Vol 14, No 1 (January 24, 2025): Translational Lung Cancer Research

Editorial Commentary

Lorlatinib in frontline treatment of advanced ALK-positive non-small cell lung cancer: a highly efficient new standard of care but still challenging to manage
Mylène Wespiser, Aurélie Swalduz, Maurice Pérol
Translational Lung Cancer Research  
2025;
14
(1)
:1-6
.
Advancing leptomeningeal metastases treatment in EGFR-mutated non-small cell lung cancer: lessons from the BLOSSOM trial
Martina Bortolot, Jarno W. J. Huijs, Dieta Brandsma, Annette Compter, Robin M. J. M. van Geel, Lizza E. L. Hendriks
Translational Lung Cancer Research  
2025;
14
(1)
:7-13
.

Original Article

Lobectomy plus lobe-specific lymphadenectomy as the minimum standards of curative resection for hypermetabolic clinical stage IA non-small cell lung cancer
Runze Li, Zhifei Li, Peng Li, Jianchuan Chen, Bin Qiu, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He
Translational Lung Cancer Research  
2025;
14
(1)
:14-26
.
Patient-reported outcomes in the early postoperative period following resection of unilateral multiple pulmonary nodules: implications for surgical decision-making
Qian Hong, Hang Yi, Yan Wang, Wenqi Li, Chang Zhan, Shuai Zhu, Ding Yang, Rui Han, Guochao Zhang, Juwei Mu
Translational Lung Cancer Research  
2025;
14
(1)
:27-39
.
Anlotinib enhances the anti-tumor activity of osimertinib in patients with non-small cell lung cancer by reversing drug resistance
Xin Hua, Xiaodi Wu, Liting Lv, Yanli Gu, Suhua Zhu, Xin Liu, Tangfeng Lv, Yong Song
Translational Lung Cancer Research  
2025;
14
(1)
:40-57
.
Video-assisted mediastinocopic lymphadenectomy (VAMLA) for restaging clinical N2–3 non-small cell lung cancer (NSCLC) after neoadjuvant treatment
Nina Reig-Oussedik, Sergi Call, Carme Obiols, Bruno Garcia-Cabo, José Sanz-Santos, Lucía Reyes Cabanillas-Paredes, Juan Manuel Ochoa-Alba, Mireia Serra-Mitjans, Ramón Rami-Porta
Translational Lung Cancer Research  
2025;
14
(1)
:58-71
.
Association between immunotherapy timing and efficacy in non-small cell lung cancer: a comprehensive analysis at a high-volume specialist centre
Igor Gomez-Randulfe, Mark Pearce, Daniel Netto, Rebecca Ward, Raffaele Califano
Translational Lung Cancer Research  
2025;
14
(1)
:72-80
.
A novel optimization of cone beam CT frequency for lung radiation therapy based on an image-guided radiation therapy protocol and patient classification method
Jinghao Zhou, Arun Gopal, Baoshe Zhang, Huijun Xu, Shifeng Chen, ByongYong Yi, Giovanni Lasio
Translational Lung Cancer Research  
2025;
14
(1)
:81-95
.
Clinical features and outcomes of unresectable locally advanced lung adenocarcinoma with uncommon EGFR mutations: a retrospective multi-center Chinese study
Kunpeng Xu, Xiao-Li Zheng, Ming Chen, Mingyan E, Li Zhang, Jianzhong Cao, Xu Zhang, Xiao Ding, Bing Xia, Lujun Zhao, Hongbin Wang, Jiancheng Li, Chen Hu, Wei Jiang, Hong Ge, Nan Bi, Luhua Wang
Translational Lung Cancer Research  
2025;
14
(1)
:96-106
.
SMARCA4/BRG1-deficient non-small cell lung cancer: clinical, imaging, pathological features, and follow-up results of 23 patients
Xieraili Wumener, Xiaoxing Ye, Yarong Zhang, Tuya E, Jiuhui Zhao, Ying Liang, Jun Zhao
Translational Lung Cancer Research  
2025;
14
(1)
:107-123
.
Potential utility of miRNAs derived from pleural fluid extracellular vesicles to differentiate between benign and malignant pleural effusions
Tian Mun Chee, Caeli J. Zahra, Kwun M. Fong, Ian A. Yang, Rayleen V. Bowman
Translational Lung Cancer Research  
2025;
14
(1)
:124-138
.
Efficacy of adjuvant tegafur-uracil (UFT) in early-stage non-small cell lung cancer with poor prognostic factors
Takuya Watanabe, Masayuki Tanahashi, Eriko Suzuki, Naoko Yoshii, Takuya Kohama, Kensuke Iguchi, Takumi Endo
Translational Lung Cancer Research  
2025;
14
(1)
:139-149
.
Deep learning-based lung cancer risk assessment using chest computed tomography images without pulmonary nodules ≥8 mm
Su Yang, Sang-Heon Lim, Jeong-Ho Hong, Jae Seok Park, Jonghong Kim, Hae Won Kim
Translational Lung Cancer Research  
2025;
14
(1)
:150-162
.
Efficacy and safety of first-line immunotherapy-based regimens for patients with extensive-stage small cell lung cancer: a systematic review and network meta-analysis
Wengang Zhang, Wencheng Zhao, Xinyu Zhang, Zhiyi Guo, Li Ye, Zhimin Chen, Kandi Xu, Lishu Zhao, Xinyue Liu, Yujin Liu, Hao Wang, Yayi He
Translational Lung Cancer Research  
2025;
14
(1)
:163-175
.
Association of systemic therapy with survival among adults with advanced non-small cell lung cancer
Nikki M. Carroll, Jennifer Eisenstein, Jared M. Freml, Andrea N. Burnett-Hartman, Robert T. Greenlee, Stacey A. Honda, Christine M. Neslund-Dudas, Katharine A. Rendle, Anil Vachani, Debra P. Ritzwoller
Translational Lung Cancer Research  
2025;
14
(1)
:176-193
.
The utility and feasibility of three-dimensional reconstruction in surgical planning for multiple pulmonary nodules: a prospective self-controlled study
Zhifei Li, Runze Li, Lei Liu, Peng Li, Yue Peng, Yuichi Saito, Alberto Salvicchi, Satoshi Fumimoto, Bin Qiu, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He
Translational Lung Cancer Research  
2025;
14
(1)
:194-208
.
Single-cell and spatial transcriptomics reveal a potential role of ATF3 in brain metastasis of lung adenocarcinoma
Chaoliang Xu, Jingpiao Bao, Deshen Pan, Kehong Wei, Qing Gao, Weihong Lin, Yujie Ma, Meiqing Lou, Cheng Chang, Deshui Jia
Translational Lung Cancer Research  
2025;
14
(1)
:209-223
.
MS4A15 gene expression as a prognostic marker for clinical outcomes in lung adenocarcinoma
Lingxiao Qiu, Tingcheng Li, Bin Qing, Cailin Zhao, Xinye Zhang, Satoshi Watanabe, Armida D’Incecco, Ninh M. La-Beck, Tracy L. Leong, Chuangye Wang, Jincheng Liu, Qi Li, Li Bai, Gang Liu, Xueping Liu, Zhi Xu
Translational Lung Cancer Research  
2025;
14
(1)
:224-238
.
GNGT1 remodels the tumor microenvironment and promotes immune escape through enhancing tumor stemness and modulating the fibrinogen beta chain-neutrophil extracellular trap signaling axis in lung adenocarcinoma
Lin-Lin Fan, Xiao-Wei Wang, Xiu-Mei Zhang, Zhi-Yong Wei, Hui-Yi Wu, Qin-Xin Yang, Da Fu, Ramon Andrade de Mello, Jie-Wei Lin, Hong Yu, Geng-Xi Jiang
Translational Lung Cancer Research  
2025;
14
(1)
:239-259
.
Intraoperative longitude-latitude-depth three-dimensional localization of pulmonary nodules
Yue Zhao, Jianhao Qiu, Anna Bright, Renchang Zhao, Rongyang Li, Zhanpeng Tang, Weiming Yue, Hui Tian, Zhenguo Sun
Translational Lung Cancer Research  
2025;
14
(1)
:260-271
.

Case Report

Recurrence as a small cell lung cancer transformation in a resected stage IIIA EGFR-mutated non-small cell lung cancer treated with adjuvant osimertinib: a case report
Julie Lasvergnas, Isabelle Monnet, Jean-Bernard Auliac, Gaelle Rousseau-Bussac, Christos Chouaid, Jean-Baptiste Assié
Translational Lung Cancer Research  
2025;
14
(1)
:287-291
.
Hyperthermic intrathoracic chemotherapy in overcoming tyrosine kinase inhibitor resistance in a patient with malignant pleural effusion: a case report
Xiao-Long Jiang, Wei-Hao Deng, Zhen-Yu Hu, Wei-Jie Cai, Xian-Yu Qin, Hao-Sheng Zheng, Jian Tan, Yu-Zhen Zheng, Hong-Ying Liao
Translational Lung Cancer Research  
2025;
14
(1)
:292-299
.

Letter to the Editor

Immortal time bias in survival outcomes when comparing treatment with chemotherapy versus immunochemotherapy for non-small cell lung cancer
Kaitlyn M. Tsuruda, Helga H. Hektoen, Denise Reis Costa, Bettina Kulle Andreassen
Translational Lung Cancer Research  
2025;
14
(1)
:300-302
.
Methodological aspects of studies on survival after immunotherapy in stage IV non-small cell lung cancer
Stephanie Tuminello, Matthew Untalan, Krishna Patel, Emanuela Taioli
Translational Lung Cancer Research  
2025;
14
(1)
:303-304
.