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Translational Lung Cancer Research (TLCR) is indexed in DOAJ

On September 7, 2026, we received the good news from DOAJ (the Directory of Open Access Journals) that Translational Lung Cancer Research (TLCR) has been accepted for inclusion in DOAJ. The information of TLCR on DOAJ is available at: https://doaj.org/toc/2226-4477.

New Impact Factor for Translational Lung Cancer Research: 3.4

We are pleased to announce that the Translational Lung Cancer Research (TLCR) has attained its latest impact factor for the 2025 citation year: 3.4.

Translational Lung Cancer Research 2025 CiteScore Released: 4.6

We are pleased to announce that the Translational Lung Cancer Research (TLCR) has achieved its 2025 CiteScore: 4.6, ranking 183 out of 428 journals in the Oncology category. This milestone underscores our ongoing commitment to publishing impactful research in the field.

TLCR Annual Report 2025

Welcome to the 2025 annual report for Translational Lung Cancer Research. In 2025, the TLCR has continued its mission to increase the quality and impact of the journal, and to provide readers with a novel, well-organized, informative, enlightening and educational journal.

We would like to sincerely thank our Editorial Board Members, Guest editors, Reviewers, Authors, Readers for all your supports and contributions to TLCR in 2025, and we look forward to continuing our work with you in the new year.

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles

October 2, 2025 — Wolters Kluwer Health announced a new collaboration with AME Publishing Company, an Open Access publisher specializing in medical journals and books, headquartered in Hong Kong, China.

Interviews with Outstanding Authors (2026)

In 2026, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors, with a brief interview of their thoughts and insights as authors. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Reviewer of the Month (2026)

In 2026, TLCR reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Interviews with Editorial Board Members

TLCR features a distinguished editorial board, the members of which continue to instill the power of their expertise for the journal’s development. By launching this column, we are glad to introduce to you some of them in the form of interviews, in which they will share their unique career experiences and perspectives. We believe their insights will shed light on the knowledge of related fields.

Interviews with Guest Editors

Over the years, a number of TLCR guest editors have made valuable contributions to the journal. This column features interviews with our guest editors, who graciously share their experience in scientific careers and provide insightful perspectives on the special series.

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Vol 15, No 9 (September, 2026)

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Original Article

Association of baseline hormone levels with outcomes of first-line immunotherapy in extensive-stage small cell lung cancer

Shuxing Wang, Rui Meng, Jiheng Liu, Yang Zhao, Qian Sui, Yiyang Li, Dan Fan, Min Lu, Yue Zeng, Lu Chen, Zimeng Chen, Wenxin Li, Haohui Wang, Shijiao Yao, Aoxi Liang, Ji’an Zou, Yurong Peng, Xuecheng Liu, Zhenhua Qiu, Fang Wu

Translational Lung Cancer Research

2026;

(9)

:268

(30 September 2026)

PDF Full Text (120) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Adjuvant alectinib versus crizotinib in completely resected ALK-positive non-small-cell lung cancer: a real-world retrospective cohort study

Yitao Yang, Shenhua Liang, Ruihe Liu, Jiayuan Tian, Xingyu Luo, Guowei Ma

Translational Lung Cancer Research

2026;

(9)

:269

(30 September 2026)

PDF Full Text (66) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Toripalimab combined with chemotherapy in the treatment of primary tracheal squamous cell carcinoma: a phase II proof-of-concept study

Jie Dai, Xinyun Fang, Xinsheng Zhu, Xinnan Xu, Dongliang Bian, Xiaogang Liu, Wenxin He, Liang Duan, Peng Zhang, Gening Jiang

Translational Lung Cancer Research

2026;

(9)

:270

(30 September 2026)

PDF Full Text (66) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Impact of different TP53 mutation subtypes on response and outcome in advanced lung adenocarcinoma receiving first-line immunotherapy or chemo-immunotherapy

Xiru Quan, Wendi Xuzhang, Shengping Shen, Ying Yang, Yongfeng Yu, Shun Lu

Translational Lung Cancer Research

2026;

(9)

:271

(30 September 2026)

PDF Full Text (63) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Synergistic effects and molecular mechanisms of pirfenidone combined with EGFR-TKIs in non-small cell lung cancer

Pan Tang, Chen Huang, Fengmei Zhang, Jiayi Li, Weimin Li, Chenliang Zhang, Zhoufeng Wang

Translational Lung Cancer Research

2026;

(9)

:272

(30 September 2026)

PDF Full Text (53) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Plasma proteomic profiles associated with low-dose computed tomography findings and incident lung cancer: a prospective pilot study

Antti Tikkanen, Sanna Iivanainen, Milla E. K. Luukkainen, Jussi P. Koivunen

Translational Lung Cancer Research

2026;

(9)

:273

(30 September 2026)

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Electromagnetic navigation bronchoscopy-guided three-dimensional conformal microwave ablation for unresectable peripheral high-risk pulmonary nodules: a mid-term assessment with no real-time intraoperative CT/cone-beam computed tomography guidance

Yawei Liu, Yan Huang, Xiaodan Lin, Yi Rong, Liurong Mao, Shijie Lu, Junying Chen, Jiyang Chen, Xiuying Xie, Kongjia Luo

Translational Lung Cancer Research

2026;

(9)

:274

(30 September 2026)

PDF Full Text (48) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Activity and specificity of KRAS variants-directed Revolution Medicines compounds (RMC) for pleural effusion-derived non-small cell lung cancer cell lines

Sandra Stickler, Marie-Therese Eggerstorfer, Maximilian Rieche, Lukas Weigl, Martin Hohenegger, Karl Kashofer, Maximilian J. Hochmair, Gerhard Hamilton

Translational Lung Cancer Research

2026;

(9)

:275

(30 September 2026)

PDF Full Text (89) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prognostic impact of immune-related adverse events in non-completers of durvalumab consolidation therapy for non-small cell lung cancer: a single-center retrospective cohort study

Noriyuki Ebi, Ryoma Kawabata, Makoto Fujimoto, Ami Hirata, Yuuka Sakaki, Yusuke Otsuka, Eriko Kinoshita, Yuki Shundo, Toyoshi Yanagihara, Hiroyuki Inoue, Masaki Fujita

Translational Lung Cancer Research

2026;

(9)

:276

(30 September 2026)

PDF Full Text (40) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A structural dose-response relationship between lymph node yield and survival after anatomical segmentectomy for early-stage NSCLC: a SEER-based retrospective cohort study

Ye Tian, Edoardo Zanfrini, Etienne Abdelnour-Berchtold, Jean Yannis Perentes, Thorsten Krueger, Michel Gonzalez

Translational Lung Cancer Research

2026;

(9)

:277

(30 September 2026)

PDF Full Text (53) Reporting Checklist Peer Review File COI Form Open Access

Efficacy and safety of third-generation EGFR-TKI rechallenge therapy in advanced non-small cell lung cancer patients with EGFR mutation: a retrospective cohort study

Jiajie Sun, Xinjing Li, Bingxue Wang, Zhangxuan Chen, Yang Yao, Ranpu Wu, Xiaohua Pan, Xuanhao Xu, Yunxiao Si, Hongbing Liu

Translational Lung Cancer Research

2026;

(9)

:278

(30 September 2026)

PDF Full Text (41) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Multimodal digital assessment of early recovery after chest tube omission in early-stage lung cancer patients undergoing wedge resection: a post hoc analysis of a prospective cohort

Yang Chen, Runchen Wang, Youfang Li, Menghan He, Kaishen Chen, Xiaoqing Lan, Taimin Zhu, Hengrui Liang, Wei Wang, Jianxing He, Wenwei Guo, Zhexue Hao

Translational Lung Cancer Research

2026;

(9)

:279

(30 September 2026)

PDF Full Text (46) Reporting Checklist Peer Review File COI Form Open Access

A modified cryobiopsy specimen retrieval method using a thin bronchoscope and small guide sheath for the diagnosis of peripheral pulmonary lesions

Yuki Takigawa, Kenichiro Kudo, Ken Sato, Mayu Goda, Keisuke Shiraha, Takeru Ichikawa, Shoichiro Matsumoto, Suzuka Matsuoka, Sho Mitsumune, Jun Nishimura, Hiromi Watanabe, Keiichi Fujiwara

Translational Lung Cancer Research

2026;

(9)

:280

(30 September 2026)

PDF Full Text (36) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Interpretable deep learning and radiomics for predicting the occurrence of brain metastases following prophylactic brain irradiation in small cell lung cancer

Xingtong Zhang, Lei Zhao, Jie Wang, Xuerou Zhang, Xilong Liang, Wenwei Cao, Ying Huang, Yunhua Xu

Translational Lung Cancer Research

2026;

(9)

:281

(30 September 2026)

PDF Full Text (44) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Bioelectrical impedance-derived body composition and systemic therapy outcomes in non-small cell lung cancer

Xin Zheng, Rui Gao, Boao Jiang, Yihai Wei, Jingwen Diao, Bo Cheng, Jianfu Li, Jingting Su, Yuejiao Su, Wenhai Fu, Peiling Chen, Xianzhe Fan, Wenhua Liang, Ying Deng

Translational Lung Cancer Research

2026;

(9)

:282

(30 September 2026)

PDF Full Text (38) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Regional disparities in lung cancer surgery and survival in South Korea: a nationwide population-based retrospective cohort study using linked cancer registry and national health insurance data

Hee Sung Kim, Kyoung Eun Yeob, So Young Kim, Hye Sook Han, Jong Hyock Park

Translational Lung Cancer Research

2026;

(9)

:283

(30 September 2026)

PDF Full Text (33) Reporting Checklist Peer Review File COI Form Open Access

Amivantamab plus chemotherapy vs. chemotherapy in participants with EGFR-mutant advanced non-small cell lung cancer after progression on osimertinib: a MARIPOSA-2 analysis of the Asian subgroup

Jin-Yuan Shih, Jie Wang, Yongsheng Wang, Jialei Wang, Se-Hoon Lee, Koichi Azuma, Toshiaki Takahashi, Jiunn-Liang Tan, Chien-Chung Lin, Sandip Ganguly, Victor Ho-Fun Lee, Zeynep Hande Turna, Richu Sharma, Yu Jung Kim, Pei-Ling Chu, Sujay Shah, Brooke Diorio, Byoung Chul Cho

Translational Lung Cancer Research

2026;

(9)

:284

(30 September 2026)

PDF Full Text (100) Peer Review File COI Form Open Access

Efficacy and safety of osimertinib combined with anlotinib in EGFR-mutant non-squamous non-small cell lung cancer with gradual progression after first-line osimertinib therapy: a single-center retrospective cohort study

Li Hao, Haiyang Yu, Yong Wang, Yueyin Pan, Xinghua Han

Translational Lung Cancer Research

2026;

(9)

:285

(30 September 2026)

PDF Full Text (57) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Targeted dual-responsive nanocapsules for synergistic cisplatin and paclitaxel prodrug delivery in the treatment of lung cancer

Xinyu Wang, Dan Qin, Chunyu Yao, Xiang Ji, Chuankui Li, Tao Tao, Xinyu Chen, Qicai Li, Yifan Yang, Lixiang Li, Zuyi Wang, Xiaonan Zhang, Guowen Wang

Translational Lung Cancer Research

2026;

(9)

:286

(30 September 2026)

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Retrospective real-world associations between EGFR alterations and furmonertinib outcomes in advanced non-small cell lung cancer

Yameng Cui, Shaozhang Zhou, Zheng Liu, Qichuan Wang, Liuchun Wang, Yanhong Shang, Jinghao Jia, Hongjiang Yu, Yan Jiang, Zihui An, Zhansheng Jiang, Junli Cao

Translational Lung Cancer Research

2026;

(9)

:287

(30 September 2026)

PDF Full Text (69) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A T-cell exhaustion-related signature for predicting response to immunotherapy among patients with lung adenocarcinoma

Chengcheng Yang, Zefeng Wang, Jintao Xie, Huanhuan Zhao, Tianqi Song, Shiqi Luo, Xinyan Wang

Translational Lung Cancer Research

2026;

(9)

:288

(30 September 2026)

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Expert Consensus

Vietnamese expert consensus on the diagnosis and multidisciplinary management of resectable non-small cell lung cancer

Que Kim Do, Dung Xuan Pham, Hoa Thi Thai Nguyen, Nguyen Hoang Binh, Khoi Tuan Nguyen, Trung Quoc Lam, Thiet Thanh Truong, Dung Tuan Trinh, Dung Thanh Le, Anh Tuan Le, Ha Thu Le, Dung Thi Ngoc Nguyen

Translational Lung Cancer Research

2026;

(9)

:289

(30 September 2026)

PDF Full Text (146) Reporting Checklist Peer Review File COI Form Open Access

Case Report

Extremely rare primary tracheal hyalinizing clear cell carcinoma: two case reports

Dixuan Zhang, Chudong Wang, Yuxuan Li, YenZhir Tay, Shuben Li

Translational Lung Cancer Research

2026;

(9)

:290

(30 September 2026)

PDF Full Text (51) Reporting Checklist Peer Review File COI Form Open Access

Sustained remission of NELL-1-positive membranous nephropathy after lung adenocarcinoma resection and during subsequent atezolizumab therapy in a 68-year-old man: a case report

Masafumi Ikezawa, Yasuyuki Ikezawa, Mina Eguchi, Fumihiko Hattanda, Akihiro Yokoyama, Tetsuaki Shoji, Makoto Araki, Mitsuru Yanai, Yayoi Ogawa, Jun Sakakibara-Konishi, Satoshi Konno

Translational Lung Cancer Research

2026;

(9)

:291

(30 September 2026)

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Study Protocol

Exploratory study to evaluate the combined effect of CBM588: Clostridium butyricum in platinum plus pemetrexed with pembrolizumab for non-small cell lung cancer—protocol of MIYABRO study

Ryuta Tagawa, Hirokazu Taniguchi, Norihito Kaku, Kazumasa Akagi, Hiromi Tomono, Noritaka Honda, Yosuke Dotsu, Midori Matsuo, Shinnosuke Takemoto, Akisato Itagaki, Koki Yamashita, Yasuhiro Umeyama, Hiroshi Gyotoku, Takaya Ikeda, Nanae Sugasaki, Kazutoshi Yoshiyama, Takeshi Kitazaki, Katsumi Nakatomi, Daisuke Takao, Minoru Fukuda, Katsunori Yanagihara, Hiroshi Mukae

Translational Lung Cancer Research

2026;

(9)

:292

(30 September 2026)

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Editorial Commentary

Deferring or delivering stereotactic radiosurgery in EGFR-mutated non-small cell lung cancer: lessons from the STARLET randomized analysis

Jason P. Sheehan, Jared H. Chung, Georgios Mantziaris, David R. Penberthy, Camilo E. Fadul

Translational Lung Cancer Research

2026;

(9)

:293

(30 September 2026)

PDF Full Text (58) Peer Review File COI Form Open Access

Unlocking the central nervous system sanctuary in EGFR-mutant non-small cell lung cancer: molecular insights and therapeutic signals from amivantamab-lazertinib in leptomeningeal disease

Elvire Pons-Tostivint, Manon Robert, Chloé Sauzay

Translational Lung Cancer Research

2026;

(9)

:294

(30 September 2026)

PDF Full Text (43) Peer Review File COI Form Open Access

Review Articles

Management of ground-glass opacities: should all pulmonary lesions with ground-glass opacity be surgically resected?

Yoshihisa Kobayashi, Tetsuya Mitsudomi

Published online: 22 October 2013

PDF Full Text (339435) Open Access

Editorial Commentary

Ground glass nodules with 5 years’ stability can grow after 10-year follow-up: do genetic features determine the fate?

Yoshihisa Kobayashi, Tetsuya Mitsudomi

Published online: 31 December 2019

PDF Full Text (91518) Open Access

Review Article

Non-small cell lung cancer: current treatment and future advances

Cecilia Zappa, Shaker A. Mousa

Published online: 30 June 2016

PDF Full Text (84316) Open Access

Review Articles

Irreversible EGFR-TKIs: dreaming perfection

Lorenza Landi, Federico Cappuzzo

Published online: 14 January 2013

PDF Full Text (70617) Open Access

Review Article

Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Jian-Wei Gao, Stefania Rizzo, Li-Hong Ma, Xiang-Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia-Wei Zou, Qian Li, Marco Femia, Tang-Feng Lv, Yong Song, written on behalf of the AME Lung Cancer Collaborative Group

Published online: 28 February 2017

PDF Full Text (61843) Open Access

Review Article

Recurrence after surgery in patients with NSCLC

Hidetaka Uramoto, Fumihiro Tanaka

Published online: 28 August 2014

PDF Full Text (49538) Open Access

Review Article

Treatment of uncommon EGFR mutations in non-small cell lung cancer: new evidence and treatment

Tianli Zhang, Bing Wan, Yuan Zhao, Chuling Li, Hongbing Liu, Tangfeng Lv, Ping Zhan, Yong Song

Published online: 30 June 2019

PDF Full Text (49411) Open Access

Review Article

Ground-glass nodules of the lung in never-smokers and smokers: clinical and genetic insights

Yoshihisa Kobayashi, Chiara Ambrogio, Tetsuya Mitsudomi

Published online: 28 August 2018

PDF Full Text (46350) Chinese (7056) Open Access

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future

Bryan A. Chan, Brett G.M. Hughes

Published online: 24 February 2015

PDF Full Text (44407) Open Access

Review Article

Lung cancer prediction using machine learning and advanced imaging techniques

Timor Kadir, Fergus Gleeson

Published online: 14 June 2018

PDF Full Text (43269) Open Access

Review Article

The past, present and future of immunotherapy against tumor

Tao Jiang, Caicun Zhou

Published online: 24 June 2015

PDF Full Text (39816) Open Access

Review Article

The epidemiology of lung cancer

Patricia M. de Groot, Carol C. Wu, Brett W. Carter, Reginald F. Munden

Published online: 14 June 2018

PDF Full Text (35715) Open Access

Review Article

Lung cancer screening: nodule identification and characterization

Ioannis Vlahos, Konstantinos Stefanidis, Sarah Sheard, Arjun Nair, Charles Sayer, Joanne Moser

Published online: 14 June 2018

PDF Full Text (34749) Open Access

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung

Yoon Jin Cha, Hyo Sup Shim

Published online: 11 October 2017

PDF Full Text (33452) Open Access

Review Article

Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey

Jeffrey P. Gregg, Tianhong Li, Ken Y. Yoneda

Published online: 30 June 2019

PDF Full Text (32954) Open Access

Review Articles

KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach

Javier de Castro Carpeño, Cristóbal Belda-Iniesta

Published online: 03 April 2013

PDF Full Text (32675) Open Access

Consensus

Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou)

Jianxing He, Hengrui Liang, Wei Wang, Andrey Akopov, Alberto Aiolfi, Keng-Leong Ang, Luca Bertolaccini, Kaican Cai, Qingdong Cao, Baojun Chen, Chang Chen, Chun Chen, Donglai Chen, Fengxia Chen, Jun Chen, Lei Chen, Mingwu Chen, Yongbing Chen, Zhuxing Chen, Chao Cheng, Dong Cui, Fei Cui, Tianyang Dai, Qinglong Dong, Paolo A. Ferrari, Raja M. Flores, Junke Fu, Soichiro Funaki, Marios E. Froudarakis, Xiangfeng Gan, Mingfei Geng, Jialong Guo, Qiang Guo, Yongtao Han, Jintao He, Kaiming He, Kyoji Hirai, Jian Hu, Shuqiao Hu, Jian Huang, Jun Huang, Wenfa Jiang, Kyung Soo Kim, Gabor Kiss, Fanyi Kong, Lan Lan, Xuefeng Leng, Bin Li, Gaofeng Li, Hecheng Li, Hefei Li, Heng Li, Jiwei Li, Xiaoqiang Li, Shuben Li, Yinfen Li, Zhuoyi Li, Yi Liang, Lixia Liang, Wenhua Liang, Yongde Liao, Wanli Lin, Xu Lin, Hongxu Liu, Hui Liu, Jixian Liu, Jun Liu, Xiang Liu, Zihao Liu, Xingzhao Lu, Qingquan Luo, Naiquan Mao, Qi Pan, Dazhi Pang, Jun Peng, Jun Peng, Eugenio Pompeo, Rulin Qian, Kun Qiao, Bassam Redwan, Zi Sang, Wenlong Shao, Jianfei Shen, Weiyu Shen, Sook-Whan Sung, Wenfang Tang, Tianhu Wang, Guangsuo Wang, Haitao Wang, Huien Wang, Jiyong Wang, Wen Wang, Yongyong Wang, Zhenyuan Wang, Li Wei, Wei Wei, Hao Wu, Jie Wu, Zhaohua Xia, Chenyang Xu, Enwu Xu, Hai Xu, Ning Xu, Quan Xu, Rongyu Xu, Shun Xu, Chaokun Yang, Hanyu Yang, Shengli Yang, Jun Yi, Guangjian Zhang, Hao Zhang, Jia Zhang, Man Zhang, Xiao Zhang, Yajie Zhang, Zhe Zhang, Zhifeng Zhang, Honglin Zhao, Jian Zhao, Xiaodong Zhao, Jianping Zhou, Yanran Zhou, Chengchu Zhu, Shaojin Zhu, Xinhai Zhu, Jian Cui, Yubo Yan, Ke-Neng Chen

Published online: 28 August 2021

PDF Full Text (31479) COI Form Open Access

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer

Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto

Published online: 19 April 2015

PDF Full Text (30248) Open Access

Review Article

Global trends of lung cancer mortality and smoking prevalence

Farhad Islami, Lindsey A. Torre, Ahmedin Jemal

Published online: 20 August 2015

PDF Full Text (29999) Open Access

Review Articles

Angiogenesis in cancer: anti-VEGF escape mechanisms

Gerald W. Prager, Marina Poettler, Matthias Unseld, Christoph C. Zielinski

Published online: 18 February 2012

PDF Full Text (29605) Open Access

Full Most Read article list >>

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis

Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song

BRAF mutations in non-small cell lung cancer

Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper

The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer

Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper

Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice

Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song

Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer

Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song

Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer

Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen

The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants

Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden

The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices

Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer

Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto

Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement

Hyojin Kim, Jin-Haeng Chung

Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer

Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu

Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review

Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao

Clinical trials for lung cancer in China

Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu

Recurrence after surgery in patients with NSCLC

Hidetaka Uramoto, Fumihiro Tanaka

Prognostic markers in lung cancer: is it ready for prime time?

Chang-Qi Zhu, Ming-Sound Tsao

Potential biomarkers for lung cancer screening

Gabriella Sozzi, Mattia Boeri

Particle therapy in non-small cell lung cancer

Zhongxing Liao, Charles B. Simone II

Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions

Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai

Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer

Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft

Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors

Suchit H. Patel, Andreas Rimner, Roger B. Cohen

Intraoperative near-infrared imaging of mesothelioma

Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal

BAP1, a tumor suppressor gene driving malignant mesothelioma

Mitchell Cheung, Joseph R. Testa

Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation

Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh

Diagnostic and prognostic biomarkers for malignant mesothelioma: an update

Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang

Immunotherapy for malignant pleural mesothelioma: current status and future directions

Jordan Dozier, Hua Zheng, Prasad S. Adusumilli

Biology and clinical significance of circulating tumor cell subpopulations in lung cancer

Linda O’Flaherty, Harriet Wikman, Klaus Pantel

Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?

Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace

Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer

Sumitra Mohan, Francesca Chemi, Ged Brady

Biophysical technologies for understanding circulating tumor cell biology and metastasis

Derrick W. Su, Jorge Nieva

Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer

Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno

Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer

Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Editorial

An alternative way to initiate Notch1 signaling in non-small cell lung cancer

Yi-Lin Yang, David Jablons, Liang You

Combination MET- and EGFR-directed therapy in MET-overexpressing non-small cell lung cancers: time to move on to better biomarkers?

Fernando C. Santini, Siddharth Kunte, Alexander Drilon

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis

Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

China Lung Cancer Research Highlight

Dll4/Notch1 signaling from tip/stalk endothelial cell specification to stroma-dependent lung tumor inhibition: a flavor of Dll4/Notch1 pleiotropy in tumor cell biology

Maria Felice Brizzi, Paola Defilippi

Editorials

Dulanermin in cancer therapy: Still much to do

Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data

Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner

Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung

Pedro Mendez, Jose Luis Ramirez

Role of HGF/MET axis in resistance of lung cancer to contemporary management

Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr

Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review

Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Ceritinib

Clinical development and approval of second generation ALK inhibitors for ALK rearranged lung cancer

Daniel B. Costa

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack

Lorenza Landi, Federico Cappuzzo

Nivolumab

Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients with advanced non-small cell lung cancer

Arun Rajan, James L. Gulley

Brief Report

The role of Imaging and Radiation Oncology Core for precision medicine era of clinical trial

Ying Xiao, Mark Rosen

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung

Yoon Jin Cha, Hyo Sup Shim

Immunohistochemistry for predictive biomarkers in non-small cell lung cancer

Mari Mino- Kenudson

Original Article

Efficacy and safety of anlotinib in bevacizumab-pretreated patients with non-squamous non-small cell lung cancer (AN-BELIEF study): a multicenter retrospective study

Jiale Wang, Xinxin Zhi, Jinzhang Chen, Bingzhong Zhang, Haitao Lan, Feng Jiao, Yiwei Liu, Fengying Wu, Jia Yu, Aiwu Li, Cheng Ji, Qiyu Fang, Shengxiang Ren

Published online: 10 October 2026

Case Report

Surgical Conversion After Anaplastic Lymphoma Kinase-Tyrosine Kinase Inhibitors Therapy in N3 Stage ALK-Positive NSCLC: A Report of Three Cases

Beike Xiao, Hao Guo, Jiatao Zhang, Xue-ning Yang

Published online: 30 September 2026

Original Article

Machine-learning-assisted multi-omics profiling identifies CALB1 as a subtype-associated regulator of PI3K/AKT signaling and malignant progression in non-small cell lung cancer

Feng Mao, Ning Wang, Yuming Wang, Ziang Wang, Hui Zhang, Qingquan Luo

Published online: 29 September 2026

Original Article

Surgical de-escalation strategies for non-small cell lung cancer following neoadjuvant chemoimmunotherapy: a propensity score-matched analysis

Yulong Wang, Bengang Hui, Xin Wang, Guihu Lin, Xun Wang, Xiao Li

Published online: 29 September 2026

Original Article

A cross-sectional benchmark of seven large language models for national comprehensive cancer network guideline adherence in non-small cell lung cancer management

Zewen Sun, Tian Guan, Jiayi Geng, Junwei Liu, Dexin Su, Tao Sun, Gangzeng Jin, Heng Zhao, Shaodong Wang, Geyun Chang, Guihu Lin, Changtai Zhao, Kexin Feng, Hongchengcheng Chen, Jiaming Deng, Ruzhen Li, Jun Wang, Peihao Li, Liqi Liu, Yun Li, Fan Yang, Jun Wang, Xin Wang, Ailing Yu, Yuan Xia, Dongjie Tao, Hualei Zhou, Chunxiao Guo, Peng Wei, Jian Wang, Jinjie Gu, Yanyun Wang, Jing Zhao, Shuai Zhen, Kezhong Chen, Ping Wang, Xiuyuan Chen

Published online: 29 September 2026

Original Article

Pathological high-risk feature count and survival outcomes in patients with stage I invasive lung adenocarcinoma (≤3 cm): a retrospective cohort study

Jie Cao, Nan Chen, Yin Ku, Zhiyu Peng, Zhaokang Huang, Zetao Liu, Xizhou Liao, Xiaorong Zong, Peidi Li, Chenglin Guo, Jiandong Mei, Lunxu Liu

Published online: 29 September 2026

Original Article

Development and internal validation of a multimodal deep learning model integrating imaging, clinical and pathological features to predict false-negatives in non-specific benign lung biopsies: a dual-center study

Jing Yuan, Wei Li, Chunhua Liu, Luxing He, Qian Yang, Ruili Mao, Xuequan Huang, Weiguo Zhang, Jingjing Liu

Published online: 29 September 2026

Original Article

Prognostic value of a three-dimensional spatial classification system for clinical T1a-bN0 non-small cell lung cancer in the superior segment

Yihan Yang, Angat Naresh Chadha, Yingchao Gu, Ruizhi Gong, Qianrui Ren, Xinfeng Xu, Wei Wen, Zhibo Wang, Quan Zhu

Published online: 29 September 2026

Original Article

Genomic characteristics, survival, and prognostic analysis of advanced non-small cell lung cancer with KRAS mutations and brain metastases

Yi Chen, Xiheng Yu, Mengqi Bao, Xiaoqing Yu, Yuwei Li, Jing Sun, Linjing Zhou, Yunfeng Tong, Yun Fan

Published online: 29 September 2026

Original Article

Perioperative and early oncologic outcomes of complex segmentectomy via uniportal video-assisted thoracic surgery for primary lung cancer

Takuya Watanabe, Eriko Suzuki, Naoko Yoshii, Takuya Kohama, Kensuke Iguchi, Masayuki Tanahashi, Katsuhiro Okuda

Published online: 29 September 2026

Original Article

Segmental distribution of hepatic steatosis on opportunistic low-dose CT: a Couinaud-based analysis

Ingrid Galvis, Jonathan Alis, Mary Salvatore

Published online: 29 September 2026

Case Report

Lung adenocarcinoma with rapid progression and fatal outcome through spread through air spaces: an autopsy case report

Jun Arinami, Yu Saida, Shintaro Yoneyama, Satoshi Watanabe, Tomoki Sekiya, Ryo Suzuki, Naohiro Yanagimura, Miyuki Sato, Koichiro Nozaki, Tomohiro Tanaka, Saori Takashima, Yusuke Tani, Kazuyuki Ozaki, Takeshi Kashimura, Takayuki Inomata, Toshiaki Kikuchi

Published online: 29 September 2026

Original Article

Single cell imaging mass spectrometry spatial immune profiling of brain metastasis from non-small-cell lung cancer patients treated with immune checkpoint inhibitors

Dan Zhao, Haiqing Li, Isa Mambetsariev, Tamara Mirzapoiazova, Jeremy Fricke, Javier Arias-Romero, Leonidas Arvanitis, Massimo D’Apuzzo, Bradford Tan, Michelle Afkhami, Brian Armstrong, Mike Y. Chen, Behnam Badie, Bihong Beth Chen, Arya Amini, Ravi Salgia

Published online: 29 September 2026

Original Article

Explainable machine learning for predicting grade ≥3 treatment-related adverse events in resectable non-small cell lung cancer receiving neoadjuvant chemoimmunotherapy: predominant contribution of hematologic toxicity

Fei-Hang Zhi, Yunzeng Zhang, Tengfei Ge, Lei Yang, Yichen Dong, Jialiang Wen, Haojie Si, Jingyu Chen, Yuzhou Wang, Delun Yang, Yicheng Wang, Minglei Yang, Huikang Xie, Junqi Wu, Long Xu, Deping Zhao, Chang Chen

Published online: 29 September 2026

Original Article

Quantitative CT definition of solid components in pulmonary ground-glass nodules: a pixel-level annotation-based development and internal validation study

Yuhao Chen, Nan Chen, Yuhuan Ye, Han Zhang, Wanting Xia, Kunhao Wu, Nanzhi Luo, Zhenyi Niu, Le Yi, Qiang Pu, Xiuyuan Xu, Lunxu Liu

Published online: 29 September 2026

Original Article

Real-World Outcomes of Neoadjuvant Targeted Therapy in Resectable Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer: A Retrospective Study

Jia Li, Yinguang Zhang, Jie Gao, Hui Deng, Zhiming Luo, Xidong Ma, Mei Xie, Xinying Xue

Published online: 29 September 2026

Case Report

Diagnostic challenge of delayed immune-related hepatitis during zongertinib treatment after nivolumab plus ipilimumab in a 52-year-old man with HER2-mutant non-small cell lung cancer: a case report

Tomohiro Oba, Shunya Shiohira, Yoko Machida, Daisuke Nakatani, Keiichi Akasaka, Masako Amano, Hidekazu Matsushima

Published online: 29 September 2026

Review Article

Perioperative treatment for resectable non-small cell lung cancer harboring EGFR exon 20 insertion mutations: a narrative review from advanced-stage evidence to whole-course precision management

Zhuoran Li, Yichao Han, Wenzhao Zhong, Hecheng Li

Published online: 29 September 2026

Original Article

Emphysema reprograms neutrophils toward a tumor-promoting phenotype in lung cancer

Mohamad Qaisi, Merav E. Shaul, Nuha Alsharif, Naomi Kaisar-Iluz, Sojod Mahroum, Osnath Bouhanna, Yael Volman, Zvi G. Fridlender

Published online: 28 September 2026

Original Article

Bronchoalveolar lavage fluid cfDNA liquid biopsy-guided neoadjuvant lazertinib in resectable EGFR-mutant non-small cell lung cancer: a prospective phase II study

In Ae Kim, Heejoung Kim, Jae Young Hur, Wan Seop Kim, Young Whan Kim, Song Am Lee, Jae Joon Hwang, Kye Young Lee

Published online: 28 September 2026

Original Article

Efficacy and safety of stereotactic body radiotherapy combined with immune checkpoint inhibitors for non-small cell lung cancer: a systematic review and reconstructed individual patient data meta-analysis

Pengfei Ji, Zhihui Zhao, Xinpu Tang, Zhangyi Dai, Xingqi Mi, Yikai Xing, Yafei Xie, Wei Liao, Xiaolong Zhang, Qiang Pu

Published online: 28 September 2026

Original Article

Functional decline at progression after durvalumab in stage III non-small cell lung cancer: prognostic impact and treatment patterns in a multicenter retrospective cohort study

Maja Lisik-Habib, Krzysztof Smółka, Rafał Stando, Grzegorz Chmielewski, Mateusz Bilski, Katarzyna Galwas, Damian Tworek, Mirosława Puskulluoglu, Agnieszka Roman, Małgorzata Terlecka-Maciejewska, Jacek Fijuth, Łukasz Kuncman

Published online: 28 September 2026

Review Article

Antibody-drug conjugates in the perioperative treatment of resectable non-small cell lung cancer: a narrative review of research advances and prospects

Ying Xiong, Lu Sun, Yi Peng

Published online: 28 September 2026

Original Article

An integrated baseline CT model for predicting growth heterogeneity in solid lung cancer with transcriptomic annotation

Jiaqi Chen, Linlin Qi, Jianing Liu, Fenglan Li, Shulei Cui, Sainan Cheng, Weixiong Tan, Jianwei Wang

Published online: 24 September 2026

Original Article

Association between adjuvant EGFR-TKI therapy and survival outcomes in completely resected stage I invasive lung adenocarcinoma (≤3 cm) with sensitizing EGFR mutations and pathological high-risk features

Jie Cao, Zhaokang Huang, Fang Qiu, Nan Chen, Zhiyu Peng, Zetao Liu, Xizhou Liao, Xiaorong Zong, Peidi Li, Chenglin Guo, Jiandong Mei, Lunxu Liu

Published online: 24 September 2026

Journal Highlight more

Translational Lung Cancer Research is an international, peer-reviewed, open-access journal indexed by Science Citation Index Expanded (SCIE) and PubMed/PubMed Central, focusing on cutting-edge development on the transition from preclinical to clinical research, including but not limited to multimodality therapy, markers, imaging, tumor biology, pathology, chemoprevention, and technical advances related to lung cancer and relevant thoracic diseases.