Vol 14, No 12 (December 31, 2025): Translational Lung Cancer Research

Editorial Commentary

Ivonescimab: promise or reality for advanced non-small cell lung cancer?
Alejandro Olivares-Hernández, Pedro Gonzalez Santa-Catalina, Emilio Fonseca-Sánchez, Edel del Barco-Morillo
Translational Lung Cancer Research  
2025;
14
(12)
:5203-5207
.
 (31 December 2025) 
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Original Article

Real-world outcomes of trastuzumab deruxtecan as second- or further-line treatment in patients with HER2-mutant metastatic non-small cell lung cancer: a retrospective study
Kuofang Huang, Zhihuang Hu, Shifei Pan, Jialin Qian, Xianghua Wu, Huijie Wang, Kai Wang, Haijiao Lu, Huishu Dong, Tianqing Chu, Jialei Wang
Translational Lung Cancer Research  
2025;
14
(12)
:5208-5217
.
 (31 December 2025) 
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Clinical characteristics of post-operative N2 nodal upstaging in non-small cell lung cancer: a retrospective cohort study
Sun Young Choi, Myung Jin Song, Byung Soo Kwon, Yeon Wook Kim, Jong Sun Park, Sukki Cho, Jae Ho Lee, Choon-Taek Lee, Sung Yoon Lim
Translational Lung Cancer Research  
2025;
14
(12)
:5218-5229
.
 (31 December 2025) 
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Computer-aided quantitative stromal analysis: a comprehensive investigation of its prognostic significance in lung squamous cell carcinoma
Xin Zhang, Jin Chen, Xiaodong Bu, Qitang Huang, Yuqing Li, Dan Zhang, Jun Yang, Anning Feng, Fanqing Meng, Wei Li, Qi Sun, Chun Xu
Translational Lung Cancer Research  
2025;
14
(12)
:5230-5242
.
 (31 December 2025) 
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O-GlcNAcylation levels predict radiotherapy outcome in non-small cell lung cancer
Xiaoliang Wang, Yujiao Ma, Ying Dong, Yanling Wang, Jupeng Yuan, Jinming Yu, Dawei Chen
Translational Lung Cancer Research  
2025;
14
(12)
:5243-5256
.
 (31 December 2025) 
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Patient-reported outcomes of radiofrequency ablation-video-assisted thoracoscopic surgery (VATS) hybrid surgery vs. uniportal VATS for multiple primary lung nodules: a longitudinal cohort study
Ruifeng Xu, Guochao Zhang, Na Ren, Fanmao Meng, Tiejun Liu, Mengbai Tian, Mufei Sun, Hongrui Wang, Yitong Lu, Xin Liang, Yu Tian, Qi Xue, Xin Sun, Yun Che, Shugeng Gao, Liang Zhao
Translational Lung Cancer Research  
2025;
14
(12)
:5257-5272
.
 (31 December 2025) 
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Additional 1.1-mm cryobiopsy trial guided by rapid on-site cytologic evaluation of touch imprint cytology result of small forceps biopsy in peripheral pulmonary lesions: a prospective single-center study
Yuki Takigawa, Ken Sato, Suzuka Matsuoka, Mayu Goda, Keisuke Shiraha, Takeru Ichikawa, Shoichiro Matsumoto, Tomoyoshi Inoue, Miho Fujiwara, Jun Nishimura, Hiromi Watanabe, Kenichiro Kudo, Akiko Sato, Tetsuya Isoda, Yoko Shinno, Keiichi Fujiwara, Takuo Shibayama
Translational Lung Cancer Research  
2025;
14
(12)
:5273-5282
.
 (31 December 2025) 
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Exon-level TP53 alterations and PD-L1 expression identified by pretreatment NGS stratify survival in EGFR-mutant non-small cell lung cancer treated with first-line osimertinib
Seong-Eun Kim, Yongjae Kim, Do Kyung Yoon, Hwan Park, Kang-Seo Park, Deokhoon Kim, Hee Sang Hwang, Bokyung Ahn, Ji Eun Park, Sang-We Kim, Se Jin Jang, Shinkyo Yoon, Ho-Su Lee, Dae Ho Lee
Translational Lung Cancer Research  
2025;
14
(12)
:5283-5295
.
 (31 December 2025) 
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Development of a multimodal fully automated ensemble model to predict EGFR mutation and efficacy of EGFR-TKI in non-small cell lung cancer
Shiting Xu, Taichi Miyawaki, Takehito Shukuya, Kazuhiro Suzuki, Shoko Sonobe Shimamura, Hironari Matsuda, Ryota Kanemaru, Tetsuhiko Asao, Tomoyasu Mimori, Yujiro Otsuka, Kazuhisa Takahashi
Translational Lung Cancer Research  
2025;
14
(12)
:5296-5304
.
 (31 December 2025) 
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A systematic literature review and meta-analysis on the efficacy and safety of PD-(L)1 inhibitors for the first- and second-line treatment of locally advanced or metastatic non-small cell lung cancer in Asian and non-Asian patients
Nicolas Girard, Daniel Tan, Diego Cortinovis, Gilberto Lopes, Pei Jye Voon, Mesha Austin Taylor, Nadeem Ghali, Lin Zhan, Sheng Xu, Kirsha Naicker, Solange Peters
Translational Lung Cancer Research  
2025;
14
(12)
:5305-5322
.
 (31 December 2025) 
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Radiotherapy vs. photodynamic therapy: a comparison of antitumor effects and pulmonary toxicity in preclinical models
Yoshihisa Hiraishi, Takamasa Koga, Hiroyuki Ogawa, Andrew Effat, Lili Ding, Juan Chen, Jonathan Allen, Takahiro Yanagihara, Fumi Yokote, Nicholas Bernards, Masato Aragaki, Kate Kazlovich, Nadia Mohammed, Tsukasa Ishiwata, Yusuke Fujibayashi, Akira Saito, Hidenori Kage, Jonathan Yeung, Gang Zheng, Kazuhiro Yasufuku
Translational Lung Cancer Research  
2025;
14
(12)
:5323-5334
.
 (31 December 2025) 
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Evaluating cancer risk profiles in lung transplant recipients
Yanwei Lin, Jiaqin Zhang, Caikang Luo, Xin Xu, Yining Pan, Chao Yang, Guilin Peng, Xuanlin Zhang, Jie Zhang, Wenhua Liang, Jiang Shi, Jianxing He
Translational Lung Cancer Research  
2025;
14
(12)
:5335-5346
.
 (31 December 2025) 
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Electromagnetic navigation bronchoscopy for localization of bilateral multiple pulmonary nodules: a comparative evaluation of safety and efficacy
Chudong Wang, Jianwei Gao, Rui Wang, Zijian Li, Dixuan Zhang, Zhihao Jiang, YenZhir Tay, Jianxing He, Shuben Li
Translational Lung Cancer Research  
2025;
14
(12)
:5347-5356
.
 (31 December 2025) 
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Exploring perioperative treatment for non-small cell lung cancer patients harboring EGFR mutation: a real-world multicenter cohort study
Yu Zhou, Zihan Wei, Min Li, Juan Li, Rui Meng, Fang Wu, Guanming Jiang, Baihua Zhang, Bolin Chen, Chunhua Zhou, Wenjuan Jiang, Liang Zeng, Lin Wu, Xiang Yan, Xingxiang Pu
Translational Lung Cancer Research  
2025;
14
(12)
:5357-5371
.
 (31 December 2025) 
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Completion lobectomy following segmentectomy for malignant lung tumors: a multi-institutional study of surgical feasibility, oncologic outcomes, and diagnostic challenges (ESSG-02 study)
Takuya Watanabe, Kosuke Fujino, Tadashi Sakane, Yoshinori Handa, Takefumi Doi, Natsuko Kawatani, Seshiru Nakazawa, Takahiro Iida, Ryutaro Hanawa, Shuichi Shinohara, Atsushi Ito, Masayuki Tanahashi
Translational Lung Cancer Research  
2025;
14
(12)
:5372-5382
.
 (31 December 2025) 
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Metabolic tumor volume on 18F-fluorodeoxyglucose uptake as prognostic marker for osimertinib in patients with non-small cell lung cancer harboring sensitive EGFR mutation
Kosuke Hashimoto, Kyoichi Kaira, Hisao Imai, Atsuto Mouri, Ou Yamaguchi, Ichiei Kuji, Hiroshi Kagamu
Translational Lung Cancer Research  
2025;
14
(12)
:5383-5392
.
 (31 December 2025) 
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Endocrine immune-related adverse events in advanced lung cancer patients receiving immune checkpoint inhibitors: incidence, predictors and outcomes
Yi Liu, Jiarui Zhang, Linhui Yang, Jiadi Gan, Huohuo Zhang, Qi Qi, Wanqin Fang, Junyi Zhu, Rui Xu, Xianya Hu, Yufang Xie, Sha Liu, Weimin Li, Dan Liu
Translational Lung Cancer Research  
2025;
14
(12)
:5393-5404
.
 (31 December 2025) 
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Prognosis of segmentectomy and lobectomy for clinical T1c solid-dominant lung cancer
Ziyao Zhang, Fangqiu Fu, Xiangze Li, Yang Zhang, Haiquan Chen
Translational Lung Cancer Research  
2025;
14
(12)
:5405-5414
.
 (31 December 2025) 
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Development and validation of an interpretable machine learning model for prediction of occult lymph node metastasis in clinical stage T1 lung adenocarcinoma
Yuxing Chen, Jiahui Jin, Yihan Mao, Chengkai Zhou, Qingpeng Zeng, Jun Zhao
Translational Lung Cancer Research  
2025;
14
(12)
:5415-5430
.
 (31 December 2025) 
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Development and validation of machine learning models based on blood routine tests and tumor markers in early screening of primary bronchogenic lung cancer
Wenjing Deng, Lijuan Pan, Haolin Wang, Yulong Liu, Xuelian Peng, Chunyan Yang, Jin Li, Baoru Han
Translational Lung Cancer Research  
2025;
14
(12)
:5431-5446
.
 (31 December 2025) 
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A lactylation-driven prognostic model for lung adenocarcinoma: cellular lactylation heterogeneity and immune insights
Ziheng Yang, Hui Cheng, Sheng Zhang, Fan Li, Bo Zhao
Translational Lung Cancer Research  
2025;
14
(12)
:5447-5464
.
 (31 December 2025) 
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Real-world outcomes of first-line immunotherapy and subsequent systemic therapies in pleural mesothelioma: a multicenter study in China
Binhe Tian, Boyu Sun, Zixiang Zhou, Shuman Kuang, Jiongyuan Li, Weixuan Pan, Zhe Zhu, Xiaoyan Si, Li Zhang, Jun Liu, Juhong Shi, Fang Wu, Haitao Zhao, Hanping Wang
Translational Lung Cancer Research  
2025;
14
(12)
:5465-5478
.
 (31 December 2025) 
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The effects of neoadjuvant sintilimab versus pembrolizumab combined with chemotherapy on resectable non-small cell lung cancer: a multicenter propensity score-matched study
Yichen Sun, Zhiyuan Gao, Zhilin Luo, Liping Tong, Yong Zhang, Xiaoping Dong, Junying Wang, Wenjing Li, Ziyi Li, Weiru Qiao, Xian Chen, Hongtao Duan, Xiaolong Yan
Translational Lung Cancer Research  
2025;
14
(12)
:5479-5490
.
 (31 December 2025) 
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Circulating tumor DNA as prognostic markers of non-small cell lung cancer (NSCLC): a systematic review and meta-analysis
Xiaowei Chen, Meng Zhang, Qingxin Zhou, Nana Guo, Baoshan Cao, Hongmei Zeng, Wanqing Chen, Feng Sun
Translational Lung Cancer Research  
2025;
14
(12)
:5491-5508
.
 (31 December 2025) 
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Review Article

Targeting ferroptosis to overcome drug resistance in lung cancer
Pengfei Sheng, Jiang Jin, Hao Liu, Cien Sun, Yutao Chen, Xin Chen, Dehua Ma, Jianfei Shen
Translational Lung Cancer Research  
2025;
14
(12)
:5509-5526
.
 (31 December 2025) 
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Study Protocol

A study protocol of a single-arm, prospective, open-label, non-controlled, phase II study of neoadjuvant BL-B01D1 combined with aumolertinib in resectable stage II–IIIB non-small cell lung cancer patients with EGFR mutation
Yue Chen, Jiandong Mei, Ge Gao, Benxia Zhang, Yanying Li, Zhiyu Peng, Chuan Li, Fanyi Gan, Qiang Pu, Chengwu Liu, Wenjie Yang, Lunxu Liu, Yongsheng Wang
Translational Lung Cancer Research  
2025;
14
(12)
:5527-5534
.
 (31 December 2025) 
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Case Report

Diagnostic challenge of systemic amyloidosis mimicking EGFR-TKI toxicity in lung adenocarcinoma: a case report
So-yun Kim, Hyeong Seok Kang, Joo-Eun Lee, Hyun-Yi Kim, Min-Kyung Yeo, Chaeuk Chung
Translational Lung Cancer Research  
2025;
14
(12)
:5535-5544
.
 (31 December 2025) 
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Erratum

Erratum: Navigation of video-assisted thoracoscopic surgery using electromagnetic versus CT-guided localization (NOVEL): a study protocol for comparing procedural success and complication rates in a prospective, multicenter, randomized controlled, non-inferiority phase III trial
Editorial Office
Translational Lung Cancer Research  
2025;
14
(12)
:5545-5546
.
 (31 December 2025) 
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