Vol 14, No 9 (September 30, 2025): Translational Lung Cancer Research

Editorial

From tradition to transformation: evolving paradigms in surgical lung cancer treatment
Aimée J. P. M. Franssen, Peter B. Licht, Erik R. de Loos
Translational Lung Cancer Research  
2025;
14
(9)
:3280-3283
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 (30 September 2025) 
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MicroRNA expression in pleural fluid as a diagnostic biomarker of malignant pleural effusion: promise, pragmatism, and the path forward
José M. Porcel, Maria Alba Sorolla
Translational Lung Cancer Research  
2025;
14
(9)
:3284-3291
.
 (30 September 2025) 
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Nucleic acids in pleural fluid for the etiological diagnosis of pleural effusion
Jose Diego Santotoribio, Joel Dominguez-Garcia
Translational Lung Cancer Research  
2025;
14
(9)
:3292-3298
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 (30 September 2025) 
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Expert Consensus

Multidisciplinary approach for patients with early and locally advanced non-small cell lung cancer (NSCLC): 2nd Spanish Lung Cancer Group (GECP) expert consensus statement
Aylen Vanessa Ospina-Serrano, Jose Luis González-Larriba, Ernest Nadal, Florentino Hernando Trancho, Joaquim Bosch-Barrera, Virginia Calvo, Sergio Bolufer-Nadal, José Luis Campo-Cañaveral de la Cruz, Ivan Macía-Vidueira, Antonio Álvarez-Kindelán, Edel Del Barco-Morillo, Reyes Bernabé-Caro, Joaquin Casal-Rubio, Ángel Cilleruelo-Ramos, Manuel Cobo-Dols, Manuel Dómine-Gómez, Santiago Figueroa-Almánzar, Amelia Insa-Mollá, José Ramón Jarabo-Sarceda, Unai Jiménez-Maestre, Rafael López-Castro, Margarita Majem, Alex Martinez-Marti, Elisabeth Martínez Téllez, David Sánchez-Lorente, Marta López-Valcárcel, Felipe Couñago, Rosario Garcia-Campelo, Javier de Castro, Bartomeu Massutí-Sureda, Mariano Provencio
Translational Lung Cancer Research  
2025;
14
(9)
:3299-3322
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 (30 September 2025) 
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Original Article

Integrating deep learning and radiomics in the differentiation of major histological subtypes of invasive non-mucinous lung adenocarcinoma using positron emission tomography and computed tomography
Dong Wang, Huan Liu, Zhuo Cao, Weiqian Huang, Wen Fu, Li Shao, Ji Zhang, Wanyu Su, Xianwen Yu, Ce Han, Yao Ai, Congying Xie, Xiance Jin
Translational Lung Cancer Research  
2025;
14
(9)
:3323-3336
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 (30 September 2025) 
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Outcomes and prognostic insights in primary tracheal cancer: a multicenter retrospective study
Aleksandra Piórek, Aleksandra Napieralska, Paweł Teterycz, Adam Płużański, Magdalena Knetki-Wróblewska, Kinga Winiarczyk, Sylwia Tabor, Dariusz M. Kowalski, Maciej Krzakowski
Translational Lung Cancer Research  
2025;
14
(9)
:3337-3348
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 (30 September 2025) 
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Density and maturity ratio of tertiary lymphoid structures in stage II–III non-small cell lung cancer predict postoperative recurrence risk
Yi-Ming Liu, Kai Zhao, Mei Xie, Xin-Yu Bao, Wen-Han Cai, Jia-Mei Jin, Xin-Ying Xue, Zhi-Qiang Xue
Translational Lung Cancer Research  
2025;
14
(9)
:3349-3362
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 (30 September 2025) 
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Survival benefits in non-small cell lung cancer during the immune checkpoint inhibitor era: integrating lymph node burden for prognostic precision
Yuntao Feng, Qijue Lu, Yichen Dong, Jingyu Chen, Yue Zhao, Long Xu, Junqi Wu, Bowen Shi, Deping Zhao
Translational Lung Cancer Research  
2025;
14
(9)
:3363-3377
.
 (30 September 2025) 
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Efficacy and safety of perioperative, adjuvant and neoadjuvant chemoimmunotherapy stratified by clinical stage and PD-L1 expression in resectable non-small cell lung cancer: a systematic review and network meta-analysis
Yuanyuan Wang, Lin Zhang, Xinyuan Zhao, Dongchen Sun, Huaqiang Zhou, Yaxiong Zhang, Gang Chen, Tingting Liu, Jiaqing Liu, Yuanyuan Zhao, Yan Huang, Wenfeng Fang, Li Zhang, Yunpeng Yang
Translational Lung Cancer Research  
2025;
14
(9)
:3378-3395
.
 (30 September 2025) 
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Efficacy and safety of neoadjuvant chemotherapy with or without PD-L1/PD-1 inhibitors in surgically limited-stage small-cell lung cancer
Liang Shi, Hongxia Li, Lili Guo, Junfang Tang, Yuan Yang, Song Wei, Yujie Dong, Daping Yu, Shijie Zhou, Teng Ma, Ling Yi, Jinghui Wang, Zhe Liu
Translational Lung Cancer Research  
2025;
14
(9)
:3396-3409
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 (30 September 2025) 
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Actionable mutations and targeted therapy in non-small cell lung cancer among Latin American and Hispanic patients: a systematic literature review of prognosis and meta-analysis
Juan Pablo Castañeda-González, Jonathan W. Riess, María Paula Gómez-Gómez, Daniel Clavijo Cabezas, Merideidy Plazas Vargas, Rafael Parra-Medina
Translational Lung Cancer Research  
2025;
14
(9)
:3410-3429
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 (30 September 2025) 
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Potential efficacy of anti-angiogenic therapy combined with immunotherapy for advanced SMARCA4-deficient thoracic tumor: a retrospective study
Beibei Liu, Danni Wang, Yujing Li, Fangfei Qian, Yanwei Zhang, Lele Zhang, Xinwei Wu, Xuemei Liu, Wenyan Ma, Wei Zhang, Lvkan Weng, Yuqing Lou, Rong Li
Translational Lung Cancer Research  
2025;
14
(9)
:3430-3443
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 (30 September 2025) 
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An effective and affordable blood test for lung cancer early detection using four protein markers and artificial intelligence
Bing Wei, Wenjian Wang, Shuaipeng Geng, Wei Wu, Chenyu Ding, Dandan Zhu, Shuoyao Cheng, Qiurong Zhao, Yi Luan, Shiyong Li, Mao Mao
Translational Lung Cancer Research  
2025;
14
(9)
:3444-3456
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 (30 September 2025) 
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Immune checkpoint inhibitors combined with chemotherapy as first-line treatment may improve clinical outcomes in advanced non-small cell lung cancer with bone metastases
Yohei Asano, Katsuhiro Hayashi, Shinji Miwa, Yuta Taniguchi, Miho Okuda, Seiji Yano, Satoru Demura
Translational Lung Cancer Research  
2025;
14
(9)
:3457-3467
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 (30 September 2025) 
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Tumor rim-specific computed tomography radiomics improves prediction of pathological complete response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer
Jingyi Yang, Fangyuan Qu, Qiliang Wang, Xiaoting Cai, Xueqi Wang, Yicai Zhang, Fan Liu, Jiahui E, Ying Liu
Translational Lung Cancer Research  
2025;
14
(9)
:3468-3485
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 (30 September 2025) 
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Effect of neoadjuvant vs. adjuvant systemic therapy on survival in patients with surgical resected limited stage small-cell lung cancer: a real-world retrospective cohort study from SEER database
Zewen Sun, Yan Ju, Jingwei Zhang, Geyun Chang, Changtai Zhao, Ruoyi Jin, Fan Yang, Xiang Yan, Xiao Li
Translational Lung Cancer Research  
2025;
14
(9)
:3486-3500
.
 (30 September 2025) 
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Comparative survival outcomes between EGFR-wildtype and EGFR-mutant lung adenocarcinoma following neoadjuvant chemoimmunotherapy: a retrospective cohort study from national cancer center in China
Sikai Wu, Xiaowei Chen, Jinfei Li, Zhenlin Yang, Shugeng Gao
Translational Lung Cancer Research  
2025;
14
(9)
:3501-3517
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 (30 September 2025) 
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Outcomes of radial probe endobronchial ultrasound-guided transbronchial lung cryobiopsy using guide sheath and the target fixing technique
Taehun Kim, Seong Hwan Youn, Mi-Ae Kim, Hyun Jung Kim, Yongshik Kwon, Jae Seok Park, Sun Hyo Park
Translational Lung Cancer Research  
2025;
14
(9)
:3518-3528
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 (30 September 2025) 
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Comparative study of bronchoscopic and CT-guided percutaneous microwave ablation for inoperable non-small cell lung cancer
Feng Wang, Baolu Yang, Xinglu Zhang, Keyimu Subinuer, Wan Li, Hengmo Rong, Zhaohui Tong
Translational Lung Cancer Research  
2025;
14
(9)
:3529-3541
.
 (30 September 2025) 
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Adjuvant chemotherapy before osimertinib in EGFR-mutated stage IB lung adenocarcinoma: a clinical dilemma
Sun Hyo Park, Jin Han Park, Tae Hun Kim, Sun Ha Choi, Ji Eun Park, Insu Kim, Ji Yeon Kim, Tae Hoon Kim, Taehoon Lee, Hyun Kyu Cho, Jong Hwan Jeong, Jung Wook Yang, Hyun-Kyung Lee, Ho Young Lee, Ho Jin Jung, Jung Seop Eom, June Hong Ahn
Translational Lung Cancer Research  
2025;
14
(9)
:3542-3552
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 (30 September 2025) 
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Multi-omics and Mendelian randomization identify S1PR5 as a causal protective gene and NK cell-mediated prognostic biomarker in lung adenocarcinoma
Zherui Xing, Yuanxin Liu, Xue Yang, Yang Yao, Tao Chang, Laiyan Zhou, Ren Luo, Lili Jiang, Jianxin Xue
Translational Lung Cancer Research  
2025;
14
(9)
:3553-3576
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 (30 September 2025) 
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Performance comparison of four published lung cancer prediction models applied to a cohort from the National Lung Screening Trial
Kimberly E. Schroeder, Kevin Knoernschild, Sarah L. Averill, Richard M. Hoffman, Jessica C. Sieren
Translational Lung Cancer Research  
2025;
14
(9)
:3577-3588
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 (30 September 2025) 
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Prognostic factors affecting mortality in elderly, low body mass index, and poor performance status groups with lung cancer: analysis of the 2016 Korean Association of Lung Cancer Registry (KALC-R) database
Kyu Yean Kim, Jeong Uk Lim, Ho Cheol Kim, Tae-Jung Kim, Hong Kwan Kim, Mi Hyoung Moon, Kyongmin Sarah Beck, Soon Ho Yoon, Yang-Gun Suh, Chang Hoon Song, Jin Seok Ahn, Jeong Eun Lee, Jae Hyun Jeon, Kyu-Won Jung, Eunhye Park, Chi Young Jung, Jeong Su Cho, Yoo Duk Choi, Seung-Sik Hwang, Joon Young Choi, Young Sik Park, Chang-Min Choi, Seung Hun Jang
Translational Lung Cancer Research  
2025;
14
(9)
:3589-3606
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 (30 September 2025) 
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Combination of racotumomab immunotherapy with programmed death-1 blockade in a preclinical model of non-small cell lung cancer
Valeria I. Segatori, Selene Rojo, Cynthia A. Gulino, Carla S. Capobianco, Gretel M. Ferreira, Martina Crispo, Ignacio A. Demarco, Eduardo Spitzer, Mariano R. Gabri, Daniel F. Alonso
Translational Lung Cancer Research  
2025;
14
(9)
:3607-3622
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 (30 September 2025) 
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Monocyte-Platelet-Hemoglobin-Hematocrit score and the role of hematological parameters in predicting treatment response to immune checkpoint inhibitors and survival outcomes in non-small cell lung cancer patients—a retrospective study
Katiane Tostes, Tauana Christina Dias, Gabriela Karam Rebolho, Isabela Fernandes Rivelli Cardoso, Gabriela Panini Batagelo, Flávio Augusto Ferreira da Silva, Aléxia Polo Siqueira, André Luiz Pinto, Letícia Ferro Leal, Lidia Maria Rebolho Batista Arantes
Translational Lung Cancer Research  
2025;
14
(9)
:3623-3635
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 (30 September 2025) 
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Evaluation of ultrasonic energy for sealing 5–7 mm blood vessels in thoracoscopic surgery: a noninferiority randomized controlled trial
Chengqiang Li, Zhenyi Niu, Jinming Xu, Jie Yao, Yan Yan, Zhibo Chang, Xipeng Wang, Hui Jing, Dingpei Han, Yajie Zhang, Jiaming Che, Jules Lin, Mingsong Wang, Junqiang Fan, Jian Hu, Hecheng Li
Translational Lung Cancer Research  
2025;
14
(9)
:3636-3644
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 (30 September 2025) 
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Biomarkers for non-small cell lung cancer risk using multi-omics approaches: a nested case-control study
Youngmin Han, Keum Ji Jung, Seong Gyu Choi, Yeun Soo Yang, Kwangbae Lee, Sun Ha Jee
Translational Lung Cancer Research  
2025;
14
(9)
:3645-3658
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 (30 September 2025) 
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The pathogenic mutations in smokers with non-small cell lung cancer: a next-generation sequencing study
Shi Yan, Hui Li, Yan Liu, Rixin Li, Ying Liu, Lixia Ma, Jing Zhu, Yang Zhang, Ying Cheng
Translational Lung Cancer Research  
2025;
14
(9)
:3659-3672
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 (30 September 2025) 
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Expression of YAP1 delineates distinct subtypes of pulmonary large cell neuroendocrine carcinoma with divergent therapeutic implications
Yanli Zhu, Haiyue Wang, Jingjing Wang, Youjun Cao, Jianghua Wu, Kaiwen Chi, Xinting Diao, Xiaozheng Huang, Minglei Zhuo, Dongmei Lin
Translational Lung Cancer Research  
2025;
14
(9)
:3673-3689
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 (30 September 2025) 
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Radiomic phenotypes of oligometastatic non-small cell lung cancer
Kevin M. Boehm, Emily S. Lebow, N. Ari Wijetunga, Justin Haseltine, Andreas Rimner, Narek Shaverdian, Helena Yu, Bob T. Li†, James M. Isbell, Rosna Mirtcheva-Trocheva, Puneeth Iyengar, Daniel R. Gomez
Translational Lung Cancer Research  
2025;
14
(9)
:3690-3702
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 (30 September 2025) 
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Imaging biomarkers related to tumor-associated macrophage in immunotherapy treatment planning for non-small cell lung cancer
Shanshan Li, Yao Fu, Shuangshuang Ma, Fang Shi, Lingfei Liu, Jia Liu, Zengzhen Wang, Yuanyuan Yan, Wei Mu
Translational Lung Cancer Research  
2025;
14
(9)
:3703-3719
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 (30 September 2025) 
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Osimertinib resistance-based immune prognostic related gene signature in EGFR mutant lung adenocarcinoma, in which PSMD11 promotes tumor progression
Yuquan Bai, He Xu, Peilong Bao, Yang Gao, Jingwei Sun, Yang Shen, Jinbo Zhao, Tao Jiang
Translational Lung Cancer Research  
2025;
14
(9)
:3720-3739
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 (30 September 2025) 
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Myelopreservation effect of trilaciclib in extensive-stage small cell lung cancer (ES-SCLC): a systematic review and meta-analysis with trial sequential analysis of randomized clinical trials
Yiling Ding, Zhijie Deng, Xun Yuan, Yamin Shu, Jing Chen, Shiyi Cao, Qian Chu
Translational Lung Cancer Research  
2025;
14
(9)
:3740-3752
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 (30 September 2025) 
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The difference in tumor immune microenvironment and IFN-γ response between solid and non-solid adenocarcinoma
Shuichi Shinohara, Daisuke Muraoka, Ayako Demachi-Okamura, Katsuhiro Masago, Eiichi Sasaki, Reina Nishida, Shin Shomura, Takashi Ohki, Yoshiki Shigematsu, Fumiaki Watanabe, Katsutoshi Adachi, Kazuya Fujinaga, Shinji Kaneda, Motoshi Takao, Hiroaki Kuroda, Takashi Ohtsuka, Rui Yamaguchi, Tsukasa Nabekura, Hirokazu Matsushita
Translational Lung Cancer Research  
2025;
14
(9)
:3753-3768
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 (30 September 2025) 
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Synergistic camrelizumab therapy inhibits P53-mutant osimertinib-resistant solid lung adenocarcinoma via the TGF-β signaling pathway
Xiaoqin Shi, Min Zheng, Xiaolan Wang, Xiujun Chang, Kang’an Li, Le Cai, Yiran Cai
Translational Lung Cancer Research  
2025;
14
(9)
:3769-3795
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 (30 September 2025) 
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C1orf116 inhibits acquired resistance to EGFR inhibitors in EGFR mutant lung adenocarcinoma by suppressing the ATM/ATR pathways
Fen Wang, Chang Lu, Xiaorong Yang, Xuewu Wei, Weichi Luo, Lv Wu, Honghong Yan, Zhihong Chen, Qing Zhou
Translational Lung Cancer Research  
2025;
14
(9)
:3796-3810
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 (30 September 2025) 
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Real-world insights into atezolizumab plus bevacizumab, carboplatin, and paclitaxel for advanced non-squamous non-small cell lung cancer
Masatoshi Kanayama, Masaru Takenaka, Takehiko Manabe, Katsuma Yoshimatsu, Yukiko Nemoto, Rintaro Oyama, Hiroki Matsumiya, Masataka Mori, Koji Kuroda Kazuhiro Yatera, Fumihiro Tanaka
Translational Lung Cancer Research  
2025;
14
(9)
:3811-3823
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 (30 September 2025) 
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Molecular and clonal evolution of primary lesions vs. brain metastasis in EGFR-mutated NSCLC: a retrospective cohort study
Alejandro Ruíz-Patiño, Jairo Zuluaga, Nicolle Wagner-Gutierrez, Oscar Arrieta, Leonardo Rojas, Claudio Martín, Luis Corrales, Lucia Viola, Stella Martínez, Carlos Carvajal, Alejandro Gonzalez, Hernán Carranza, Carlos Vargas, Jorge Otero, July Rodríguez, Javier Jacobo, Jorge Aristizábal, Diego Pineda, Christian Rolfo, Natalia Sánchez, Andrés F. Cardona
Translational Lung Cancer Research  
2025;
14
(9)
:3824-3835
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 (30 September 2025) 
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Metabolic phenotype and gender may predict treatment outcomes of atezolizumab in extensive-stage small cell lung cancer
Peter May, Christof Winter, Inga Hubrecht, Eva Ortner, Selina Strathmeyer, Roland Geyer, Steffen Heelemann, Jan Stratmann, Folker Schneller, Florian Bassermann, Aaron Becker von Rose
Translational Lung Cancer Research  
2025;
14
(9)
:3836-3846
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 (30 September 2025) 
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Induction chemoimmunotherapy and surgery for unresectable stage III non-small cell lung cancer
Suyu Wang, Shiqi Hu, Yifei Zhou, Shuangyi Li, Tao Ge, Ziyun Shen, Jie Yang
Translational Lung Cancer Research  
2025;
14
(9)
:3847-3860
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 (30 September 2025) 
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Real-world outcomes and association between immune-related adverse events and therapeutic efficacy of nivolumab plus ipilimumab in elderly patients (≥75 years) with advanced non-small cell lung cancer
Soichiro Minami, Tsuyoshi Doman, Yukihiro Toi, Keito Fukuzawa, Yusuke Yamazaki, Shin Saito, Akane Narumi, Tetsuo Odaka, Takahiro Ogasawara, Hisashi Shimizu, Jun Sugisaka, Kana Ono, Tomoiki Aiba, Sachiko Kawana, Shinsuke Yamanda, Yuichiro Kimura, Shunichi Sugawara
Translational Lung Cancer Research  
2025;
14
(9)
:3861-3871
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 (30 September 2025) 
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Patients’ survival outcomes in clinical stage IA lung adenocarcinoma not affected by preoperative staging brain magnetic resonance imaging
Mengwen Liu, Xin Wen, Xue Zhang, Chengyi Jiang, Xin Liang, Jiuming Jiang, Meng Li, Li Zhang, Hongmei Zhang
Translational Lung Cancer Research  
2025;
14
(9)
:3872-3885
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 (30 September 2025) 
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Multi-institutional development and validation of habitat imaging for predicting outcomes of first-line immunotherapy in advanced non-small cell lung cancer
Zhe Zhang, Zhenhua Liu, Mengqi Yang, Miaomiao Zhao, John Moraros, Xin Li, Qingzhu Jia, Yajie Liu, Haonan Xiao, Bo Zhu, Shuihua Wang, Yuhui Huang
Translational Lung Cancer Research  
2025;
14
(9)
:3886-3899
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 (30 September 2025) 
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Prognostic impact of dose to circulating blood cells in non-small cell lung cancer patients after chemoradiotherapy
Sangseok Ha, Byung-Hee Kang, Hak Jae Kim, Hong-Gyun Wu, Joo Ho Lee, Wonmo Sung
Translational Lung Cancer Research  
2025;
14
(9)
:3900-3912
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 (30 September 2025) 
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PD-L1 expression as a prognostic factor for postoperative outcomes in pleural mesothelioma
Masatoshi Kanayama, Takehiko Manabe, Katsuma Yoshimatsu, Yukiko Nemoto, Hiroki Matsumiya, Masataka Mori, Masaru Takenaka, Koji Kuroda, Fumihiro Tanaka
Translational Lung Cancer Research  
2025;
14
(9)
:3913-3923
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 (30 September 2025) 
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Long-term follow-up results from the GLORY study: phase II study of gumarontinib in East Asian patients with MET exon 14 skipping mutated non-small cell lung cancer
Shun Lu, Yongfeng Yu, Jianya Zhou, Xingya Li, Koichi Goto, Xuhong Min, Kazumi Nishino, Jiuwei Cui, Ling Wu, Jun Sakakibara, Yongqian Shu, Xiaorong Dong, Lu Li, Yasuto Yoneshima, Chengzhi Zhou, Xiaoling Li, Yiping Zhang, Dingzhi Huang, Aimin Zang, Wei Zhang, Xiuwen Wang, Li Zhang, Chong Bai, Jian Fang, Lejie Cao, Yanqiu Zhao, Yan Yu, Meiqi Shi, Diansheng Zhong, Fugen Li, Wenhao Duanmu, Yibin Wang
Translational Lung Cancer Research  
2025;
14
(9)
:3924-3938
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 (30 September 2025) 
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Prognostic biomarkers for extensive-stage small cell lung cancer receiving amrubicin following failure of chemoimmunotherapy: a retrospective cohort study
Kyoichi Kaira, Hisao Imai, Kosuke Hashimoto, Ayako Shiono, Ou Yamaguchi, Yu Miura, Atsuto Mouri, Hiroshi Kagamu
Translational Lung Cancer Research  
2025;
14
(9)
:3939-3950
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 (30 September 2025) 
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Genome-scale metabolic modeling and machine learning unravel metabolic reprogramming and mast cell role in lung cancer: a multi-level analysis
Masoud Tabibian, Tahereh Razmpour, Rajib Saha
Translational Lung Cancer Research  
2025;
14
(9)
:3951-3974
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 (30 September 2025) 
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Tumor immune microenvironment analysis in different pathologic responses to neoadjuvant immunotherapy combined with chemotherapy in non-small cell lung cancer
Zhaofeng Wang, Yunchang Meng, Fang Zhang, Ping Zhan, Tangfeng Lv, Yong Song, Hongbing Liu
Translational Lung Cancer Research  
2025;
14
(9)
:3975-3987
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 (30 September 2025) 
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TTF-1 and p40 co-expression defines a distinct subtype of non-small cell lung cancer with frequent TP53 mutations and FGFR pathway dysregulation
Marcin Braun, Julia Sołek, Grzegorz Jan Stępień, Aleksandra Izabela Masłowska, Mateusz Kamecki, Paulina Antosik, Jacek Jassem, Bartłomiej Tomasik, Radzisław Kordek
Translational Lung Cancer Research  
2025;
14
(9)
:3988-4001
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 (30 September 2025) 
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Single-cell and spatial analysis reveals macrophage-T cell crosstalk in non-small cell lung cancer immunosuppression
Pengyuan Zhu, Zhenchuan Liu, Hatim Husain, Qian Wang, Yongxin Zhou
Translational Lung Cancer Research  
2025;
14
(9)
:4002-4020
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 (30 September 2025) 
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Risk of conversion and severe postoperative complications in older patients with non-small cell lung cancer and a history of COVID-19: a population-based study
Hanbo Pan, Ye Dong, Yeqin Guo, Ling Li, Wanyu Li, Jiaqi Zhang, Haizhen Jin, Weicheng Kong, Hang Chen, Zhen Ge, Yu Tian, Junwei Ning, Zhiyuan Bao, Qiyang Qiu, Difan Zhang, Yixing Tao, Fan Shen, Weiqiu Jin, Guomo Ruan, Zongxiang Duan, Min Zheng, Liang Fang, Chengwei Zhou, Guodong Xu, Ming Zhang, Jia Huang, Hui Yin, Qingquan Luo, Hui Wang
Translational Lung Cancer Research  
2025;
14
(9)
:4021-4036
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 (30 September 2025) 
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Pre-screening value of serum albumin and the glucose-lymphocyte ratio as the “transport-activation” effectors of immune checkpoint inhibitors in small cell lung cancer
Chenxi Wang, Jinhe Xu, Ying Chen, Shuting Lu, Weiwei Xue, Feng Cheng, Yuxin Guo, Wenting Zhang, Ruiying Rao, Xinyu Zhang, Nong Zhou, Liangchong Shi, Masatsugu Hamaji, Hirokazu Taniguchi, Zongyang Yu
Translational Lung Cancer Research  
2025;
14
(9)
:4037-4050
.
 (30 September 2025) 
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Case Series

A case series of nonintubated robotic-assisted bronchoscopy: a feasible alternative to intubated techniques
Jiawei Chen, Zhongqiao Mo, Hongsheng Deng, Calvin S. H. Ng, Zeyong Zhang, Shuben Li, Jianxing He
Translational Lung Cancer Research  
2025;
14
(9)
:4051-4056
.
 (30 September 2025) 
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Study Protocol

Multimodal prehabilitation to prevent loss of cardiorespiratory fitness in patients with locally advanced lung cancer undergoing chemoimmunotherapy: protocol for a non-randomized multicentre study
Yu Xiao Chen, Raquel Sebio-Garcia, Maria Jose Arguis, Noemi Reguart, Ainara Arcocha, Alejandro Navarro, Ricard Navarro-Ripoll, Fairuz Boujibar, Silvia Muñoz-Borrajo, Marc Boada, Anna Ureña, Angela Guirao, Marina Sisó, Ana Cardeña-Gutiérrez, Raquel Pérez-García, Irene Bello, Graciela Martínez-Pallí; on behalf of the Hospital Clinic Prehabilitation Group
Translational Lung Cancer Research  
2025;
14
(9)
:4057-4067
.
 (30 September 2025) 
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Review Article

Artificial intelligence in medical education for pulmonary nodule management: a narrative review
Weixuan Pan, Shuofeng Li, Binhe Tian, Yongchang Zheng, Hanping Wang
Translational Lung Cancer Research  
2025;
14
(9)
:4068-4077
.
 (30 September 2025) 
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The evolving role of wedge resection in early-stage non-small cell lung cancer: a literature review
Ilaria Ceccarelli, Marion Durand, Agathe Seguin-Givelet
Translational Lung Cancer Research  
2025;
14
(9)
:4078-4094
.
 (30 September 2025) 
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Metabolite biomarkers in lung cancer: unlocking the potential of body fluid analysis for early detection and prognosis—a narrative review
Su Min Kim, Jiyeon Yoon, Jing Zhang, Seong Eun Lee, Bon Jeong Ku, Junyoung O. Park, Chaeuk Chung, Jun Young Heo, Yea Eun Kang, Da Hyun Kang
Translational Lung Cancer Research  
2025;
14
(9)
:4095-4111
.
 (30 September 2025) 
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Decoding the tumor immune microenvironment in lung squamous cell carcinoma: characteristics, regulatory mechanisms, and future directions in immunotherapy
Yunfeng Tong, Yuxia Wang, Yunfei Chen, Yun Fan, Hui Li
Translational Lung Cancer Research  
2025;
14
(9)
:4112-4130
.
 (30 September 2025) 
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Case Report

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) by osimertinib and continued treatment with dose reduction for postoperative recurrence of lung adenocarcinoma: a case report
Machiko Nishii, Masanori Shimomura, Satoru Okada, Tatsuo Furuya, Taiyo Kawamura, Takumi Nakagawa, Rintaro Kawanishi, Masayoshi Inoue
Translational Lung Cancer Research  
2025;
14
(9)
:4131-4136
.
 (30 September 2025) 
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First case report of immune checkpoint inhibitor-related pneumonitis triggered by bispecific antibody (anti-PD-L1 and anti-CTLA-4) in a patient with non-small cell lung cancer: case report
Haishuang Sun, Yu Liu, Zihong Chen, Wenfeng Fang, Li Zhang, Yaxiong Zhang
Translational Lung Cancer Research  
2025;
14
(9)
:4137-4142
.
 (30 September 2025) 
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Pseudoprogression of pleural effusion in lung cancer treated with immunotherapy: a case report
Hiroyasu Kaneda, Lan Wang, Takako Oka, Yoko Tani, Hiroaki Nagamine, Yoshiya Matsumoto, Akira Sugimoto, Megumi Mizutani, Tatsuo Kimura, Tomoya Kawaguchi
Translational Lung Cancer Research  
2025;
14
(9)
:4143-4148
.
 (30 September 2025) 
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Editorial Commentary

Tackling a caveat of the FLAURA trial and building solid evidence for frail patients in thoracic oncology
Timothe Guinel, Ludovic Doucet, Judith Raimbourg
Translational Lung Cancer Research  
2025;
14
(9)
:4149-4152
.
 (30 September 2025) 
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Refining maintenance strategies for metastatic nonsquamous non-small cell lung cancer: insights from the KEYLYNK-006 study
Marcel Kemper, Frank Griesinger, Annalen Bleckmann
Translational Lung Cancer Research  
2025;
14
(9)
:4153-4158
.
 (30 September 2025) 
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Early checkpoint inhibition before chemoradiation: is the strategy ready for stage III non-small cell lung cancer?
Nazmul Hasan, Jeremy P. Harris, Misako Nagasaka
Translational Lung Cancer Research  
2025;
14
(9)
:4159-4164
.
 (30 September 2025) 
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Sacituzumab govitecan: another emerging treatment option for patients with relapsed small cell lung cancer
Bingnan Zhang, Carl M. Gay
Translational Lung Cancer Research  
2025;
14
(9)
:4165-4169
.
 (30 September 2025) 
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Utility of ctDNA-molecular residual disease in predicting minimal residual disease in non-small cell lung cancer patients after radical resection
Katsuhiro Masago, Yoshitsugu Horio, Eiichi Sasaki, Shiro Fujita
Translational Lung Cancer Research  
2025;
14
(9)
:4170-4174
.
 (30 September 2025) 
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NY-ESO-1 targeting in non-small cell lung cancer: promise and challenges of letetresgene autoleucel
Federico Monaca, Igor Gómez-Randulfe, Raffaele Califano
Translational Lung Cancer Research  
2025;
14
(9)
:4175-4179
.
 (30 September 2025) 
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