Vol 14, No 7 (July 31, 2025): Translational Lung Cancer Research

Editorial Commentary

Navigating treatment sequencing in ALK-positive non-small cell lung cancer: lorlatinib as a key to prolonged survival?
Maiken Parm Ulhøi, Peter Meldgaard
Translational Lung Cancer Research  
2025;
14
(7)
:2359-2363
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 (31 July 2025) 
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Lorlatinib in ALK-positive non-small cell lung cancer: final survival data that reshape the therapeutic landscape
Yuki Katayama
Translational Lung Cancer Research  
2025;
14
(7)
:2364-2368
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 (31 July 2025) 
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A new reality of molecular surveillance for resected lung cancer
Shuo Shi, Petros Christopoulos
Translational Lung Cancer Research  
2025;
14
(7)
:2369-2373
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 (31 July 2025) 
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KRAS and STK11 co-mutations in resectable non-small cell lung cancer: enduring prognostic value and impaired immunotherapy response
Luisana Sisca, Priscilla Cascetta, Ayesha Aijaz, Chiara Catania, Francesco Facchinetti, Abdul Rafeh Naqash, Biagio Ricciuti, Alessio Cortellini
Translational Lung Cancer Research  
2025;
14
(7)
:2374-2382
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 (31 July 2025) 
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The role of perioperative chemoimmunotherapy in resectable non-small cell lung cancer: insights from the NADIM trial
Amira de Koning, Ilias Houda, Ezgi B. Ulas, Idris Bahce
Translational Lung Cancer Research  
2025;
14
(7)
:2383-2386
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 (31 July 2025) 
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Expert Consensus

Expert recommendations for biomarker evaluation of advanced non-small cell lung cancer in Thailand
Shanop Shuangshoti, Naiyarat Prasongsook, Lucksamon Thamlikitkul, Thanyanan Reungwetwattana, Naravat Poungvarin, Artit Jinawath, Chinachote Teerapakpinyo, Songkhun Vinyuvat, Virote Sriuranpong
Translational Lung Cancer Research  
2025;
14
(7)
:2387-2402
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 (31 July 2025) 
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Surgical consensus for screening, diagnosis, staging, multimodal management and surveillance of early-stage resectable non-small cell lung cancer (NSCLC) in Malaysia
Anand Sachithanandan, Adli Azam Mohammad Razi, Sivakumar Krishnasamy, Kok Meng John Chan, Hong Yoong Lam, Nguk Chai Diong, Narasimman Sathiamurthy, Adrian Seng Wae Ooi, Sing Yang Soon
Translational Lung Cancer Research  
2025;
14
(7)
:2403-2426
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 (31 July 2025) 
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Original Article

Upfront osimertinib and as sequential therapy in patients with EGFR-mutant non-small cell lung cancer (NSCLC): benefit across patients groups in a real-world retrospective cohort—the smile study
Edouard Auclin, Pauline Du Rusquec, Victor Albarran-Artahona, Frank Aboubakar, Helena Gerber, Nicolas Epaillard, Gonzalo Recondo, Andrea De Giglio, Hugo Berthou, Juan Carlos Laguna, Teresa Gorria, Juan Bautista Blaquier, Beatriz Jimenez-Munarriz, Marco Tagliamento, Alessandro Di Federico, Gianluca Sacco, José Minatta, Nicolas Girard, Teresa Moran-Bueno, Rafael Lopez-Castro, Benjamin Besse, Laura Mezquita
Translational Lung Cancer Research  
2025;
14
(7)
:2427-2436
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 (31 July 2025) 
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Association of cholesterol and triglyceride levels with the recurrence of early-stage lung adenocarcinoma with micropapillary pattern
Si Liang, Qinglin Wang, Zi Wang, Xuming Song, Gaochao Dong, Qixing Mao, Feng Jiang
Translational Lung Cancer Research  
2025;
14
(7)
:2437-2451
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 (31 July 2025) 
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Risk factors behind the global lung cancer burden: a pan-database exploration
Wenhan Cao, Zhixuan You, Zihui Wang, Zhiman Liang, Haiyang Li, Zhenglin Chang, Youpeng Chen, Guanghui Dong, Zhangkai Jason Cheng, Baoqing Sun
Translational Lung Cancer Research  
2025;
14
(7)
:2452-2469
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 (31 July 2025) 
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Prognostic models for large cell neuroendocrine lung carcinoma: a machine learning and regression approach
Xian Gong, Maojie Pan, Yuxing Lin, Xiaoxuan Ye, Jiekun Qian, Guoliang Liao, Jianting Du, Bin Zheng, Chun Chen, Zhang Yang
Translational Lung Cancer Research  
2025;
14
(7)
:2470-2482
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 (31 July 2025) 
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Efficacy and safety of first-generation epidermal growth factor receptor tyrosine kinase inhibitors in retreatment of patients without T790M
Juwhan Choi, Jae Cheol Lee, In Ae Kim, Kye Young Lee, Jeong Eun Lee, Seung Hun Jang, Seong Hoon Yoon, In-Jae Oh, Sang Hoon Lee, Eun Young Kim, Sung Yong Lee
Translational Lung Cancer Research  
2025;
14
(7)
:2483-2493
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 (31 July 2025) 
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Prognostic impact of negative TTF-1 biomarker in metastatic lung adenocarcinoma treated with chemo-immunotherapy: a retrospective cohort study
Luis Posado-Domínguez, Alejandro Olivares-Hernández, Daniel Morchón-Araujo, Luis Figuero-Perez, Lorena Bellido-Hernández, Laura Corvo-Felix, Jonnathan Roldan-Ruiz, Iñigo San Miguel, Emilio Fonseca-Sanchez, Edel Del Barco-Morillo
Translational Lung Cancer Research  
2025;
14
(7)
:2494-2508
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 (31 July 2025) 
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Synergistic anti-tumor effect of fenbendazole and diisopropylamine dichloroacetate in immunodeficient BALB/c nude mice transplanted with A549 lung cancer cells
Thai Q. Nguyen, Uyen T. T. Phan, Mao V. Can, Dang H. Nguyen, Bo Han, Ba X. Hoang
Translational Lung Cancer Research  
2025;
14
(7)
:2509-2521
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 (31 July 2025) 
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MiR-200a regulates PD-L1 and predicts response to immune checkpoint inhibitors in advanced non-small cell lung cancer
Ayami Kaneko, Nobuaki Kobayashi, Sousuke Kubo, Satoshi Nagaoka, Suguru Muraoka, Nobuhiko Fukuda, Kohei Somekawa, Hiromi Matsumoto, Seigo Katakura, Shuhei Teranishi, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Makoto Kudo, Takeshi Kaneko
Translational Lung Cancer Research  
2025;
14
(7)
:2522-2536
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 (31 July 2025) 
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Prognostic impacts of skip metastasis in N2a and N2b subgroups of non-small cell lung cancer: insights from a large cohort
Shenhua Liang, Yitao Yang, Jiayuan Tian, Xingyu Luo, Zhesheng Wen, Guowei Ma
Translational Lung Cancer Research  
2025;
14
(7)
:2537-2559
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 (31 July 2025) 
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International cost-effectiveness analysis of nivolumab plus ipilimumab-based for metastatic non-small cell lung cancer with PD-L1 lower than 1%
Wolong Zhou, Shuishi Li, Yanwu Zhou
Translational Lung Cancer Research  
2025;
14
(7)
:2560-2570
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 (31 July 2025) 
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Prognostic implications of MDM2 expression in surgically resected epidermal growth factor receptor mutant lung cancer with pathological lymph node metastasis
Tetsuya Isaka, Yohei Miyagi, Rika Kasajima, Kota Washimi, Shuji Murakami, Haruhiro Saito, Yui Sueishi, Naoko Shigeta, Ikki Takada, Ryotaro Matsuyama, Chiaki Kanno, Takuya Nagashima, Hiroyuki Ito
Translational Lung Cancer Research  
2025;
14
(7)
:2571-2583
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 (31 July 2025) 
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Radiomics-clinical integration guides prophylactic cranial irradiation decisions in limited-stage small cell lung cancer: a brain metastasis risk stratification model
Yuntao Zhou, Li Xiao, Siyi Yang, Chengwen Yang, Jifeng Sun, Jiehan Wu, Zhiyong Cui, Lujun Zhao, Yunchuan Sun, Ningbo Liu
Translational Lung Cancer Research  
2025;
14
(7)
:2584-2597
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 (31 July 2025) 
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Survival outcomes and risk factors after lung transplantation in patients with pre-transplant malignancy: a national cohort study
Xiaoqing Lan, Caikang Luo, Junjie He, Yining Pan, Fei Huang, Wei He, Jiaqin Zhang, Yanwei Lin, Zhiwei Wang, Chao Yang, Guilin Peng, Jiang Shi, Xin Xu
Translational Lung Cancer Research  
2025;
14
(7)
:2598-2610
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 (31 July 2025) 
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Pleural mesothelioma patients and ex-exposed asbestos workers are immunologically poor responders to oncogenic Merkel cell polyomavirus
Chiara Mazziotta, Carmen Lanzillotti, Christian Felice Cervellera, Giada Badiale, Roberta Libener, Antonio Maconi, Elisabetta Casalone, Alessandra Allione, Giuseppe Matullo, Manlio Mencoboni, Ilaria Bononi, Fernanda Martini, John Charles Rotondo, Mauro Tognon
Translational Lung Cancer Research  
2025;
14
(7)
:2611-2625
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 (31 July 2025) 
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Minimally invasive vs. open chest wall resection in non-small cell lung cancer: a systematic review and meta-analysis
Paula Duarte D’Ambrosio, Rachid Eduardo Noleto da Nobrega Oliveira, Marcelo Albuquerque Barbosa Martins, Isabella Cabianca Moriguchi Caetano Salvador, Luiza Gonzalez de Andrade, Ricardo Mingarini Terra, Paulo Manuel Pêgo-Fernandes, José Ribas Milanez Campos
Translational Lung Cancer Research  
2025;
14
(7)
:2626-2635
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 (31 July 2025) 
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Real-world efficacy of immune checkpoint inhibitors in PD-L1 negative non-small cell lung cancer: a multicenter retrospective study
Suguru Muraoka, Nobuaki Kobayashi, Ayami Kaneko, Kohei Somekawa, Yukihito Kajita, Tomofumi Hirose, Anna Tanaka, Shuhei Teranishi, Kenji Miura, Kentaro Yumoto, Toshinori Tsukahara, Nobuhiko Fukuda, Ryuichi Nishihira, Nobuyuki Horita, Yu Hara, Makoto Kudo, Naoki Miyazawa, Takeshi Kaneko
Translational Lung Cancer Research  
2025;
14
(7)
:2636-2645
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 (31 July 2025) 
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Single-cell and spatial transcriptomics profile the interaction of SPP1+ macrophages and FAP+ fibroblasts in non-small cell lung cancer
Minqin Xiao, Yiqi Deng, Hang Guo, Zhixiang Ren, Yajiao He, Xia Ren, Li-Bin Huang, Wei-Han Zhang, Hai-Ning Chen, Yang Shu, Fanxin Zeng, Yan Zhang, Heng Xu, Lanlan Wang
Translational Lung Cancer Research  
2025;
14
(7)
:2646-2669
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 (31 July 2025) 
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An online explainable ensemble machine learning model for predicting epidermal growth factor receptor mutation status in lung adenocarcinoma
Qilong Song, Xiaohu Li, Biao Song, Tingting Zhang, Xiankuo Hu, Ao Li, Dongchun Ma, Xuhong Min, Yongqiang Yu
Translational Lung Cancer Research  
2025;
14
(7)
:2670-2687
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 (31 July 2025) 
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Assessing the prognosis of metastatic or recurrent non-small cell lung cancer in the era of modern systemic therapies: a multivariable analysis of 343 patients treated in Poland
Rafal Suwinski, Marzena Kysiak, Bożena Cybulska-Stopa, Monika Giglok, Iwona Dębosz-Suwinska, Adam Idasiak, Seweryn Gałecki, Agata Wilk, Andrzej Świerniak
Translational Lung Cancer Research  
2025;
14
(7)
:2688-2699
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 (31 July 2025) 
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Comparative efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) monotherapy versus combined EGFR-TKI and chemotherapy in resectable EGFR-mutant non-small cell lung cancer: a real-world multicenter retrospective study
Mengying Fan, Zerui Zhao, Wanpu Yan, Hao Fu, Shijie Huang, Minglei Zhuo, Rong Yu, Xin Yang, Liping Qi, Zhen Liang, Hongchao Xiong, Jinbiao Xie, Hao Long, Ke-Neng Chen
Translational Lung Cancer Research  
2025;
14
(7)
:2700-2709
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 (31 July 2025) 
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A preliminary analysis of integrating thymosin α1 into concurrent chemoradiotherapy and consolidative immunotherapy in unresectable locally advanced non-small cell lung cancer
Hao-Ting Zhang, Fang-Jie Liu, Da-Quan Wang, Yi-Xin Xiong, Yuan-Yuan Zhao, Wen-Zhuo He, Peng-Xin Zhang, Shi-Yang Zheng, Biao Xia, Yu Situ, Meng-Ru Wang, Qian-Wen Liu, Yi Hu, Liang-Ping Xia, Bo Qiu, Hui Liu
Translational Lung Cancer Research  
2025;
14
(7)
:2710-2722
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 (31 July 2025) 
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Incidence and risk factors of pneumonitis in ALK-rearranged non-small cell lung cancer patients treated with alectinib and thoracic radiotherapy
Yiyue Xu, Wenting Qie, Xiao Zhong, Butuo Li, Linlin Yang, Bing Zou, Linlin Wang, Jinming Yu
Translational Lung Cancer Research  
2025;
14
(7)
:2723-2735
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 (31 July 2025) 
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Safety and efficacy of transbronchial radiofrequency ablation for stage IA peripheral lung cancer: a retrospective cohort study
Siyuan Hong, Lin Ye, Junxiang Chen, Fangfang Xie, Chuanjia Gu, Du Xu, George Cheng, Jiayuan Sun
Translational Lung Cancer Research  
2025;
14
(7)
:2736-2746
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 (31 July 2025) 
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Reducing radiation pneumonitis in lung cancer patients: from Chinese expert consensus to practice
Yaoyao Zhu, Yujie Yan, Jiamei Fu, Qing Shao, Ying Zhang, Xiaoshuai Yuan, Jingjing Kang, Min Hu, Chenxue Jiang, Minren Hu, Ruifeng Zhao, Lan Zhao, Yaping Xu, Shuangyan Yang
Translational Lung Cancer Research  
2025;
14
(7)
:2747-2759
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 (31 July 2025) 
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Prognostic significance of micropapillary pattern and risk factors in patients with resected stage I lung adenocarcinoma and possible benefit of adjuvant therapy: a real-world multicenter study
Jianjie Li, Yujia Chi, Bo Jia, Qiwen Zheng, Minghan Yuan, Jianjun Zhang, Aishen Zhou, Wei Sun, Yue Yang, Jun Zhao, Tongtong An, Yuyan Wang, Minglei Zhuo, Xue Yang, Hanxiao Chen, Jingjing Wang, Xiaoyu Zhai, Yidi Tai, Yuling He, Lingdong Kong, Xumeng Ji, Yiliang Liu, Nan Wu, Ken Onodera, Paul Van Schil, Mathew Thomas, Fan Yang, Ziping Wang
Translational Lung Cancer Research  
2025;
14
(7)
:2760-2770
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 (31 July 2025) 
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Overexpression of PPM1G promotes cell metabolism and activates the NOTCH signaling pathway in lung adenocarcinoma
Guangmin Xi, Caibo Zhang, Cong Yu, Yiya Wang, Jinfeng Fu, Haining Qi, Kenichi Suda, Guoying Wu
Translational Lung Cancer Research  
2025;
14
(7)
:2771-2787
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 (31 July 2025) 
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First-line immunotherapy in advanced non-squamous non-small cell lung cancer patients with rare mutations: a retrospective cohort study
Wenli Cao, Furong Kou, Weiheng Hu, Li Hu, Jun Nie, Ling Dai, Jie Zhang, Jinqiu Rui, Magdalena Knetki-Wróblewska, Mara B. Antonoff, Jian Fang, Yang Wang
Translational Lung Cancer Research  
2025;
14
(7)
:2788-2798
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 (31 July 2025) 
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Review Article

Literature review of advances and challenges in KRAS G12C mutant non-small cell lung cancer
Jiang-Xia Yuan, Yue Hao, Xian-Zi Dai, Jiao-Jiao Hong, Cheng-Yu Chen, Zheng-Xing Huo, Jia Zhu, Qian Wang
Translational Lung Cancer Research  
2025;
14
(7)
:2799-2820
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 (31 July 2025) 
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Mechanistic insights into the immune biomarker of perioperative immune checkpoint inhibitors for non-small cell lung cancer
Yanting Long, Runsen Jin, Hecheng Li
Translational Lung Cancer Research  
2025;
14
(7)
:2821-2841
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 (31 July 2025) 
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The pharmacokinetics of capmatinib and its efficacy in non-small cell lung cancer treatment: a narrative review
Bingtian Bi, Jing Zhan, Beichen Fan, Wenfeng Fang, Su Li
Translational Lung Cancer Research  
2025;
14
(7)
:2842-2852
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 (31 July 2025) 
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Advances in immunotherapy for driver gene-positive non-small cell lung cancer: a narrative review
Fangfei Qian, Runbo Zhong, Hua Zhong
Translational Lung Cancer Research  
2025;
14
(7)
:2853-2868
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 (31 July 2025) 
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Case Report

A case report and literature review of a pathologic complete response to alectinib in ALK-positive stage IV non-small cell lung cancer
Mélanie Janson, Hubert Curcio, Jean-Philippe Le Rochais, Gaëtane Planchard, Pierre Demontrond, Radj Gervais
Translational Lung Cancer Research  
2025;
14
(7)
:2869-2874
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 (31 July 2025) 
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Successful rechallenge of immune checkpoint inhibitors after severe immune-related hepatitis, thyroiditis and hypophysitis in TMB-high NSCLC: a case report
Zixiang Zhou, Hanping Wang
Translational Lung Cancer Research  
2025;
14
(7)
:2875-2879
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 (31 July 2025) 
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Immunotherapy with lymphocytes derived from banked tumor tissue in two refractory NSCLC patients with leptomeningeal metastases: a report of two cases
Ai-Hong Zheng, Chong Yu, Yong-Rui Su, Min Peng, Jian-Yuan Chen, Fu-Wei Wang, Xiu-Ming Zhu, Pei-Yuan Yan, Hai-Tao Wang, Jian Shen, Wei-Jun Chen, Qiang Li, Yuan Chen, Yi Chen, Yin-Shuang Wang, Hang-Yu Gu, Zhuo-Nan Meng, Jing-Wen Zhao, Wan-Mao Ni, Tian-Hua Wang, Sheng-Lian Wu, Min Li, Zheng Wang, Ai-Ping Cheng, Xiao-Xian Huang, Zi-Yan Yang, Jia-Hong Jiang, Qun-Jiang Wang, Jing Qu, Shi-Tai Zhang, Ke-Ke Shi, Hua-Xin Zhang, Da-Hong Zhang, Guo-Qing Wu
Translational Lung Cancer Research  
2025;
14
(7)
:2880-2890
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 (31 July 2025) 
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Letter to the Editor

Targeting arachidonic acid-modulated autophagy: a novel axis in crizotinib resistance
Shameer Tahir
Translational Lung Cancer Research  
2025;
14
(7)
:2891-2892
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 (31 July 2025) 
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Arachidonic acid-mediated autophagy regulation drives crizotinib resistance in lung cancer: therapeutic opportunities and challenges
Hui Jie, Hongjin Lai, Zihuai Wang, Lunxu Liu, Senyi Deng, Chenglin Guo
Translational Lung Cancer Research  
2025;
14
(7)
:2893-2894
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 (31 July 2025) 
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