Vol 14, No 4 (April 30, 2025) - Translational Lung Cancer Research

Expert Consensus

Multidisciplinary international expert consensus on perioperative airway management

Hengrui Liang, Guowei Che, Fei Cui, Junguo Dong, Weiquan Gu, Chundong Gu, Shun Xu, Yufeng Ba, Kaican Cai, Qingdong Cao, Chang Chen, Chun Chen, Qixun Chen, Liyang Cheng, Gang Feng, Yunjiu Gou, Wenwei Guo, Jinxi He, Junming He, Jian Hu, Ying Huang, Wenxi Wang, Wenjie Jiao, Shunjun Jiang, Jun Liu, Lan Lan, Wei Li, Xiaofei Li, Zhongcheng Li, Yin Li, Zhu Liang, Hongxu Liu, Yingbin Liu, Xinyu Mei, Xicheng Song, Daqiang Sun, Hui Tian, Ziqiang Tian, Jianhua Wang, Guangsuo Wang, Xin Xu, Xudong Xiang, Guobing Xu, Tao Xue, Chao Yang, Xiaolong Yan, Nuo Yang, Feng Yao, Dalong Yin, Xiaochuan Yin, Bentong Yu, Wei Zhai, Yu Zhang, Guangjian Zhang, Xiaowen Zhang, Qiang Zhang, Yi Zhang, Jun Zhao, Haihui Zhong, Alessandro Brunelli, Till Ploenes, Luca Bertolaccini, John Kit Chung Tam, Min P. Kim, Majed Refai, Michel Gonzalez, Adam R. Dyas, Nicoletta Pia Ardò, Hiran C. Fernando, Giulio Maurizi, Gregor J. Kocher, Giuseppe Marulli, Álvaro Fuentes-Martín, Gianluca Perroni, Kyung Soo Kim, Maria Rodriguez, Marcus Taylor, Xusen Zou, Wei Wang, Jianxing He

PDF Pages: 1042-1060 Full Text (127) Peer Review File COI Form Open Access

Original Article

Deep learning model for predicting spread through air spaces of lung adenocarcinoma based on transfer learning mechanism

Jia-Ning Zhang, Zhuo-Fu Li, Sun-Yi Zheng, Jiao-Jiao Li, Lei-Na Sun, Zhao-Xiang Ye

PDF Pages: 1061-1075 Full Text (159) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Integrating radiomics and deep learning for enhanced prediction of high-grade patterns in stage IA lung adenocarcinoma

Zhongxiao Chen, Hao Liu, Hua Sun, Cheng Xu, Bingyu Hu, Luyu Qu, William C. Cho, Thivanka Witharana, Chengchu Zhu, Jianfei Shen

PDF Pages: 1076-1088 Full Text (105) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

DNA damage and repair (DDR) gene mutation profiles in driver gene wild-type advanced non-small cell lung cancer and the predictive role of response to platinum-based chemotherapy

Tianxiu Wu, Yu Xu, Qiuyue Song, Xiuqing Liao, Wei Yao, Guangsong Wang, Yu Yang, Bin Wang, Liang Guo, Mingzhou Zhang, Guoming Wu, Li Luo, Li Bai, Yan Wang, Mingdong Hu, Zhi Xu

PDF Pages: 1089-1103 Full Text (85) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Using human genetics to understand the epidemiological association between neuroticism and lung cancer

Dongsheng Wu, Yongcheng Liu, Shuqiao Liu, Xiaohu Hao, Xin Li, Quan Zheng, Tengyong Wang, Yuchen Huang, Shiyou Wei, Jian Zhou, Lunxu Liu

PDF Pages: 1104-1117 Full Text (123) Reporting Checklist Peer Review File COI Form Open Access

Development and validation of machine learning models based on molecular features for estimating the probability of multiple primary lung carcinoma versus intrapulmonary metastasis in patients presenting multiple non-small cell lung cancers

Ning Liu, Xue Li, Xu Luo, Bin Liu, Jie Tang, Fei Xiao, Weiya Wang, Yuan Tang, Pei Shu, Benxia Zhang, Yue Chen, Diyuan Qin, Qizhi Ma, Fuchun Guo, Xiaojun Tang, Daxing Zhu, Jiandong Mei, Weizhi Chen, Dan Li, Lili Jiang, Yongsheng Wang

PDF Pages: 1118-1137 Full Text (122) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Exosomal miR-182-5p is a potential diagnostic marker for malignant pleural effusion

Wen Zhao, Jian-Xun Wen, Yan Niu, Li Yan, Mei-Ying Wang, Wei Jiao, Ya-Fei Wang, Wen-Hui Gao, Dan-Ni Yang, Wen-Qi Zheng, Zhi-De Hu

PDF Pages: 1138-1148 Full Text (81) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Factors predicting early recurrence in patients with unresectable stage III non-small cell lung cancer on durvalumab consolidation after chemoradiotherapy

Ji Eun Park, Chanmi Kim, Sun Ha Choi, Jong Geol Jang, Kyung Soo Hong, Yong Shik Kwon, Keum-Ju Choi, Jung Seop Eom, Saerom Kim, Hee Yun Seol, Jehun Kim, Insu Kim, Jin Han Park, Tae Hoon Kim, June Hong Ahn

PDF Pages: 1149-1157 Full Text (97) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Comparison of the effectiveness of alectinib versus crizotinib followed by alectinib in patients with ALK-positive advanced non-small-cell lung cancer in real-world setting and in the ALEX study

Xue Yang, Yutao Liu, Gen Lin, Jinliang Wang, Yudong Wang, Yan Zhang, Qinxiang Guo, Fei Liang, Jun Zhao, Bo Jin, Xiaorong Dong

PDF Pages: 1158-1167 Full Text (87) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Integrative radiomics analysis of peri-tumoral and habitat zones for predicting major pathological response to neoadjuvant immunotherapy and chemotherapy in non-small cell lung cancer

Dan Han, Junfeng Zhao, Shaoyu Hao, Shenbo Fu, Ran Wei, Xin Zheng, Qian Zhao, Chengxin Liu, Hongfu Sun, Chengrui Fu, Zhongtang Wang, Wei Huang, Baosheng Li

PDF Pages: 1168-1184 Full Text (77) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Impact of immune-related adverse events on clinical outcomes in patients with advanced non-small cell lung cancer with low PD-L1 expression, focusing on pneumonitis: a multicenter retrospective study in Japan

Shiho Goda, Tadaaki Yamada, Kenji Morimoto, Tae Hata, Yasuhiro Goto, Akihiko Amano, Yoshiki Negi, Satoshi Watanabe, Naoki Furuya, Tomohiro Oba, Tatsuki Ikoma, Akira Nakao, Keiko Tanimura, Hirokazu Taniguchi, Akihiro Yoshimura, Tomoya Fukui, Daiki Murata, Kyoichi Kaira, Shinsuke Shiotsu, Asuka Okada, Makoto Hibino, Yusuke Chihara, Takashi Kijima, Koichi Takayama

PDF Pages: 1185-1196 Full Text (105) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Diagnostic accuracy of serum biomarkers MMP11 and SPP1 in non-small cell lung cancer: an analysis of sensitivity, specificity, and area under the curve

Minha Lea Yoon, Sang Yean Kim, Hyelim Chun, Jina Park, Woo-Jeong Seo, Jung Young Lee, Jung Hwan Yoon

PDF Pages: 1197-1211 Full Text (78) Reporting Checklist Peer Review File COI Form Open Access

Comparing neutrophil-to-lymphocyte ratio (NLR), absolute neutrophil count (ANC) and derived NLR as predictive biomarkers in first-line immunotherapy for non-small cell lung cancer: a retrospective study

Elise Longueville, Maxime Dewolf, Véronique Dalstein, Anne Durlach, Alexandre Vivien, Béatrice Nawrocki-Raby, Myriam Polette, Gaëtan Deslée, Julien Ancel

PDF Pages: 1212-1230 Full Text (80) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Efficacy and safety of finotonlimab plus docetaxel vs. docetaxel in previously treated advanced squamous cell non-small-cell lung cancer: a randomized, double-blinded, phase III trial

Baohui Han, Lin Wu, Runxiang Yang, Hongbo Wu, Wei Li, Yan Yu, Mingjuan Zhang, Hongmei Sun, Tianqing Chu, Fukuan Zhong, Yong Fang, Rong Wu, Tao Bian, Xiaoqing Guo, Meili Sun, Yanming Zhang, Lianke Liu, Xuewen Liu, Yueyin Pan, Ou Jiang, Zonghui Wei, Haifeng Lin, Wei Guo, Jian Fang, Jialei Wang, Cuimin Ding, Yanping Hu, Feng Ye, Wu Zhuang, Shucheng Ye, Lihong Wang, Zhe Huang, Chang Liu, Ling Yang, Jinling Wang, Liangzhi Xie

PDF Pages: 1231-1241 Full Text (79) Reporting Checklist Trial Protocol Data Sharing Statement Peer Review File COI Form Open Access

Metabolic tumor volume on ¹⁸F-FDG uptake as a negative predictor after ipilimumab plus nivolumab in advanced non-small cell lung cancer

Kosuke Hashimoto, Kyoichi Kaira, Atsuto Mouri, Ayako Shiono, Yu Miura, Ou Yamaguchi, Hisao Imai, Hiroshi Kagamu, Ichiei Kuji

PDF Pages: 1242-1253 Full Text (65) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prevalence of EGFR gene mutations in patients with early-stage resectable non-small cell lung cancer in Spain: the ORIGEN study

Mar Varela, Cristina Teixidó, Carlos Álvarez-Fernández, Hugo Arasanz, Sergio Peralta, Martín Lázaro, Virginia Calvo, Rosa Álvarez, Javier Baena, Javier Valdivia, Edurne Arriola, Reyes Bernabé, Dolores Isla, Carmen Camacho, Bartomeu Massutí, Ana Blasco, Teresa García, Manuel Cobo, Marc Campayo, Sara Hijazo-Pechero, Ángel Callejo, Marta Domínguez, Ernest Nadal

PDF Pages: 1254-1265 Full Text (161) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Tracheobronchial resection and reconstruction: to wrap or not to wrap the anastomosis?

Chudong Wang, Zihao Liu, Rui Wang, Biao Hu, Binbin Xiang, Zijian Li, Jianxing He, Shuben Li

PDF Pages: 1266-1273 Full Text (45) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Uniportal video-assisted thoracoscopic surgery does not increase recurrence rates following pneumonectomy in non-small cell lung cancer: a retrospective study from the National Cancer Center of China

Sikai Wu, Xiaowei Chen, Guangyu Bai, Yang Liu, Zhenlin Yang, Shugeng Gao

PDF Pages: 1274-1289 Full Text (37) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Budesonide/glycopyrronium/formoterol fumarate co-suspension metered dose inhaler relieves cough after lobectomy: a randomized controlled study

Junguo Dong, Shunjun Jiang, Yuan Qiu, Jingpei Li, Fei Cui, Hengrui Liang, Shen Lao, Zixian Xie, Jun Huang, Zhexue Hao, Huanghe He, Xin Xv, Man Zhang, Miao He, Yuan Zhang, Jianxing He, Wei Wang

PDF Pages: 1290-1300 Full Text (43) Reporting Checklist Trial Protocol Data Sharing Statement Peer Review File COI Form Open Access

Characterization of the xeno-GVHD response generated by advanced lung cancer patient peripheral blood mononuclear cells in NSG-SGM3 mice

Vered Fuchs, Laila Roisman, Maha Msamra, Yael Refaely, Aharon Yehonatan Cohen, Angel Porgador, Nir Peled, Ariel Sobarzo

PDF Pages: 1301-1319 Full Text (62) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

FOXO3a regulation of non-small cell lung cancer radiotherapy resistance through the PINK1/Parkin pathway of protective mitophagy

Xiaoting Wu, Litang Huang, Lu Meng, Shilan Luo, Paola Anna Jablonska, Chi Zhang, Anqi Zhang, Peng Li, Xiaomei Gong

PDF Pages: 1320-1339 Full Text (84) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Predictive value of the monocyte-to-high-density lipoprotein ratio in the prognosis of non-small cell lung cancer patients after surgery

Yi Liu, Wen-Long Zhang, Song-Ping Cui, Aimée J. P. M. Franssen, Erik R. de Loos, Yuichiro Ueda, Takahiro Homma, James Shahoud, Qing Zhao, Yang Gu, Yi-Li Fu, Bin Hu

PDF Pages: 1340-1350 Full Text (58) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

LNCAROD was stabilized through N⁶-methyladenosine methylation and exerted its anticancer effects in lung squamous cell carcinoma by inhibiting SIRT1 activity via CCAR2

Qihang Yan, Wingshing Wong, Jinsong Lei, Dachuan Liang, Jie Yang, Li Gong, Rossana Berardi, Shuqin Dai, Junye Wang

PDF Pages: 1351-1370 Full Text (60) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Efficacy and safety of anlotinib plus EGFR tyrosine kinase inhibitors in slow- or locally progressing non-small cell lung cancer after adjuvant therapy

Jiayue Ye, Jiacong Liu, Yucheng Ma, Wang Lv, Wenzhen Xu, Masaya Aoki, Yuhong Yang, Pinghui Xia, Luming Wang, Linhai Zhu, Jian Hu

PDF Pages: 1371-1383 Full Text (62) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Clinical implication of tumor spread through air spaces in stage IA lung adenocarcinoma: prognostic impact and association with the International Association for the Study of Lung Cancer (IASLC) grade

Jinghan Shi, Kuan Xu, Xufeng Liu, Martin P. Barr, Jeffrey B. Velotta, Ninh M. La-Beck, Chenxi Zhong, Feng Yao

PDF Pages: 1384-1394 Full Text (54) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Identification and validation of diagnostic alternative splicing events in tumor-educated platelets for non-small cell lung cancer in patients with ground-glass opacity: a multicenter study

Mengqi Shao, Wanwen Li, Jieming Cao, Li Wang, Shenglong Xie, Yan Hu, Gang Feng, Feredun Azari, Luca Bertolaccini, Wenliang Liu, Bin He

PDF Pages: 1395-1407 Full Text (68) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Effect of the number of induction chemotherapy cycles on the efficacy of first-line atezolizumab combined with chemotherapy in extensive-stage small cell lung cancer

Mengxing You, Jiayu Liu, Fei Teng, Lige Wu, Haifeng Qin, Yan Zhang, Cuiying Zhang, Ziling Liu, Kewei Ma, Esteban C. Gabazza, Jacopo Vannucci, Xuezhi Hao, Junling Li, Puyuan Xing

PDF Pages: 1408-1417 Full Text (62) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access