Vol 10, No 7 (July 30, 2021): Translational Lung Cancer Research

Original Article

Mitogen signal-associated pathways, energy metabolism regulation, and mediation of tumor immunogenicity play essential roles in the cellular response of malignant pleural mesotheliomas to platinum-based treatment: a retrospective study
Alexander Mathilakathu, Sabrina Borchert, Michael Wessolly, Elena Mairinger, Hendrik Beckert, Julia Steinborn, Thomas Hager, Daniel C. Christoph, Jens Kollmeier, Jeremias Wohlschlaeger, Thomas Mairinger, Kurt Werner Schmid, Robert F. H. Walter, Luka Brcic, Fabian D. Mairinger
Translational Lung Cancer Research  
2021;
10
(7)
:3030-3042
.
 (30 July 2021) 
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Diagnosis-to-surgery interval and survival for different histologies of stage I–IIA lung cancer
Lu Zhang, Mei-Chin Hsieh, Lior Rennert, Paige Neroda, Xiao-Cheng Wu, Chindo Hicks, Jiande Wu, Ronald Gimbel
Translational Lung Cancer Research  
2021;
10
(7)
:3043-3058
.
 (30 July 2021) 
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Bevacizumab plus platinum-based chemotherapy in advanced non-squamous non-small-cell lung cancer: a randomized, open- label phase 2 study (CLEAR)
Hibiki Udagawa, Eri Sugiyama, Toshiyuki Harada, Shinji Atagi, Ryo Koyama, Satoshi Watanabe, Yukiko Nakamura, Daijiro Harada, Osamu Hataji, Fumihiro Tanaka, Hiroshi Kida, Miyako Satouchi, Ken Maeno, Akira Inoue, Kiyotaka Yoh, Yuki Yamane, Yoshiko Urata, Hiroshige Yoshioka, Takeharu Yamanaka, Koichi Goto
Translational Lung Cancer Research  
2021;
10
(7)
:3059-3070
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 (30 July 2021) 
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Tumor PD-L1 expression is associated with outcomes in stage III non-small cell lung cancer (NSCLC) patients treated with consolidation durvalumab
Khalid Jazieh, Mohamed Gad, Anas Saad, Wei Wei, Nathan A. Pennell
Translational Lung Cancer Research  
2021;
10
(7)
:3071-3078
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 (30 July 2021) 
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Randomized phase II trial of a first-in-human cancer cell lysate vaccine in patients with thoracic malignancies
Mary Zhang, Julie A. Hong, Tricia F. Kunst, Colleen D. Bond, Cara M. Kenney, Cheryl L. Warga, Javier Yeray, Min-Jung Lee, Akira Yuno, Sunmin Lee, Markku Miettinen, R. Taylor Ripley, Chuong D. Hoang, Sacha Gnjatic, Jane B. Trepel, David S. Schrump
Translational Lung Cancer Research  
2021;
10
(7)
:3079-3092
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 (30 July 2021) 
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Efficacy of docetaxel plus ramucirumab as palliative second-line therapy following first-line chemotherapy plus immune-checkpoint-inhibitor combination treatment in patients with non-small cell lung cancer (NSCLC) UICC stage IV
Wolfgang M. Brueckl, Martin Reck, Achim Rittmeyer, Jens Kollmeier, Claas Wesseler, Gunther H. Wiest, Petros Christopoulos, Albrecht Stenzinger, Amanda Tufman, Petra Hoffknecht, Bernhard Ulm, Fabian Reich, Joachim H. Ficker, Eckart Laack
Translational Lung Cancer Research  
2021;
10
(7)
:3093-3105
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 (30 July 2021) 
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Is there any place for PD-1/CTLA-4 inhibitors combination in the first-line treatment of advanced NSCLC?—a trial-level meta-analysis in PD-L1 selected subgroups
Francesco Passiglia, Antonio Galvano, Valerio Gristina, Nadia Barraco, Marta Castiglia, Alessandro Perez, Maria La Mantia, Antonio Russo, Viviana Bazan
Translational Lung Cancer Research  
2021;
10
(7)
:3106-3119
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 (30 July 2021) 
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Shared decision-making for prophylactic cranial irradiation in extensive-stage small-cell lung cancer: an exploratory study
Anshu Ankolekar, Dirk De Ruysscher, Bart Reymen, Ruud Houben, Andre Dekker, Cheryl Roumen, Rianne Fijten
Translational Lung Cancer Research  
2021;
10
(7)
:3120-3131
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 (30 July 2021) 
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Subsequent systemic therapy for non-small cell lung cancer patients with immune checkpoint inhibitor-related interstitial lung disease
Yusuke Sato, Satoshi Watanabe, Takeshi Ota, Kohei Kushiro, Toshiya Fujisaki, Miho Takahashi, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Kosuke Ichikawa, Satoshi Hokari, Rie Kondo, Masachika Hayashi, Hiroyuki Ishikawa, Takao Miyabayashi, Tetsuya Abe, Satoru Miura, Hiroshi Tanaka, Masaaki Okajima, Masaki Terada, Takashi Ishida, Akira Iwashima, Kazuhiro Sato, Hirohisa Yoshizawa, Nobumasa Aoki, Yasuyoshi Ohshima, Toshiyuki Koya, Toshiaki Kikuchi
Translational Lung Cancer Research  
2021;
10
(7)
:3132-3143
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 (30 July 2021) 
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Systemic immune-inflammation index is a stage-dependent prognostic factor in patients with operable non-small cell lung cancer
Fangqiu Fu, Chaoqiang Deng, Zhexu Wen, Zhendong Gao, Yue Zhao, Han Han, Shanbo Zheng, Shengping Wang, Yuan Li, Hong Hu, Yang Zhang, Haiquan Chen
Translational Lung Cancer Research  
2021;
10
(7)
:3144-3154
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 (30 July 2021) 
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Exosomal miR-375-3p breaks vascular barrier and promotes small cell lung cancer metastasis by targeting claudin-1
Shuangshuang Mao, Sufei Zheng, Zhiliang Lu, Xinfeng Wang, Yan Wang, Guochao Zhang, Haiyan Xu, Jianbing Huang, Yuanyuan Lei, Chengming Liu, Nan Sun, Jie He
Translational Lung Cancer Research  
2021;
10
(7)
:3155-3172
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 (30 July 2021) 
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Risk-score model to predict prognosis of malignant airway obstruction after interventional bronchoscopy
Minlin Jiang, Hao Xu, Dongmei Yu, Li Yang, Wenhui Wu, Hao Wang, Hui Sun, Jun Zhu, Wencheng Zhao, Qiyu Fang, Jia Yu, Peixin Chen, Shengyu Wu, Zixuan Zheng, Liping Zhang, Likun Hou, Huixian Zhang, Ye Gu, Yayi He
Translational Lung Cancer Research  
2021;
10
(7)
:3173-3190
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 (30 July 2021) 
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Association of hepatitis B virus infection status with outcomes of non-small cell lung cancer patients undergoing anti-PD-1/PD-L1 therapy
Xuanye Zhang, Dan Tian, Yue Chen, Chen Chen, Li-Na He, Yixin Zhou, Haifeng Li, Zuan Lin, Tao Chen, Yuhong Wang, Alessandro Russo, Ernest Nadal, Francesco Passiglia, Ross Andrew Soo, Satoshi Watanabe, Teresa Moran, In-Jae Oh, Sha Fu, Shaodong Hong, Li Zhang
Translational Lung Cancer Research  
2021;
10
(7)
:3191-3202
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 (30 July 2021) 
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A simplified model for determining the cutting plane during thoracoscopic anatomical partial lobectomy of the right lower lobe
Yun Liu, Bin Qiu, Songlin Zhang, Chaobing Liu, Ming Yan, Lailong Sun, Dominique Gossot, Takahiro Homma, Fariha Sheikh, Peter J. Kneuertz
Translational Lung Cancer Research  
2021;
10
(7)
:3203-3212
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 (30 July 2021) 
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Detection of epidermal growth factor receptor (EGFR) mutations from preoperative circulating tumor DNA (ctDNA) as a prognostic predictor for stage I–III non-small cell lung cancer (NSCLC) patients with baseline tissue EGFR mutations
Kai Guo, Changjian Shao, Lu Han, Honggang Liu, Zhiqiang Ma, Yang Yang, Yingtong Feng, Minghong Pan, Mariacarmela Santarpia, Maria Carmo-Fonseca, Catarina Silveira, Kye Young Lee, Jing Han, Xiaofei Li, Xiaolong Yan
Translational Lung Cancer Research  
2021;
10
(7)
:3213-3225
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 (30 July 2021) 
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Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features
Bo Wang, Ying Jiang, Shi Yu Li, Rui Lan Niu, Justin D. Blasberg, Jussuf T. Kaifi, Gang Liu, Zhi Li Wang
Translational Lung Cancer Research  
2021;
10
(7)
:3226-3235
.
 (30 July 2021) 
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Serum tumor markers for the prediction of concordance between genomic profiles from liquid and tissue biopsy in patients with advanced lung adenocarcinoma
Xiao-Dong Jiao, Li-Ren Ding, Chuan-Tao Zhang, Bao-Dong Qin, Ke Liu, Lian-Ping Jiang, Xi Wang, Li-Ting Lv, Hao Ding, Dao-Ming Li, Hui Yang, Xue-Qin Chen, Wen-Yu Zhu, Ying Wu, Yan Ling, Xi He, Jun Liu, Lin Shao, Hao-Zhe Wang, Yan Chen, Jing-Jing Zheng, Naoki Inui, Yuan-Sheng Zang
Translational Lung Cancer Research  
2021;
10
(7)
:3236-3250
.
 (30 July 2021) 
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The prognostic role of the Transducin-like Enhancer of split protein family in lung adenocarcinoma
Qianli Ma, Fei Xiao, Yang Hao, Zhiyi Song, Jin Zhang, Chaozeng Si, Chaoyang Liang, Deruo Liu
Translational Lung Cancer Research  
2021;
10
(7)
:3251-3263
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 (30 July 2021) 
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Review Article

A narrative review of primary research endpoints of neoadjuvant therapy for lung cancer: past, present and future
Sijia Ren, Anyi Xu, Yilian Lin, D. Ross Camidge, Massimo Di Maio, Raffaele Califano, Toyoaki Hida, Antonio Rossi, Nicolas Guibert, Chengchu Zhu, Jianfei Shen
Translational Lung Cancer Research  
2021;
10
(7)
:3264-3275
.
 (30 July 2021) 
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Hyperprogression under immunotherapy: a new form of immunotherapy response?—a narrative literature review
Miaozhen Lin, Ben G. L. Vanneste, Qiwen Yu, Zebin Chen, Jiayu Peng, Xiuyu Cai
Translational Lung Cancer Research  
2021;
10
(7)
:3276-3291
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 (30 July 2021) 
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Case Report

Adrenal crisis and acute exacerbation of interstitial lung disease after thymoma needle biopsy: a case report and literature review
Hengyi Yan, Qi Qi, Kai Zhang, Bing He, Guoming Chu, Guan Wang, Hua Wen, Yanyan Zhao, Hongxu Liu, Li Zhao, Yu Chen
Translational Lung Cancer Research  
2021;
10
(7)
:3292-3302
.
 (30 July 2021) 
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Acute anti-Ma2 paraneoplastic encephalitis associated to pembrolizumab: a case report and review of literature
Víctor Albarrán, Javier Pozas, Fernando Rodríguez, Ángela Carrasco, Elena Corral, Yolanda Lage, Pablo Álvarez-Ballesteros, Ainara Soria, Pilar Garrido
Translational Lung Cancer Research  
2021;
10
(7)
:3303-3311
.
 (30 July 2021) 
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Mobile 3-dimensional (3D) C-arm system-assisted transbronchial biopsy and ablation for ground-glass opacity pulmonary nodules: a case report
Junxiang Chen, Fangfang Xie, Xiaoxuan Zheng, Ying Li, Shuaiyang Liu, Kevin C. Ma, Taichiro Goto, Tobias Müller, Edward D. Chan, Jiayuan Sun
Translational Lung Cancer Research  
2021;
10
(7)
:3312-3319
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 (30 July 2021) 
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Editorial on Oligometastatic NSCLC: Definition and Treatment Opportunities1

Oligometastatic non-small cell lung cancer: from biology to clinical practice
Maurizio V. Infante, Thierry Berghmans
Translational Lung Cancer Research  
2021;
10
(7)
:3320-3323
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 (30 July 2021) 
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Local for advanced, is this a paradox?
Maristella Bungaro, Chiara Paratore, Paolo Bironzo, Silvia Novello
Translational Lung Cancer Research  
2021;
10
(7)
:3324-3328
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 (30 July 2021) 
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Review Article on Oligometastatic NSCLC: Definition and Treatment Opportunities1

Defining oligometastatic non-small cell lung cancer: concept versus biology, a literature review
Jill F. Mentink, Marthe S. Paats, Daphne W. Dumoulin, Robin Cornelissen, Joris B. W. Elbers, Alexander P. W. M. Maat, Jan H. von der Thüsen, Anne-Marie C. Dingemans
Translational Lung Cancer Research  
2021;
10
(7)
:3329-3338
.
 (30 July 2021) 
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Epidemiology of oligometastatic non-small cell lung cancer: results from a systematic review and pooled analysis
Elisa Gobbini, Luca Bertolaccini, Niccolò Giaj-Levra, Jessica Menis, Matteo Giaj-Levra
Translational Lung Cancer Research  
2021;
10
(7)
:3339-3350
.
 (30 July 2021) 
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Narrative review: molecular and genetic profiling of oligometastatic non-small cell lung cancer
Sawsan Rashdan, Puneeth Iyengar, John D. Minna, David E. Gerber
Translational Lung Cancer Research  
2021;
10
(7)
:3351-3368
.
 (30 July 2021) 
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A narrative review on tumor microenvironment in oligometastatic and oligoprogressive non-small cell lung cancer: a lot remains to be done
Lorenzo Belluomini, Alessandra Dodi, Alberto Caldart, Dzenete Kadrija, Marco Sposito, Miriam Casali, Giulia Sartori, Miriam Grazia Ferrara, Alice Avancini, Emilio Bria, Jessica Menis, Michele Milella, Sara Pilotto
Translational Lung Cancer Research  
2021;
10
(7)
:3369-3384
.
 (30 July 2021) 
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Diagnostic and prognostic biomarkers in oligometastatic non-small cell lung cancer: a literature review
Diego Cortinovis, Umberto Malapelle, Fabio Pagni, Alessandro Russo, Giuseppe Luigi Banna, Elisa Sala, Christian Rolfo
Translational Lung Cancer Research  
2021;
10
(7)
:3385-3400
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 (30 July 2021) 
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Clinical prognostic factors in surgically treated oligometastatic non-small cell lung cancer: a systematic review
Luca Bertolaccini, Monica Casiraghi, Giulia Sedda, Filippo de Marinis, Lorenzo Spaggiari
Translational Lung Cancer Research  
2021;
10
(7)
:3401-3408
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 (30 July 2021) 
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The role of the surgeon in the management of oligometastatic non-small cell lung cancer: a literature review
Lawek Berzenji, Sophie Debaenst, Jeroen M. H. Hendriks, Suresh Krishan Yogeswaran, Patrick Lauwers, Paul E. Van Schil
Translational Lung Cancer Research  
2021;
10
(7)
:3409-3419
.
 (30 July 2021) 
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Radiotherapy for oligometastatic non-small cell lung cancer: a narrative review
Nora Sundahl, Yolande Lievens
Translational Lung Cancer Research  
2021;
10
(7)
:3420-3431
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 (30 July 2021) 
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Alternative methods for local ablation—interventional pulmonology: a narrative review
Gerard Olive, Rex Yung, Henry Marshall, Kwun M. Fong
Translational Lung Cancer Research  
2021;
10
(7)
:3432-3445
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 (30 July 2021) 
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Local ablative therapies in oligometastatic NSCLC-upfront or outback?—a narrative review
Michael C. Tjong, Alexander V. Louie, Puneeth Iyengar, Benjamin J. Solomon, David A. Palma, Shankar Siva
Translational Lung Cancer Research  
2021;
10
(7)
:3446-3456
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 (30 July 2021) 
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Local ablative therapy in oncogenic-driven oligometastatic non-small cell lung cancer: present and ongoing strategies—a narrative review
Vincent Fallet, Lise Matton, Antoine Schernberg, Anthony Canellas, François H. Cornelis, Jacques Cadranel
Translational Lung Cancer Research  
2021;
10
(7)
:3457-3472
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 (30 July 2021) 
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Current and future research efforts in oligometastatic non-small cell lung cancer—a systematic review
Mariana Brandão, Valérie Durieux, Thierry Berghmans
Translational Lung Cancer Research  
2021;
10
(7)
:3473-3485
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 (30 July 2021) 
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How to optimize the incorporation of immunotherapy in trials for oligometastatic non-small cell lung cancer: a narrative review
Jordi Remon, Jessica Menis, Antonin Levy, Dirk K. M. De Ruysscher, Lizza E. L. Hendriks
Translational Lung Cancer Research  
2021;
10
(7)
:3486-3502
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 (30 July 2021) 
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Disclosure:

1. The series “Oligometastatic NSCLC: definition and treatment opportunities” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Maurizio V. Infante and Thierry Berghmans served as the unpaid Guest Editors for the series.