang, Jiyong Wang, Wen Wang, Yongyong Wang, Zhenyuan Wang, Li Wei, Wei Wei, Hao Wu, Jie Wu, Zhaohua Xia, Chenyang Xu, Enwu Xu, Hai Xu, Ning Xu, Quan Xu, Rongyu Xu, Shun Xu, Chaokun Yang, Hanyu Yang, Shengli Yang, Jun Yi, Guangjian Zhang, Hao Zhang, Jia Zhang, Man Zhang, Xiao Zhang, Yajie Zhang, Zhe Zhang, Zhifeng Zhang, Honglin Zhao, Jian Zhao, Xiaodong Zhao, Jianping Zhou, Yanran Zhou, Chengchu Zhu, Shaojin Zhu, Xinhai Zhu, Jian Cui, Yubo Yan, Ke-Neng Chen
Published online: 28 August 2021
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Review Article 
Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Published online: 19 April 2015
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Review Article 
Global trends of lung cancer mortality and smoking prevalence
Farhad Islami, Lindsey A. Torre, Ahmedin Jemal
Published online: 20 August 2015
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Review Articles 
Angiogenesis in cancer: anti-VEGF escape mechanisms
Gerald W. Prager, Marina Poettler, Matthias Unseld, Christoph C. Zielinski
Published online: 18 February 2012
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Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis
Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song
BRAF mutations in non-small cell lung cancer
Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper
The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer
Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper
Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice
Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song
Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song
Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer
Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen
The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden
The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices
Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement
Hyojin Kim, Jin-Haeng Chung
Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer
Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Clinical trials for lung cancer in China
Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Recurrence after surgery in patients with NSCLC
Hidetaka Uramoto, Fumihiro Tanaka
Prognostic markers in lung cancer: is it ready for prime time?
Chang-Qi Zhu, Ming-Sound Tsao
Potential biomarkers for lung cancer screening
Gabriella Sozzi, Mattia Boeri
Particle therapy in non-small cell lung cancer
Zhongxing Liao, Charles B. Simone II
Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions
Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer
Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft
Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors
Suchit H. Patel, Andreas Rimner, Roger B. Cohen
Intraoperative near-infrared imaging of mesothelioma
Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal
BAP1, a tumor suppressor gene driving malignant mesothelioma
Mitchell Cheung, Joseph R. Testa
Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation
Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh
Diagnostic and prognostic biomarkers for malignant mesothelioma: an update
Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Immunotherapy for malignant pleural mesothelioma: current status and future directions
Jordan Dozier, Hua Zheng, Prasad S. Adusumilli
Biology and clinical significance of circulating tumor cell subpopulations in lung cancer
Linda O’Flaherty, Harriet Wikman, Klaus Pantel
Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?
Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace
Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer
Sumitra Mohan, Francesca Chemi, Ged Brady
Biophysical technologies for understanding circulating tumor cell biology and metastasis
Derrick W. Su, Jorge Nieva
Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer
Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer
Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Editorial

An alternative way to initiate Notch1 signaling in non-small cell lung cancer
Yi-Lin Yang, David Jablons, Liang You
Combination MET- and EGFR-directed therapy in MET-overexpressing non-small cell lung cancers: time to move on to better biomarkers?
Fernando C. Santini, Siddharth Kunte, Alexander Drilon

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis
Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

China Lung Cancer Research Highlight

Dll4/Notch1 signaling from tip/stalk endothelial cell specification to stroma-dependent lung tumor inhibition: a flavor of Dll4/Notch1 pleiotropy in tumor cell biology
Maria Felice Brizzi, Paola Defilippi

Editorials

Dulanermin in cancer therapy: Still much to do
Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data
Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung
Pedro Mendez, Jose Luis Ramirez
Role of HGF/MET axis in resistance of lung cancer to contemporary management
Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr
Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review
Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Ceritinib

Clinical development and approval of second generation ALK inhibitors for ALK rearranged lung cancer
Daniel B. Costa

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack
Lorenza Landi, Federico Cappuzzo

Nivolumab

Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients with advanced non-small cell lung cancer
Arun Rajan, James L. Gulley

Brief Report

The role of Imaging and Radiation Oncology Core for precision medicine era of clinical trial
Ying Xiao, Mark Rosen

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung
Yoon Jin Cha, Hyo Sup Shim
Immunohistochemistry for predictive biomarkers in non-small cell lung cancer
Mari Mino- Kenudson

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Translational Lung Cancer Research is an international, peer-reviewed, open-access journal indexed by Science Citation Index Expanded (SCIE) and PubMed/PubMed Central, focusing on cutting-edge development on the transition from preclinical to clinical research, including but not limited to multimodality therapy, markers, imaging, tumor biology, pathology, chemoprevention, and technical advances related to lung cancer and relevant thoracic diseases.

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In 2026, TLCR reviewers continue to make outstanding contributions to the peer review process. More >>
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