Vol 9, No 5 (October 28, 2020) - Translational Lung Cancer Research

Editorial

Can CT radiomics differentiate benign from malignant N2 adenopathy in non-small cell lung cancer

Robert J. Cerfolio, William H. Moore

PDF Pages: 1710-1711 Full Text (1089) COI Form Open Access

On the way of the new strategies aimed to improve the efficacy of PD-1/PD-L1 immune checkpoint blocking mAbs in small cell lung cancer

Pierpaolo Correale, Rocco Giannicola, Rita Emilena Saladino, Valerio Nardone, Luigi Pirtoli, Pierfrancesco Tassone, Amalia Luce, Salvatore Cappabianca, Marianna Scrima, Pierosandro Tagliaferri, Michele Caraglia

PDF Pages: 1712-1719 Full Text (1756) COI Form Open Access

EGFR tyrosine kinase inhibitors (TKIs) for adjuvant therapy of early-stage non-small cell lung cancer (NSCLC): ready for the clinic?

Conor E. Steuer, Suresh S. Ramalingam

PDF Pages: 1720-1723 Full Text (2388) COI Form Open Access

Adjuvant epidermal growth factor receptor tyrosine kinase inhibitors: are we actually ready?

Fabrizio Tabbò, Maria Lucia Reale, Silvia Novello

PDF Pages: 1724-1727 Full Text (1245) COI Form Open Access

Adjuvant TKI therapy in resected EGFR-mutant non-small-cell lung cancer—ready for prime time?

Surein Arulananda, Thomas John

PDF Pages: 1728-1731 Full Text (1065) COI Form Open Access

Second-line therapy for disseminated small-cell lung cancer: optimal management remains to be defined

Christos Chouaïd, Nathalie Baize, Isabelle Monnet

PDF Pages: 1732-1735 Full Text (1583) COI Form Open Access

Original Article

Nivolumab in pre-treated advanced non-small cell lung cancer: long term follow up data from the Dutch expanded access program and routine clinical care

Robert D. Schouten, Lucie Egberink, Mirte Muller, Cornedine J. De Gooijer, Erik van Werkhoven, Michel M. van den Heuvel, Paul Baas

PDF Pages: 1736-1748 Full Text (2103) Reporting Checklist Data Sharing Statement COI Form Open Access

The different central nervous system efficacy among gefitinib, erlotinib and afatinib in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer

Hyun Ae Jung, Sook Young Woo, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun

PDF Pages: 1749-1758 Full Text (4384) Reporting Checklist Data Sharing Statement COI Form Open Access

KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples

Herbert Ho-Fung Loong, Nan Du, Chunyan Cheng, Hanqing Lin, Jian Guo, Gen Lin, Mingjiang Li, Tao Jiang, Zhihua Shi, Yanzhi Cui, Xianfeng Jin, Jicheng Yao, Yutong Xing, Ming Yao, Kai Wang, Tony S. K. Mok, Lunxu Liu

PDF Pages: 1759-1769 Full Text (6251) Reporting Checklist COI Form Open Access

The effect of PD-L1 categories-directed pembrolizumab plus chemotherapy for newly diagnosed metastatic non-small-cell lung cancer: a cost-effectiveness analysis

Bin Wu, Shun Lu

PDF Pages: 1770-1784 Full Text (3484) Reporting Checklist Data Sharing Statement COI Form Open Access

Treatments for combined small cell lung cancer patients

Jiaxi He, Songhui Xu, Hui Pan, Shuben Li, Jianxing He

PDF Pages: 1785-1794 Full Text (3897) Reporting Checklist Peer Review File COI Form Open Access

Ex vivo culture of circulating tumour cells derived from non-small cell lung cancer

Joanna Kapeleris, Arutha Kulasinghe, Majid Ebrahimi Warkiani, Connor Oleary, Ian Vela, Paul Leo, Peter Sternes, Kenneth O’Byrne, Chamindie Punyadeera

PDF Pages: 1795-1809 Full Text (5040) Data Sharing Statement COI Form Open Access

SRC and PIM1 as potential co-targets to overcome resistance in MET deregulated non-small cell lung cancer

Ilaria Attili, Laura Bonanno, Niki Karachaliou, Jillian Wilhelmina Paulina Bracht, Jordi Berenguer, Carles Codony-Servat, Jordi Codony-Servat, Erika Aldeguer, Ana Gimenez-Capitan, Alessandro Dal Maso, Matteo Fassan, Imane Chaib, Miguel Angel Molina-Vila, Antonio Passaro, Filippo de Marinis, Giulia Pasello, Valentina Guarneri, Pier Franco Conte, Rafael Rosell

PDF Pages: 1810-1821 Full Text (2751) Reporting Checklist Data Sharing Statement COI Form Open Access

Significant diaphragm elevation suggestive of phrenic nerve injury after thoracoscopic lobectomy for lung cancer: an underestimated problem

Luigi Ventura, Weigang Zhao, Tangbing Chen, Zhexin Wang, Jian Feng, Zhitao Gu, Chunyu Ji, Wentao Fang

PDF Pages: 1822-1830 Full Text (2470) Reporting Checklist Data Sharing Statement COI Form Open Access

Interactions between the enhanced recovery after surgery pathway and risk factors for lung infections after pulmonary malignancy operation

Xianfei Zhang, Runsen Jin, Yuyan Zheng, Dingpei Han, Kai Chen, Jian Li, Hecheng Li

PDF Pages: 1831-1842 Full Text (1299) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Establishment and validation of a mathematical diagnosis model to distinguish benign pulmonary nodules from early non-small cell lung cancer in Chinese people

Qiang Wei, Weizhen Fang, Xi Chen, Zhongzhen Yuan, Yumei Du, Yanbin Chang, Yonghong Wang, Shulin Chen

PDF Pages: 1843-1852 Full Text (1523) Reporting Checklist Data Sharing Statement COI Form Open Access

Pemetrexed-based chemotherapy for non-small-cell lung cancer patients with EGFR exon 20 insertion mutation: a multicenter study

Chun-Wei Xu, Wen-Xian Wang, Dong Wang, Qi-Ming Wang, Xing-Xiang Pu, You-Cai Zhu, Jian-Hui Huang, Zong-Yang Yu, Zhao-Lei Cui, Xiao-Hui Chen, Jin-Luan Li, Yong Fang, Hong Wang, Wu Zhuang, Shi-Jie Lan, Xin Cai, Yin-Bin Zhang, Wen-Bin Gao, Li-Ping Wang, Ke-Lin She, Chuang-Zhou Rao, Yue-Fen Zhou, Mei-Yu Fang, Li-Yun Miao, Lei Lei, Tang-Feng Lv, Yong Song, on behalf of AME Lung Cancer Collaborative Group

PDF Pages: 1853-1861 Full Text (3032) Reporting Checklist Data Sharing Statement COI Form Open Access

Stereotactic body radiation therapy for empirically treated hypermetabolic lung lesions: a single-institutional experience identifying the Charlson score as a key prognostic factor

Roman O. Kowalchuk, Michael R. Waters, Sujith Baliga, K. Martin Richardson, Kelly M. Spencer, James M. Larner, Charles R. Kersh

PDF Pages: 1862-1872 Full Text (1195) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Longitudinal multi-gene panel assessment of circulating tumor DNA revealed tumor burden and molecular characteristics along treatment course of non-small cell lung cancer

Gloria Y. F. Ho, Tao Wang, Hoi-Hin Kwok, Rehana Rasul, Rita Peila, Maria Guzman, Mary S. M. Ip, David C. L. Lam

PDF Pages: 1873-1884 Full Text (2013) Reporting Checklist Data Sharing Statement COI Form Open Access

ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma

Chaoyang Liang, Xiaowei Wang, Zhenrong Zhang, Fei Xiao, Hongxiang Feng, Qianli Ma, Jingjing Huang, Guangliang Qiang, Dingrong Zhong, Deruo Liu

PDF Pages: 1885-1903 Full Text (2006) Reporting Checklist Data Sharing Statement COI Form Open Access

Epithelial-to-mesenchymal transition is a resistance mechanism to sequential MET-TKI treatment of MET-amplified EGFR-TKI resistant non-small cell lung cancer cells

Michelle Simone Clement, Kristine Raaby Gammelgaard, Anders Lade Nielsen, Boe Sandahl Sorensen

PDF Pages: 1904-1914 Full Text (2864) Reporting Checklist Peer Review File COI Form Open Access

Prognostic implications of preoperative versus postoperative circulating tumor DNA in surgically resected lung cancer patients: a pilot study

Shuta Ohara, Kenichi Suda, Kazuko Sakai, Masaya Nishino, Masato Chiba, Masaki Shimoji, Toshiki Takemoto, Toshio Fujino, Takamasa Koga, Akira Hamada, Junichi Soh, Kazuto Nishio, Tetsuya Mitsudomi

PDF Pages: 1915-1923 Full Text (2960) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

How long is cessation of preoperative smoking required to improve postoperative survival of patients with pathological stage I non-small cell lung cancer?

Toshiyuki Shima, Tomonari Kinoshita, Mao Uematsu, Naomichi Sasaki, Yusuke Sugita, Reiko Shimizu, Masahiko Harada, Tsunekazu Hishima, Hirotoshi Horio

PDF Pages: 1924-1939 Full Text (1266) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

SMO mutations confer poor prognosis in malignant pleural mesothelioma

Diego Signorelli, Claudia Proto, Laura Botta, Annalisa Trama, Marcello Tiseo, Giulia Pasello, Giuseppe Lo Russo, Alessandra Fabbri, Martina Imbimbo, Adele Busico, Arsela Prelaj, Roberto Ferrara, Giulia Galli, Alessandro De Toma, Elena Tamborini, Ugo Pastorino, Filippo de Braud, Gemma Gatta, Marina Chiara Garassino, Monica Ganzinelli

PDF Pages: 1940-1951 Full Text (1902) Reporting Checklist Data Sharing Statement COI Form Open Access

Low T790M relative allele frequency indicates concurrent resistance mechanisms and poor responsiveness to osimertinib

Ye Wang, Yanqi He, Panwen Tian, Weiya Wang, Ke Wang, Shannon Chuai, Yalun Li, Shuang Zhao, Yu Wang, Weimin Li

PDF Pages: 1952-1962 Full Text (1612) Reporting Checklist Data Sharing Statement COI Form Open Access

A pilot study of the ultrathin cryoprobe in the diagnosis of peripheral pulmonary ground-glass opacity lesions

Simin Jiang, Xiaojun Liu, Junxiang Chen, Haifeng Ma, Fangfang Xie, Jiayuan Sun

PDF Pages: 1963-1973 Full Text (3062) Reporting Checklist Data Sharing Statement COI Form Open Access

Enumeration and molecular characterization of circulating tumor cells enriched by microcavity array from stage III non-small cell lung cancer patients

Evan N. Cohen, Gitanjali Jayachandran, Hui Gao, Wei Qiao, Suyu Liu, Jianzhong He, Yawei Qiao, Luyang Yao, Steven H. Lin, James M. Reuben

PDF Pages: 1974-1985 Full Text (1961) Reporting Checklist Data Sharing Statement COI Form Open Access

Is clinical target volume necessary?—a failure pattern analysis in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy using intensity-modulated radiotherapy technique

Liqing Zou, Li Chu, Fan Xia, Lijun Zhou, Xi Yang, Jianjiao Ni, Junchao Chen, Zhengfei Zhu

PDF Pages: 1986-1995 Full Text (2743) Reporting Checklist Data Sharing Statement COI Form Open Access

Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio associations with heart and body dose and their effects on patient outcomes in locally advanced non-small cell lung cancer treated with definitive radiotherapy

Wu-Yan Xia, Xue-Ru Zhu, Wen Feng, Jun Liu, Jia-Ming Wang, Chang-Xing Lv, Qin Zhang, Wen Yu, Xu-Wei Cai, Xiao-Long Fu

PDF Pages: 1996-2007 Full Text (2065) Reporting Checklist Data Sharing Statement COI Form Open Access

Study Protocol

GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/ unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy

Qing Zhou, Ming Chen, Gang Wu, Jian-Hua Chang, Ou Jiang, Jiu-Wei Cui, Guang Han, Qin Lin, Jian Fang, Gong-Yan Chen, Yi-Long Wu

PDF Pages: 2008-2015 Full Text (4716) Reporting Checklist COI Form Open Access

Evaluating the diagnostic accuracy of a ctDNA methylation classifier for incidental lung nodules: protocol for a prospective, observational, and multicenter clinical trial of 10,560 cases

Wenhua Liang, Dan Liu, Min Li, Wei Wang, Zheng Qin, Jian Zhang, Yong Zhang, Yang Hu, Hairong Bao, Yi Xiang, Bo Wang, Jing Wu, Jianyu Sun, Chengping Hu, Xianwei Ye, Xiangyan Zhang, Wei Xiao, Chunmei Yun, Dejun Sun, Wei Wang, Ning Chang, Yunhui Zhang, Jianping Zhao, Xin Zhang, Jinfu Xu, Di Wu, Xiaoju Liu, Yubiao Guo, Qichuan Zhang, Wei Zhang, Lan Yang, Zhanqing Li, Xiaoju Zhang, Baohui Han, Zhaohui Tong, Jianxing He, Jieming Qu, Jian-Bing Fan, Nanshan Zhong

PDF Pages: 2016-2026 Full Text (4684) Reporting Checklist COI Form Open Access

Technical Note

Dynamic titanium prosthesis based on 3D-printed replica for chest wall resection and reconstruction

Jacopo Vannucci, Elisa Scarnecchia, Rossella Potenza, Silvia Ceccarelli, Donato Monopoli, Francesco Puma

PDF Pages: 2027-2032 Full Text (Video) (1801) COI Form Open Access

Review Article

Optimizing current standard of care therapy for stage III non-small cell lung cancer

Vivek Verma, Steven H. Lin

PDF Pages: 2033-2039 Full Text (1960) Reporting Checklist COI Form Open Access

A narrative review of toxicity of chemoradiation and immunotherapy for unresectable, locally advanced non-small cell lung cancer

Rahul N. Prasad, Terence M. Williams

PDF Pages: 2040-2050 Full Text (2343) Reporting Checklist Peer Review File COI Form Open Access

Narrative review of the emerging role of molecular biomarkers in guiding the definitive management of unresectable non-small cell lung cancer

Eric K. Singhi, Carl M. Gay

PDF Pages: 2051-2058 Full Text (1929) Reporting Checklist COI Form Open Access

Treatment of stage III non-small cell lung cancer in the era of immunotherapy: pathological complete response to neoadjuvant pembrolizumab and chemotherapy

Zhang-Ru Yang, Mi-Na Liu, Jia-Hua Yu, Yun-Hai Yang, Tian-Xiang Chen, Yu-Chen Han, Lei Zhu, Ji-Kai Zhao, Xiao-Long Fu, Xu-Wei Cai

PDF Pages: 2059-2073 Full Text (4469) COI Form Open Access

A narrative review of lung cancer cytology in the times of coronavirus: what physicians should know

Pasquale Pisapia, Umberto Malapelle, Maria Salatiello, Rafael Rosell, Giancarlo Troncone

PDF Pages: 2074-2081 Full Text (1881) Reporting Checklist COI Form Open Access

A narrative review of synergistic drug administration in unresectable locally advanced non-small cell lung cancer: current landscape and future prospects in the era of immunotherapy

Shuyan Li, Xiao Chu, Luxi Ye, Jianjiao Ni, Zhengfei Zhu

PDF Pages: 2082-2096 Full Text (2494) Reporting Checklist COI Form Open Access

Radiotherapy for unresectable locally advanced non-small cell lung cancer: a narrative review of the current landscape and future prospects in the era of immunotherapy

Tiantian Guo, Liqing Zou, Jianjiao Ni, Xiao Chu, Zhengfei Zhu

PDF Pages: 2097-2112 Full Text (2564) Reporting Checklist COI Form Open Access

A narrative review of biosimilars: a continued journey from the scientific evidence to practice implementation

Jorge J. García, Luis E. Raez, Daniel Rosas

PDF Pages: 2113-2119 Full Text (2329) Reporting Checklist COI Form Open Access

Radiotherapy for non-small cell lung cancer in the immunotherapy era: the opportunity and challenge—a narrative review

Wu-Yan Xia, Wen Feng, Chen-Chen Zhang, Yu-Jia Shen, Qin Zhang, Wen Yu, Xu-Wei Cai, Xiao-Long Fu

PDF Pages: 2120-2136 Full Text (3082) Reporting Checklist COI Form Open Access

Perspective on treatment for unresectable locally advanced non-small cell lung cancer with oncogene-driven mutation: a narrative review

Liyang Jiang, Xiangjiao Meng, Xianguang Zhao, Ligang Xing, Jinming Yu

PDF Pages: 2137-2144 Full Text (2679) Reporting Checklist COI Form Open Access

Case Report

Novel ALK mutation with durable response to brigatinib—a case report

Hira Latif, Stephen V. Liu

PDF Pages: 2145-2148 Full Text (2555) Reporting Checklist COI Form Open Access

Development of autoimmune diabetes with severe diabetic ketoacidosis and immune-related thyroiditis secondary to durvalumab: a case report

Ana Rita Lopes, Alessandro Russo, Andrew Y. Li, Michael G. McCusker, Jeffrey Myles Kroopnick, Katherine Scilla, Ranee Mehra, Christian Rolfo

PDF Pages: 2149-2156 Full Text (2252) Reporting Checklist COI Form Open Access

A pathological complete response to neoadjuvant chemotherapy and immunotherapy in a non-small cell lung cancer patient

Pengqiang Gao, Hao Chen, Taidui Zeng, Weidong Wu, Guobing Xu, Chi Xu, Bin Zheng, Yong Zhu, Wei Zheng, Chun Chen

PDF Pages: 2157-2160 Full Text (2170) Reporting Checklist COI Form Open Access

Editorial Commentary

New fissure-attached nodules in lung cancer screening: more practical implications from the NELSON study?

Helen Morgan, Emma L. O’Dowd, Arjun Nair, David R. Baldwin

PDF Pages: 2161-2164 Full Text (2758) COI Form Open Access

FLAURA strikes again: efficacy of osimertinib is independent of PD-L1 expression

Pamela Abdayem, David Planchard

PDF Pages: 2165-2172 Full Text (2233) COI Form Open Access

Finding chinks in the osimertinib resistance armor

Jose Luis Leal, Benjamin Solomon, Thomas John

PDF Pages: 2173-2177 Full Text (989) COI Form Open Access

HER2-D16 oncogenic driver mutation confers osimertinib resistance in EGFR mutation-positive non-small cell lung cancer

Toshimitsu Yamaoka, Junji Tsurutani, Hironori Sagara, Tohru Ohmori

PDF Pages: 2178-2183 Full Text (1645) COI Form Open Access

The KEYNOTE-189 trial as a new paradigm making cure a reality for metastatic non-squamous non-small cell lung cancer

Yanye Wang, Shikang Zhao, Jun Chen, Song Xu

PDF Pages: 2184-2187 Full Text (2654) COI Form Open Access

Letter to the Editor

Meningeal metastasis patients with EGFR G724S who develop resistance to osimertinib benefit from the addition of afatinib

Yibin Li, Yantang Lin, Jingxun Wu, Feng Ye

PDF Pages: 2188-2190 Full Text (1305) COI Form Open Access

Editorial on New Developments in Lung Cancer Diagnosis and Pathological Patient Management Strategies¹

New developments in lung cancer diagnosis and pathological patient management strategies

Helmut Popper

PDF Pages: 2191-2193 Full Text (997) COI Form Open Access

Outsourcing predictive biomarker testing in non-small cell carcinoma: a personal view of pathologists

Luka Brcic, Izidor Kern

PDF Pages: 2194-2198 Full Text (1122) COI Form Open Access

Review Article on New Developments in Lung Cancer Diagnosis and Pathological Patient Management Strategies¹

New insights into the interaction of the immune system with non-small cell lung carcinomas

Paul Hofman

PDF Pages: 2199-2213 Full Text (2525) COI Form Open Access

Patient-derived cell line, xenograft and organoid models in lung cancer therapy

Ku-Geng Huo, Elisa D’Arcangelo, Ming-Sound Tsao

PDF Pages: 2214-2232 Full Text (9679) COI Form Open Access

New molecular classification of large cell neuroendocrine carcinoma and small cell lung carcinoma with potential therapeutic impacts

Sylvie Lantuejoul, Lynnette Fernandez-Cuesta, Francesca Damiola, Nicolas Girard, Anne McLeer

PDF Pages: 2233-2244 Full Text (8307) COI Form Open Access

How should molecular findings be integrated in the classification for lung cancer?

Yin P. Hung, Lucian R. Chirieac

PDF Pages: 2245-2254 Full Text (2207) COI Form Open Access

A narrative review of digital pathology and artificial intelligence: focusing on lung cancer

Taro Sakamoto, Tomoi Furukawa, Kris Lami, Hoa Hoang Ngoc Pham, Wataru Uegami, Kishio Kuroda, Masataka Kawai, Hidenori Sakanashi, Lee Alex Donald Cooper, Andrey Bychkov, Junya Fukuoka

PDF Pages: 2255-2276 Full Text (10954) Reporting Checklist Peer Review File COI Form Open Access

Primary tumor and metastasis—sectioning the different steps of the metastatic cascade

Helmut Popper

PDF Pages: 2277-2300 Full Text (5342) COI Form Open Access

Erratum

Erratum to clinical impact of the lung tissue transcriptome in a teenager with multifocal invasive mucinous adenocarcinoma—a case report

Emma Di Carlo, Giuseppe Cipollone, Felice Mucilli, Carlo Sorrentino

PDF Pages: 2301 Full Text (736) Open Access

Disclosure:

1. The series “New Developments in Lung Cancer Diagnosis and Pathological Patient Management Strategies” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Helmut Popper served as the unpaid Guest Editor for the series.

Vol 9, No 5 (October 28, 2020): Translational Lung Cancer Research