Yang Yang, MD

Dr. Yang is specialized at Thoracoscopic Surgeries, Video-associated Thoracic Surgery(VATS), and adept at screening, diagnosis and prognosis of early lung cancer, perioperative comprehensive treatment based on molecular typing of lung cancer. He is also engaged in the valuation, maintenance and acquisition of OPO lung transplantation organs. Dr. Yang takes the lead in introducing VATS with small trauma and quick post-operational recovery in Asia. He has been successfully developing the Shanghai Pulmonary Hospital VATS International Learning Course for 26 terms and 595 trainees from 76 countries and regions including the United States, Spain, Japan and Israel were trained by far.

As an associate research fellow, Yang yang led his scientific research team to establish the thoracic surgery experimental center and precision medical testing platform of Tongji University Affiliated Pulmonary Hospital. The platform has tested accurately over 15000 patients and analyzed the major known driven genes of lung cancer to build genomic variation model of Chinese lung cancer patients. Dr. Yang has been dedicated to the research on the construction and application of antitumor nano-biomaterials since working independently. By integrating oncology with nano-biomaterials, the tumor detection rate is improved in terms of accuracy and specificity.

In accurate tumor recognition, highly sensitive lung cancer molecular probe and antitumor drugs with high affinity were synthesized by Dr. Yang and his scientific research team based on NIR-II biowindow which has deeper penetration depth of biological tissue and higher MPE(maximum permissible exposure), significantly improving the accuracy of tumor site orientation, detection and treatment. Dr. Yang with his scientific research team also constructed a silver sulfide quantum dots based nanochain probes with NIR-II response by regulating APP self-assembly of amphiphilic peptides, chemical crosslinking of silver sulfide quantum dots and tumor targeting peptide RGD. Small tumor with diameter of 0.2mm was detected and peritoneal metastasis with maximum quantity, minimum volume and maximum accuracy were resected on animal models by the integration of NIR-II fluorescence with multivalent tumor cell targeting induced by probe configuration.These novel efficient NIR-II nanochain probes provided a new strategy for clinical fluorescence guided tumor staging, preoperative diagnosis and intraoperative navigation.

In terms of target designing of antitumor drugs, a new generation of antitumor drug was designed and synthesized, and the first bispecific antibody targeting both HER2 and VEGF was successfully constructed. The novel integrated Fenton reagent——ferrous phosphide nanorods, designed by Dr.Yang with his scientific research team, has sound NIR-II optical absorption. The ferrous phosphide nanorods have great photothermal conversion (PTC) performance by laser irradiation under 1064 nm. The efficiency of Fenton reaction by ferrous phosphide nanorods is increasingly improved under photothermal and ultrasonic effect. Therefore, ferrous phosphide nanorods have therapeutic effects on deep tumor with NIR-Ⅱphoto-/ultrasonic dual response. In addition, the excellent PTC efficiency and inherent magnetic property makes ferrous phosphide nanorods the great photoacoustic and magnetic resonance imaging contrast agent, providing a new idea for biologically efficient application of Fenton reagent.

Dr. Yang has been in charge of a series of scientific projects which are funded by municipal or national institutes including Natural Science Foundation of China (NSFC), China Post-doctoral Science Foundation and the like. He also won the Excellent Youth Program of NSFC and the New Excellent Youth Program of Shanghai Municipal Health System. Yang yang has published more than 40 articles in international journals including Advanced Materials, AngewandteChemie International Edition, Small and Small Methods as correspondent or first author. The overall thesis cited times were up to 213. He also compiled 4 English works and applied for 2 Chinese invention patents. He was invited to make scientific conference and invitation reports at home and abroad for over 100 times. In 2018, Dr. Yang won the San Rafael Award -- the only prize joint set by the Rafael Hervada Foundation of Spain and Spanish Ministry of Health.

Editorial Board
Terms of Appointment: June 2020 - May 2022