Vol 10, No 4 (April 29, 2021): Translational Lung Cancer Research

Original Article

Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma: an international multicenter study
Luka Brcic, Thomas Klikovits, Zsolt Megyesfalvi, Berta Mosleh, Katharina Sinn, Richard Hritcu, Viktoria Laszlo, Tanja Cufer, Ales Rozman, Izidor Kern, Katja Mohorcic, Marko Jakopovic, Miroslav Samarzija, Sven Seiwerth, Vitezslav Kolek, Ondřej Fischer, Petr Jakubec, Jozef Škarda, Balazs Gieszer, Balazs Hegedus, Janos Fillinger, Ferenc Renyi-Vamos, Anna Buder, Agnes Bilecz, Walter Berger, Michael Grusch, Konrad Hoetzenecker, Walter Klepetko, Mir Alireza Hoda, Martin Filipits, Balazs Dome
Translational Lung Cancer Research  
2021;
10
(4)
:1594-1607
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 (29 April 2021) 
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Transbronchial microwave ablation of lung nodules with electromagnetic navigation bronchoscopy guidance—a novel technique and initial experience with 30 cases
Joyce W. Y. Chan, Rainbow W. H. Lau, Jenny C. L. Ngai, Carita Tsoi, Cheuk Man Chu, Tony S. K. Mok, Calvin S. H. Ng
Translational Lung Cancer Research  
2021;
10
(4)
:1608-1622
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 (29 April 2021) 
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Plasma pre-treatment T790M relative allelic frequency in patients with advanced EGFR-mutated non-small cell lung cancer predicts treatment response to subsequent-line osimertinib
Pei N. Ding, Tara L. Roberts, Wei Chua, Therese M. Becker, Nicole Caixeiro, Paul de Souza, Bo Gao, Chee K. Lee, Malinda Itchins, Helen Westman, Stephen Clarke, Prunella Blinman, Steven Kao, Tom John, Jose L. Leal, Victoria J. Bray
Translational Lung Cancer Research  
2021;
10
(4)
:1623-1634
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 (29 April 2021) 
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Is flexible bronchoscopy necessary in the preoperative workup of patients with peripheral cT1N0 subsolid lung cancer? —a prospective multi-center cohort study
Ting Ye, Zongwei Chen, Dongchun Ma, Sufeng Chen, Guozhan Xia, Yiliang Zhang, Hang Li, Yang Zhang, Xiaoyang Luo, Longsheng Miao, Longfei Ma, Yihua Sun, Yunjian Pan, Hong Hu, Yawei Zhang, Jiaqing Xiang, Longlong Shao, Haoxuan Wu, Bin Li, Qingyuan Huang, Xiao Ma, Difan Zheng, Shanbo Zheng, Chongze Yuan, Tao Yu, Yunyun Lu, Yuan Li, Qiao Li, Yajia Gu, Shengping Wang, Di Ge, Jie Gu, Feng Zhu, Jingshun Zhang, Fudong Wang, Yuan Weng, Chunyi Jia, Shilei Liu, Wenqun Xing, Kaihong Lin, Shaoqing Tang, Bin Qian, Michael Hsin, Haiquan Chen
Translational Lung Cancer Research  
2021;
10
(4)
:1635-1641
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 (29 April 2021) 
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Impact of docetaxel plus ramucirumab on metastatic site in previously treated patients with non-small cell lung cancer: a multicenter retrospective study
Kinnosuke Matsumoto, Akihiro Tamiya, Yoshinobu Matsuda, Yoshihiko Taniguchi, Shinji Atagi, Hayato Kawachi, Motohiro Tamiya, Satoshi Tanizaki, Junji Uchida, Kiyonobu Ueno, Takafumi Yanase, Hidekazu Suzuki, Tomonori Hirashima
Translational Lung Cancer Research  
2021;
10
(4)
:1642-1652
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 (29 April 2021) 
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EPAC-lung: European pooled analysis of the prognostic value of circulating tumour cells in small cell lung cancer
Victoria Foy, Colin R. Lindsay, Alexandra Carmel, Fabiola Fernandez-Gutierrez, Matthew G. Krebs, Lynsey Priest, Mathew Carter, Harry J. M. Groen, T. Jeroen. N. Hiltermann, Antonella de Luca, Francoise Farace, Benjamin Besse, Leon Terstappen, Elisabetta Rossi, Alessandro Morabito, Francesco Perrone, Andrew Renehan, Corinne Faivre-Finn, Nicola Normanno, Caroline Dive, Fiona Blackhall, Stefan Michiels
Translational Lung Cancer Research  
2021;
10
(4)
:1653-1665
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 (29 April 2021) 
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Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma
Daniel Kazdal, Eugen Rempel, Cristiano Oliveira, Michael Allgäuer, Alexander Harms, Kerstin Singer, Elke Kohlwes, Steffen Ormanns, Ludger Fink, Jörg Kriegsmann, Michael Leichsenring, Katharina Kriegsmann, Fabian Stögbauer, Luca Tavernar, Jonas Leichsenring, Anna-Lena Volckmar, Rémi Longuespée, Hauke Winter, Martin Eichhorn, Claus Peter Heußel, Felix Herth, Petros Christopoulos, Martin Reck, Thomas Muley, Wilko Weichert, Jan Budczies, Michael Thomas, Solange Peters, Arne Warth, Peter Schirmacher, Albrecht Stenzinger, Mark Kriegsmann
Translational Lung Cancer Research  
2021;
10
(4)
:1666-1678
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 (29 April 2021) 
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Identification of PD-1 ligands: PD-L1 and PD-L2 on macrophages in lung cancer milieu by flow cytometry
Iwona Kwiecień, Elżbieta Rutkowska, Małgorzata Polubiec-Kownacka, Agata Raniszewska, Piotr Rzepecki, Joanna Domagała-Kulawik
Translational Lung Cancer Research  
2021;
10
(4)
:1679-1689
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 (29 April 2021) 
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A nomogram for predicting overall survival in patients with resected non-small cell lung cancer treated with chemotherapy
Yuan Zeng, Nicholas Mayne, Chi-Fu Jeffrey Yang, Jun Liu, Fei Cui, Jingpei Li, Wenhua Liang, Jianxing He, written on behalf of the AME Thoracic Surgery Collaborative Group
Translational Lung Cancer Research  
2021;
10
(4)
:1690-1699
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 (29 April 2021) 
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Blood transfusions may adversely affect survival outcomes of patients with lung cancer: a systematic review and meta-analysis
Sukjoo Cho, Jonghanne Park, Misuk Lee, Dongyup Lee, Horyun Choi, Gahyun Gim, Leeseul Kim, Cyra Y. Kang, Youjin Oh, Pedro Viveiros, Elena Vagia, Michael S. Oh, Geum Joon Cho, Ankit Bharat, Young Kwang Chae
Translational Lung Cancer Research  
2021;
10
(4)
:1700-1710
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 (29 April 2021) 
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Watershed analysis of the target pulmonary artery for real-time localization of non-palpable pulmonary nodules
Xiang-Peng Chu, Zi-Hao Chen, Shao-Min Lin, Jia-Tao Zhang, Zhao-Wen Qiu, Wen-Fang Tang, Rui Fu, Zhen-Bin Qiu, Xue-Ning Yang, Yi-Long Wu, Qiang Nie, Wen-Zhao Zhong
Translational Lung Cancer Research  
2021;
10
(4)
:1711-1719
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 (29 April 2021) 
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Age at first birth and lung cancer: a two-sample Mendelian randomization study
Haoxin Peng, Xiangrong Wu, Yaokai Wen, Xiaoqin Du, Caichen Li, Hengrui Liang, Jinsheng Lin, Jun Liu, Fan Ge, Zhenyu Huo, Jianxing He, Wenhua Liang
Translational Lung Cancer Research  
2021;
10
(4)
:1720-1733
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 (29 April 2021) 
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Presentation of EGFR mutations in 162 family probands with multiple primary lung cancer
Chunxiang Li, Yalong Wang, Kai Su, Yu Liu, Liyu Wang, Bo Zheng, Na Yan, Dawei Yuan, Yanxiang Zhang, Liyan Xue, Shugeng Gao, Jie He
Translational Lung Cancer Research  
2021;
10
(4)
:1734-1746
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 (29 April 2021) 
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Distinct patterns of somatic genomic alterations and mutational signatures in central and peripheral-type small-cell lung cancer
Lei Wang, Jing Wang, Juanni Hu, Lele Song, Jian Ni, Yayi He, Caicun Zhou
Translational Lung Cancer Research  
2021;
10
(4)
:1747-1760
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 (29 April 2021) 
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Spanish Lung Cancer Group SCAT trial: surgical audit to lymph node assessment based on IASLC recommendations
José Ramón Jarabo Sarceda, Sergio Bolufer Nadal, Roberto Mongil Poce, Pedro López de Castro, Ramón Moreno Balsalobre, Juan Carlos Peñalver Cuesta, Raul Embún Flor, Joaquín Pac Ferrer, Francisco Javier Algar Algar, Antonio Pablo Gámez García, Marcelo F. Jiménez, Jesús Gabriel Sales-Badía, Eva Pereira, Bartomeu Massuti, Mariano Provencio, Florentino Hernando Trancho
Translational Lung Cancer Research  
2021;
10
(4)
:1761-1772
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 (29 April 2021) 
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MicroRNA expression profiling and biomarker validation in treatment-naïve and drug resistant non-small cell lung cancer
Lauren MacDonagh, Michael F. Gallagher, Brendan Ffrench, Claudia Gasch, Steven G. Gray, Marie Reidy, Siobhan Nicholson, Niamh Leonard, Ronan Ryan, Vincent Young, John J. O’Leary, Sinead Cuffe, Stephen P. Finn, Kenneth J. O’Byrne, Martin P. Barr
Translational Lung Cancer Research  
2021;
10
(4)
:1773-1791
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 (29 April 2021) 
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Genomic evolutionary trajectory of metastatic squamous cell carcinoma of the lung
Arthur Krause, Luca Roma, Thomas Lorber, Tanja Dietsche, Valeria Perrina, David C. Müller, Didier Lardinois, Christian Ruiz, Spasenija Savic Prince, Salvatore Piscuoglio, Charlotte KY Ng, Lukas Bubendorf
Translational Lung Cancer Research  
2021;
10
(4)
:1792-1803
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 (29 April 2021) 
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Role of the epithelial-mesenchymal transition-related circular RNA, circ-10720, in non-small-cell lung cancer
Jara Martín, Joan Josep Castellano, Ramón María Marrades, Jordi Canals, Nuria Viñolas, Tania Díaz, Laureano Molins, Daniel Martinez, Bing Han, Jorge Moisés, Yangyi He, Mariano Monzó, Alfons Navarro
Translational Lung Cancer Research  
2021;
10
(4)
:1804-1818
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 (29 April 2021) 
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Safety and efficacy of anti-PD-1 inhibitors in Chinese patients with advanced lung cancer and hepatitis B virus infection: a retrospective single-center study
Fei Xu, Zhu Zeng, Bing Yan, Yiqi Fu, Yilan Sun, Guangdie Yang, Lingfang Tu, Satoshi Watanabe, Salma K. Jabbour, Sara Bravaccini, Francesca Fanini, Jianying Zhou, Yihong Shen
Translational Lung Cancer Research  
2021;
10
(4)
:1819-1828
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 (29 April 2021) 
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Derivation and validation of a nomogram model for pulmonary thromboembolism in patients undergoing lung cancer surgery
Yuping Li, Lei Shen, Junrong Ding, Dong Xie, Jian Yang, Yanfeng Zhao, Angelo Carretta, René Horsleben Petersen, Sebastien Gilbert, Yasuhiro Hida, Servet Bölükbas, Hiran C. Fernando, Gening Jiang, Yuming Zhu
Translational Lung Cancer Research  
2021;
10
(4)
:1829-1840
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 (29 April 2021) 
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Let-7b-3p inhibits tumor growth and metastasis by targeting the BRF2-mediated MAPK/ERK pathway in human lung adenocarcinoma
Yongmeng Li, Rui Dong, Ming Lu, Chuanle Cheng, Zitong Feng, Renchang Zhao, Jinghui Liang, Jingyi Han, Jin Jiang, Meng Xu-Welliver, Stéphane Renaud, Hui Tian
Translational Lung Cancer Research  
2021;
10
(4)
:1841-1856
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 (29 April 2021) 
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Targeting histone deacetylase enhances the therapeutic effect of Erastin-induced ferroptosis in EGFR-activating mutant lung adenocarcinoma
Tuo Zhang, Beibei Sun, Chenxi Zhong, Ke Xu, Zhexin Wang, Paul Hofman, Tatsuya Nagano, Antoine Legras, Daniel Breadner, Biagio Ricciuti, Duilio Divisi, Ralph A. Schmid, Ren-Wang Peng, Haitang Yang, Feng Yao
Translational Lung Cancer Research  
2021;
10
(4)
:1857-1872
.
 (29 April 2021) 
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Anlotinib combined with gefitinib can significantly improve the proliferation of epidermal growth factor receptor-mutant advanced non-small cell lung cancer in vitro and in vivo
Tao Li, Yuxian Qian, Chenfei Zhang, Junji Uchino, Mariano Provencio, Yan Wang, Xiangrong Shi, Yan Zhang, Xiaodong Zhang
Translational Lung Cancer Research  
2021;
10
(4)
:1873-1888
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 (29 April 2021) 
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Review Article

A narrative review of tumor-associated macrophages in lung cancer: regulation of macrophage polarization and therapeutic implications
Sahar Sadat Sedighzadeh, Amin Pastaki Khoshbin, Sepideh Razi, Mahsa Keshavarz-Fathi, Nima Rezaei
Translational Lung Cancer Research  
2021;
10
(4)
:1889-1916
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 (29 April 2021) 
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Case Report

Immune-checkpoint inhibitors for lung cancer patients amid the COVID-19 pandemic: a case report of severe meningoencephalitis after switching to an extended-interval higher flat-dose nivolumab regimen
Anna Pous, Cristina Izquierdo, Marc Cucurull, Silvia Sánchez, Clara Lezcano, Marta Domenech, Laia Llobera, Andrea Plaja, Teresa Moran
Translational Lung Cancer Research  
2021;
10
(4)
:1917-1923
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 (29 April 2021) 
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Editorial Commentary

From CheckMate 227 to CheckMate 9LA: rethinking the status of chemotherapy in the immunotherapy era—chemo-free or chemo-reform?
Haiyi Deng, Chengzhi Zhou
Translational Lung Cancer Research  
2021;
10
(4)
:1924-1927
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 (29 April 2021) 
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Editorial on Radiotherapy in Thoracic Malignancies1

Radiotherapy in thoracic malignancies: the preface
Jacek Jassem, Rafał Dziadziuszko
Translational Lung Cancer Research  
2021;
10
(4)
:1928-1929
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 (29 April 2021) 
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Review Article on Radiotherapy in Thoracic Malignancies1

Stereotactic radiotherapy for early stage non-small cell lung cancer: current standards and ongoing research
Eugenia Vlaskou Badra, Michael Baumgartl, Silvia Fabiano, Aurélien Jongen, Matthias Guckenberger
Translational Lung Cancer Research  
2021;
10
(4)
:1930-1949
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 (29 April 2021) 
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Preoperative and postoperative radiotherapy (RT) for non-small cell lung cancer: still an open question
Paul Van Houtte, Luigi Moretti, Florian Charlier, Martine Roelandts, Dirk Van Gestel
Translational Lung Cancer Research  
2021;
10
(4)
:1950-1959
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 (29 April 2021) 
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Original Article on Radiotherapy in Thoracic Malignancies1

Stage III N2 non-small cell lung cancer treatment: decision-making among surgeons and radiation oncologists
Markus Glatzer, Pawel Leskow, Francesca Caparrotti, Olgun Elicin, Markus Furrer, Franco Gambazzi, André Dutly, Hans Gelpke, Matthias Guckenberger, Jürg Heuberger, Rolf Inderbitzi, Stefano Cafarotti, Wolfram Karenovics, Peter Kestenholz, Gregor Jan Kocher, Peter Kraxner, Thorsten Krueger, Francesco Martucci, Christoph Oehler, Mahmut Ozsahin, Alexandros Papachristofilou, Dirk Wagnetz, Kathrin Zaugg, Daniel Zwahlen, Isabelle Opitz, Paul Martin Putora
Translational Lung Cancer Research  
2021;
10
(4)
:1960-1968
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 (29 April 2021) 
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Review Article on Radiotherapy in Thoracic Malignancies1

Dose and fractionation schedules in radiotherapy for non-small cell lung cancer
Lucyna Kepka, Joanna Socha
Translational Lung Cancer Research  
2021;
10
(4)
:1969-1982
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 (29 April 2021) 
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Challenges in the target volume definition of lung cancer radiotherapy
Susan Mercieca, José S. A. Belderbos, Marcel van Herk
Translational Lung Cancer Research  
2021;
10
(4)
:1983-1998
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 (29 April 2021) 
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Evolving target volume concepts in locally advanced non-small cell lung cancer
Ursula Nestle, Cecile Le Pechoux, Dirk De Ruysscher
Translational Lung Cancer Research  
2021;
10
(4)
:1999-2010
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 (29 April 2021) 
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Tumour motion management in lung cancer: a narrative review
Angela Botticella, Antonin Levy, Guillaume Auzac, Isabelle Chabert, Céline Berthold, Cécile Le Pechoux
Translational Lung Cancer Research  
2021;
10
(4)
:2011-2017
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 (29 April 2021) 
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Concurrent chemoradiotherapy for stage III non-small-cell lung cancer: recent progress and future perspectives (a narrative review)
Małgorzata Łazar-Poniatowska, Artur Bandura, Rafał Dziadziuszko, Jacek Jassem
Translational Lung Cancer Research  
2021;
10
(4)
:2018-2031
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 (29 April 2021) 
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Combining radiotherapy with targeted therapies in non-small cell lung cancer: focus on anti-EGFR, anti-ALK and anti-angiogenic agents
Anna Wrona, Rafał Dziadziuszko, Jacek Jassem
Translational Lung Cancer Research  
2021;
10
(4)
:2032-2047
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 (29 April 2021) 
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An overview of the published and running randomized phase 3 clinical results of radiotherapy in combination with immunotherapy
Ben G. L. Vanneste, Evert J. Van Limbergen, Kobe Reynders, Dirk De Ruysscher
Translational Lung Cancer Research  
2021;
10
(4)
:2048-2058
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 (29 April 2021) 
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Thoracic radiotherapy in small cell lung cancer—a narrative review
Antonin Levy, Angela Botticella, Cécile Le Péchoux, Corinne Faivre-Finn
Translational Lung Cancer Research  
2021;
10
(4)
:2059-2070
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 (29 April 2021) 
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Prophylactic cranial irradiation in SCLC
Rafal Suwinski
Translational Lung Cancer Research  
2021;
10
(4)
:2071-2078
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 (29 April 2021) 
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Controversies in the role of radiotherapy in pleural mesothelioma
Gerard G. Hanna, Thomas John, David L. Ball
Translational Lung Cancer Research  
2021;
10
(4)
:2079-2087
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 (29 April 2021) 
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Radiotherapy for thymic epithelial tumours: a review
Krisztian Süveg, Paul Martin Putora, Markus Joerger, Thomas Iseli, Galina Farina Fischer, Karlheinz Ammann, Markus Glatzer
Translational Lung Cancer Research  
2021;
10
(4)
:2088-2100
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 (29 April 2021) 
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Erratum

Erratum to latest CT technologies in lung cancer screening: protocols and radiation dose reduction
Editorial Office
Translational Lung Cancer Research  
2021;
10
(4)
:2101-2102
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 (29 April 2021) 
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Disclosure:

1. The series “Radiotherapy in Thoracic Malignancies” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Jacek Jassem and Rafał Dziadziuszko served as the unpaid Guest Editors for the series.