Vol 15, No 5 (May 31, 2026): Translational Lung Cancer Research

Editorial Commentary

Targeting heterogeneity in atypical epidermal growth factor receptor-mutated non-small cell lung cancer: insights from CHRYSALIS-2
Yosuke Dotsu, Hiroshi Mukae
Translational Lung Cancer Research  
2026;
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Original Article

The impact of neoadjuvant chemoimmunotherapy on pulmonary function in non-small cell lung cancer patients
Ao Zeng, Zhilong Xu, Abudumijiti Abuduwayiti, Jiarui Wang, Yanze Yin, Keyi Chen, Mengtao Wang, Xiao Zhou, Jie Dai
Translational Lung Cancer Research  
2026;
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:117
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 (31 May 2026) 
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Development and external validation of a multivariable nomogram for predicting severe immune checkpoint inhibitor-associated myocarditis in advanced lung cancer
Tao Luan, Kangjing Ma, Shuaiying Wang, Qingqing Yang, Hongbin Ma, Wei Liu, Junyi Mo, Can Huang, Jiawen Chen, Xinqing Lin, Zekun Chenli, Zijun Rong, Baodan Yu, Shanshan Li, Yang Luan, Qun Lv, Hanxiu Lu, Gang Yang, Yunhui Zhang, Leyang Yao, Yijie Fang, Xinfei He, Zhenyi Lin, Panxiao Shen, Suneng Fu, Xiaowu Tan, Xiaohong Xie, Limin Wang, Chengzhi Zhou
Translational Lung Cancer Research  
2026;
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:118
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 (31 May 2026) 
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ZNF528 as a novel driver of metastasis in lung cancer: insights from single-cell transcriptomics
Huiying Li, Yongjuan Lin, Yue Wang, Xin Chen, Yu Xie, Tingting Yu, Jian He, Zhenyu Yin, Mao Xia
Translational Lung Cancer Research  
2026;
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:119
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 (31 May 2026) 
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Duration of systemic therapy in patients with metastatic EGFR-mutated non-small cell lung cancer and brain metastases
Michael Yan, Michael Tjong, Natalie Coburn, Lena Nguyen, Arjun Sahgal, Alexander V. Louie, Ambica Parmar
Translational Lung Cancer Research  
2026;
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:120
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 (31 May 2026) 
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Dacomitinib for EGFR-L858R-mutated non-small cell lung cancer following acquired resistance to third-generation EGFR-TKIs: a retrospective real-world study
Qian Wang, Xiaoyan Yin, Kaikai Zhao, Yankang Li, Lingling Kong, Liyang Jiang, Hong Zhao, Xin Wang, Xiaolin Li, Yu Chen, Xiangjiao Meng
Translational Lung Cancer Research  
2026;
15
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:121
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 (31 May 2026) 
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Dynamic changes in liver-to-spleen ratio: can it be a prognostic biomarker for chemo-immunotherapy in small cell lung cancer?
Yi Ren, Weiwei Liu, Jie Lou, Bingxin Gong, Yi Li, Qing Sun, Jing Li, Shanshan Jiang, Yuyang Wang, Ziqiao Lei, Lian Yang
Translational Lung Cancer Research  
2026;
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:122
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 (31 May 2026) 
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Elevated baseline C-reactive protein predicts poorer survival in lung cancer: a 22-year retrospective cohort study
Xiaomin Wei, Xiaoyan Liu, Mei Li, Hanping Wang, Wei Zhong, Xiaotong Zhang, Xiaoxing Gao, Mengzhao Wang, Xuefei Wu, Meng Rui, Ruzetuoheti Yiminniyaze, Xiaoyan Si, Li Zhang
Translational Lung Cancer Research  
2026;
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:123
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 (31 May 2026) 
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Pleural effusion volume as a novel biomarker for prognostic and therapeutic stratification in small cell lung cancer: a translationally-focused cohort study
Wanjun Lu, Qiuxia Wu, Xin Liu, Yuxin Jiang, Yong Song, Ping Zhan, Tangfeng Lv
Translational Lung Cancer Research  
2026;
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:124
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 (31 May 2026) 
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Surgical strategy after neoadjuvant immunochemotherapy for central-type NSCLC: restaging-guided versus pre-treatment-guided decision-making
Shoucheng Feng, Yuheng Zhou, Weizhen Sun, Nengqi Lin, Qinglin Wang, Zerui Zhao, Yaobin Lin, Hao Long
Translational Lung Cancer Research  
2026;
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:125
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 (31 May 2026) 
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Biweekly carboplatin plus nab-paclitaxel with concurrent radiotherapy followed by durvalumab consolidation for unresectable locally advanced non-small cell lung cancer: a real-world retrospective cohort study
Yasuhito Nunomura, Hisashi Tanaka, Shintaro Oyama, Toko Miura, Haruka Odagiri, Yuri Kobori, Kei Chubachi, Mina Ishidoya, Hiroaki Sakamoto, Tomonori Makiguchi, Dai Miura, Takeshi Morimoto, Yukihiro Hasegawa, Kageaki Taima, Sadatomo Tasaka
Translational Lung Cancer Research  
2026;
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:126
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 (31 May 2026) 
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Gut microbiome in advanced non-small cell lung cancer: effect of chemotherapy and impact on efficacy
Narumol Trachu, Insee Sensorn, Khantong Khiewngam, Nanamon Monnamo, Wasun Chantratita, Ekaphop Sirachainan, Thanyanan Reungwetwattana, Songporn Oranratnachai
Translational Lung Cancer Research  
2026;
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:127
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 (31 May 2026) 
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Real-world outcomes of consolidative durvalumab after concurrent chemoradiotherapy in stage III non-small cell lung cancer: the prognostic role of clinical frailty in the post-PACIFIC era
Yoo-Kang Kwak, Ji Sang Kim, So Jung Lee, Hye Jin Kang, Myung Soo Kim
Translational Lung Cancer Research  
2026;
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:128
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 (31 May 2026) 
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Exploring the effectiveness and sequence of brain local treatment combined with thoracic surgery in non-small cell lung cancer patients with brain oligometastasis
Ruihe Liu, Jiayuan Tian, Shenhua Liang, Yitao Yang, Xingyu Luo, Guowei Ma
Translational Lung Cancer Research  
2026;
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:129
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 (31 May 2026) 
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Comparative analysis of lung cancer risk factors between never-smokers and heavy smokers: a nationwide population-based study in Korea
Chiwook Chung, Kyu Na Lee, Dong Wook Shin, Sei Won Lee, Kyungdo Han
Translational Lung Cancer Research  
2026;
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:130
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 (31 May 2026) 
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CEACAM5 as a biomarker of semi-solid, lepidic lung adenocarcinoma
Justin M. Bader, William de Santis, Emma Kane, Anjali Jaiswal, Christina Cho, Michal Kidacki, Lieping Chen, Sanja Dacic, Gavitt A. Woodard
Translational Lung Cancer Research  
2026;
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:131
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 (31 May 2026) 
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3D computed tomography airway geometry for predicting bronchoscopic accessibility in peripheral pulmonary nodules: a prospective study
Byeong-Ho Jeong, Jonghoon Kim, Hwanho Cho, Youjin Oh, Ho Yun Lee
Translational Lung Cancer Research  
2026;
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:132
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 (31 May 2026) 
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Adjuvant epidermal growth factor receptor tyrosine kinase inhibitor in resected stage N2 non-small cell lung cancer harboring EGFR mutation
Yinyin Xue, Qiang Wu, Wen Li, Feng Xu, Yan Li, Qinghua Zhou
Translational Lung Cancer Research  
2026;
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:133
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 (31 May 2026) 
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Development and validation of a nomogram for predicting overall survival in small cell lung cancer: a multicenter analysis integrating multimodal therapy and molecular pathology
Zhihong Huang, Peng Mo, Naicheng Song, Yi Li, Lian Yang, Ai Huang, Junping Li, Ke Jiang
Translational Lung Cancer Research  
2026;
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:134
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 (31 May 2026) 
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CDKN1A promotes paclitaxel resistance through mediating formation of polyploid giant cancer cells and enhancing neosis in non-small cell lung cancer
Pan Sun, Zhenyu Huang, Yanjie Ji, Haizhen Jin, Han Zhang, Xiaohua Yang, Na Zhang, Lili Guo, Kai Wang, Ling Tian
Translational Lung Cancer Research  
2026;
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:135
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 (31 May 2026) 
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Pulmonary ground-glass opacity associated with cystic airspace: clinicopathological features and aggressiveness
Ziwen Yu, Jianfu Li, Hongsheng Deng, Caichen Li, Zhuxing Chen, Shan Xiong, Feng Li, Ran Zhong, Haixuan Wang, Chunyan Li, Danman Zhong, Yimin Zhong, Liping Liu, Wenhua Liang, Jianxing He
Translational Lung Cancer Research  
2026;
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:136
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 (31 May 2026) 
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Major histocompatibility complex II serves as a prognostic biomarker in resectable pulmonary sarcomatoid carcinoma: development of a prediction model
Hao Wang, Li Ye, Xinyue Liu, Yujie Li, Zhimin Chen, Wengang Zhang, Yujin Liu, Xuyang Chen, Wencheng Zhao, Qianqian Zhang, Runze Huang, Jialin Zeng, Shiying Chen, Yuhang Li, Lishu Zhao, Kandi Xu, Yayi He
Translational Lung Cancer Research  
2026;
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(5)
:137
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 (31 May 2026) 
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Diagnostic accuracy and safety of 1.1-mm cryoprobe biopsy for peripheral pulmonary lesions with or without oversheath
Geunin Lee, Mindong Sung, Hyeyung Hong, Ala Woo, Youngmok Park, Sang Hoon Lee, Eun Young Kim, Seung Hyun Yong
Translational Lung Cancer Research  
2026;
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:138
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 (31 May 2026) 
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Prognostic value of ROS1 rearrangement in lung adenocarcinoma stratified by clinicopathologic and radiological features: a retrospective cohort study
Yi Liu, Zelin Ma, Shuxiao Ma, Abuduwaili Yasheng, Zelin Deng, Chenglin Guo, Lunxu Liu
Translational Lung Cancer Research  
2026;
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:139
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 (31 May 2026) 
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Patterns of central nervous system disease and molecular landscape in epidermal growth factor receptor exon 20 insertion mutated non-small cell carcinoma
Amanda Reyes, Isa Mambetsariev, Jeremy Fricke, Jonathan R. Young, Bihong T. Chen, Arya Amini, Colton Ladbury, Javier Arias-Romero, Danny Nguyen, Evan Pisick, Vicki Doctor, Bradford Tan, Michelle Afkhami, Waasil Kareem, Xiaochen Li, Ravi Salgia
Translational Lung Cancer Research  
2026;
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:140
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 (31 May 2026) 
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BTLA and PD-1 combined with radiotherapy for enhancing antitumor immune response in lung cancer via the regulation of memory B cells to promote T-cell infiltration
Yingying Zhang, Yang Li, Can Feng, Yunxin Yang, Ning Liang, Lili Qiao, Jian Xie, Yan Zhang, Pingping Hu, Guodong Deng, Jiandong Zhang
Translational Lung Cancer Research  
2026;
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:141
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 (31 May 2026) 
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Utilizing clinical features, genetic mutations, and a 14-gene molecular assay for optimizing the management of multiple primary lung cancer
Bowen Li, Zhibo Zheng, Zhina Wang, Daoyun Wang, Lan Su, Zhicheng Huang, Yadong Wang, Jianchao Xue, Chao Guo, Chao Gao, Yuxiao Lin, Yang Song, Yuan Xu, Zhongxing Bing, Haochen Li, Ruirui Li, Zhe Feng, Jian Cui, Ka Luk Fung, Heqing Xu Rachel, Shanqing Li, Nan Zhang, Naixin Liang
Translational Lung Cancer Research  
2026;
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:142
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 (31 May 2026) 
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Brief Report

Long-term outcomes of ALK inhibitors in metastatic ALK-positive non-small cell lung cancer: an updated indirect comparison using reconstructed patient-level data
Andrea Ossato, Vera Damuzzo, Luna Del Bono, Lorenzo Gasperoni, Tiziano Lupi, Arianna Colicchio, Stefania Gori, Alessandro Inno
Translational Lung Cancer Research  
2026;
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:143
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 (31 May 2026) 
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Review Article

Lung cancer with EGFR PACC mutations: a practical review of available treatment options and novel therapies on the horizon
Julia M. Berg, Hollis Viray, Jenna Green, Paul A. VanderLaan, Susumu S. Kobayashi, Xiuning Le, Daniel B. Costa, Deepa Rangachari
Translational Lung Cancer Research  
2026;
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:144
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 (31 May 2026) 
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Advances in translational lung cancer research in 2025: a narrative review
Yuhan Xu, Yanbin Kuang, Yeqin Guo, Yuqing Lou
Translational Lung Cancer Research  
2026;
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:145
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 (31 May 2026) 
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Annual progress in transbronchial diagnosis and treatment of pulmonary malignant tumors [2025]: a narrative review
Ao Sun, Dongyang Xu, Jiayuan Sun
Translational Lung Cancer Research  
2026;
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:146
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 (31 May 2026) 
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Clinical practice review of systemic treatment in large cell neuroendocrine carcinoma
Amanda S. Cass, Isabella C. Luckage, Albert G. Linden, Robert A. Ramirez
Translational Lung Cancer Research  
2026;
15
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:147
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 (31 May 2026) 
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Applying artificial intelligence to ensure high quality and equitable lung cancer screening
Jessica C. Sieren, John D. Newell Jr, Carmen E. Guerra, Richard M. Hoffman
Translational Lung Cancer Research  
2026;
15
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:148
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 (31 May 2026) 
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Application of organoid models in basic and translational research of lung cancer: a narrative review
Yulong Jin, Hui Li, Chenchen Tang, Shaowei Lan, Haifeng Liu
Translational Lung Cancer Research  
2026;
15
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:149
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 (31 May 2026) 
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The role of tumor metabolic reprogramming in acquired anti-PD-1/PD-L1 resistance
Cize Gao, Jianing Chen, Boyue Pang, Chunxia Su
Translational Lung Cancer Research  
2026;
15
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:150
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 (31 May 2026) 
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Long-term survival and biomarkers of immunotherapy in small cell lung cancer: a systematic review
Sandra Laguna, Amaya Sádaba, Idoia Morilla, Lucía Teijeira, Maite Martínez-Aguillo, Ana Elsa Huerta-Hernández, Ibone Labiano, Arturo Lecumberri, Irene Cáseda, Miriam Redrado, Maider Artola, Rosalinda Termini, Claudia Agra, Nerea Otegui, Alfonso Calvo, Mónica Beunza-Sola, Natalia Castro, Ruth Vera, Maria Alsina, Hugo Arasanz
Translational Lung Cancer Research  
2026;
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:151
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 (31 May 2026) 
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Macrophages in lung cancer: principal factors, regulatory mechanisms, and therapeutic opportunities: a narrative review
Yuanjing Tian, Yanan Wu, Song Mi, Yingying Zhang, Pingping Hu, Lili Qiao, Guodong Deng, Ning Liang, Yan Zhang, Jiandong Zhang
Translational Lung Cancer Research  
2026;
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:152
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 (31 May 2026) 
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Study Protocol

Endostar combined with PD-1 blockade, radiotherapy, GM-CSF, and IL-2 (PRaG 2.0E) for refractory non-small cell lung cancer: a single-arm, phase II clinical trial (PRaG2.0E Study Protocol)
Shuaiyi Huang, Xiao Yang, Xiangrong Zhao, Yuehong Kong, Liyuan Zhang, Pengfei Xing
Translational Lung Cancer Research  
2026;
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:153
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 (31 May 2026) 
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Case Report

Case report: durable response to osimertinib, radiotherapy, and chemotherapy combination in advanced non-small cell lung cancer with atypical metastasis
Javier Arias-Romero, Isa Mambetsariev, Jeremy Fricke, Razmig Babikian, Pauline Kim, Shaira Therese Dingal, Trilokesh D. Kidambi, Evan Pisick, Leonidas Arvanitis, Yu Liang, Bihong T. Chen, Mustafa Raoof, Arya Amini, Ravi Salgia
Translational Lung Cancer Research  
2026;
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:154
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 (31 May 2026) 
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Pathological and molecular characterization of a four-component combined small cell lung carcinoma: a case report
Yasuyuki Ikezawa, Yoshiki Shinomiya, Kanako C. Hatanaka, Keishi Makita, Hiroki Nishimura, Toichiro Takagi, Yukiko Tabata, Mikio Watanabe, Satoshi Konno, Yutaka Hatanaka, Yasutaka Kawai
Translational Lung Cancer Research  
2026;
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:155
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 (31 May 2026) 
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Case report: first-line lorlatinib in metastatic lung adenocarcinoma with a novel WIPF1-ALK and EML4-ALK dual fusion
Sili Wang, Xinxin Chen, Yangyang Ma, Qiuyuan Xia, Dongmei Yuan, Tangfeng Lv, Yanwen Yao
Translational Lung Cancer Research  
2026;
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:156
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 (31 May 2026) 
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Neoadjuvant chemo-immunotherapy in a kidney transplant recipient with locally advanced non-small cell lung cancer: a case report of a therapeutic dilemma
Joffroy Rogier, Lucie Charon, Anne Durlach, Maxime Dewolf, Laëtitia Mokri, Antoine Braconier, Gaëtan Deslee, Julien Ancel
Translational Lung Cancer Research  
2026;
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:157
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 (31 May 2026) 
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Distinct multiplex immunofluorescence-based immune and stromal marker expression profile of subcutaneously metastatic SMARCA4-deficient undifferentiated thoracic tumor: a case report
Hongmin Li, Ying Liang, Yufei Wang, Mengjie Li, Yudong Su, Peng Chen, Jinghua Zhang
Translational Lung Cancer Research  
2026;
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:158
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 (31 May 2026) 
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Letter to the Editor

Challenges for first-line therapy in elderly patients with metastatic non-small cell lung cancer
Thierry Landre, Lorenzo Tommasi, Christos Chouaïd
Translational Lung Cancer Research  
2026;
15
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:159
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 (31 May 2026) 
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