Vol 14, No 6 (June 30, 2025): Translational Lung Cancer Research

Editorial

Redefining the role of surgery in advanced lung cancer: a new paradigm of adjuvant lung surgery to systemic therapy
Ran Zhong, Junguo Dong, Hengrui Liang, Jianxing He
Translational Lung Cancer Research  
2025;
14
(6)
:1892-1895
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 (30 June 2025) 
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Original Article

Cytokine-driven modulation of WT1 and IL-10 in lung cancer progression
Juan Manuel Izaguirre-Alvarez, Pablo Zapata-Benavides, Mariela Arellano-Rodríguez, Norma Cesilia Arellano-Rodríguez, Felipe-de-Jesús Torres-Del-Muro, Moisés Armides Franco-Molina, María Cristina Rodríguez-Padilla
Translational Lung Cancer Research  
2025;
14
(6)
:1896-1913
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 (30 June 2025) 
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Impact of KRAS mutation subtypes on morphological heterogeneity and immune landscape in surgically treated lung adenocarcinoma
Klara Torok, Bence Ferencz, Kristiina Boettiger, Maria Dorothea Pozonec, Orsolya Pipek, Julianna Bogos, Andras Lantos, Zita Hegedus, Karin Schelch, Peter Radeczky, Krisztina Bogos, Vivien Teglas, Evelyn Megyesfalvi, Anita Ferenczy, Ferenc Renyi-Vamos, Clemens Aigner, Zsolt Megyesfalvi, Balazs Dome, Janos Fillinger
Translational Lung Cancer Research  
2025;
14
(6)
:1914-1928
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 (30 June 2025) 
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Development and validation of growth prediction models for multiple pulmonary ground-glass nodules based on CT features, radiomics, and deep learning
Shulei Cui, Linlin Qi, Weixiong Tan, Yujian Wang, Fenglan Li, Jianing Liu, Jiaqi Chen, Sainan Cheng, Zhen Zhou, Jianwei Wang
Translational Lung Cancer Research  
2025;
14
(6)
:1929-1944
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 (30 June 2025) 
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Monitoring pembrolizumab response in patients with metastatic non-small cell lung cancer using circulating tumour DNA and circulating tumour cells
Andrea C. Kakouri, Maria Spiliotaki, Eleni M. Loizidou, Ioannis Stylianou, Elisavet Papageorgiou, Christina G. Panayi, Andreas I. Constantinou, Haris Charalambous, Constantinos Deltas, Gregory Papagregoriou
Translational Lung Cancer Research  
2025;
14
(6)
:1945-1960
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 (30 June 2025) 
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Evaluation of gut leakage and bacterial translocation as efficacy biomarkers of immunotherapy in advanced non-small cell lung cancer (NSCLC)
Pierre Magdelaine, Adrien Costantini, Paul Takam Kamga, Christy Gaella Kotokpo Youkou, Jennifer Arrondeau, Marie Wislez, Jean-François Emile, Etienne Giroux-Leprieur
Translational Lung Cancer Research  
2025;
14
(6)
:1961-1971
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 (30 June 2025) 
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Predictors of survival and recurrence patterns following definitive chemoradiotherapy in stage III non-small cell lung cancer—a retrospective cohort study
Erika Broström, Johan Isaksson, Panagiotis Xanthoulis, Rebecka Börjesson, Linda Willén, Tomas Hansen, Georg Holgersson, Simon Ekman, Johan Botling, Kristina Lamberg Lundström, Patrick Micke, Magnus Lindskog
Translational Lung Cancer Research  
2025;
14
(6)
:1972-1985
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 (30 June 2025) 
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Utility of serum CYFRA 21-1 as a prognostic biomarker in ALK-positive non-small cell lung cancer treated with ALK-TKIs: a retrospective cohort study
Ryo Sawada, Tadaaki Yamada, Yasuhiro Goto, Yoshiki Negi, Akira Nakao, Akihiro Yoshimura, Naoki Furuya, Tomohiro Oba, Makoto Hibino, Haruka Nakatani, Hirokazu Taniguchi, Aya Ohtsubo, Satoshi Watanabe, Takahiro Yamada, Yusuke Chihara, Takashi Kijima, Koichi Takayama
Translational Lung Cancer Research  
2025;
14
(6)
:1986-2000
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 (30 June 2025) 
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Impact of mutant protein expression on clinical outcomes in patients with EGFR L858R-mutated non-small cell lung cancer
Ryota Nakamura, Tadaaki Yamada, Kenji Morimoto, Akihiro Yoshimura, Shinsuke Shiotsu, Nozomu Motono, Hidetaka Uramoto, Tatsuya Imabayashi, Yoshizumi Takemura, Yuki Katayama, Naoya Nishioka, Masahiro Iwasaku, Shinsaku Tokuda, Satoru Okada, Masanori Shimomura, Masayoshi Inoue, Noriyuki Tanaka, Aya Miyagawa-Hayashino, Koichi Takayama
Translational Lung Cancer Research  
2025;
14
(6)
:2001-2010
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 (30 June 2025) 
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An explainable AI approach to surgical and radiotherapy interventions for optimized treatment decision-making in early-stage non-small cell lung cancer
Qunzhe Ding, Chendong Wang, Zhe Zhang, Junjie Liao, Lufan Tang, Jiade Jay Lu, Zhibo Tan
Translational Lung Cancer Research  
2025;
14
(6)
:2011-2030
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 (30 June 2025) 
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A retrospective real-world single-arm study evaluating the efficacy and safety of neoadjuvant chemotherapy in patients with selected limited-stage small-cell lung cancer
Wengang Zhang, Yujie Li, Jing Nie, Wencheng Zhao, Zhiyi Guo, Shunjia Li, Qianqian Zhang, Bing Bo, Xuyang Chen, Li Ye, Zhimin Chen, Hao Wang, Kandi Xu, Lishu Zhao, Xinyue Liu, Yujin Liu, Yuhang Li, Lihua Huang, Yayi He
Translational Lung Cancer Research  
2025;
14
(6)
:2031-2046
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 (30 June 2025) 
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Assessing the clinical impact of severe lung cancer on non-small cell lung cancer: a single-center retrospective study
Huixin Jiang, Ling Yi, Du Feng, Hao Deng, Qiexinhao Li, Wenhui Guan, Yue Zhu, Yijia Li, Bin He, Gengda Huang, Ying Wu, Xinqing Lin, Chengzhi Zhou
Translational Lung Cancer Research  
2025;
14
(6)
:2047-2061
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 (30 June 2025) 
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Response of non-small cell lung cancer harboring different epidermal growth factor receptor mutations to ablative radiotherapy
Areej Al Rabea, Ian J. Gerard, Paul Daniel, Sophie Camilleri-Broët, Ayman Oweida, Siham Sabri, Bassam Abdulkarim
Translational Lung Cancer Research  
2025;
14
(6)
:2062-2073
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 (30 June 2025) 
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The effect of durvalumab consolidation after definitive radiochemotherapy for non-operable stage III non-small cell lung cancer on the dose effect relation for therapy related pulmonary infiltrates as a risk factor for pneumonitis
Andreas Herz, Maja Guberina, Christoph Pöttgen, Thomas Gauler, That Truong Mike Ton, Gerrit Fischedick, Lars Oliver Kiwitt, Wolfgang Lübcke, Christian Hoffmann, Martin Schuler, Martin Metzenmacher, Benedikt M. Schaarschmidt, Denise Bos, Marcel Opitz, Hubertus Hautzel, Kaid Darwiche, Servet Bölükbas, Konstantinos Grapatsas, Verena Jendrossek, Lena Gockeln, Florian Wirsdörfer, Mario Hetzel, Emil Mladenov, Martin Stuschke, Nika Guberina
Translational Lung Cancer Research  
2025;
14
(6)
:2074-2088
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 (30 June 2025) 
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Radiographic ground-glass nodules predict less aggressive features and favorable immune landscapes in early lung adenocarcinoma and its precursors
Runzhe Chen, Mingdian Wang, Qi Quan, Dijian Shen, Qiong Li, Xiujiao Shen, Xuan Li, Ming Chen
Translational Lung Cancer Research  
2025;
14
(6)
:2089-2099
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 (30 June 2025) 
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Utility of CK8/18 in identifying circulating tumor cells derived from lesions in patients with non-small cell lung cancer
Tetsuya Sakai, Mami Onishi, Yoshitaka Zenke, Eri Morita Yamamoto, Yuichi Ijiri, Kana Kawasaki, Fumie Kato, Tomoko Sugano, Bishnu Devi Maharjan, Ali Asgar S. Bhagat, Tomokazu Yoshida, Shigeki Iwanaga, Masatoshi Yanagida, Koichi Goto
Translational Lung Cancer Research  
2025;
14
(6)
:2100-2112
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 (30 June 2025) 
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Serum levels of C-terminal peptides of alpha-1 antitrypsin as potential biomarkers in non-small cell lung cancer
Marc A. Schneider, Friedemann R. Boerner, Michael Kiehntopf, Thomas Muley, Sabina Janciauskiene
Translational Lung Cancer Research  
2025;
14
(6)
:2113-2124
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 (30 June 2025) 
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Identification of prognostic-related tumor microenvironment genes in lung adenocarcinoma and establishment of a prognostic prediction model
Xisheng Fang, Shaopeng Zheng, Zekui Fang, Xiping Wu, Erin L. Schenk, Lorenzo Belluomini, Huizhen Fan
Translational Lung Cancer Research  
2025;
14
(6)
:2125-2144
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 (30 June 2025) 
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Enhancing the intraoperative identification of high-grade patterns in invasive lung adenocarcinoma via radiomics
Yuanxin Sun, Hao Dong, Weiqiu Jin, Haoxiang Xuan, Zheng Yuan, Lukas Käsmann, Leilei Shen, Tingting Wang, Xiaodan Ye, Mengsu Zeng
Translational Lung Cancer Research  
2025;
14
(6)
:2145-2158
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 (30 June 2025) 
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Development of a 3D-3 co-culture microbead consisting of cancer-associated fibroblasts and human umbilical vein endothelial cells for the anti-tumor drug assessment of lung cancer
Shuisheng Chen, Wei Chen, Ziyun Guan, Luwen Lei, Yiyan Lei, Kejing Tang, Xiao Chen, Robert Hsu, Yong Dong, Yubo Tang
Translational Lung Cancer Research  
2025;
14
(6)
:2159-2179
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 (30 June 2025) 
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Natural course of lung adenocarcinoma manifesting as ground-glass nodules: invasiveness assessment based on growth evaluation
Yuanhui Wei, Zhen Yang, Zirui Wang, Jiabo Ren, Yue Yin, Shangshu Liu, Xiaoyan Su, Sara Ricciardi, Takehiro Izumo, Wei Zhao, Liang-An Chen
Translational Lung Cancer Research  
2025;
14
(6)
:2180-2196
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 (30 June 2025) 
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Efficacy of immunotherapy in advanced ALK-rearranged non-small cell lung cancer patients with disease progression on ALK-TKIs
Danni Wang, Yujing Li, Beibei Liu, Yuqing Lou, Lele Zhang, Yueran Sun, Fangfei Qian, Jun Lu, Fusheng Li, Edyta M. Urbanska, Diego Kauffmann-Guerrero, Xinwei Wu, Baohui Han, Yanwei Zhang, Wei Zhang
Translational Lung Cancer Research  
2025;
14
(6)
:2197-2209
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 (30 June 2025) 
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Endoplasmic reticulum stress-related genes contribute to lung cancer risk: a multiomics data integration study
Zhaoxun Li, Suqin Wang, Zhen Yang, Fujun Yang, Jiayan Tan, Yaqin Wei, Esteban C. Gabazza, Mariacarmela Santarpia, Yimu Wu, Gening Jiang, Ya Li
Translational Lung Cancer Research  
2025;
14
(6)
:2210-2226
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 (30 June 2025) 
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Surgical treatment of small-cell lung cancer: long-term prognosis and patterns of adjuvant therapy
Ruichen Cui, Xiaohu Hao, Jiahan Cheng, Jacobo Rogado, Qiang Pu, Yunke Zhu
Translational Lung Cancer Research  
2025;
14
(6)
:2227-2238
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 (30 June 2025) 
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Fructose-diphosphate aldolase C as a novel diagnostic biomarker for early-stage non-small cell lung cancer: a low-abundance proteomics study
Changsen Bai, Qianhui Hao, Yunxiang Chen, Jiayi Wang, Jiawei Xiao, Da Hyun Kang, Li Ren
Translational Lung Cancer Research  
2025;
14
(6)
:2239-2256
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 (30 June 2025) 
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Review Article

Towards the development of next-generation lung cancer immunotherapy
Yoshinobu Ichiki, Nako Saito, Ryo Taguchi, Tetsuya Umesaki, Hiroyuki Nitanda, Hirozo Sakaguchi, Hironori Ishida, Tomonori Kawasaki, Hisao Imai, Kyoichi Kaira, Hiroshi Kagamu
Translational Lung Cancer Research  
2025;
14
(6)
:2257-2271
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 (30 June 2025) 
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Research progress on lung cancer complicated with pulmonary tuberculosis: a narrative review
Ze-Jun Zhou, Hai-Yan Xie, Luca Bertolaccini, Ning Xia, Yu Zhang
Translational Lung Cancer Research  
2025;
14
(6)
:2272-2280
.
 (30 June 2025) 
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Traditional Chinese medicine in the prevention and treatment of lung cancer metastasis by regulating tumor-associated macrophages: a narrative review
Xinyi Tu, Baozhen An, Haolong Qi, Na Zhang, Yanqiu Liu
Translational Lung Cancer Research  
2025;
14
(6)
:2281-2295
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 (30 June 2025) 
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Comorbidity of lung cancer and chronic obstructive pulmonary disease: correlation and optimization of treatment strategies
Huixin Jiang, Gengda Huang, Du Feng, Till Plönes, Robert P. Young, Ramin Salehi-Rad, Qibo Liu, Ying Meng, Chengzhi Zhou
Translational Lung Cancer Research  
2025;
14
(6)
:2296-2308
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 (30 June 2025) 
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Brief Report

Safety and efficacy of thermal ablation for small cell lung cancer liver metastases
Shunn Theingi, Ashara Mitchell, Elena N. Petre, Etay Ziv, Constantinos T. Sofocleous, Stephen B. Solomon, Erica S. Alexander
Translational Lung Cancer Research  
2025;
14
(6)
:2309-2316
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 (30 June 2025) 
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Case Report

Needle tract seeding after endobronchial ultrasound-guided intranodal forceps biopsy and cryobiopsy: a case report
Kohei Yamamoto, Tatsuya Imabayashi, Yukari Kano, Toshiyuki Tanaka, Kazuki Jinno, Shunya Tanaka, Sayaka Uda, Tatsuya Yuba, Chieko Takumi
Translational Lung Cancer Research  
2025;
14
(6)
:2317-2323
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 (30 June 2025) 
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Liquid biopsy perspectives in pleomorphic carcinoma of the lung: case report
Tania Rossi, Michela Cortesi, Michele Zanoni, Sara Bandini, Camilla Sbrighi, Davide Angeli, Valentina Masciale, Giulia Grisendi, Matteo Costantini, Franco Stella, Paola Ulivi, Beatrice Aramini
Translational Lung Cancer Research  
2025;
14
(6)
:2324-2336
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 (30 June 2025) 
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Good responses to first-line immunotherapy-included treatment in lung squamous carcinoma with rare driver gene mutations: a report of three cases
Li Tu, Yanyang Liu, Xiaoming Qiu, Jiewei Liu
Translational Lung Cancer Research  
2025;
14
(6)
:2337-2346
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 (30 June 2025) 
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Editorial Commentary

Paving the way for ctDNA-guided trials in lung cancer: insights from the LIBELULE study
Jose Carlos Benitez, Antonio Rueda-Domínguez
Translational Lung Cancer Research  
2025;
14
(6)
:2347-2352
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 (30 June 2025) 
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Long-term efficacy and improved overall survival of lorlatinib in anaplastic lymphoma kinase-rearranged lung cancer: is cure a dream or a reality?
Yoshitsugu Horio, Hiroaki Kuroda, Eiichi Sasaki, Katsuhiro Masago
Translational Lung Cancer Research  
2025;
14
(6)
:2353-2358
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 (30 June 2025) 
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