Vol 9, No 6 (December 31, 2020): Translational Lung Cancer Research

Editorial

Cyclin D1 expression in KRAS mutant non-small cell lung cancer—old wine into new skins
Kah Yee Goh, Wan-Teck Lim
Translational Lung Cancer Research  
2020;
9
(6)
:2302-2304
.
The gut microbiome and its interaction with health, disease, treatment response and toxicity in patients advanced cancer: focus on lung cancer and immunotherapy
Nadina Tinsley, Natalie Cook
Translational Lung Cancer Research  
2020;
9
(6)
:2305-2307
.
Radiomics signature for prediction of N2 disease: fascinating but still a long way to go for clinical application
Kwon Joong Na, Hongyoon Choi, Young Tae Kim
Translational Lung Cancer Research  
2020;
9
(6)
:2308-2310
.
Current and future aspects of TIM-3 as biomarker or as potential targeted in non-small cell lung cancer scope: is there a role in clinical practice?
Ramon Andrade De Mello, Jin-Hui Zhu, Jairo Iavelberg, Artur Henrique Potim, Débora Simonetti, José Antônio Silva Jr, Pedro Castelo-Branco, Daniel Humberto Pozza, Carla Chizuru Tajima, Maria Tolia, Georgio Antoniou
Translational Lung Cancer Research  
2020;
9
(6)
:2311-2314
.

Original Article

Pre-radiotherapy lymphocyte count and platelet-to-lymphocyte ratio may improve survival prediction beyond clinical factors in limited stage small cell lung cancer: model development and validation
Yishan Yu, Linlin Wang, Shufen Cao, Siming Gao, Weili Wang, Lianne Mulvihill, Mitchell Machtay, Pingfu Fu, Jinming Yu, Feng-Ming (Spring) Kong
Translational Lung Cancer Research  
2020;
9
(6)
:2315-2327
.
Stereotactic body radiotherapy for early stage non-small cell lung cancer in patients with subclinical interstitial lung disease
Yuanjun Liu, Yaoyao Zhu, Ran Wu, Min Hu, Lingnan Zhang, Qingren Lin, Denghu Weng, Xiaojiang Sun, Yu Liu, Yaping Xu
Translational Lung Cancer Research  
2020;
9
(6)
:2328-2336
.
Metformin reverses chemoresistance in non-small cell lung cancer via accelerating ubiquitination-mediated degradation of Nrf2
Sha Huang, Tianyu He, Sijia Yang, Hongxu Sheng, Xiuwen Tang, Feichao Bao, Yiqing Wang, Xu Lin, Wenfeng Yu, Fei Cheng, Wang Lv, Jian Hu
Translational Lung Cancer Research  
2020;
9
(6)
:2337-2355
.
Investigation on the potential of circulating tumor DNA methylation patterns as prognostic biomarkers for lung squamous cell carcinoma
Yutao Liu, Yu Feng, Ting Hou, Analyn Lizaso, Feng Xu, Puyuan Xing, Hongyu Wang, Qiaolin Kang, Lu Zhang, Yuankai Shi, Xingsheng Hu
Translational Lung Cancer Research  
2020;
9
(6)
:2356-2366
.
Predictive values of genomic variation, tumor mutational burden, and PD-L1 expression in advanced lung squamous cell carcinoma treated with immunotherapy
Yanjun Xu, Hui Li, Zhiyu Huang, Kaiyan Chen, Xiaoqing Yu, Jiamin Sheng, Han-Han Zhang, Yun Fan
Translational Lung Cancer Research  
2020;
9
(6)
:2367-2367
.
The feasibility of navigation bronchoscopy-guided pulmonary microcoil localization of small pulmonary nodules prior to thoracoscopic surgery
Junxiang Chen, Xufeng Pan, Chuanjia Gu, Xiaoxuan Zheng, Haibin Yuan, Jun Yang, Jiayuan Sun
Translational Lung Cancer Research  
2020;
9
(6)
:2380-2390
.
Immunotherapy beyond progression in patients with advanced non-small cell lung cancer
Xiangwei Ge, Zhibo Zhang, Sujie Zhang, Fang Yuan, Fan Zhang, Xiang Yan, Xiao Han, Junxun Ma, Lijie Wang, Haitao Tao, Xiaoyan Li, Xiaoyu Zhi, Zhiyue Huang, Paul Hofman, Arsela Prelaj, Giuseppe Luigi Banna, Luciano Mutti, Yi Hu, Jinliang Wang
Translational Lung Cancer Research  
2020;
9
(6)
:2391-2400
.
Survival benefit and toxicity profile of adjuvant icotinib for patients with EGFR mutation-positive non-small cell lung carcinoma: a retrospective study
Ziqing Zeng, Bo Yan, Yulong Chen, Lianmin Zhang, Jianquan Zhu, Fan Yang, Feng Wei, Terence Chi Chun Tam, Diego Kauffmann-Guerrero, Ross Andrew Soo, Xiubao Ren, Jian You
Translational Lung Cancer Research  
2020;
9
(6)
:2401-2410
.
Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma
Hou-Lei Wang, Hui-Ren Wang, Yun Liang, An-Nan Hu, Francisco J. Enguita, Xiao-Gang Zhou, Jian Dong
Translational Lung Cancer Research  
2020;
9
(6)
:2411-2427
.
Whole exome sequencing (WES) analysis of transformed small cell lung cancer (SCLC) from lung adenocarcinoma (LUAD)
Tongji Xie, Yan Li, Jianming Ying, Weijing Cai, Junling Li, Kye Young Lee, Biagio Ricciuti, Jose Pacheco, Puyuan Xing
Translational Lung Cancer Research  
2020;
9
(6)
:2428-2439
.
The protective effects of granulocyte-macrophage colony-stimulating factor against radiation-induced lung injury
Dan Hu, Yan Zhang, Ruiqi Cao, Yuying Hao, Xiaoye Yang, Tiantian Tian, Jiandong Zhang
Translational Lung Cancer Research  
2020;
9
(6)
:2440-2459
.

Protocol

Treatment patterns, clinical outcomes, and healthcare resource use associated with advanced/metastatic lung cancer in China: protocol for a retrospective observational study
Bin Qiu, Gaofeng Li, Feng Luo, Xiaohong Cai, Lin Wu, Jianhua Chen, Yanping Hu, Zhiliu Tang, Shuo Yang, Jie He
Translational Lung Cancer Research  
2020;
9
(6)
:2460-2468
.

Review Article

A narrative review of progress in diagnosis and treatment of small cell lung cancer patients with hyponatremia
Ranpu Wu, Chuling Li, Zimu Wang, Hang Fan, Yong Song, Hongbing Liu
Translational Lung Cancer Research  
2020;
9
(6)
:2469-2478
.
A narrative review of evolving roles of radiotherapy in advanced non-small cell lung cancer: from palliative care to active player
Yue Zhou, Fan Yu, Yang Zhao, Ya Zeng, Xi Yang, Li Chu, Xiao Chu, Yida Li, Liqing Zou, Tiantian Guo, Zhengfei Zhu, Jianjiao Ni
Translational Lung Cancer Research  
2020;
9
(6)
:2479-2493
.

Case Report

Coexistence of a novel CCNY-ALK and ATIC-ALK double-fusion in one patient with ALK-positive NSCLC and response to crizotinib: a case report
Xuan Wu, Hanqiong Zhou, Zhen He, Zhe Zhang, Wen Feng, Jiuzhou Zhao, Haiyang Chen, Shuai Wang, Wei Wang, Qiming Wang
Translational Lung Cancer Research  
2020;
9
(6)
:2494-2499
.
A case report of exceptional clinical response to chemoradiotherapy and tyrosine kinase inhibitors in a patient with EML4-ALK fusion variant 1 non-small cell lung cancer
Xinyan Xu, Di Liu, Junmiao Wen, Jiayan Chen, Min Fan
Translational Lung Cancer Research  
2020;
9
(6)
:2500-2507
.

Editorial Commentary

Comment on “EURACAN/IASLC proposals for updating the histologic classification of pleural mesothelioma: towards a more multidisciplinary approach”
Wickii T. Vigneswaran, Muaiad Kittaneh
Translational Lung Cancer Research  
2020;
9
(6)
:2508-2510
.
Perspective of gene therapy with replication competent viruses
Makoto Maemondo
Translational Lung Cancer Research  
2020;
9
(6)
:2511-2513
.

Letter to the Editor

Osimertinib in combination with bevacizumab in EGFR-Mutated NSCLC with leptomeningeal metastases
Tao Jiang, Xiaobo Xu, Xiaojuan Chen, Ning Ding, Qin Hu, Caicun Zhou, Jie Hu
Translational Lung Cancer Research  
2020;
9
(6)
:2514-2517
.

Editorial on Looking for Chimeras in NSCLC: Widen Therapeutic Options Targeting Oncogenic Fusions1

Targeting chimeras fusion proteins in non-small cell lung cancer: where are we going?
Francesco Passiglia, Silvia Novello
Translational Lung Cancer Research  
2020;
9
(6)
:2518-2520
.

Review Article on Looking for Chimeras in NSCLC: Widen Therapeutic Options Targeting Oncogenic Fusions1

How to select the best upfront therapy for metastatic disease? Focus on ALK-rearranged non-small cell lung cancer (NSCLC)
Bing Xia, Misako Nagasaka, Viola W. Zhu, Sai-Hong Ignatius Ou, Ross A. Soo
Translational Lung Cancer Research  
2020;
9
(6)
:2521-2534
.
How selecting best therapy for metastatic NTRK fusion-positive non-small cell lung cancer?
Simon Ekman
Translational Lung Cancer Research  
2020;
9
(6)
:2535-2544
.
Resistance to anaplastic lymphoma kinase inhibitors: knowing the enemy is half the battle won
Fabrizio Tabbò, Maria Lucia Reale, Paolo Bironzo, Giorgio V. Scagliotti
Translational Lung Cancer Research  
2020;
9
(6)
:2545-2556
.
The role of plasma genotyping in ALK- and ROS1-rearranged lung cancer
Ibiayi Dagogo-Jack, Lauren L. Ritterhouse
Translational Lung Cancer Research  
2020;
9
(6)
:2557-2570
.
Decade in review: a new era for RET-rearranged lung cancers
Noura J. Choudhury, Alexander Drilon
Translational Lung Cancer Research  
2020;
9
(6)
:2571-2580
.
Overcoming TKI resistance in fusion-driven NSCLC: new generation inhibitors and rationale for combination strategies
Alessandro Russo, Andrés F. Cardona, Christian Caglevic, Paolo Manca, Alejandro Ruiz-Patiño, Oscar Arrieta, Christian Rolfo
Translational Lung Cancer Research  
2020;
9
(6)
:2581-2598
.
Central nervous system metastases and oligoprogression during treatment with tyrosine kinase inhibitors in oncogene-addicted non-small cell lung cancer: how to treat and when?
Janna Josephus Anna Oda Schoenmaekers, Marthe Sentijna Paats, Anne-Marie Clasina Dingemans, Lizza Elisabeth Lucia Hendriks
Translational Lung Cancer Research  
2020;
9
(6)
:2599-2617
.
Emerging oncogenic fusions other than ALK, ROS1, RET, and NTRK in NSCLC and the role of fusions as resistance mechanisms to targeted therapy
Kenichi Suda, Tetsuya Mitsudomi
Translational Lung Cancer Research  
2020;
9
(6)
:2618-2628
.
Future perspectives from lung cancer pre-clinical models: new treatments are coming?
Francesca Bersani, Deborah Morena, Francesca Picca, Alessandro Morotti, Fabrizio Tabbò, Paolo Bironzo, Luisella Righi, Riccardo Taulli
Translational Lung Cancer Research  
2020;
9
(6)
:2629-2644
.
Narrative review of molecular pathways of kinase fusions and diagnostic approaches for their detection in non-small cell lung carcinomas
Matthias S. Matter, Obinna Chijioke, Spasenija Savic, Lukas Bubendorf
Translational Lung Cancer Research  
2020;
9
(6)
:2645-2655
.
Integrating immune checkpoint inhibitors and targeted therapies in the treatment of early stage non-small cell lung cancer: a narrative review
Ana Ortega-Franco, Virginia Calvo, Fabio Franco, Mariano Provencio, Raffaele Califano
Translational Lung Cancer Research  
2020;
9
(6)
:2656-2673
.
Is there any place for immune-checkpoint inhibitors in the treatment algorithm of fusion-driven non-small cell lung cancer?—a literature review
Gianmarco Leone, Francesco Passiglia, Paolo Bironzo, Valentina Bertaglia, Silvia Novello
Translational Lung Cancer Research  
2020;
9
(6)
:2674-2685
.
How selecting best upfront therapy for metastatic disease?—Focus on ROS1-rearranged disease
Lorenza Landi, Federico Cappuzzo
Translational Lung Cancer Research  
2020;
9
(6)
:2686-2695
.

Consensus

Expert consensus on neoadjuvant immunotherapy for non-small cell lung cancer
Wenhua Liang, Kaican Cai, Chun Chen, Haiquan Chen, Qixun Chen, Junke Fu, Jian Hu, Tao Jiang, Wenjie Jiao, Shuben Li, Changhong Liu, Deruo Liu, Wei Liu, Yang Liu, Haitao Ma, Xiaojie Pan, Guibin Qiao, Hui Tian, Li Wei, Yi Zhang, Song Zhao, Xiaojing Zhao, Chengzhi Zhou, Yuming Zhu, Ran Zhong, Feng Li, Rafael Rosell, Mariano Provencio, Erminia Massarelli, Mara B. Antonoff, Toyoaki Hida, Marc de Perrot, Steven H. Lin, Massimo Di Maio, Antonio Rossi, Dirk De Ruysscher, Robert A. Ramirez, Wolfram C. M. Dempke, D. Ross Camidge, Nicolas Guibert, Raffaele Califano, Qi Wang, Shengxiang Ren, Caicun Zhou, Jianxing He
Translational Lung Cancer Research  
2020;
9
(6)
:2696-2715
.

Disclosure:

1. The series “Looking for Chimeras in NSCLC: Widen Therapeutic Options Targeting Oncogenic Fusions” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Silvia Novello and Francesco Passiglia served as the unpaid Guest Editors for the series.