Vol 14, No 11 (November 30, 2025): Translational Lung Cancer Research

Editorial Commentary

Perioperative chemo immunotherapy in non-small-cell lung cancer: what can we learn from the long-term results of NADIM?
Xavier Fremand, Ilaria Onorati, Boris Duchemann
Translational Lung Cancer Research  
2025;
14
(11)
:4704-4710
.
Letetresgene autoleucel in advanced non-small cell lung cancer: a step towards truly personalized immunotherapy?
M. Alejandra Molina-Pérez, Sergio Martínez-Recio, Andrés Barba, Mikel Portu, Judit Sanz-Beltran, Margarita Majem
Translational Lung Cancer Research  
2025;
14
(11)
:4711-4714
.
T cell receptor (TCR)-based therapy in advanced non-small cell lung cancer: a new hope?
Adrien Costantini, Etienne Giroux Leprieur
Translational Lung Cancer Research  
2025;
14
(11)
:4715-4718
.

Original Article

Defining the surgical curative time window: identifying patients with an absence of recurrence for 5 years following surgical resection of stage I invasive non-small cell lung cancer
Tong Li, Yang Zhang, Hong Hu, Ting Ye, Yihua Sun, Yawei Zhang, Jiaqing Xiang, Haiquan Chen
Translational Lung Cancer Research  
2025;
14
(11)
:4719-4732
.
Selecting optimal immunotherapy based on inflammation in stage IV PD-L1 ≥50% gene mutation-negative non-small cell lung cancer: pembrolizumab monotherapy versus combination chemoimmunotherapy
Yusuke Kunimatsu, Naoya Nishioka, Tadaaki Yamada, Hayato Kawachi, Motohiro Tamiya, Yoshiki Negi, Yasuhiro Goto, Akira Nakao, Shinsuke Shiotsu, Keiko Tanimura, Takayuki Takeda, Asuka Okada, Taishi Harada, Koji Date, Yusuke Chihara, Isao Hasegawa, Nobuyo Tamiya, Masaki Ishida, Takashi Kijima, Koichi Takayama
Translational Lung Cancer Research  
2025;
14
(11)
:4733-4745
.
Integrative modeling of longitudinal cell-free DNA and tumor volume dynamics: a multimodal quantitative prognostic framework
Jihwan Choi, Jooyong Shim, Jonghoon Kim, Yeon Jeong Kim, Changha Hwang, Woong-Yang Park, Jae Myoung Noh, Hongryull Pyo, Ho Yun Lee
Translational Lung Cancer Research  
2025;
14
(11)
:4746-4755
.
Efficacy and safety of immune checkpoint inhibitors in advanced non-small cell lung cancer with idiopathic interstitial pneumonia or interstitial lung abnormalities: NJLCG2301
Fumihiko Okumura, Hisashi Tanaka, Katsuhiro Onodera, Ryo Morita, Minehiko Inomata, Aya Suzuki, Jun Sugisaka, Hiroyuki Minemura, Daisuke Jingu, Satoshi Kudo, Hajime Kikuchi, Naruo Yoshimura, Fumiyasu Tsushima, Shingo Kakeda, Sadatomo Tasaka
Translational Lung Cancer Research  
2025;
14
(11)
:4756-4767
.
Deep structural lipidomic profiling reveals C=C positional isomers as potential biomarkers in lung adenocarcinoma tissue
Yang Gu, Ming-Ming Shao, Song-Ping Cui, Bin Hu, Xin Li
Translational Lung Cancer Research  
2025;
14
(11)
:4768-4783
.
Subtype-specific RNA sequencing using micro-dissection revealed extracellular matrix alterations as key factors in lung adenocarcinoma invasion
Chongze Yuan, Xiao Chen, Yizhou Peng, Qiang Zheng, Yunjian Pan, Xuxia Shen, Xiaoting Tao, Xingxin Yao, Hui Hong, Hongbin Ji, Yawei Zhang, Yihua Sun
Translational Lung Cancer Research  
2025;
14
(11)
:4784-4795
.
Treatment interruption during neoadjuvant immuno-chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of randomized controlled trials
Yi Liu, Zhihao Wang, Shuxiao Ma, Zhenyu Yang, Yile Li, Abuduwaili Yasheng, Zelin Deng, Zheng Liu, Chuan Li, Liang Xia, Lugang Zhou, Chengwu Liu
Translational Lung Cancer Research  
2025;
14
(11)
:4796-4810
.
Real-world first-line outcomes of alectinib and brigatinib in anaplastic lymphoma kinase-positive non-small cell lung cancer: a nationwide South Korean cohort study using the health insurance review and assessment data
Hee Jun Kim, Eunyoung Angela Lee, Jin-Hee Park, Hyun Woo Lee
Translational Lung Cancer Research  
2025;
14
(11)
:4811-4823
.
Prognostic impact of ALK rearrangement in surgically treated stage I lung adenocarcinoma: a retrospective cohort study
Yuchen Huang, Jian Zhou, Cheng Shen, Ruijia Yang, Quan Zheng, Yang Qiu, Xiaoli Mei, Kunhao Wu, Dongsheng Wu, Jinghan Wang, Wenjing Jiang, Hu Liao
Translational Lung Cancer Research  
2025;
14
(11)
:4824-4837
.
High GLUT1 protein expression is associated with unfavorable tumor features and poor prognosis in non-small cell lung cancer
Birgit Hantzsch-Kuhn, Nina Schraps, Martin Reck, Sönke von Weihe, Till Olchers, David Benjamin Ellebrecht, Katharina Moeller, Christoph Fraune, Maximilian Lennartz, Florian Lutz, Martina Kluth, Georgia Makrypidi-Fraune, Ronald Simon, Guido Sauter, Stefan Steurer
Translational Lung Cancer Research  
2025;
14
(11)
:4838-4848
.
Comparative effectiveness and safety of systemic therapies for treatment-naïve, PD-L1 expression <1% advanced NSCLC: a systematic review and network meta-analysis
Mengyun Zhou, Junfang Huang, Zhou Jin, Qingqing Hao, Xueying Li, Kunyao Yu, Kunyan Sun, Xiang Zhao, Meng Zhang, Guangfa Wang, Yuan Cheng
Translational Lung Cancer Research  
2025;
14
(11)
:4849-4867
.
Establishment and characterization of an orthotopic implanted lung cancer model to mimic human tumor structure, microenvironment, and metastatic spread
Beñat Picabea, Daniel Orive, Covadonga Rodríguez, Miren Mailharin, María Sangüesa, Maeva Houry, Andrea Arricibita, Mirari Echepare, Ane Álava, Cristina Viu-Idocin, Alfonso Calvo, Joaquín Fernández-Irigoyen, Enrique Santamaría, Mikel Ariz, Luis M. Montuenga, Karmele Valencia
Translational Lung Cancer Research  
2025;
14
(11)
:4868-4895
.
Is seeing believing?—signal differentiation in a preclinical transbronchial imaging study implementing a composite optical fiber bronchoscope to detect a folate receptor-targeted near-infrared fluorophore
Yoshihisa Hiraishi, Tsukasa Ishiwata, Theodore Husby, Yuki Sata, Alexander Gregor, Takamasa Koga, Hiroyuki Ogawa, Shinsuke Kitazawa, Fumi Yokote, Masato Aragaki, Kate Kazlovich, Andrew Effat, Nicholas Bernards, Hidenori Kage, Brian C. Wilson, Kazuhiro Yasufuku
Translational Lung Cancer Research  
2025;
14
(11)
:4896-4905
.
Whole genome characterization of patient-derived lung cancer organoids
Hoi-Hin Kwok, Nerissa Chui-Mei Lee, Junyang Deng, Jiashuang Yang, Lynn Yim-Wah Shong, Cally Ka-Lai Ho, Kwok-Fai Lee, Michael Kuan-Yew Hsin, Hongjing Zang, Joshua Jing-Xi Li, David Chi-Leung Lam
Translational Lung Cancer Research  
2025;
14
(11)
:4906-4922
.
PD-L1 expression in primary lung tumor as a superior predictive biomarker to metastatic lymph nodes for first-line immunochemotherapy in advanced KRAS-mutant non-small cell lung cancer
Hongping Jin, Yidan Zhang, Honglei Huang, Jianlin Xu, Yingqi Xu, Yiqing Wu, Tengfei Liu, Hua Zhong, Jie Chen, Qian Miao, Runbo Zhong
Translational Lung Cancer Research  
2025;
14
(11)
:4923-4941
.
Stage- and smoking-associated microRNA expression in lung adenocarcinoma
Min Huang, Yimin Ge, Huiqin Chen, Caimiao Wei, David Cogdell, Cristina Ivan, Meng Chen, Wei Zhang, George A. Calin, Ming Guo
Translational Lung Cancer Research  
2025;
14
(11)
:4942-4961
.
Association of PD-L1 expression with systemic immune parameters in non-small cell lung cancer
Mary E. Gwin, Mitchell S. von Itzstein, Jialiang Liu, Farjana J. Fattah, Hong Mu-Mosley, Jeffrey A. SoRelle, Sheena Bhalla, Jonathan E. Dowell, Sawsan Rashdan, Jason Y. Park, Donghan M. Yang, Yang Xie, David E. Gerber
Translational Lung Cancer Research  
2025;
14
(11)
:4962-4972
.
Unveiling the clinical impact of plasma-only mutations in non-small cell lung cancer: a Korean multicenter experience
Ji Won Lee, Yoon Ji Choi, Jung Sun Kim, Eun Joo Kang, Mi Sun Ahn, Yu Jung Kim, Seong Yoon Yi, Seungtaek Lim, Ji Yoon Lee, Ju Won Kim, Sang Won Shin, Yeul Hong Kim
Translational Lung Cancer Research  
2025;
14
(11)
:4973-4982
.
A public data-based molecular classification of small cell lung cancer by neuroactive signaling networks unveils distinct microenvironment landscapes and immunotherapy-related prognostic biomarkers
Wensheng Zhou, Yujie Tang, Jiyuan Zeng, Xiaoyi Zhang, Haotian Meng, Wenhui Guan, Yue Zhu, Huixin Jiang, Yansheng Wang, Xiaohong Xie, Chengzhi Zhou, Ming Liu
Translational Lung Cancer Research  
2025;
14
(11)
:4983-4999
.
Immune checkpoint inhibitors have limited efficacy in SMARCA4-deficient non-small cell lung cancer
Ying Han, Jing Wang, Boyue Pang, Jiali Zhang, Xiaoliang Zhao, Shuan Hao, Qiang Zhang, Xiubao Ren, Leina Sun
Translational Lung Cancer Research  
2025;
14
(11)
:5000-5016
.
Comparison of efficacy and surgery-related safety of perioperative tislelizumab and pembrolizumab with neoadjuvant chemotherapy for resectable non-small cell lung cancer: a retrospective cohort study
Yizhang Li, Jialing Jiang, Xin Yao, Zhaoyang Wang, Changjian Shao, Jian Wang, Jie Lei, Jinbo Zhao, Masaya Aoki, Hiroyuki Adachi, Yunfeng Ni, Yong Liu, Hongtao Duan, Xiaolong Yan
Translational Lung Cancer Research  
2025;
14
(11)
:5017-5030
.
c-MET expression and immune landscape in locally advanced patients with non-small cell lung cancer undergoing radiochemotherapy and consolidative immunotherapy
Lisha Ye, Xiaoling Xu, Ying Zhang, Wei Zhang, Leilei Wu, Chunyan Wu, Yaoyao Zhu, Yaping Xu
Translational Lung Cancer Research  
2025;
14
(11)
:5031-5043
.
Alectinib versus crizotinib as the first-line treatment in patients with advanced ALK-positive non-small cell lung cancer: a Chinese real-world cohort study
Haoran Zhang, Zhaozhen Wu, Tao Lu, Hui Zhang, Ji Li, Dongming Zhang, Siyuan Yu, Xiaobei Guo, Xiaoyi Feng, Jia Liu, Yuequan Shi, Xiaoxing Gao, Xiaoyan Liu, Minjiang Chen, Jing Zhao, Wei Zhong, Ying Hu, Yan Xu, Mengzhao Wang
Translational Lung Cancer Research  
2025;
14
(11)
:5044-5058
.
Development and validation of a multivariable prognostic model incorporating black-blood magnetic resonance imaging-based meningeal lymphatic remodeling to predict therapy response in non-small cell lung cancer brain metastases
Wei Shao, Zongbo Li, Feng Qiu, Hengsen Zhang, Shudong Hu, Yifan Liu, Duoduo Li, Yuxi Ge, Hua Lu
Translational Lung Cancer Research  
2025;
14
(11)
:5059-5073
.

Brief Report

Circulating stem-like exhausted CD8 T cells point to better outcomes in lung cancer: a brief report
Linda Ye, Ian Dick, Tina Firth, Bruce W. Robinson, Jenette Creaney, Alec Redwood
Translational Lung Cancer Research  
2025;
14
(11)
:5074-5081
.

Review Article

Redefining treatment interval in lung cancer surgery in the era of prehabilitation: a systematic review
Lisa D. Geomini, Quirine C. A. van Steenwijk, Shiromani Janki, Iris Hoogendoorn, Gerrit D. Slooter, Frank J. C. van den Broek, Geertruid M. H. Marres
Translational Lung Cancer Research  
2025;
14
(11)
:5082-5098
.
Exosomal biomarkers and therapeutics in lung cancer: a narrative review on their role in early detection and targeted treatment
Jorge Rodríguez-Sanz, Elisa Mincholé Lapuente, Dinora Polanco Alonso, Manuel David Viñuales Aranda, Marta Marín-Oto, Juan Antonio Domingo Morera, José María Marín Trigo, David Sanz-Rubio
Translational Lung Cancer Research  
2025;
14
(11)
:5099-5117
.
A narrative review of pathologic response in non-small cell lung cancer: challenges, implications, and future directions
Yuan Li, Fei Liang, Suijun Xiao, Chao Yuan, Haiquan Chen
Translational Lung Cancer Research  
2025;
14
(11)
:5118-5136
.
The pathogenesis and therapeutic management of rare pulmonary sarcomatoid carcinoma: a narrative review
Qianyi Wang, Haoyue Guo, Yuanyuan Wang, Taiping He, Meng Diao, Yuhan Wu, Anwen Xiong, Fei Zhou, Wei Li, Lei Cheng, Chao Zhao, Xuefei Li, Caicun Zhou
Translational Lung Cancer Research  
2025;
14
(11)
:5137-5158
.
Robotic-assisted and electromagnetic navigation bronchoscopy for multi-focal lung cancers: a narrative review
Wei Liu, Aliss T. C. Chang, Joyce W. Y. Chan, Rainbow W. H. Lau, Tony S. K. Mok, Calvin S. H. Ng
Translational Lung Cancer Research  
2025;
14
(11)
:5159-5180
.
Decoding the enigma of multiple primary lung cancers: from mechanism to bedside—a narrative review
Pan Yang, Siyu Liu, Yuansi Chen, Yihan Guo, Yi Li, Zhen Wang, Weimin Li, Zhoufeng Wang
Translational Lung Cancer Research  
2025;
14
(11)
:5181-5197
.

Letter to the Editor

A new hope for aggressive thoracic cancers: foundational efficacy of frontline immunotherapy in SMARCA4-deficient tumors
Qiang Wu, Li Wang, Hao Su, Ting Lei
Translational Lung Cancer Research  
2025;
14
(11)
:5198-5199
.
Retrospective evaluation of anti-angiogenic and immune checkpoint inhibitor combination therapy in SMARCA4-deficient thoracic tumors: efficacy, safety, and biomarker considerations
Beibei Liu, Danni Wang, Yujing Li, Fangfei Qian, Yanwei Zhang, Lele Zhang, Xinwei Wu, Xuemei Liu, Wenyan Ma, Wei Zhang, Lvkan Weng, Yuqing Lou, Rong Li
Translational Lung Cancer Research  
2025;
14
(11)
:5200-5202
.