Home - Translational Lung Cancer Research

Reviewer of the Month (2025)

In 2025, TLCR reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Join us at the 105th Annual Meeting of American Association for Thoracic Surgery (AATS)

The 105th Annual Meeting of American Association for Thoracic Surgery (AATS) is going to be held at the Seattle Convention Center, Seattle, WA, USA from May 2 to 5, 2025: https://events.aats.org/am25.

As the world's most prestigious thoracic surgery event, the annual meeting of AATS helps grow one’s expertise, network with leading experts, and build the future of thoracic surgery.

This year Translational Lung Cancer Research (TLCR) as well as its sister journals and books published by AME Publishing Company will be on display during this exciting academic event! We would like to seize this great opportunity to meet our authors, editorial board members and readers.

TLCR Annual Report 2024

Welcome to the 2024 annual report for Translational Lung Cancer Research. In 2024, the TLCR has continued its mission to increase the quality and impact of the journal, and to provide readers with a novel, well-organized, informative, enlightening and educational journal.

We would like to sincerely thank our Editorial Board Members, Guest editors, Reviewers, Authors, Readers for all your supports and contributions to TLCR in 2024, and we look forward to continuing our work with you in the new year.

Interviews with Editorial Board Members

TLCR features a distinguished editorial board, the members of which continue to instill the power of their expertise for the journal’s development. By launching this column, we are glad to introduce to you some of them in the form of interviews, in which they will share their unique career experiences and perspectives. We believe their insights will shed light on the knowledge of related fields.

Interviews with Guest Editors

Over the years, a number of TLCR guest editors have made valuable contributions to the journal. This column features interviews with our guest editors, who graciously share their experience in scientific careers and provide insightful perspectives on the special series.

New Impact Factor for Translational Lung Cancer Research: 4

We are pleased to announce that the Translational Lung Cancer Research (TLCR) has attained its latest impact factor update for the 2023 citation year: 4.

Translational Lung Cancer Research 2023 CiteScore Released: 7.2

We are pleased to announce that the Translational Lung Cancer Research (TLCR) has received its 2023 CiteScore: 7.2, ranking 92 out of 404 journals in the Oncology category.

Furthermore, we are delighted to highlight the remarkable achievements made by all AME journals in the CiteScore ranking.

Interviews with Outstanding Authors (2024)

In 2024, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors, with a brief interview of their thoughts and insights as authors. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

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Vol 14, No 1 (January, 2025)

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Editorial Commentary

Lorlatinib in frontline treatment of advanced ALK-positive non-small cell lung cancer: a highly efficient new standard of care but still challenging to manage

Mylène Wespiser, Aurélie Swalduz, Maurice Pérol

PDF Pages: 1-6 Full Text (274) Peer Review File COI Form Open Access

Advancing leptomeningeal metastases treatment in EGFR-mutated non-small cell lung cancer: lessons from the BLOSSOM trial

Martina Bortolot, Jarno W. J. Huijs, Dieta Brandsma, Annette Compter, Robin M. J. M. van Geel, Lizza E. L. Hendriks

PDF Pages: 7-13 Full Text (425) Peer Review File COI Form Open Access

Original Article

Lobectomy plus lobe-specific lymphadenectomy as the minimum standards of curative resection for hypermetabolic clinical stage IA non-small cell lung cancer

Runze Li, Zhifei Li, Peng Li, Jianchuan Chen, Bin Qiu, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He

PDF Pages: 14-26 Full Text (334) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Patient-reported outcomes in the early postoperative period following resection of unilateral multiple pulmonary nodules: implications for surgical decision-making

Qian Hong, Hang Yi, Yan Wang, Wenqi Li, Chang Zhan, Shuai Zhu, Ding Yang, Rui Han, Guochao Zhang, Juwei Mu

PDF Pages: 27-39 Full Text (225) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Anlotinib enhances the anti-tumor activity of osimertinib in patients with non-small cell lung cancer by reversing drug resistance

Xin Hua, Xiaodi Wu, Liting Lv, Yanli Gu, Suhua Zhu, Xin Liu, Tangfeng Lv, Yong Song

PDF Pages: 40-57 Full Text (347) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Video-assisted mediastinocopic lymphadenectomy (VAMLA) for restaging clinical N2–3 non-small cell lung cancer (NSCLC) after neoadjuvant treatment

Nina Reig-Oussedik, Sergi Call, Carme Obiols, Bruno Garcia-Cabo, José Sanz-Santos, Lucía Reyes Cabanillas-Paredes, Juan Manuel Ochoa-Alba, Mireia Serra-Mitjans, Ramón Rami-Porta

PDF Pages: 58-71 Full Text (Video) (390) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Association between immunotherapy timing and efficacy in non-small cell lung cancer: a comprehensive analysis at a high-volume specialist centre

Igor Gomez-Randulfe, Mark Pearce, Daniel Netto, Rebecca Ward, Raffaele Califano

PDF Pages: 72-80 Full Text (238) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A novel optimization of cone beam CT frequency for lung radiation therapy based on an image-guided radiation therapy protocol and patient classification method

Jinghao Zhou, Arun Gopal, Baoshe Zhang, Huijun Xu, Shifeng Chen, ByongYong Yi, Giovanni Lasio

PDF Pages: 81-95 Full Text (209) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Clinical features and outcomes of unresectable locally advanced lung adenocarcinoma with uncommon EGFR mutations: a retrospective multi-center Chinese study

Kunpeng Xu, Xiao-Li Zheng, Ming Chen, Mingyan E, Li Zhang, Jianzhong Cao, Xu Zhang, Xiao Ding, Bing Xia, Lujun Zhao, Hongbin Wang, Jiancheng Li, Chen Hu, Wei Jiang, Hong Ge, Nan Bi, Luhua Wang

PDF Pages: 96-106 Full Text (272) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

SMARCA4/BRG1-deficient non-small cell lung cancer: clinical, imaging, pathological features, and follow-up results of 23 patients

Xieraili Wumener, Xiaoxing Ye, Yarong Zhang, Tuya E, Jiuhui Zhao, Ying Liang, Jun Zhao

PDF Pages: 107-123 Full Text (290) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Potential utility of miRNAs derived from pleural fluid extracellular vesicles to differentiate between benign and malignant pleural effusions

Tian Mun Chee, Caeli J. Zahra, Kwun M. Fong, Ian A. Yang, Rayleen V. Bowman

PDF Pages: 124-138 Full Text (309) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Efficacy of adjuvant tegafur-uracil (UFT) in early-stage non-small cell lung cancer with poor prognostic factors

Takuya Watanabe, Masayuki Tanahashi, Eriko Suzuki, Naoko Yoshii, Takuya Kohama, Kensuke Iguchi, Takumi Endo

PDF Pages: 139-149 Full Text (265) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Deep learning-based lung cancer risk assessment using chest computed tomography images without pulmonary nodules ≥8 mm

Su Yang, Sang-Heon Lim, Jeong-Ho Hong, Jae Seok Park, Jonghong Kim, Hae Won Kim

PDF Pages: 150-162 Full Text (369) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Efficacy and safety of first-line immunotherapy-based regimens for patients with extensive-stage small cell lung cancer: a systematic review and network meta-analysis

Wengang Zhang, Wencheng Zhao, Xinyu Zhang, Zhiyi Guo, Li Ye, Zhimin Chen, Kandi Xu, Lishu Zhao, Xinyue Liu, Yujin Liu, Hao Wang, Yayi He

PDF Pages: 163-175 Full Text (326) Reporting Checklist Peer Review File COI Form Open Access

Association of systemic therapy with survival among adults with advanced non-small cell lung cancer

Nikki M. Carroll, Jennifer Eisenstein, Jared M. Freml, Andrea N. Burnett-Hartman, Robert T. Greenlee, Stacey A. Honda, Christine M. Neslund-Dudas, Katharine A. Rendle, Anil Vachani, Debra P. Ritzwoller

PDF Pages: 176-193 Full Text (281) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

The utility and feasibility of three-dimensional reconstruction in surgical planning for multiple pulmonary nodules: a prospective self-controlled study

Zhifei Li, Runze Li, Lei Liu, Peng Li, Yue Peng, Yuichi Saito, Alberto Salvicchi, Satoshi Fumimoto, Bin Qiu, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He

PDF Pages: 194-208 Full Text (229) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Single-cell and spatial transcriptomics reveal a potential role of ATF3 in brain metastasis of lung adenocarcinoma

Chaoliang Xu, Jingpiao Bao, Deshen Pan, Kehong Wei, Qing Gao, Weihong Lin, Yujie Ma, Meiqing Lou, Cheng Chang, Deshui Jia

PDF Pages: 209-223 Full Text (353) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

MS4A15 gene expression as a prognostic marker for clinical outcomes in lung adenocarcinoma

Lingxiao Qiu, Tingcheng Li, Bin Qing, Cailin Zhao, Xinye Zhang, Satoshi Watanabe, Armida D’Incecco, Ninh M. La-Beck, Tracy L. Leong, Chuangye Wang, Jincheng Liu, Qi Li, Li Bai, Gang Liu, Xueping Liu, Zhi Xu

PDF Pages: 224-238 Full Text (279) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

GNGT1 remodels the tumor microenvironment and promotes immune escape through enhancing tumor stemness and modulating the fibrinogen beta chain-neutrophil extracellular trap signaling axis in lung adenocarcinoma

Lin-Lin Fan, Xiao-Wei Wang, Xiu-Mei Zhang, Zhi-Yong Wei, Hui-Yi Wu, Qin-Xin Yang, Da Fu, Ramon Andrade de Mello, Jie-Wei Lin, Hong Yu, Geng-Xi Jiang

PDF Pages: 239-259 Full Text (532) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Intraoperative longitude-latitude-depth three-dimensional localization of pulmonary nodules

Yue Zhao, Jianhao Qiu, Anna Bright, Renchang Zhao, Rongyang Li, Zhanpeng Tang, Weiming Yue, Hui Tian, Zhenguo Sun

PDF Pages: 260-271 Full Text (206) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Case Report: iMDT Corner

Reirradiation using helical tomotherapy-based hypofractionated stereotactic radiotherapy for 19 brain metastases after the second recurrence of distant brain failure: a case report and literature review

Tao Wang, Hongfu Zhao, Rafal Suwinski, Guanghui Cheng, Wei Guan

PDF Pages: 272-286 Full Text (271) Reporting Checklist Peer Review File COI Form Open Access

Case Report

Recurrence as a small cell lung cancer transformation in a resected stage IIIA EGFR-mutated non-small cell lung cancer treated with adjuvant osimertinib: a case report

Julie Lasvergnas, Isabelle Monnet, Jean-Bernard Auliac, Gaelle Rousseau-Bussac, Christos Chouaid, Jean-Baptiste Assié

PDF Pages: 287-291 Full Text (377) Reporting Checklist Peer Review File COI Form Open Access

Hyperthermic intrathoracic chemotherapy in overcoming tyrosine kinase inhibitor resistance in a patient with malignant pleural effusion: a case report

Xiao-Long Jiang, Wei-Hao Deng, Zhen-Yu Hu, Wei-Jie Cai, Xian-Yu Qin, Hao-Sheng Zheng, Jian Tan, Yu-Zhen Zheng, Hong-Ying Liao

PDF Pages: 292-299 Full Text (Video) (276) Reporting Checklist Peer Review File COI Form Open Access

Letter to the Editor

Immortal time bias in survival outcomes when comparing treatment with chemotherapy versus immunochemotherapy for non-small cell lung cancer

Kaitlyn M. Tsuruda, Helga H. Hektoen, Denise Reis Costa, Bettina Kulle Andreassen

PDF Pages: 300-302 Full Text (218) COI Form Open Access

Methodological aspects of studies on survival after immunotherapy in stage IV non-small cell lung cancer

Stephanie Tuminello, Matthew Untalan, Krishna Patel, Emanuela Taioli

PDF Pages: 303-304 Full Text (213) COI Form Open Access

Review Articles

Management of ground-glass opacities: should all pulmonary lesions with ground-glass opacity be surgically resected?

Yoshihisa Kobayashi, Tetsuya Mitsudomi

Published online: 22 October 2013

PDF Pages: 354-363 Full Text (338256) Open Access

Editorial Commentary

Ground glass nodules with 5 years’ stability can grow after 10-year follow-up: do genetic features determine the fate?

Yoshihisa Kobayashi, Tetsuya Mitsudomi

Published online: 31 December 2019

PDF Pages: S425-S427 Full Text (80156) Open Access

Review Article

Non-small cell lung cancer: current treatment and future advances

Cecilia Zappa, Shaker A. Mousa

Published online: 30 June 2016

PDF Pages: 288-300 Full Text (75490) Open Access

Review Articles

Irreversible EGFR-TKIs: dreaming perfection

Lorenza Landi, Federico Cappuzzo

Published online: 14 January 2013

PDF Pages: 40-49 Full Text (69918) Open Access

Review Article

Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Jian-Wei Gao, Stefania Rizzo, Li-Hong Ma, Xiang-Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia-Wei Zou, Qian Li, Marco Femia, Tang-Feng Lv, Yong Song, written on behalf of the AME Lung Cancer Collaborative Group

Published online: 28 February 2017

PDF Pages: 68-75 Full Text (57882) Open Access

Review Article

Recurrence after surgery in patients with NSCLC

Hidetaka Uramoto, Fumihiro Tanaka

Published online: 28 August 2014

PDF Pages: 242-249 Full Text (45824) Open Access

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future

Bryan A. Chan, Brett G.M. Hughes

Published online: 24 February 2015

PDF Pages: 36-54 Full Text (42523) Open Access

Review Article

Lung cancer prediction using machine learning and advanced imaging techniques

Timor Kadir, Fergus Gleeson

Published online: 14 June 2018

PDF Pages: 304-312 Full Text (42278) Open Access

Review Article

Treatment of uncommon EGFR mutations in non-small cell lung cancer: new evidence and treatment

Tianli Zhang, Bing Wan, Yuan Zhao, Chuling Li, Hongbing Liu, Tangfeng Lv, Ping Zhan, Yong Song

Published online: 30 June 2019

PDF Pages: 302-316 Full Text (41000) Open Access

Review Article

The past, present and future of immunotherapy against tumor

Tao Jiang, Caicun Zhou

Published online: 24 June 2015

PDF Pages: 253-264 Full Text (39281) Open Access

Review Article

Ground-glass nodules of the lung in never-smokers and smokers: clinical and genetic insights

Yoshihisa Kobayashi, Chiara Ambrogio, Tetsuya Mitsudomi

Published online: 28 August 2018

PDF Pages: 487-497 Full Text (35636) Chinese (4585) Open Access

Review Article

The epidemiology of lung cancer

Patricia M. de Groot, Carol C. Wu, Brett W. Carter, Reginald F. Munden

Published online: 14 June 2018

PDF Pages: 220-233 Full Text (32456) Open Access

Review Articles

KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach

Javier de Castro Carpeño, Cristóbal Belda-Iniesta

Published online: 03 April 2013

PDF Pages: 142-151 Full Text (32282) Open Access

Review Article

Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey

Jeffrey P. Gregg, Tianhong Li, Ken Y. Yoneda

Published online: 30 June 2019

PDF Pages: 286-301 Full Text (31634) Open Access

Review Article

Lung cancer screening: nodule identification and characterization

Ioannis Vlahos, Konstantinos Stefanidis, Sarah Sheard, Arjun Nair, Charles Sayer, Joanne Moser

Published online: 14 June 2018

PDF Pages: 288-303 Full Text (31537) Open Access

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung

Yoon Jin Cha, Hyo Sup Shim

Published online: 11 October 2017

PDF Pages: 508-512 Full Text (31380) Open Access

Consensus

Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou)

Jianxing He, Hengrui Liang, Wei Wang, Andrey Akopov, Alberto Aiolfi, Keng-Leong Ang, Luca Bertolaccini, Kaican Cai, Qingdong Cao, Baojun Chen, Chang Chen, Chun Chen, Donglai Chen, Fengxia Chen, Jun Chen, Lei Chen, Mingwu Chen, Yongbing Chen, Zhuxing Chen, Chao Cheng, Dong Cui, Fei Cui, Tianyang Dai, Qinglong Dong, Paolo A. Ferrari, Raja M. Flores, Junke Fu, Soichiro Funaki, Marios E. Froudarakis, Xiangfeng Gan, Mingfei Geng, Jialong Guo, Qiang Guo, Yongtao Han, Jintao He, Kaiming He, Kyoji Hirai, Jian Hu, Shuqiao Hu, Jian Huang, Jun Huang, Wenfa Jiang, Kyung Soo Kim, Gabor Kiss, Fanyi Kong, Lan Lan, Xuefeng Leng, Bin Li, Gaofeng Li, Hecheng Li, Hefei Li, Heng Li, Jiwei Li, Xiaoqiang Li, Shuben Li, Yinfen Li, Zhuoyi Li, Yi Liang, Lixia Liang, Wenhua Liang, Yongde Liao, Wanli Lin, Xu Lin, Hongxu Liu, Hui Liu, Jixian Liu, Jun Liu, Xiang Liu, Zihao Liu, Xingzhao Lu, Qingquan Luo, Naiquan Mao, Qi Pan, Dazhi Pang, Jun Peng, Jun Peng, Eugenio Pompeo, Rulin Qian, Kun Qiao, Bassam Redwan, Zi Sang, Wenlong Shao, Jianfei Shen, Weiyu Shen, Sook-Whan Sung, Wenfang Tang, Tianhu Wang, Guangsuo Wang, Haitao Wang, Huien Wang, Jiyong Wang, Wen Wang, Yongyong Wang, Zhenyuan Wang, Li Wei, Wei Wei, Hao Wu, Jie Wu, Zhaohua Xia, Chenyang Xu, Enwu Xu, Hai Xu, Ning Xu, Quan Xu, Rongyu Xu, Shun Xu, Chaokun Yang, Hanyu Yang, Shengli Yang, Jun Yi, Guangjian Zhang, Hao Zhang, Jia Zhang, Man Zhang, Xiao Zhang, Yajie Zhang, Zhe Zhang, Zhifeng Zhang, Honglin Zhao, Jian Zhao, Xiaodong Zhao, Jianping Zhou, Yanran Zhou, Chengchu Zhu, Shaojin Zhu, Xinhai Zhu, Jian Cui, Yubo Yan, Ke-Neng Chen

Published online: 28 August 2021

PDF Pages: 3503-3519 Full Text (29544) COI Form Open Access

Review Articles

New TNM classification: achievements and hurdles

Peter Goldstraw

Published online: 17 August 2013

PDF Pages: 264-272 Full Text (28829) Open Access

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer

Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto

Published online: 19 April 2015

PDF Pages: 156-164 Full Text (28749) Open Access

Review Articles

Angiogenesis in cancer: anti-VEGF escape mechanisms

Gerald W. Prager, Marina Poettler, Matthias Unseld, Christoph C. Zielinski

Published online: 18 February 2012

PDF Pages: 14-25 Full Text (28441) Open Access

Full Most Read article list >>

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis

Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song

BRAF mutations in non-small cell lung cancer

Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper

The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer

Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper

Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice

Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song

Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer

Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song

Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer

Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen

The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants

Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden

The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices

Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer

Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto

Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement

Hyojin Kim, Jin-Haeng Chung

Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer

Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu

Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review

Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao

Clinical trials for lung cancer in China

Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu

Recurrence after surgery in patients with NSCLC

Hidetaka Uramoto, Fumihiro Tanaka

Prognostic markers in lung cancer: is it ready for prime time?

Chang-Qi Zhu, Ming-Sound Tsao

Potential biomarkers for lung cancer screening

Gabriella Sozzi, Mattia Boeri

Particle therapy in non-small cell lung cancer

Zhongxing Liao, Charles B. Simone II

Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions

Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai

Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer

Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft

Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors

Suchit H. Patel, Andreas Rimner, Roger B. Cohen

Intraoperative near-infrared imaging of mesothelioma

Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal

BAP1, a tumor suppressor gene driving malignant mesothelioma

Mitchell Cheung, Joseph R. Testa

Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation

Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh

Diagnostic and prognostic biomarkers for malignant mesothelioma: an update

Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang

Immunotherapy for malignant pleural mesothelioma: current status and future directions

Jordan Dozier, Hua Zheng, Prasad S. Adusumilli

Biology and clinical significance of circulating tumor cell subpopulations in lung cancer

Linda O’Flaherty, Harriet Wikman, Klaus Pantel

Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?

Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace

Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer

Sumitra Mohan, Francesca Chemi, Ged Brady

Biophysical technologies for understanding circulating tumor cell biology and metastasis

Derrick W. Su, Jorge Nieva

Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer

Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno

Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer

Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Editorial

An alternative way to initiate Notch1 signaling in non-small cell lung cancer

Yi-Lin Yang, David Jablons, Liang You

Combination MET- and EGFR-directed therapy in MET-overexpressing non-small cell lung cancers: time to move on to better biomarkers?

Fernando C. Santini, Siddharth Kunte, Alexander Drilon

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis

Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

China Lung Cancer Research Highlight

Dll4/Notch1 signaling from tip/stalk endothelial cell specification to stroma-dependent lung tumor inhibition: a flavor of Dll4/Notch1 pleiotropy in tumor cell biology

Maria Felice Brizzi, Paola Defilippi

Editorials

Dulanermin in cancer therapy: Still much to do

Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data

Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner

Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung

Pedro Mendez, Jose Luis Ramirez

Role of HGF/MET axis in resistance of lung cancer to contemporary management

Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr

Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review

Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Ceritinib

Clinical development and approval of second generation ALK inhibitors for ALK rearranged lung cancer

Daniel B. Costa

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack

Lorenza Landi, Federico Cappuzzo

Nivolumab

Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients with advanced non-small cell lung cancer

Arun Rajan, James L. Gulley

Brief Report

The role of Imaging and Radiation Oncology Core for precision medicine era of clinical trial

Ying Xiao, Mark Rosen

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung

Yoon Jin Cha, Hyo Sup Shim

Immunohistochemistry for predictive biomarkers in non-small cell lung cancer

Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

Original Article

Clinical application of three-dimensional reconstruction in anatomical analysis of the right anterior, lateral, and posterior basal segments (RS8, RS9, and RS10) for RS9 segmentectomy

Jiafu Zhu, Sui Chen, Yukang Lin, Jiangshan Huang, Marcus Taylor, Junji Ichinose, Yeon Wook Kim, Zihao Zheng, Jinyang Shi, Litao Yang, Jiangbo Lin

Published online: 21 February 2025

Case Report

Novel LZTR1 germline mutation as a mechanism of resistance to osimertinib in EGFR-mutated lung adenocarcinoma: a case report

Wai Park, Jeremy Fricke, Isa Mambetsariev, Giovanny Velasquez, Reza Nadaf-Rahrov, Shaira Therese Dingal, Pauline Kim, Razmig Babikian, Arya Amini, Michelle Afkhami, Ravi Salgia

Published online: 18 February 2025

Editorial Commentary

Will “Sun”-WUKONG, the monkey king, conquer EGFR exon 20 insertion mutation positive non-small cell lung cancer?

Molly Li, Ross A. Soo

Published online: 18 February 2025

Review Article

Lung cancer organoids: a new strategy for precision medicine research

Yuan Meng, Xinyi Shu, Jie Yang, Yangyueying Liang, Meiying Zhu, Xuerui Wang, Yue Li, Fanming Kong

Published online: 18 February 2025

Original Article

Real-world comparison of neoadjuvant pembrolizumab plus chemotherapy versus tislelizumab plus chemotherapy in patients with resectable non-small cell lung cancer: a retrospective cohort study of treatment outcomes

Yan Hu, Siying Ren, Juan Feng, Chao Zeng, Lulu Yang, Jinyou Liu, Fang Wu, Wenliang Liu

Published online: 14 February 2025

Original Article

Immunotherapy efficacy between exon 19 deletion and exon 21 L858R mutation in advanced EGFR mutant non-small-cell lung cancer: a direct and indirect meta-analysis

Zihong Chen, Lanlan Pang, Yuwen Yang, Xinyi He, Jianhua Zhan, Lin Zhang, Kangqiao Xiong, Wenfeng Fang, Li Zhang, Yaxiong Zhang

Published online: 12 February 2025

Original Article

Comparison of metastasis and treatment patterns among different histopathologic types of lung cancer: analysis of 6 years of nationwide lung cancer cohort data in Korea

Jeong Uk Lim, Kyu Yean Kim, Ho Cheol Kim, Tae-Jung Kim, Hong Kwan Kim, Mi Hyoung Moon, Kyongmin Sarah Beck, Yang Gun Suh, Chang Hoon Song, Jin Seok Ahn, Jeong Eun Lee, Jae Hyun Jeon, Chi Young Jung, Jeong Su Cho, Yoo Duk Choi, Seung Sik Hwang, Young Sik Park, Soon Ho Yoon, Joon Young Choi, Chang-Min Choi, Seung Hun Jang; Korean Association for Lung Cancer; Korea Central Cancer Registry

Published online: 21 January 2025

Journal Highlight more

Translational Lung Cancer Research is an international, peer-reviewed, open-access journal indexed by Science Citation Index Expanded (SCIE) and PubMed/PubMed Central, focusing on cutting-edge development on the transition from preclinical to clinical research, including but not limited to multimodality therapy, markers, imaging, tumor biology, pathology, chemoprevention, and technical advances related to lung cancer and relevant thoracic diseases.