TLR7 induces autophagy in non-small cell lung cancer tumor cells and influences anti-tumors responses in patients

Autophagy is a fundamental catabolic process with context-dependent roles in cancer. In non-small cell lung cancer (NSCLC), its clinical significance and therapeutic implications remain unclear. Toll-like receptor 7 (TLR7) has been implicated in the modulation of tumor-immune interactions, but its connection to autophagy and treatment response has not been defined. Here, we aimed to investigate whether TLR7 signaling regulates autophagy in NSCLC and to determine its impact on tumor progression and therapeutic responses.