Establishment of a malignant pleural effusion mouse model: pathogenesis pathways

A malignant pleural effusion (MPE), a significant clinical problem, may indirectly be caused by the cancer or its treatment, predominantly lung and breast adenocarcinoma or may appear as pleural effusion unrelated to the cancer (1). More specifically, the development of malignant mesothelioma or, most commonly, pleural metastasis of different cancers, are the main causes for resulting MPE. Systemic spread of disease and reduction of life expectancy and quality are the main implications of MPE (1).