Vol 15, No 4 (April 30, 2026): Translational Lung Cancer Research

Expert Consensus

International Consensus on Severe Lung Cancer—The Second Edition
Xinqing Lin, Qian Chu, Yuchao Dong, Min Li, Tangfeng Lv, Gen Lin, Ling Sang, Panwen Tian, Yang Xia, Zhanhong Xie, Haiming Chen, Cheng Hong, Juan Jiang, Haoru Jin, Zhongkai Kuai, Ming Liu, Weizhan Luo, Yongbei Luo, Qian Miao, Wei Mo, Dan Pu, Yuan Qiu, Zhe Qian, Jiancong Sun, Hui Shi, Qinying Sun, Yutao Sun, Zihui Yu, Xiaohong Xie, Wanting Xu, Minxiao Yi, Dongmei Yuan, Longfeng Zhang, Fei Zhao, Changhao Zhong, Ping Zhan, Xiaobin Zheng, Cunxue Bai, Enguo Chen, Rui Chen, Xin Chen, Yuan Cheng, Quanfang Chen, Linbo Cai, Xiuyu Cai, Liangan Chen, Yan Chen, Wen Dong, Haiyi Deng, Wenfeng Fang, Xin Gan, Yue Hao, Weidong Hu, Yong He, Yi Hu, Jie Hu, Baohui Han, Chengping Hu, Minjuan Hu, Yongliang Jiang, Yang Jin, Dan Liu, Weiting Liu, Wen Li, Jing Li, Laiyu Liu, Jun Liu, Weifeng Li, Wenhua Liang, Jie Lin, Hongbing Liu, Ziming Li, Weimin Li, NiHong Lu, Shun Lu, Chuanyong Mu, Hongxia Ma, Liyun Miao, Xinlin Mu, Xingxiang Pu, Jing Peng, Hongbing Peng, Jianwen Qin, Yinyin Qin, Shengxiang Ren, Longhua Sun, Chunxia Su, Yong Song, Xiaowu Tan, Kejing Tang, Xiaomei Tang, Jianlin Tong, Wenxian Wang, Di Wu, Lin Wu, Mengzhao Wang, Huijuan Wang, Yuehong Wang, Hongmei Wang, Qi Wang, Zhijie Wang, Jie Wang, Kai Wang, Fei Wang, Chunwei Xu, Min Xie, Aiguo Xu, Kui Xiao, Xin Xu, Fei Xu, Xianwei Ye, Meng Yang, Boyan Yang, Xiaoqun Ye, Feng Ye, Zongyang Yu, Dongsheng Yue, Qichuan Zhang, Juntao Zou, Jian Zhang, Li Zhuang, Jianying Zhou, Jianya Zhou, Bicheng Zhang, Jian Zhang, Jianqing Zhang, Xiaoju Zhang, Wei Zhao, Bo Zhu, Zhengfei Zhu, Wenzhao Zhong, Caicun Zhou, Yanbin Zhou, Jianxing He, Nanshan Zhong, Yuichi Saito, Satoshi Watanabe, Francesco Petrella, Takeo Nakada, Taichiro Goto, Alfonso Fiorelli, Piergiorgio Solli, Rossana Berardi, Yoshinobu Ichiki, Marcin Braun, Misako Nagasaka, Christos Chouaïd, Rajat Thawani, Pedro Gonzalez Santa-Catalina, Kim Styrvoky, Baptiste Abbar, Mariano Provencio, Shiyue Li, Rongchang Chen, Chengzhi Zhou
Translational Lung Cancer Research  
2026;
15
(4)
:69
.

Original Article

Deep learning model based on automated CT image segmentation for predicting the optimal radiotherapy protocol in limited-stage small cell lung cancer patients: a multicenter study
Junfeng Zhao, Zongqian Yuan, Jinquan Yao, Ying Li, Haining Luo, Chengxin Liu
Translational Lung Cancer Research  
2026;
15
(4)
:70
.
Association of PD-L1 expression and clinical outcomes in ROS1-rearranged advanced non-small cell lung cancer treated with entrectinib
Lixuan Chen, Wenhui Shi, Zhengqi Cao, Li Lu, Anni Wang, Jing Sun, Yuxin Ouyang, Peiyi Xu, Junjie Tang, Ziming Li
Translational Lung Cancer Research  
2026;
15
(4)
:71
.
DNA hypomethylation-activated PRAME drives early-stage lung adenocarcinoma recurrence via ZNF740 and PI3K/AKT/mTOR signaling
Guo-Nian Zhu, Qian Zheng, Pan Yang, Xue-Fei He, Pan Tang, Cheng-Di Wang, Jun Tang, Wei-Min Li, Zhou-Feng Wang
Translational Lung Cancer Research  
2026;
15
(4)
:72
.
Predictors of radiation pneumonitis after postoperative radiotherapy in completely resected pathologic stage III-N2 non-small cell lung cancer: a secondary analysis of a prospective cohort
Nengyang Wang, Aihui Feng, Hongxuan Li, Changlu Wang, Jindong Guo, Yuxi Yi, Qin Zhang, Jun Liu, Wen Yu, Zhiyong Xu, Xuwei Cai, Wen Feng, Xiaolong Fu
Translational Lung Cancer Research  
2026;
15
(4)
:73
.
Perioperative anxiety and depression predict long-term survival after neoadjuvant therapy in non-small cell lung cancer: a multicenter analysis
Yuxing Lin, Qichang Xie, Maojie Pan, Xin Yan, Renjie Huang, Guobing Xu, Bin Zheng, Zhang Yang, Chun Chen
Translational Lung Cancer Research  
2026;
15
(4)
:74
.
TLR7 induces autophagy in non-small cell lung cancer tumor cells and influences anti-tumors responses in patients
Lucas Leonardi, Solenne Marmier, Nathalie Josseaume, Sophie Sibéril, Mathilde Prieto, Karen Leroy, Audrey Mansuet-Lupo, Diane Damotte, Marco Alifano, Isabelle Cremer, Pierre-Emmanuel Joubert
Translational Lung Cancer Research  
2026;
15
(4)
:75
.
Prognostic nomogram for extensive-stage small-cell lung cancer in the immunotherapy era: a multicenter study of first-line platinum-etoposide with or without a PD-1/PD-L1 inhibitor
Yuhao Jing, Yifan Zhao, Zhenbao Zhou, Jianyu Wang, Yanbo Wang, Kai Ma, Zhiguang Sun, Qiuqiao Mu, Wei Li, Yun Ding, Han Zhang, Yuhang Jiang, Xiaoteng Jia, Lin Tan, Meng Wang, Xin Li
Translational Lung Cancer Research  
2026;
15
(4)
:76
.
LUADnet: a deep learning model for prediction of clinical outcomes in lung adenocarcinoma based on gene expression signatures
Cheng Cheng, Zhanlue Liang, Renjie Xu, Yanlin Gu, Shicheng Wu, Haoyu Wang, Nini Shi, Die Zhang, Huilin Zhong, Yiwen Tao, Weimin Li
Translational Lung Cancer Research  
2026;
15
(4)
:77
.
Perioperative inflammation, anesthesia modulation and cellular signaling in lung cancer: an integrated transcriptomic and single- cell analysis
Weixiang Lu, Qing Ai, Ze Wang, Tao Zhang, Shiyu Deng, Jianxing He, Wenlong Shao
Translational Lung Cancer Research  
2026;
15
(4)
:78
.
Mid-term efficacy and safety of transbronchial cryoablation for stage IA peripheral lung cancer: a retrospective analysis
Rui Yang, Junxiang Chen, Fangfang Xie, Chuanjia Gu, Siyuan Hong, Haiyu Zhu, Yifeng Jiang, Jiayuan Sun
Translational Lung Cancer Research  
2026;
15
(4)
:79
.
Preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)-based strategy for predicting negative mediastinal lymph node metastasis status in non-small cell lung cancer
Juntian Yao, Fangqiu Fu, Nan Li, Chaoqiang Deng, Shaoli Song, Yang Zhang, Haiquan Chen
Translational Lung Cancer Research  
2026;
15
(4)
:80
.
Distinct mutation landscape with similar immune microenvironment in primary simultaneous operable squamous cell carcinoma and peripheral-type small-cell lung cancer
Xiaoke Chen, Liqiang Qian, Jia Huang, Wei Mao, Jiaxin Zhong, Xiaoling Weng, Ting Wang, Zhengping Ding, Yun Liu, Fatao Liu, Xiaomin Niu
Translational Lung Cancer Research  
2026;
15
(4)
:81
.
Impact of effective dose to immune cells (EDIC) on survival in limited-stage small cell lung cancer treated with radiotherapy and immunotherapy
Mengqian Jiang, Yuantao Qi, Zihong Zhu, Wenqing Cui, Ran Zhang, Jinming Yu, Dawei Chen
Translational Lung Cancer Research  
2026;
15
(4)
:82
.
Air pollution, driver mutations, and survival in non-small cell lung cancer: insights from a high-altitude Hispanic cohort
Mateo Tamayo, Nicolás Duque Clavijo, Astrid Berena Herrera López, Manuela Estrada Schweineberg, Andres Felipe Bejarano, Juliana Pardo Aljure, Laura Baldovino-Chiquillo, David Uscategui-López, Sebastián Dueñas-Hernández, María Paula Molina, María José García, Diana Cañon, Margarita Baldión, Sergio Cruz, Luis Eduardo Pino, Henry Vargas, Javier Segovia, Erick Cantor, O. Valencia Estupiñán, Olga L. Sarmiento, Andrés F. Cardona, Beatriz Wills Sanin
Translational Lung Cancer Research  
2026;
15
(4)
:83
.
TROP2 expression as a prognostic predictor for osimertinib in patients with EGFR-mutant non-small cell lung cancer
Naohito Hashimoto, Kyoichi Kaira, Hisao Imai, Shota Takei, Kosuke Hashimoto, Ou Yamaguchi, Atsuto Mouri, Mei Hamada, Taku Honma, Hiroshi Kagamu
Translational Lung Cancer Research  
2026;
15
(4)
:84
.
Occupational physical workload and risk of lung cancer and chronic respiratory diseases: a prospective cohort study of the UK Biobank
Shuxiao Ma, Yi Liu, Zihuai Wang, Xuyuan Shi, Min Yi, Lunxu Liu
Translational Lung Cancer Research  
2026;
15
(4)
:85
.
Accelerating tumor evolution and enhancing immunotherapy efficacy in lung adenocarcinoma based on EXO1 inhibition
Xianfei Zhang, Liangjiao Yao, Zhengxin Yin, Fangxiu Luo, Yu Li, Anqi Yang, Runsen Jin, Wei Lu, Hecheng Li
Translational Lung Cancer Research  
2026;
15
(4)
:86
.
“Variant matters”: the impact of ALK fusion subtypes on progression and response in non-small-cell lung cancer—data from clinical practice from Polish centers
Kinga Winiarczyk, Katarzyna Seliga, Paweł Krawczyk, Aleksandra Nowak, Izabela Chmielewska, Andrzej Tysarowski, Małgorzata Szołkowska, Michał Gil, Dariusz M. Kowalski, Janusz Milanowski, Maciej Krzakowski
Translational Lung Cancer Research  
2026;
15
(4)
:87
.
Association between patient-reported outcomes and pathological response in neoadjuvant chemoimmunotherapy—a post hoc analysis of the TD-FOREKNOW trial
Bengang Hui, Na Zhang, Jiangnan Duan, Xiaojing Wang, Runmin Jiang, Rongxin Shang, Bowei Qiao, Weibo Yang, Chao Wang, Yanning Zhang, Xiaolong Yan, Tao Jiang, Jie Lei
Translational Lung Cancer Research  
2026;
15
(4)
:88
.
Evaluating the early therapeutic response of radiofrequency ablation in rabbit VX2 lung tumors: a comparison of four diffusion weighted imaging models
Qinqin Yan, Wen Ye, Fei Shan, Yuxin Shi, Zhiyong Zhang, Zenghui Cheng
Translational Lung Cancer Research  
2026;
15
(4)
:89
.
Novel lipid metabolism-related gene signature associated with clinical and immune features in lung adenocarcinoma patients experiencing lymph node metastasis
Shen Lao, Zisheng Chen, Yuan Zhang, Jianfu Li, Hengrui Liang, Yongmei Zheng, Xiaoyan Liu, Wei Wang, Wenhua Liang
Translational Lung Cancer Research  
2026;
15
(4)
:90
.
Assessing current diagnostic, staging, and treatment practices in community and academic centers for individuals with stage IB–IIIA non-small cell lung cancer
Matthew P. Smeltzer, Jhanelle E. Gray, Michelle Shiller, Jamie L. Studts, David J. Feller-Kopman, Jennifer Aversano, Percy Lee, Brendon M. Stiles, Benjamin Wei, Bianca Alvarez, Ashley Lile, Molly Kisiel, Rania Emara, Joseph Kim, Elana Plotkin
Translational Lung Cancer Research  
2026;
15
(4)
:91
.
The IASLC grading system as a predictor for EGFR-TKI therapy in patients with EGFR-mutant lung adenocarcinoma
Chaoqiang Deng, Molin Zhang, Fangqiu Fu, Qiang Zheng, Yuan Li, Yang Zhang, Haiquan Chen
Translational Lung Cancer Research  
2026;
15
(4)
:92
.
Beyond miRNAs: exploratory profiling of PIWI-interacting RNAs and small nucleolar RNAs in non-small cell lung cancer-related malignant pleural effusions
Joel Gabàs, Rui Alves, José M. Porcel, Anabel Sorolla
Translational Lung Cancer Research  
2026;
15
(4)
:93
.
Pre-clinical efficacy of trastuzumab deruxtecan plus sotorasib in KRASG12C-mutant non-small cell lung cancer and exploratory HER2 profiling in human tumors
Hilal Ozakinci, Bina Desai, Denise Kalos, Dung-Tsa Chen, Menkara Henry, Hitendra Solanki, Theresa A. Boyle, Humberto E. Trejo Bittar, Gina S. Nazario, Eric B. Haura, Andriy Marusyk, Bruna Pellini
Translational Lung Cancer Research  
2026;
15
(4)
:94
.
Timing of definitive pleural intervention within systemic anticancer therapy in malignant pleural effusion from high-response lung cancers: a retrospective single-center cohort study
Ana Pardessus Otero, Sergio Martínez-Recio, Albert Rafecas-Codern, Génesis Parada Pérez, Joel Lakhani Lakhani, Carlos Reyes, Ángel Fernández i Rebollo, Havid Jesús Colina Beltrán, Andrés Barba Joaquín, Margarita Majem, Juan Carlos Trujillo, Elisabeth Martínez, Pere Serra-Mitjà, Virginia Pajares
Translational Lung Cancer Research  
2026;
15
(4)
:95
.
Consolidative thoracic radiotherapy after first-line chemoimmunotherapy in extensive-stage small-cell lung cancer: a multicenter retrospective study
Shengxin Zhang, Nan Lin, Xiaojuan Gu, Ziyang Cheng, Xiang Lin, Xiao Liang, Xinggang Yang, Jie Chen, Xuelei Ma, Hu Liao
Translational Lung Cancer Research  
2026;
15
(4)
:96
.
Real-world effectiveness and safety of adebrelimab as first-line treatment in patients with extensive-stage small cell lung cancer
Tangfeng Lv, Bi Chen, Wei Chen, Yanmin Wu, Haitao Fei, Surong Fang, Lingfeng Min, Chong Li, Shuhua Han, Zhitong Zuo, Shencun Fang, Yahui Shen, Fenhong Qian, Bo Shen, Haitao Zhang, Ruifeng Zhang, Hui Liu, Lifeng Wang, Yong Song
Translational Lung Cancer Research  
2026;
15
(4)
:97
.
Identification of prognostic biomarkers and immunotherapy response predictors in lung adenocarcinoma: integrative Mendelian randomization and machine learning analysis
Chenlin Cao, Wan Qin, Ruoxuan Gong, Zhiyong Luo, Hong Zhang, Xianglin Yuan, Yanmei Zou, Shengling Fu, Hua Xiong
Translational Lung Cancer Research  
2026;
15
(4)
:98
.
Cadonilimab induction and consolidation for unresectable stage III non-small cell lung cancer patients receiving concurrent chemoradiation: safety run-in results of a prospective, phase II trial
Jianjiao Ni, Zilu Zheng, Xi Yang, Xiao Chu, Yue Zhou, Yechun Pang, Hongru Chen, Silai Yu, Fei Liang, Zhengfei Zhu, Li Chu
Translational Lung Cancer Research  
2026;
15
(4)
:99
.
Gender disparities in the overall survival of patients with minimally invasive squamous cell carcinoma of the lung: a retrospective analysis of the Surveillance, Epidemiology, and End Results Program database
Yucheng Ma, Jiayue Ye, Jiacong Liu, Yonghui Wang, Wang Lv, Luming Wang, Sheng Hu, Jian Hu
Translational Lung Cancer Research  
2026;
15
(4)
:100
.

Review Article

The resistance landscape of EGFR tyrosine kinase inhibitors in advanced non-small cell lung cancer: molecular mechanisms and novel therapeutic strategies
Shuotong Liu, Linsen Zhou, Yongze He, Qianyi Liu, Ying Tang, Zhen Liu, Xianhu Zeng, Jiangping Li
Translational Lung Cancer Research  
2026;
15
(4)
:101
.
Understanding the dual role of granulocyte-macrophage colony-stimulating factor in the lung cancer tumor microenvironment and its therapeutic implications
Gang Wei, Xuanji Zhu, Rui Zhong
Translational Lung Cancer Research  
2026;
15
(4)
:102
.
From biology to the clinic: research evidence and therapeutic advances of TROP2-targeted antibody-drug conjugates in small cell lung cancer
Haoyu Lu, Meiying Zhu, Yaning Luo, Qiyu Fan, Lihan Shang, Na Wang, Fanming Kong
Translational Lung Cancer Research  
2026;
15
(4)
:103
.
Pulmonary ground glass opacity tumor: a curable subtype of lung cancer when treated within the “surgical curative time window”
Ting Ye, Haoxuan Wu, Haiquan Chen
Translational Lung Cancer Research  
2026;
15
(4)
:104
.
Methylated circulating tumor DNA: technical challenges and clinical applications in non-small cell lung cancer patients—a narrative review
Manon Robert, Chloé Sauzay, Sandrine Théoleyre, Audrey Vallée, Delphine Fradin, Elvire Pons-Tostivint, Marc G. Denis
Translational Lung Cancer Research  
2026;
15
(4)
:105
.
Targeted therapy for stage IA non-small cell lung cancer with EGFR mutations: a scoping review
Yafei Xie, Liang Xia, Zhenyi Niu, Xiaolong Zhang, Yikai Xing, Xingqi Mi, Zhangyi Dai, Guangjian Zhang, Jian Hu, Qiang Pu
Translational Lung Cancer Research  
2026;
15
(4)
:106
.
Lung cancer associated with cystic airspaces in the perioperative immunotherapy era: radiologic and pathologic pitfalls, surgical extent, and management implications
Xue He, Qi Liu, Weijia Zeng, Qingchun Liang, Jiadi Luo, Juan Chen, Fenglei Yu, Wenliang Liu, Chen Chen
Translational Lung Cancer Research  
2026;
15
(4)
:107
.
Narrative review of the similarities and differences between immune checkpoint inhibitor- and antibody-drug conjugate-associated pneumonitis
Ruiting Tan, Fangfei Qian, Yao Zhang, Shuhui Cao, Hua Zhong
Translational Lung Cancer Research  
2026;
15
(4)
:108
.

Case Report

A lung squamous cell carcinoma demonstrating spontaneous partial regression of the primary tumor with lymph node metastasis: a case report with analysis of the tumor immune microenvironment
Hiroyuki Yamada, Yoshihiro Komohara, Takamasa Koga, Shukang Zhao, Rin Yamada, Shoichi Murai, Ko Nakao, Taro Muramoto, Yusuke Shinchi, Eri Matsubara, Kosuke Fujino, Koei Ikeda, Makoto Suzuki
Translational Lung Cancer Research  
2026;
15
(4)
:109
.
Prolonged complete metabolic response to chemotherapy combined with amivantamab with high grade cutaneous toxicity after osimertinib resistance in an uncommon T751_I759delinsAsp EGFR-mutant lung adenocarcinoma: a case report
Jean-Baptiste Barbe-Richaud, Erwan Pencreach, Roland Schott, Emilie Holder, Laura Somme
Translational Lung Cancer Research  
2026;
15
(4)
:110
.
Clonal relationship in a rare pulmonary mixed tumor: shared ALK fusion in atypical carcinoid and adenocarcinoma—a case report
Kyoung Min Kim, Jong Hun Kim, Myoung Ja Chung
Translational Lung Cancer Research  
2026;
15
(4)
:111
.
Two-year treatment-free sustained remission after chemo-immunotherapy in a 52-year-old male with recurrent ARID1A-mutant lung adenocarcinoma: a case report
Pedro Gonzalez Santa-Catalina, Daniel Morchón-Araujo, Marta Rodríguez-González, José María Sayagués, Mar Abad, Lorena Bellido-Hernández, Emilio Fonseca-Sánchez, Alejandro Olivares-Hernández, Edel del Barco-Morillo
Translational Lung Cancer Research  
2026;
15
(4)
:112
.
ALK-tyrosine kinase inhibitor resistance due to acquired MET amplification in ALK-fusion positive advanced NSCLC effectively treated by lorlatinib-vebreltinib combination: a case report and literature review
Peng Song, Dahong Liu, Yi Liu
Translational Lung Cancer Research  
2026;
15
(4)
:113
.

Editorial Commentary

Precision medicine in the first-line treatment of EGFR-mutated non-small cell lung cancer: moving beyond “one-size-fits-all”
Hiroaki Ikushima, Hidenori Kage
Translational Lung Cancer Research  
2026;
15
(4)
:114
.
Survival, toxicity, and sequencing: navigating the new first-line standard established by FLAURA2
Satoshi Ikeda, Keigo Araki, Mai Kitagawa, Natsuno Makihara, Yutaro Nagata, Kazuki Fujii, Kiyori Yoshida, Tatsuki Ikoma, Kahori Nakahama, Yuki Takeyasu, Utae Katsushima, Yuta Yamanaka, Takayasu Kurata
Translational Lung Cancer Research  
2026;
15
(4)
:115
.