Vol 12, No 6 (June 30, 2023): Translational Lung Cancer Research

Original Article

Biomarker analysis of the phase II JO25567 study comparing erlotinib with or without bevacizumab in first-line advanced EGFR+ non-small-cell lung cancer
Makoto Nishio, Shinji Atagi, Koichi Goto, Yukio Hosomi, Takashi Seto, Toyoaki Hida, Kazuhiko Nakagawa, Hiroshige Yoshioka, Naoyuki Nogami, Makoto Maemondo, Seisuke Nagase, Isamu Okamoto, Noboru Yamamoto, Yuriko Igawa, Kosei Tajima, Masahiro Fukuoka, Nobuyuki Yamamoto, Kazuto Nishio
Clinical validity of oncogenic driver genes detected from circulating tumor DNA in the blood of lung cancer patients
Sheehyun Kim, Sungjae Kim, Se Hyun Kim, Eun Hee Jung, Koung Jin Suh, Yu Jung Kim, Nak-Jung Kwon, Hyojin Kim, Jin-Haeng Chung, Jong Seok Lee
Real-world analysis of first-line afatinib in patients with EGFR-mutant non-small cell lung cancer and brain metastasis: survival and prognostic factors
Jehun Kim, Tae Won Jang, Chang Min Choi, Mi Hyun Kim, Sung Yong Lee, Cheol Kyu Park, Yoon Soo Chang, Kye Young Lee, Seung Joon Kim, Sei Hoon Yang, Jeong Seon Ryu, Jeong Eun Lee, Shin Yup Lee, Chan Kwon Park, Sang Hoon Lee, Seung Hun Jang, Seong Hoon Yoon
Personal and clinical characteristics associated with immunotherapy effectiveness in stage IV non-small cell lung cancer
Krishna H. Patel, Naomi Alpert, Stephanie Tuminello, Emanuela Taioli
High NHLRC2 expression is associated with shortened survival in lung adenocarcinoma
Mervi A. Kreus, Siri T. Lehtonen, Johanna M. Mäkinen, H. Elisa Lappi-Blanco, Kirsi E. M. Laitakari, Shirley A. Johnson, Reetta M. L. Hinttala, Riitta L. Kaarteenaho
Homologous recombination pathway gene variants identified by tumor-only sequencing assays in lung carcinoma patients
Ju-Yoon Yoon, Jacquelyn J. Roth, Chase A. Rushton, Jennifer J. D. Morrissette, Katherine L. Nathanson, Roger B. Cohen, Jason N. Rosenbaum
Concordance between cryobiopsy and forceps biopsy specimens in assessment of immunohistochemistry staining for non-small cell lung carcinoma
Kanako Nishimatsu, Yuji Matsumoto, Jumpei Kashima, Tatsuya Imabayashi, Keigo Uchimura, Hideaki Furuse, Ken Masuda, Yuki Shinno, Yusuke Okuma, Tatsuya Yoshida, Yasushi Goto, Hidehito Horinouchi, Noboru Yamamoto, Takaaki Tsuchida, Yuichiro Ohe, Yasushi Yatabe
A pilot study of anlotinib with third-generation epidermal growth factor receptor tyrosine kinase inhibitors in untreated EGFR-mutant patients with advanced non-small cell lung cancer
Ting Li, Kejie Chang, Xin Qiu, Zhirong Lai, Yuanling Luo, Jiaqun Chen, Weize Lv, Zhong Lin, Xiaofeng Pei, Xiangwen Wu, Xiaojin Wang
A comparison of the microbiome composition in lower respiratory tract at different sites in early lung cancer patients
Kai Su, Yibo Gao, Jie He
Treatment options and prognosis of patients with lung squamous cell cancer in situ: a comparative study of lung adenocarcinoma in situ and stage IA lung squamous cell cancer
Kaixuan Zhang, Hao Chen, Yan Jiang, Qiankun Chen, Bo Su, Xiao Zhou
Five-year follow-up after stereotactic body radiotherapy for medically inoperable early-stage non-small cell lung cancer: a multicenter study
Yanling Guo, Yaoyao Zhu, Ran Zhang, Shuangyan Yang, Lucyna Kepka, Gustavo Arruda Viani, Michael T. Milano, Terence T. Sio, Xiaojiang Sun, Hongyu Wu, Ligang Xing, Yaping Xu

Review Article

Patient-led advocacy in ALK-positive lung cancer
Colin Barton, Morhaf Al Achkar, Jennifer A. Blender, Summer Hall Farmen, Raymond B. Hall, Afroditi Maria Konidari, Debbi Martinez, Nancee Pronsati, Marc Rosenzweig, Carla Vass, Emily S. Venanzi, William Westlake, Marc A. T. Muskavitch

Study Protocol

Rechallenge of afatinib for EGFR-mutated non-small cell lung cancer previously treated with osimertinib: a multicenter phase II trial protocol (REAL study)
Taisuke Araki, Shintaro Kanda, Masamichi Komatsu, Kei Sonehara, Kazunari Tateishi, Munetake Takada, Akane Kato, Manabu Yamamoto, Kenichi Nishie, Mineyuki Hama, Toshihiko Agatsuma, Yumiko Kakizaki, Fumiaki Yoshiike, Akemi Matsuo, Tomoshige Chiaki, Kanae Samizo, Yoshiko Takagi, Maki Yamaura, Masayuki Hanaoka, Tomonobu Koizumi

Editorial Commentary

Divide and conquer: towards isoform-specific diagnosis and therapy of KRAS-mutant lung cancer
Anna T. Allemann, Oliver Gautschi
Prolonged disease control with local treatments in oligo-acquired resistance to immune-checkpoint inhibitors
Hugo Arasanz, Idoia Morilla, Maite Martínez-Aguillo, Lucía Teijeira, Ruth Vera, Maria Alsina
Intracranial responses with selective KRAS-G12C inhibitors in non-small cell lung cancer
Kevin Lu, Hatim Husain
CLOCK’ing differences in DNA methylation signatures to understand the molecular etiology of lung cancer
Aaron M. Neely, Minxiao Yang, Crystal N. Marconett
Clinical applications of DNA methylation profiling in lung cancer
Sergio Castro-Gonzalez, Marta Cuadros, Pedro P. Medina
Quantitative spatial profiling of PD-1/PD-L1 interaction in patients with cancer
Taiki Hakozaki
LSD1-targeted therapy—a multi-purpose key to unlock immunotherapy in small cell lung cancer
Martin Sattler, Ravi Salgia
Tarlatamab: the promising immunotherapy on its way from the lab to the clinic
Daolin Tang, Rui Kang