Vol 14, No 10 (October 31, 2025): Translational Lung Cancer Research

Editorial Commentary

Molecular minimal residual disease in resected non-small cell lung cancer: “flattening the curve”
Marc G. Denis
Translational Lung Cancer Research  
2025;
14
(10)
:4180-4183
.
 (31 October 2025) 
PDF Full Text (258) Peer Review File COI Form Open Access Get Permission
KRAS under attack: recent advances in targeted therapies involving G12C inhibitors and XPO1 inhibition
Markus Falk, Stefanie Schatz, Markus Tiemann, Joachim H. Ficker, Wolfgang M. Brueckl
Translational Lung Cancer Research  
2025;
14
(10)
:4184-4186
.
 (31 October 2025) 
PDF Full Text (285) Peer Review File COI Form Open Access Get Permission

Original Article

Survival after wedge resection, segmentectomy and lobectomy for clinical stage IA non-small cell lung cancer: a systematic review and network meta-analysis
Cien Sun, Jiang Jin, Jiawen Chen, Hao Liu, Pasan Witharana, Minghui Yang, Zimin Wang, Ying Zhang, Pengfei Sheng, Yutao Chen, Chengchu Zhu, Jianfei Shen
Translational Lung Cancer Research  
2025;
14
(10)
:4187-4209
.
 (31 October 2025) 
PDF Full Text (512) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Analysis of second-line therapy in patients with prior pneumonitis receiving first-line combination immunotherapy for advanced non-small cell lung cancer
Noriyuki Ebi, Hiroyuki Inoue, Makoto Fujimoto, Ami Hirata, Maiya Chen, Natsumi Kushima, Yuuka Sakaki, Takato Ikeda, Yuki Shundo, Toyoshi Yanagihara, Masaki Fujita
Translational Lung Cancer Research  
2025;
14
(10)
:4210-4220
.
 (31 October 2025) 
PDF Full Text (258) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Predicting the prognosis of patients with lung adenocarcinoma treated with third-generation EGFR-TKI alone using nomograms based on CT radiomic and clinicopathological factors
Junfeng Zhao, Xinhang Gu, Jiaxiao Geng, Ying Li, Yan Wang, Chengxin Liu
Translational Lung Cancer Research  
2025;
14
(10)
:4221-4234
.
 (31 October 2025) 
PDF Full Text (276) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Single-cell RNA profiling reveals an immunosuppressive microenvironment in EGFR double-mutant non-small cell lung cancer
Jiao Yang, Jun-Wei Su, Hong-Rui Li, Mei-Mei Fang, Xu-Hui Guan, Xiao-Cheng Lin, Ke-Jun Liu, Li-Xu Yan, Xu-Chao Zhang, Xue-Ning Yang, Wen-Zhao Zhong, Hua-Jun Chen, Jia Liu, Wendy Wu, Jin-Ji Yang
Translational Lung Cancer Research  
2025;
14
(10)
:4235-4255
.
 (31 October 2025) 
PDF Full Text (526) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Investigation of non-completion factors for durvalumab maintenance therapy in locally advanced non-small cell lung cancer
Masaaki Kotake, Yuki Sakai, Satoshi Watanabe, Toshiaki Kikuchi, Akira Toyama
Translational Lung Cancer Research  
2025;
14
(10)
:4256-4267
.
 (31 October 2025) 
PDF Full Text (231) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Feasibility of next-generation sequencing using bronchoscopic specimens in potentially resectable non-small cell lung cancer
Kaito Yano, Yuji Matsumoto, Hideaki Furuse, Keigo Uchimura, Tatsuya Imabayashi, Keisuke Asakura, Takaaki Tsuchida
Translational Lung Cancer Research  
2025;
14
(10)
:4268-4284
.
 (31 October 2025) 
PDF Full Text (230) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Influencing factors and prediction of growth heterogeneity in solid nodule non-small cell lung cancer based on artificial intelligence: a prospective study
Jiaqi Chen, Jianing Liu, Linlin Qi, Fenglan Li, Shulei Cui, Jianwei Wang
Translational Lung Cancer Research  
2025;
14
(10)
:4285-4300
.
 (31 October 2025) 
PDF Full Text (280) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Deep learning radiomics and 18F-FDG PET/CT imaging: mediastinal lymph node characteristics as predictors of metastasis in non-small cell lung cancer
Furui Duan, Hanyu Zu, Rui Zhang, Yan Li, Yu Zhao, Xuewei Wang, Minghui Zhang, Ping Li, Dalong Wang
Translational Lung Cancer Research  
2025;
14
(10)
:4301-4314
.
 (31 October 2025) 
PDF Full Text (453) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Evaluation of gefitinib alone or combined with bevacizumab in patients with EGFR L858R-positive advanced non-squamous non-small cell lung cancer: an open-label, randomized, phase 2 trial (BEVA-FLFX-001) with exploratory analysis of plasma biomarkers
Xinmin Zhao, Xianghua Wu, Huijie Wang, Hui Yu, Si Sun, Zhihuang Hu, Ying Lin, Yao Zhang, Bo Yu, Zhenhua Wu, Kangli Xiong, Cuicui Liu, Song Wang, Hua Bao, Qiuxiang Ou, Jialei Wang
Translational Lung Cancer Research  
2025;
14
(10)
:4315-4330
.
 (31 October 2025) 
PDF Full Text (315) Reporting Checklist Trial Protocol Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Treatment intensity-dependent association between the number of oral hypoglycemic agents and insulin use and lung cancer risk in patients with type 2 diabetes
Chiwook Chung, Kyu Na Lee, Kyungdo Han, Dong Wook Shin, Sei Won Lee
Translational Lung Cancer Research  
2025;
14
(10)
:4331-4342
.
 (31 October 2025) 
PDF Full Text (269) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Treatment outcome and safety of durvalumab after concurrent chemoradiation in very elderly patients with unresectable stage III non-small cell lung cancer
So Jeong Kim, Na Young Kim, Soo Jie Chung, In Gyu Hyun, Yohwan Yeo, Ji Young Park, Seung Hun Jang, Taehee Kim, Yun Su Sim, Chang Youl Lee, Junghyun Kim
Translational Lung Cancer Research  
2025;
14
(10)
:4343-4356
.
 (31 October 2025) 
PDF Full Text (284) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
The prognostic importance of the pan-immune-inflammation value (PIV) in lung cancer: a systematic review and meta-analysis
Guangji Cao, Quanqing Liu, Hao Wen, Yuan Zeng
Translational Lung Cancer Research  
2025;
14
(10)
:4357-4370
.
 (31 October 2025) 
PDF Full Text (338) Reporting Checklist Peer Review File COI Form Open Access Get Permission
A retrospective cross-sectional study of FGFR2b alterations in Chinese patients with advanced squamous non-small cell lung cancer: prevalence, programmed death-ligand 1 co-expression patterns, and association with clinical outcomes
Xiyuan Wang, Kaiwen Chi, Haiyue Wang, Shuguang Sun, Chunxia Ao, Jiongyan Li, Yuanjie Ge, Chen Yang, Yayuan Fu, Dongmei Lin, Renhong Tang, Wei Sun
Translational Lung Cancer Research  
2025;
14
(10)
:4371-4383
.
 (31 October 2025) 
PDF Full Text (281) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Characterization of RET fusions via integrated DNA and RNA sequencing in early-stage non-small cell lung cancer: a retrospective study
Ying Ding, Gang Chen, Xiao He, Yuqian Shi, Chunhong He, Jiani C. Yin, Zhihong Zhang
Translational Lung Cancer Research  
2025;
14
(10)
:4384-4397
.
 (31 October 2025) 
PDF Full Text (252) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Comparative outcomes of treatment with versus without definitive thoracic radiotherapy in locally advanced inoperable non-small cell lung cancer during the immunotherapy era: a Chinese real-world study
Xueru Zhu, Jun Liu, Ruxin Cai, Wen Feng, Jun Liu, Wen Yu, Xuwei Cai, Qin Zhang, Xiaolong Fu
Translational Lung Cancer Research  
2025;
14
(10)
:4398-4411
.
 (31 October 2025) 
PDF Full Text (258) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Doxorubicin paclitaxel in pretreated advanced small-cell lung cancer: a large real-life retrospective study
Coraline Cheuvart, Paul Gougis, Luca Campedel, Clara Bourrachot, Camille Rolland Debord, Baptiste Abbar
Translational Lung Cancer Research  
2025;
14
(10)
:4412-4421
.
 (31 October 2025) 
PDF Full Text (214) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Characteristics of patients with non-small cell lung cancer and either limited or extensive synchronous metastatic spread in Germany—a population-based cancer registry cohort study
Sophia Bertram, Antje Schliemann, Alexander Katalinic, Soo-Zin Kim-Wanner, Ron Pritzkuleit, Dorothee Twardella, Annika Waldmann
Translational Lung Cancer Research  
2025;
14
(10)
:4422-4435
.
 (31 October 2025) 
PDF Full Text (240) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Overall survival and progression-free survival of patients with non-small cell lung cancer and either limited or extensive synchronous metastatic spread in Germany—a population-based cancer registry cohort study
Sophia Bertram, Antje Schliemann, Alexander Katalinic, Soo-Zin Kim-Wanner, Ron Pritzkuleit, Dorothee Twardella, Annika Waldmann
Translational Lung Cancer Research  
2025;
14
(10)
:4436-4448
.
 (31 October 2025) 
PDF Full Text (327) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Association between soluble immune mediators and outcomes in patients with unresectable stage III non-small cell lung cancer treated with concurrent chemoradiotherapy followed by durvalumab
Takaaki Tokito, Koichi Azuma, Kenta Murotani, Norikazu Matsuo, Goushi Matama, Daiki Murata, Tetsuro Sasada, Tomoaki Hoshino
Translational Lung Cancer Research  
2025;
14
(10)
:4449-4459
.
 (31 October 2025) 
PDF Full Text (204) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Deciphering the potential pathogeny of rare tracheal adenoid cystic carcinoma by single-cell RNA-sequencing
Jie Li, Yaping Long, Tao Wang, Haixu Hu, Yanju Yu, Jinfeng Li, Lijuan Zhang, Bo Yang, Yi Liu
Translational Lung Cancer Research  
2025;
14
(10)
:4460-4474
.
 (31 October 2025) 
PDF Full Text (255) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Deep learning-based classification of pleural malignancy using medical thoracoscopic images
Yu Jin Hong, Se Hee Ha, Seong Hyeon Park, Jick Hwan Ha, Hyung Woo Kim, Bo Ra Lee, Sang Haak Lee, Chang Dong Yeo, Jong-Yeup Kim, Joon Young Choi
Translational Lung Cancer Research  
2025;
14
(10)
:4475-4484
.
 (31 October 2025) 
PDF Full Text (226) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Incremental prognostic value of solid component volume ratio and entropy for pathological stage IA invasive lung adenocarcinoma after surgery
Zetao Liu, Xiaoqin Chen, Yanling Zheng, Xiongmu Tan, Yinqiu Wang, Linyan Huang, Jierui Zheng, Yongqian Yu, Chenglin Guo, Liqing Peng, Jiandong Mei
Translational Lung Cancer Research  
2025;
14
(10)
:4485-4499
.
 (31 October 2025) 
PDF Full Text (229) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
SuFu somatic mutations are recognized as novel markers for genomic instability and tumor growth in lung adenocarcinoma
Ji-Hong Liu, Tao Zhang, Yan Wang, Meng-Si Zhang, Jian He, Xiang-Dong Zhou
Translational Lung Cancer Research  
2025;
14
(10)
:4500-4513
.
 (31 October 2025) 
PDF Full Text (245) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Diagnostic utility of cryobiopsy for invasive mucinous lung adenocarcinoma
Atsushi Kosuge, Yuji Matsumoto, Hideaki Furuse, Kenya Sato, Jumpei Kashima, Satsuki Kishikawa, Masaya Yotsukura, Tomohiro Haruki, Yukihiro Yoshida, Shun-Ichi Watanabe, Yasushi Yatabe, Takaaki Tsuchida
Translational Lung Cancer Research  
2025;
14
(10)
:4514-4526
.
 (31 October 2025) 
PDF Full Text (257) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Immunohistochemical analysis of p53 and LKB1 as predictive biomarkers of immune checkpoint inhibitor response in non-small cell lung cancer
Kazuo Tsuchiya, Tomo Tsunoda, Hisaki Igarashi, Kazuya Hattori, Taisuke Ito, Takuro Akashi, Yoshiyuki Oyama, Yasuhiko Kitayama, Masaki Ikeda
Translational Lung Cancer Research  
2025;
14
(10)
:4527-4540
.
 (31 October 2025) 
PDF Full Text (256) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Fecal microbiota transplantation plus immune checkpoint inhibitor rechallenges in patients with advanced non-small cell lung cancer: a single-arm exploratory study
Yijia Du, Yanying Li, Min Yu, Yang Yu, Yan Zhang, Xianfeng Wang, Jianquan He, Lin Lin, Baolong Shen, Youling Gong, Jiang Zhu, Bingwen Zou, Yongmei Liu, Meijuan Huang, You Lu
Translational Lung Cancer Research  
2025;
14
(10)
:4541-4559
.
 (31 October 2025) 
PDF Full Text (603) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission

Brief Report

Identification of a novel RSPO1-NUMT insertion in a LUAD patient cohort and the challenges and insights into NUMT detection highlighting the importance of reference genomes and population databases
Ilona Tietzova, Dana Sochorova, Petr Triska, Rebecca C. Rancourt, Marek Omelka, Eva Parobkova, Michael Allgäuer, Marc A. Schneider, Karsten Senghas, Laura V. Klotz, Marketa Tesarova
Translational Lung Cancer Research  
2025;
14
(10)
:4560-4570
.
 (31 October 2025) 
PDF Full Text (211) Reporting Checklist Peer Review File COI Form Open Access Get Permission

Review Article

Time toxicity in previously untreated metastatic or unresectable epidermal growth factor receptor-mutant non-small cell lung cancer: a clinical practice review
Won Jin Jeon, Bowon Joung, Padma Sri Katikaneni, Akshit Chitkara, Neha Agrawal, Kashyap Padmaraju, Ni Ya, Sarvnaz Sadrameli, Aakash Desai, Emerson Chen, Jeremy Cetnar, Rajat Thawani
Translational Lung Cancer Research  
2025;
14
(10)
:4571-4575
.
 (31 October 2025) 
PDF Full Text (291) Peer Review File COI Form Open Access Get Permission
A narrative review of imaging intratumor heterogeneity in non-small cell lung cancer: current advances
Ping Lin, Hongbin Wang, Bingrun Zou, Ziwei Zhu, Weimin Li, Bojiang Chen
Translational Lung Cancer Research  
2025;
14
(10)
:4576-4603
.
 (31 October 2025) 
PDF Full Text (510) Reporting Checklist Peer Review File COI Form Open Access Get Permission
The role of TRPA1 in lung cancer
Diarmuid O’Connor, Stephen P. Finn, Steven G. Gray
Translational Lung Cancer Research  
2025;
14
(10)
:4604-4617
.
 (31 October 2025) 
PDF Full Text (148) Peer Review File COI Form Open Access Get Permission
Neoadjuvant systemic therapy for pleural mesothelioma patients: a systematic review
Illaa Smesseim, Jo Raskin, Jacobus A. Burgers
Translational Lung Cancer Research  
2025;
14
(10)
:4618-4627
.
 (31 October 2025) 
PDF Full Text (249) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Utility of bronchoalveolar lavage in checkpoint inhibitor pneumonitis evaluation: a narrative review
Senthuran Shivakumar, Sagun Parakh, Natalia Vukelic, Farzaneh Atashrazm, Vivek Naranbhai, Nicole Soo Leng Goh, Jessica Da Gama Duarte, Tracy Li-Tsein Leong
Translational Lung Cancer Research  
2025;
14
(10)
:4628-4637
.
 (31 October 2025) 
PDF Full Text (285) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Immune-oncology-microbiome axis in lung cancer: from carcinogenesis to therapy—a narrative review
Mengyi Shen, Yueying Chen, Jiayan Chen, Jie Yin, Chunwei Xu, Dong Wang, Tangfeng Lv
Translational Lung Cancer Research  
2025;
14
(10)
:4638-4657
.
 (31 October 2025) 
PDF Full Text (371) Reporting Checklist Peer Review File COI Form Open Access Get Permission

Study Protocol

The impact of rurality, socioeconomic status, and health literacy on lung cancer screening uptake: a systematic review protocol
Apeksha Phulgirkar, Aaleyah Kelso, Rashmikaa Ranganathan, Rebecca N. Jerome, Jennifer A. Lewis, Lucy B. Spalluto
Translational Lung Cancer Research  
2025;
14
(10)
:4658-4665
.
 (31 October 2025) 
PDF Full Text (186) Peer Review File COI Form Open Access Get Permission
Local consolidative therapy for the primary tumor in EGFR-mutant advanced non-small cell lung cancer following osimertinib plus chemotherapy: a protocol for a single-arm, open-label, phase 2 trial
Mi-Hyun Kim, Hayoung Seong, Soo Han Kim, Jung Seop Eom
Translational Lung Cancer Research  
2025;
14
(10)
:4666-4674
.
 (31 October 2025) 
PDF Full Text (332) Reporting Checklist Peer Review File COI Form Open Access Get Permission

Case Report

The granulomatous pulmonary nodules induced by tislelizumab in advanced squamous NSCLC: a case report with challenging differential diagnosis
Yangyang Ma, Xinxin Chen, Yan Liang, Sili Wang, Yanwen Yao, Tangfeng Lv, Dongmei Yuan
Translational Lung Cancer Research  
2025;
14
(10)
:4675-4681
.
 (31 October 2025) 
PDF Full Text (240) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Spontaneous regression of tumors post-chemotherapy in a patient with relapsed small cell lung cancer: a case report
Tomoha Miyaki, Shunichi Kataoka, Takehito Shukuya, Ayumi Yanai, Hitomi Shiozaki, Hiroaki Motomura, Taichi Miyawaki, Takuo Hayashi, Aritoshi Hattori, Kenji Suzuki, Kazuhisa Takahashi
Translational Lung Cancer Research  
2025;
14
(10)
:4682-4687
.
 (31 October 2025) 
PDF Full Text (267) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Lung adenocarcinoma with ALK deletion of exons 6–20 with response to sequential ALK inhibitors: a case report
Kazuki Jinno, Tatsuya Imabayashi, Toshiyuki Tanaka, Kohei Yamamoto, Shunya Tanaka, Sayaka Uda, Tatsuya Yuba, Chieko Takumi
Translational Lung Cancer Research  
2025;
14
(10)
:4688-4694
.
 (31 October 2025) 
PDF Full Text (275) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Pathological complete response in RET-positive non-small cell lung cancer: a case report of pralsetinib-based “sandwich” therapy
Qihua He, Xin Xu, DongMei Li, Yalei Zhang
Translational Lung Cancer Research  
2025;
14
(10)
:4695-4703
.
 (31 October 2025) 
PDF Full Text (273) Reporting Checklist Peer Review File COI Form Open Access Get Permission