Vol 8, No 4 (August 31, 2019): Translational Lung Cancer Research

Editorial

Lung cavitation in lung metastases of gastric and non-small-cell lung cancer patients treated with apatinib
Fabiana Letizia Cecere, Andres Aguilar, Rafael Rosell
Translational Lung Cancer Research  
2019;
8
(4)
:317-318
.
Influence and mechanism of lung cavitation development on antiangiogenic therapy: is cavitation the new caveat?
Lorenzo Calvetti, Giuseppe Aprile
Translational Lung Cancer Research  
2019;
8
(4)
:319-322
.

Original Article

Presence of intra-tumoral CD61+ megakaryocytes predicts poor prognosis in non-small cell lung cancer
Weizhe Huang, Shen Zhao, Wei Xu, Zhikui Zhang, Xiangdong Ding, Jianxing He, Wenhua Liang
Translational Lung Cancer Research  
2019;
8
(4)
:323-331
.
Prospective assessment of demographic characteristics associated with worse health related quality of life measures following definitive chemoradiation in patients with locally advanced non-small cell lung cancer
Jennifer Vogel, Xingmei Wang, Andrea B. Troxel, Charles B. Simone II, Ramesh Rengan, Lilie L. Lin
Translational Lung Cancer Research  
2019;
8
(4)
:332-339
.
Hsp90 inhibitors enhance the antitumoral effect of osimertinib in parental and osimertinib-resistant non-small cell lung cancer cell lines
Jordi Codony-Servat, Santiago Viteri, Carles Codony-Servat, Masaoki Ito, Jillian Willhelmina Paulina Bracht, Jordi Berenguer, Imane Chaib, Miguel Angel Molina-Vila, Niki Karachaliou, Rafael Rosell
Translational Lung Cancer Research  
2019;
8
(4)
:340-351
.
OX40 and OX40L protein expression of tumor infiltrating lymphocytes in non-small cell lung cancer and its role in clinical outcome and relationships with other immune biomarkers
Yayi He, Xiaoshen Zhang, Keyi Jia, Rafal Dziadziuszko, Sha Zhao, Juan Deng, Hao Wang, Fred R. Hirsch, Caicun Zhou
Translational Lung Cancer Research  
2019;
8
(4)
:352-366
.
Incidence, prognostic factors, and a nomogram of lung cancer with bone metastasis at initial diagnosis: a population-based study
Xuan-Qi Zheng, Jin-Feng Huang, Jia-Liang Lin, Liang Chen, Ting-Ting Zhou, Dong Chen, Dong-Dong Lin, Jian-Fei Shen, Ai-Min Wu
Translational Lung Cancer Research  
2019;
8
(4)
:367-379
.
Exploring barriers to lung cancer patient access, diagnosis, referral and treatment in Kwazulu-Natal, South Africa: the health providers’ perspectives
Buhle Lubuzo, Themba Ginindza, Khumbulani Hlongwana
Translational Lung Cancer Research  
2019;
8
(4)
:380-391
.
Liquid biopsies using pleural effusion-derived exosomal DNA in advanced lung adenocarcinoma
Zhengbo Song, Zhijian Cai, Junrong Yan, Yang W. Shao, Yiping Zhang
Translational Lung Cancer Research  
2019;
8
(4)
:392-400
.
Quantitative features of dual-energy spectral computed tomography for solid lung adenocarcinoma with EGFR and KRAS mutations, and ALK rearrangement: a preliminary study
Meng Li, Li Zhang, Wei Tang, Pei-Qing Ma, Li-Na Zhou, Yu-Jing Jin, Lin-Lin Qi, Ning Wu
Translational Lung Cancer Research  
2019;
8
(4)
:401-412
.
The association of PD-L1 expression with the efficacy of anti- PD-1/PD-L1 immunotherapy and survival of non-small cell lung cancer patients: a meta-analysis of randomized controlled trials
Yangyang Xu, Bing Wan, Xi Chen, Ping Zhan, Yuan Zhao, Tianli Zhang, Hongbing Liu, Muhammad Zubair Afzal, Said Dermime, Steven N. Hochwald, Paul Hofman, Hossein Borghaei, Dang Lin, Tangfeng Lv, Yong Song, written on behalf of AME Lung Cancer Collaborative Group
Translational Lung Cancer Research  
2019;
8
(4)
:413-428
.
The clinicopathological and prognostic significance of PD-L1 expression assessed by immunohistochemistry in lung cancer: a meta-analysis of 50 studies with 11,383 patients
Huijuan Li, Yangyang Xu, Bing Wan, Yong Song, Ping Zhan, Yangbo Hu, Qun Zhang, Fang Zhang, Hongbing Liu, Tianhong Li, Haruhiko Sugimura, Federico Cappuzzo, Dang Lin, Tangfeng Lv, written on behalf of AME Lung Cancer Collaborative Group
Translational Lung Cancer Research  
2019;
8
(4)
:429-449
.
Retrospective analysis of docetaxel in combination with ramucirumab for previously treated non-small cell lung cancer patients
Akihiro Yoshimura, Tadaaki Yamada, Yusuke Okuma, Rui Kitadai, Takayuki Takeda, Takanori Kanematsu, Hisatsugu Goto, Hiroto Yoneda, Taishi Harada, Yutaka Kubota, Takahiro Yamada, Koji Date, Shinsuke Shiotsu, Kazuhiro Nagata, Yusuke Chihara, Yoshiko Kaneko, Junji Uchino, Yasuhiko Nishioka, Koichi Takayama
Translational Lung Cancer Research  
2019;
8
(4)
:450-460
.
Lung cancer in Spain: information from the Thoracic Tumors Registry (TTR study)
Mariano Provencio, Enric Carcereny, Delvys Rodríguez-Abreu, Rafael López-Castro, María Guirado, Carlos Camps, Joaquim Bosch-Barrera, Rosario García-Campelo, Ana Laura Ortega-Granados, José Luis González-Larriba, Joaquín Casal-Rubio, Manuel Domine, Bartomeu Massutí, María Ángeles Sala, Reyes Bernabé, Juana Oramas, Elvira del Barco
Translational Lung Cancer Research  
2019;
8
(4)
:461-475
.
MUC16 in non-small cell lung cancer patients affected by familial lung cancer and indoor air pollution: clinical characteristics and cell behaviors
Ying Chen, Yunchao Huang, Madiha Kanwal, Guangjian Li, Jiapeng Yang, Huatao Niu, Zhenhui Li, Xiaojie Ding
Translational Lung Cancer Research  
2019;
8
(4)
:476-488
.
Metabolic profiles of serum samples from ground glass opacity represent potential diagnostic biomarkers for lung cancer
Jian-Zhong Li, Yuan-Yang Lai, Jian-Yong Sun, Li-Na Guan, Hong-Fei Zhang, Chen Yang, Yue-Feng Ma, Tao Liu, Wen Zhao, Xiao-Long Yan, Shao-Min Li
Translational Lung Cancer Research  
2019;
8
(4)
:489-499
.
Influence and mechanism of lung cavitation development on antiangiogenic therapy
Man Jiang, Chuantao Zhang, Dong Liu, Yongjie Wang, Hongmei Wang, Tianjun Li, Helei Hou, Na Zhou, Jingjuan Zhu, Hongying Lv, Chuanyu Zhang, Bingliang Fang, Xiaochun Zhang
Translational Lung Cancer Research  
2019;
8
(4)
:500-512
.

Brief Report

Sensitive molecular testing methods can demonstrate NSCLC driver mutations in malignant pleural effusion despite non-malignant cytology
Daniel P. Steinfort, Sevastjan Kranz, Anthony Dowers, Leakhena Leas, Voula Dimitriadis, Kym Pham, Arthur Hsu, Steven Bozinovski, Louis B. Irving, Paula Loveland, Michael Christie
Translational Lung Cancer Research  
2019;
8
(4)
:513-518
.

Study Protocol

Rationale and design of a phase II study to evaluate prophylactic treatment of dacomitinib-induced dermatologic adverse events in epidermal growth factor receptor-mutated advanced non-small cell lung cancer (SPIRAL-Daco study)
Masahiro Iwasaku, Junji Uchino, Tadaaki Yamada, Yusuke Chihara, Takayuki Shimamoto, Nobuyo Tamiya, Yoshiko Kaneko, Fumiaki Kiyomi, Koichi Takayama
Translational Lung Cancer Research  
2019;
8
(4)
:519-523
.

Review Article

Treatment modes for EGFR mutations in patients with brain metastases from non-small cell lung cancer: controversy, causes, and solutions
Hongqing Zhuang, Siyu Shi, Joe Y. Chang
Translational Lung Cancer Research  
2019;
8
(4)
:524-531
.

Case Report

Effective targeted therapy based on dynamic monitoring of gene mutations in non-small cell lung cancer
Tan Deng, Jiao Tang, Lijun Zhou, Huaxin Duan
Translational Lung Cancer Research  
2019;
8
(4)
:532-538
.

Editorial Commentary

The shifting paradigm of biomarker-driven care in advanced non-small cell lung cancer (NSCLC)
Greg Durm, Nasser Hanna
Translational Lung Cancer Research  
2019;
8
(4)
:539-542
.
Sex disparities in lung cancer incidence: validation of a long-observed trend
Jessica A. Hellyer, Manali I. Patel
Translational Lung Cancer Research  
2019;
8
(4)
:543-545
.
First-line immune-chemotherapy combination: the right strategy to fight squamous non-small cell lung cancer?
Francesco Passiglia, Paolo Bironzo, Giorgio V. Scagliotti
Translational Lung Cancer Research  
2019;
8
(4)
:546-549
.
Osimertinib in first line setting: for Asian patients
Keisuke Onoi, Yoshiko Kaneko, Junji Uchino
Translational Lung Cancer Research  
2019;
8
(4)
:550-552
.
Measuring tumor mutation burden in cell-free DNA: advantages and limits
Alfredo Addeo, Glen J. Weiss
Translational Lung Cancer Research  
2019;
8
(4)
:553-555
.

News

The first attempt worldwide to test PD-1 antibody on multiple “Stage 0” lung cancer
Editorial Office
Translational Lung Cancer Research  
2019;
8
(4)
:556-557
.