Commentary on tumor heterogeneity

I would like to thank all three authors Drs. Ilie and Paul Hofman, and Mari Mino-Kennudson for their state of art overview on the role of liquid biopsy present and in future and the correlation to tissue biopsy (1-4). On this topic it could not be a classical pro&con discussion, as nobody in the pathologic community would neglect liquid biopsy. However, the strategy to what extend liquid biopsy can be integrated into the daily practice in pathology remains to be defined. In that regard we can see slight differences how liquid biopsy will be implemented in the US and in Europe.