Vol 9, No 5 (October 28, 2020): Translational Lung Cancer Research

Editorial

Can CT radiomics differentiate benign from malignant N2 adenopathy in non-small cell lung cancer
Robert J. Cerfolio, William H. Moore
Translational Lung Cancer Research  
2020;
9
(5)
:1710-1711
.
On the way of the new strategies aimed to improve the efficacy of PD-1/PD-L1 immune checkpoint blocking mAbs in small cell lung cancer
Pierpaolo Correale, Rocco Giannicola, Rita Emilena Saladino, Valerio Nardone, Luigi Pirtoli, Pierfrancesco Tassone, Amalia Luce, Salvatore Cappabianca, Marianna Scrima, Pierosandro Tagliaferri, Michele Caraglia
Translational Lung Cancer Research  
2020;
9
(5)
:1712-1719
.
EGFR tyrosine kinase inhibitors (TKIs) for adjuvant therapy of early-stage non-small cell lung cancer (NSCLC): ready for the clinic?
Conor E. Steuer, Suresh S. Ramalingam
Translational Lung Cancer Research  
2020;
9
(5)
:1720-1723
.
Adjuvant epidermal growth factor receptor tyrosine kinase inhibitors: are we actually ready?
Fabrizio Tabbò, Maria Lucia Reale, Silvia Novello
Translational Lung Cancer Research  
2020;
9
(5)
:1724-1727
.
Adjuvant TKI therapy in resected EGFR-mutant non-small-cell lung cancer—ready for prime time?
Surein Arulananda, Thomas John
Translational Lung Cancer Research  
2020;
9
(5)
:1728-1731
.
Second-line therapy for disseminated small-cell lung cancer: optimal management remains to be defined
Christos Chouaïd, Nathalie Baize, Isabelle Monnet
Translational Lung Cancer Research  
2020;
9
(5)
:1732-1735
.

Original Article

Nivolumab in pre-treated advanced non-small cell lung cancer: long term follow up data from the Dutch expanded access program and routine clinical care
Robert D. Schouten, Lucie Egberink, Mirte Muller, Cornedine J. De Gooijer, Erik van Werkhoven, Michel M. van den Heuvel, Paul Baas
Translational Lung Cancer Research  
2020;
9
(5)
:1736-1748
.
The different central nervous system efficacy among gefitinib, erlotinib and afatinib in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer
Hyun Ae Jung, Sook Young Woo, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun
Translational Lung Cancer Research  
2020;
9
(5)
:1749-1758
.
KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples
Herbert Ho-Fung Loong, Nan Du, Chunyan Cheng, Hanqing Lin, Jian Guo, Gen Lin, Mingjiang Li, Tao Jiang, Zhihua Shi, Yanzhi Cui, Xianfeng Jin, Jicheng Yao, Yutong Xing, Ming Yao, Kai Wang, Tony S. K. Mok, Lunxu Liu
Translational Lung Cancer Research  
2020;
9
(5)
:1759-1769
.
The effect of PD-L1 categories-directed pembrolizumab plus chemotherapy for newly diagnosed metastatic non-small-cell lung cancer: a cost-effectiveness analysis
Bin Wu, Shun Lu
Translational Lung Cancer Research  
2020;
9
(5)
:1770-1784
.
Treatments for combined small cell lung cancer patients
Jiaxi He, Songhui Xu, Hui Pan, Shuben Li, Jianxing He
Translational Lung Cancer Research  
2020;
9
(5)
:1785-1794
.
Ex vivo culture of circulating tumour cells derived from non-small cell lung cancer
Joanna Kapeleris, Arutha Kulasinghe, Majid Ebrahimi Warkiani, Connor Oleary, Ian Vela, Paul Leo, Peter Sternes, Kenneth O’Byrne, Chamindie Punyadeera
Translational Lung Cancer Research  
2020;
9
(5)
:1795-1809
.
SRC and PIM1 as potential co-targets to overcome resistance in MET deregulated non-small cell lung cancer
Ilaria Attili, Laura Bonanno, Niki Karachaliou, Jillian Wilhelmina Paulina Bracht, Jordi Berenguer, Carles Codony-Servat, Jordi Codony-Servat, Erika Aldeguer, Ana Gimenez-Capitan, Alessandro Dal Maso, Matteo Fassan, Imane Chaib, Miguel Angel Molina-Vila, Antonio Passaro, Filippo de Marinis, Giulia Pasello, Valentina Guarneri, Pier Franco Conte, Rafael Rosell
Translational Lung Cancer Research  
2020;
9
(5)
:1810-1821
.
Significant diaphragm elevation suggestive of phrenic nerve injury after thoracoscopic lobectomy for lung cancer: an underestimated problem
Luigi Ventura, Weigang Zhao, Tangbing Chen, Zhexin Wang, Jian Feng, Zhitao Gu, Chunyu Ji, Wentao Fang
Translational Lung Cancer Research  
2020;
9
(5)
:1822-1830
.
Interactions between the enhanced recovery after surgery pathway and risk factors for lung infections after pulmonary malignancy operation
Xianfei Zhang, Runsen Jin, Yuyan Zheng, Dingpei Han, Kai Chen, Jian Li, Hecheng Li
Translational Lung Cancer Research  
2020;
9
(5)
:1831-1842
.
Establishment and validation of a mathematical diagnosis model to distinguish benign pulmonary nodules from early non-small cell lung cancer in Chinese people
Qiang Wei, Weizhen Fang, Xi Chen, Zhongzhen Yuan, Yumei Du, Yanbin Chang, Yonghong Wang, Shulin Chen
Translational Lung Cancer Research  
2020;
9
(5)
:1843-1852
.
Pemetrexed-based chemotherapy for non-small-cell lung cancer patients with EGFR exon 20 insertion mutation: a multicenter study
Chun-Wei Xu, Wen-Xian Wang, Dong Wang, Qi-Ming Wang, Xing-Xiang Pu, You-Cai Zhu, Jian-Hui Huang, Zong-Yang Yu, Zhao-Lei Cui, Xiao-Hui Chen, Jin-Luan Li, Yong Fang, Hong Wang, Wu Zhuang, Shi-Jie Lan, Xin Cai, Yin-Bin Zhang, Wen-Bin Gao, Li-Ping Wang, Ke-Lin She, Chuang-Zhou Rao, Yue-Fen Zhou, Mei-Yu Fang, Li-Yun Miao, Lei Lei, Tang-Feng Lv, Yong Song, on behalf of AME Lung Cancer Collaborative Group
Translational Lung Cancer Research  
2020;
9
(5)
:1853-1861
.
Stereotactic body radiation therapy for empirically treated hypermetabolic lung lesions: a single-institutional experience identifying the Charlson score as a key prognostic factor
Roman O. Kowalchuk, Michael R. Waters, Sujith Baliga, K. Martin Richardson, Kelly M. Spencer, James M. Larner, Charles R. Kersh
Translational Lung Cancer Research  
2020;
9
(5)
:1862-1872
.
Longitudinal multi-gene panel assessment of circulating tumor DNA revealed tumor burden and molecular characteristics along treatment course of non-small cell lung cancer
Gloria Y. F. Ho, Tao Wang, Hoi-Hin Kwok, Rehana Rasul, Rita Peila, Maria Guzman, Mary S. M. Ip, David C. L. Lam
Translational Lung Cancer Research  
2020;
9
(5)
:1873-1884
.
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma
Chaoyang Liang, Xiaowei Wang, Zhenrong Zhang, Fei Xiao, Hongxiang Feng, Qianli Ma, Jingjing Huang, Guangliang Qiang, Dingrong Zhong, Deruo Liu
Translational Lung Cancer Research  
2020;
9
(5)
:1885-1903
.
Epithelial-to-mesenchymal transition is a resistance mechanism to sequential MET-TKI treatment of MET-amplified EGFR-TKI resistant non-small cell lung cancer cells
Michelle Simone Clement, Kristine Raaby Gammelgaard, Anders Lade Nielsen, Boe Sandahl Sorensen
Translational Lung Cancer Research  
2020;
9
(5)
:1904-1914
.
Prognostic implications of preoperative versus postoperative circulating tumor DNA in surgically resected lung cancer patients: a pilot study
Shuta Ohara, Kenichi Suda, Kazuko Sakai, Masaya Nishino, Masato Chiba, Masaki Shimoji, Toshiki Takemoto, Toshio Fujino, Takamasa Koga, Akira Hamada, Junichi Soh, Kazuto Nishio, Tetsuya Mitsudomi
Translational Lung Cancer Research  
2020;
9
(5)
:1915-1923
.
How long is cessation of preoperative smoking required to improve postoperative survival of patients with pathological stage I non-small cell lung cancer?
Toshiyuki Shima, Tomonari Kinoshita, Mao Uematsu, Naomichi Sasaki, Yusuke Sugita, Reiko Shimizu, Masahiko Harada, Tsunekazu Hishima, Hirotoshi Horio
Translational Lung Cancer Research  
2020;
9
(5)
:1924-1939
.
SMO mutations confer poor prognosis in malignant pleural mesothelioma
Diego Signorelli, Claudia Proto, Laura Botta, Annalisa Trama, Marcello Tiseo, Giulia Pasello, Giuseppe Lo Russo, Alessandra Fabbri, Martina Imbimbo, Adele Busico, Arsela Prelaj, Roberto Ferrara, Giulia Galli, Alessandro De Toma, Elena Tamborini, Ugo Pastorino, Filippo de Braud, Gemma Gatta, Marina Chiara Garassino, Monica Ganzinelli
Translational Lung Cancer Research  
2020;
9
(5)
:1940-1951
.
Low T790M relative allele frequency indicates concurrent resistance mechanisms and poor responsiveness to osimertinib
Ye Wang, Yanqi He, Panwen Tian, Weiya Wang, Ke Wang, Shannon Chuai, Yalun Li, Shuang Zhao, Yu Wang, Weimin Li
Translational Lung Cancer Research  
2020;
9
(5)
:1952-1962
.
A pilot study of the ultrathin cryoprobe in the diagnosis of peripheral pulmonary ground-glass opacity lesions
Simin Jiang, Xiaojun Liu, Junxiang Chen, Haifeng Ma, Fangfang Xie, Jiayuan Sun
Translational Lung Cancer Research  
2020;
9
(5)
:1963-1973
.
Enumeration and molecular characterization of circulating tumor cells enriched by microcavity array from stage III non-small cell lung cancer patients
Evan N. Cohen, Gitanjali Jayachandran, Hui Gao, Wei Qiao, Suyu Liu, Jianzhong He, Yawei Qiao, Luyang Yao, Steven H. Lin, James M. Reuben
Translational Lung Cancer Research  
2020;
9
(5)
:1974-1985
.
Is clinical target volume necessary?—a failure pattern analysis in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy using intensity-modulated radiotherapy technique
Liqing Zou, Li Chu, Fan Xia, Lijun Zhou, Xi Yang, Jianjiao Ni, Junchao Chen, Zhengfei Zhu
Translational Lung Cancer Research  
2020;
9
(5)
:1986-1995
.
Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio associations with heart and body dose and their effects on patient outcomes in locally advanced non-small cell lung cancer treated with definitive radiotherapy
Wu-Yan Xia, Xue-Ru Zhu, Wen Feng, Jun Liu, Jia-Ming Wang, Chang-Xing Lv, Qin Zhang, Wen Yu, Xu-Wei Cai, Xiao-Long Fu
Translational Lung Cancer Research  
2020;
9
(5)
:1996-2007
.

Study Protocol

GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/ unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy
Qing Zhou, Ming Chen, Gang Wu, Jian-Hua Chang, Ou Jiang, Jiu-Wei Cui, Guang Han, Qin Lin, Jian Fang, Gong-Yan Chen, Yi-Long Wu
Translational Lung Cancer Research  
2020;
9
(5)
:2008-2015
.
Evaluating the diagnostic accuracy of a ctDNA methylation classifier for incidental lung nodules: protocol for a prospective, observational, and multicenter clinical trial of 10,560 cases
Wenhua Liang, Dan Liu, Min Li, Wei Wang, Zheng Qin, Jian Zhang, Yong Zhang, Yang Hu, Hairong Bao, Yi Xiang, Bo Wang, Jing Wu, Jianyu Sun, Chengping Hu, Xianwei Ye, Xiangyan Zhang, Wei Xiao, Chunmei Yun, Dejun Sun, Wei Wang, Ning Chang, Yunhui Zhang, Jianping Zhao, Xin Zhang, Jinfu Xu, Di Wu, Xiaoju Liu, Yubiao Guo, Qichuan Zhang, Wei Zhang, Lan Yang, Zhanqing Li, Xiaoju Zhang, Baohui Han, Zhaohui Tong, Jianxing He, Jieming Qu, Jian-Bing Fan, Nanshan Zhong
Translational Lung Cancer Research  
2020;
9
(5)
:2016-2026
.

Technical Note

Dynamic titanium prosthesis based on 3D-printed replica for chest wall resection and reconstruction
Jacopo Vannucci, Elisa Scarnecchia, Rossella Potenza, Silvia Ceccarelli, Donato Monopoli, Francesco Puma
Translational Lung Cancer Research  
2020;
9
(5)
:2027-2032
.

Review Article

Optimizing current standard of care therapy for stage III non-small cell lung cancer
Vivek Verma, Steven H. Lin
Translational Lung Cancer Research  
2020;
9
(5)
:2033-2039
.
A narrative review of toxicity of chemoradiation and immunotherapy for unresectable, locally advanced non-small cell lung cancer
Rahul N. Prasad, Terence M. Williams
Translational Lung Cancer Research  
2020;
9
(5)
:2040-2050
.
Narrative review of the emerging role of molecular biomarkers in guiding the definitive management of unresectable non-small cell lung cancer
Eric K. Singhi, Carl M. Gay
Translational Lung Cancer Research  
2020;
9
(5)
:2051-2058
.
Treatment of stage III non-small cell lung cancer in the era of immunotherapy: pathological complete response to neoadjuvant pembrolizumab and chemotherapy
Zhang-Ru Yang, Mi-Na Liu, Jia-Hua Yu, Yun-Hai Yang, Tian-Xiang Chen, Yu-Chen Han, Lei Zhu, Ji-Kai Zhao, Xiao-Long Fu, Xu-Wei Cai
Translational Lung Cancer Research  
2020;
9
(5)
:2059-2073
.
A narrative review of lung cancer cytology in the times of coronavirus: what physicians should know
Pasquale Pisapia, Umberto Malapelle, Maria Salatiello, Rafael Rosell, Giancarlo Troncone
Translational Lung Cancer Research  
2020;
9
(5)
:2074-2081
.
A narrative review of synergistic drug administration in unresectable locally advanced non-small cell lung cancer: current landscape and future prospects in the era of immunotherapy
Shuyan Li, Xiao Chu, Luxi Ye, Jianjiao Ni, Zhengfei Zhu
Translational Lung Cancer Research  
2020;
9
(5)
:2082-2096
.
Radiotherapy for unresectable locally advanced non-small cell lung cancer: a narrative review of the current landscape and future prospects in the era of immunotherapy
Tiantian Guo, Liqing Zou, Jianjiao Ni, Xiao Chu, Zhengfei Zhu
Translational Lung Cancer Research  
2020;
9
(5)
:2097-2112
.
A narrative review of biosimilars: a continued journey from the scientific evidence to practice implementation
Jorge J. García, Luis E. Raez, Daniel Rosas
Translational Lung Cancer Research  
2020;
9
(5)
:2113-2119
.
Radiotherapy for non-small cell lung cancer in the immunotherapy era: the opportunity and challenge—a narrative review
Wu-Yan Xia, Wen Feng, Chen-Chen Zhang, Yu-Jia Shen, Qin Zhang, Wen Yu, Xu-Wei Cai, Xiao-Long Fu
Translational Lung Cancer Research  
2020;
9
(5)
:2120-2136
.
Perspective on treatment for unresectable locally advanced non-small cell lung cancer with oncogene-driven mutation: a narrative review
Liyang Jiang, Xiangjiao Meng, Xianguang Zhao, Ligang Xing, Jinming Yu
Translational Lung Cancer Research  
2020;
9
(5)
:2137-2144
.

Case Report

Novel ALK mutation with durable response to brigatinib—a case report
Hira Latif, Stephen V. Liu
Translational Lung Cancer Research  
2020;
9
(5)
:2145-2148
.
Development of autoimmune diabetes with severe diabetic ketoacidosis and immune-related thyroiditis secondary to durvalumab: a case report
Ana Rita Lopes, Alessandro Russo, Andrew Y. Li, Michael G. McCusker, Jeffrey Myles Kroopnick, Katherine Scilla, Ranee Mehra, Christian Rolfo
Translational Lung Cancer Research  
2020;
9
(5)
:2149-2156
.
A pathological complete response to neoadjuvant chemotherapy and immunotherapy in a non-small cell lung cancer patient
Pengqiang Gao, Hao Chen, Taidui Zeng, Weidong Wu, Guobing Xu, Chi Xu, Bin Zheng, Yong Zhu, Wei Zheng, Chun Chen
Translational Lung Cancer Research  
2020;
9
(5)
:2157-2160
.

Editorial Commentary

New fissure-attached nodules in lung cancer screening: more practical implications from the NELSON study?
Helen Morgan, Emma L. O’Dowd, Arjun Nair, David R. Baldwin
Translational Lung Cancer Research  
2020;
9
(5)
:2161-2164
.
FLAURA strikes again: efficacy of osimertinib is independent of PD-L1 expression
Pamela Abdayem, David Planchard
Translational Lung Cancer Research  
2020;
9
(5)
:2165-2172
.
Finding chinks in the osimertinib resistance armor
Jose Luis Leal, Benjamin Solomon, Thomas John
Translational Lung Cancer Research  
2020;
9
(5)
:2173-2177
.
HER2-D16 oncogenic driver mutation confers osimertinib resistance in EGFR mutation-positive non-small cell lung cancer
Toshimitsu Yamaoka, Junji Tsurutani, Hironori Sagara, Tohru Ohmori
Translational Lung Cancer Research  
2020;
9
(5)
:2178-2183
.
The KEYNOTE-189 trial as a new paradigm making cure a reality for metastatic non-squamous non-small cell lung cancer
Yanye Wang, Shikang Zhao, Jun Chen, Song Xu
Translational Lung Cancer Research  
2020;
9
(5)
:2184-2187
.

Letter to the Editor

Meningeal metastasis patients with EGFR G724S who develop resistance to osimertinib benefit from the addition of afatinib
Yibin Li, Yantang Lin, Jingxun Wu, Feng Ye
Translational Lung Cancer Research  
2020;
9
(5)
:2188-2190
.

Editorial on New Developments in Lung Cancer Diagnosis and Pathological Patient Management Strategies1

New developments in lung cancer diagnosis and pathological patient management strategies
Helmut Popper
Translational Lung Cancer Research  
2020;
9
(5)
:2191-2193
.
Outsourcing predictive biomarker testing in non-small cell carcinoma: a personal view of pathologists
Luka Brcic, Izidor Kern
Translational Lung Cancer Research  
2020;
9
(5)
:2194-2198
.

Review Article on New Developments in Lung Cancer Diagnosis and Pathological Patient Management Strategies1

New insights into the interaction of the immune system with non-small cell lung carcinomas
Paul Hofman
Translational Lung Cancer Research  
2020;
9
(5)
:2199-2213
.
Patient-derived cell line, xenograft and organoid models in lung cancer therapy
Ku-Geng Huo, Elisa D’Arcangelo, Ming-Sound Tsao
Translational Lung Cancer Research  
2020;
9
(5)
:2214-2232
.
New molecular classification of large cell neuroendocrine carcinoma and small cell lung carcinoma with potential therapeutic impacts
Sylvie Lantuejoul, Lynnette Fernandez-Cuesta, Francesca Damiola, Nicolas Girard, Anne McLeer
Translational Lung Cancer Research  
2020;
9
(5)
:2233-2244
.
How should molecular findings be integrated in the classification for lung cancer?
Yin P. Hung, Lucian R. Chirieac
Translational Lung Cancer Research  
2020;
9
(5)
:2245-2254
.
A narrative review of digital pathology and artificial intelligence: focusing on lung cancer
Taro Sakamoto, Tomoi Furukawa, Kris Lami, Hoa Hoang Ngoc Pham, Wataru Uegami, Kishio Kuroda, Masataka Kawai, Hidenori Sakanashi, Lee Alex Donald Cooper, Andrey Bychkov, Junya Fukuoka
Translational Lung Cancer Research  
2020;
9
(5)
:2255-2276
.
Primary tumor and metastasis—sectioning the different steps of the metastatic cascade
Helmut Popper
Translational Lung Cancer Research  
2020;
9
(5)
:2277-2300
.

Erratum

Erratum to clinical impact of the lung tissue transcriptome in a teenager with multifocal invasive mucinous adenocarcinoma—a case report
Emma Di Carlo, Giuseppe Cipollone, Felice Mucilli, Carlo Sorrentino
Translational Lung Cancer Research  
2020;
9
(5)
:2301
.

Disclosure:

1. The series “New Developments in Lung Cancer Diagnosis and Pathological Patient Management Strategies” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Helmut Popper served as the unpaid Guest Editor for the series.